Genetic topography of brain morphology
Open accessAbstract
Significance: How diverse functional cortical regions develop is an important neuroscience question. Animal experiments show that regional differentiation is controlled by genes that express in a graded and regionalized pattern; however, such investigation in humans is scarce. Using noninvasive imaging techniques to acquire brain structure data of genetically related subjects (i.e., twins), we estimated the spatial pattern of genetic influences on cortical structure. We developed a genetic parcellation of cortical thickness to delineate the boundaries of cortical divisions that are—within each division—maximally under control of shared genetic influences. We also found differences in genetic influences on cortical surface area and thickness along two orthogonal axes. The concept of gradations is crucial for understanding the organization of the human brain.
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Twin studies in adults and older children find high genetic contribution to variance of global brain-tissue volumes, with heritability estimates typically greater than 80% for global grey and white matter.
“Twin studies in adults and older children find that the genetic contribution to variance of global brain-tissue volumes is high, with heritability [G] estimates typically greater than 80% for global grey and white matter142, 143.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [142]
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“These large matrices can then be explored for genetically homogeneous regions, such as were reported by Twin Hub and UCSD researchers in Science (Chen et al., 2012) and PNAS (Chen et al., 2013).”
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- Authors
- Chen, C.-H., Fiecas, M., Gutiérrez, E. D., Panizzon, M. S., Eyler, L. T., Vuoksimaa, E., Thompson, W. K., Fennema-Notestine, C., Hagler, D. J., Jernigan, T. L., Neale, M. C., Franz, C. E., Lyons, M. J., Fischl, B., Tsuang, M. T., Dale, A. M., & Kremen, W. S.
- Affiliations
- University of California San Diego (US)
- Departments of aPsychiatry,
- Cognitive Science,
- VA San Diego Healthcare System (US)
- University of Helsinki (FI)
- Radiology, and
- Virginia Commonwealth University (US)
- Boston University (US)
- Harvard University (US)
- Center of Excellence for Stress and Mental Health (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-09-30
- Volume
- 110
- Issue
- 42
- Pages
- 17089-17094
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3801007
- OpenAlex
- W1984714101
- Cited by
- 217
- References
- 53
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 23 · 2020: 23 · 2019: 16 · 2018: 18 · 2017: 19 · 2016: 22 · 2015: 23 · 2014: 12
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Aging (R01AG031224, AG031224, AG 022982, R01AG022982, AG022381, R01AG022381, AG 018384, R01AG018384, R01AG018386, AG018386)
- National Institute on Drug Abuse (RC2DA029475, DA029475)
- National Institute of Neurological Disorders and Stroke (U54NS056883, NS056883)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- brain structure, cortical thickness, cortical surface area, cortical development, dorsal-ventral axis, anterior-posterior axis, genetic correlation, brain development
- MeSH terms
- Brain, Cerebral Cortex, Genetics, Medical, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Twins, Dizygotic, Twins, Monozygotic, Cohort Studies
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