Cited by 687Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Cai, Hua, Griendling, Kathy K, Harrison, David G·2003·Trends in Pharmacological Sciences

DOI 10.1016/s0165-6147(03)00233-5

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Abstract

Activation of vascular NAD(P)H oxidases and the production of reactive oxygen species (ROS) by these enzyme systems are common in cardiovascular disease. In the past several years, a new family of NAD(P)H oxidase subunits, known as the non-phagocytic NAD(P)H oxidase (NOX) proteins, have been discovered and shown to play a role in vascular tissues. Recent studies make clearer the mechanisms of activation of the endothelial and vascular smooth muscle NAD(P)H oxidases. ROS produced following angiotensin II-mediated stimulation of NAD(P)H oxidases signal through pathways such as mitogen-activated protein kinases, tyrosine kinases and transcription factors, and lead to events such as inflammation, hypertrophy, remodeling and angiogenesis. Studies in mice that are deficient in p47(phox) and gp91(phox) (also known as NOX2) NAD(P)H oxidase subunits show that ROS produced by these oxidases contribute to cardiovascular diseases including atherosclerosis and hypertension. Recently, efforts have been devoted to developing inhibitors of NAD(P)H oxidases that will provide useful experimental tools and might have therapeutic potential in the treatment of human diseases.

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Authors: Cai, H., Griendling, K. K., & Harrison, D. G.
Affiliations: Emory University (US)
Corresponding author: Harrison, David G
ORCID: Cai, Hua
Griendling, Kathy K
Harrison, David G
Venue: Trends in Pharmacological Sciences
Publisher: Elsevier BV
Published: 2003-09
Volume: 24
Issue: 9
Pages: 471-478
ISSN: 0165-6147 (ISSN-L)
DOI: 10.1016/s0165-6147(03)00233-5
OpenAlex: W2000155150
Cited by: 687
References: 84
Citations by year: 2026: 6 · 2025: 5 · 2024: 13 · 2023: 3 · 2022: 9 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 26 · 2015: 25 · 2014: 32 · 2013: 35 · 2012: 47
FWCI: 8.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Pharmacological Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, reactive oxygen species, cardiovascular disease, p47phox, gp91phox, NOX2, angiotensin II, vascular smooth muscle, atherosclerosis, hypertension, therapeutic target, inflammation, vascular remodeling, angiogenesis
MeSH terms: Angiotensin II, Animals, Blood Vessels, Cardiovascular Agents, Cardiovascular Diseases, Enzyme Activation, Humans, Reactive Oxygen Species, NADPH Oxidases, Mice

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The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

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