Radial glia cells in the developing human brain
Open accessAbstract
Human radial glia (RG) share many of the features described in rodents, but also have a number of characteristics unique to the human brain. Results obtained from different mammalian species including human and non-human primates reveal differences in the involvement of RG in neurogenesis and oligodendrogenesis and in the timing of the initial expression of typical RG immunomarkers. A common problem in studying the human brain is that experimental procedures using modern molecular and genetic methods, such as in vivo transduction with retroviruses or creation of knockout or transgenic mutants, are not possible. Nevertheless, abundant and valuable information about the development of the human brain has been revealed using postmortem human material. Additionally, a combination and spectrum of in vitro techniques are used to gain knowledge about normal developmental processes in the human brain, including better understanding of RG as progenitor cells. Molecular and functional characterization of multipotent progenitors, such as RG, is important for future cell replacement therapies in neurological and psychiatric disorders, which are often resistant to conventional treatments. The protracted time of development and larger size of the human brain could provide insight into processes that may go unnoticed in the much smaller rodent cortex, which develops over a much shorter period. With that in mind, we summarize results on the role of RG in the human fetal brain.
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Astrocytes with mature-like morphological characteristics are observed as early as 15 postconceptional weeks.
“Astrocytes with mature-like morphological characteristics are observed as early as 15 pcw (Choi and Lapham, 1978; Howard et al., 2008).”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Howard et al., 2008
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- Authors
- Howard, B. M., Mo, Z., Filipovic, R., Moore, A. R., Antic, S. D., & Zecevic, N.
- Affiliations
- Weill Cornell Medicine (US)
- UConn Health (US)
- Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut,
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2007-11-16
- Volume
- 14
- Issue
- 5
- Pages
- 459-473
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- PMC
- PMC2702478
- OpenAlex
- W2169432354
- Cited by
- 97
- References
- 131
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS041489)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- radial glia, human brain development, neurogenesis, oligodendrogenesis, multipotent progenitors, human fetal brain, postmortem brain, cell replacement therapy
- MeSH terms
- PAX6 Transcription Factor, Animals, Brain, Eye Proteins, Fetus, Humans, Nerve Tissue Proteins, Neuroglia, Neurons, Repressor Proteins, Species Specificity, Biomarkers, Homeodomain Proteins, Body Patterning, Paired Box Transcription Factors, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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