A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome
Abstract
PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with (n=80) and without (n=27) PCOS were assessed in a cross-sectional study. End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers [hsCRP (high-sensitivity C-reactive protein)] and endothelial function [FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor)]. Women with PCOS had elevated HOMA-IR (4.1±3.4 compared with 1.9±1.4), free androgen index (9.3±5.6 compared with 4.6±3.8), total cholesterol (5.2±1.0 compared with 4.7±0.9 mmol/l) and triacylglycerols (triglycerides; 1.4±0.7 compared with 0.9±0.3 mmol/l) (P<0.05 for all), but similar hsCRP compared with women without PCOS. With regard to endothelial function, women with PCOS had elevated ADMA (1.0±0.4 compared 0.3±0.1 μmol/l, P<0.001) and PAI-1 (5.6±1.8 compared with 4.6±1.1 units/ml, P=0.006), a trend towards worsened FMD (11.8±5.0 compared with 13.5±4.0%, P=0.075) and no difference in vWF compared with controls. For all subjects, ADMA (P=0.002) and PAI-1 (P<0.001) were increased with higher tertiles of HOMA-IR. Women with PCOS are hyperandrogenic, dyslipidaemic and have IR, and have risk factors for CVD and diabetes including increased circulating markers of endothelial function (ADMA and PAI-1) and a trend towards worse FMD as a global marker of endothelial function. In PCOS, deterioration in endothelial function is related to IR, hyperandrogenism and other factors.
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In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD have been noted and are related to IR and obesity.
“In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD 29,30,83 have been noted and are related to IR and obesity. 84-89”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [83]
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- Authors
- Moran, L. J., Hutchison, S. K., Meyer, C., Zoungas, S., & Teede, H. J.
- Affiliations
- Jean Hailes (AU)
- Diabetes Unit, Southern Health, Melbourne 3168, Australia
- Corresponding author
- Zoungas, Sophia
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2009-04-15
- Volume
- 116
- Issue
- 10
- Pages
- 761-770
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2011413643
- Cited by
- 59
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- European Society of Human Reproduction and Embryology
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- polycystic ovary syndrome, endothelial dysfunction, insulin resistance, overweight women, asymmetric dimethylarginine, plasminogen activator inhibitor-1, flow-mediated dilation, von Willebrand factor, C-reactive protein, hyperandrogenism, dyslipidemia, cardiovascular risk, type 2 diabetes risk, HOMA-IR, adiponectin
- MeSH terms
- Adult, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Endothelium, Vascular, Female, Humans, Polycystic Ovary Syndrome, Regression Analysis, Biomarkers, Overweight
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