Cited by 939SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesCOVID-19 Clinical Research Studies

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness.

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Sheikh, Aziz, McMenamin, Jim, Taylor, Bob, Robertson, Chris·2021·The Lancet

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Crossref · 10.1016/s0140-6736(21)01358-1

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  • Observational postmarketing studies, including this analysis, have consistently demonstrated a strong association between vaccination and risk reductions in COVID-19 hospitalization in immunocompetent individuals.

    “Observational postmarketing studies, including this analysis, have consistently demonstrated a strong association between vaccination and risk reductions in COVID-19 hospitalization in immunocompetent individuals, suggesting that the high efficacy observed in mRNA clinical trials translates into beneficial effects in the community setting.2,3,10”
  • In case-control studies from the UK, the BNT162b vaccine was approximately 85% effective for the Delta variant whereas the AZD1222 vaccine was approximately 60% effective.

    “In case-control studies from the UK, the BNT162b vaccine was approximately 85% effective for the Delta variant whereas the AZD1222 vaccine was approximately 60% effective 232,233 .”
  • Clinical studies have reported somewhat reduced efficacy and effectiveness against the B.1.1.7, B.1.351, and B.1.617.2 variants.

    “Likewise, clinical studies have reported somewhat reduced efficacy and effectiveness against the B.1.1.7, B.1.351, and B.1.617.2 variants (10–12).”
  • Current vaccines might be less protective against symptomatic infection with some SARS-CoV-2 variants, and several studies have now shown reduced efficacy of vaccination against infection with SARS-CoV-2 variants.

    “Initial reports from clinical trials or from breakthrough community infections suggest that current vaccines might be less protective against symptomatic infection with some SARS-CoV-2 variants.5, 6”

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Authors
Sheikh, A., McMenamin, J., Taylor, B., & Robertson, C.
Affiliations
  • University of Edinburgh (GB)
  • Public Health Scotland (GB)
Corresponding author
Sheikh, Aziz
Venue
The Lancet
Publisher
Elsevier BV
Published
2021-06
Volume
397
Issue
10293
Pages
2461-2462
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W3171654353
Cited by
939
References
7
Citations by year
2026: 10 · 2025: 28 · 2024: 61 · 2023: 141 · 2022: 411 · 2021: 288
FWCI
71.42
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
Delta variant, COVID-19 pandemic, hospitalization risk, vaccine effectiveness, demographic factors, Alpha variant, Scotland
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, Aged, Child, Child, Preschool, Humans, Patient Admission, Population Surveillance, Scotland, Vaccination

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