Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish
Open accessAbstract
Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. In zebrafish, rotational stimuli need to be distinguished from translational stimuli to drive the optokinetic and the optomotor responses, respectively. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. By recording the activity of thousands of neurons within the area pretectalis (APT), we find four bilateral pairs of clusters that process horizontal whole-field motion and functionally classify eleven prominent neuron types with highly selective response profiles. APT neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The pretectum has been identified as involved in whole-field motion processing in zebrafish.
“recently identified as involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
From Neural control and modulation of swimming speed in the larval zebrafish (2014) · cites this paper as Kubo et al., 2014
The open-source simZFish faithfully reproduces the zebrafish OMR using experimentally observed neural activity.
“Benefitting from detailed experimental data (25, 29–34) and recent advances in physics simulation technologies (35), our open-source simZFish faithfully reproduces the zebrafish OMR, utilizing experimentally observed neural activity (25).”
From Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors (2025) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Global Geometric Framework for Nonlinear Dimensionality Reduction
Tenenbaum, J. B., Silva, V. D., & Langford, J. C. (2000) · Science · doi:10.1126/science.290.5500.2319 · Cited by 13,585 · see citing works
Whole-brain functional imaging at cellular resolution using light-sheet microscopy
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392 · see citing works
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging
Akerboom, J., Chen, T., Wardill, T. J., Tian, L., Marvin, J. S., Mutlu, S., Calderón, N. C., Esposti, F., Borghuis, B. G., Sun, X. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2601-12.2012 · Cited by 1,226 · see citing works
Self-citationForebrain gene expression domains and the evolving prosomeric model
Puelles, L., & Rubenstein, J. L. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00234-0 · Cited by 734 · see citing works
Higashijima, S., Hotta, Y., & Okamoto, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00206.2000 · Cited by 558 · see citing works
A behavioral screen for isolating zebrafish mutants with visual system defects.
Brockerhoff, S. E., Hurley, J. B., Janssen‐Bienhold, U., Neuhauss, S. C. F., Driever, W., & Dowling, J. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10545 · Cited by 485 · see citing works
Self-citationSelective Sensitivity to Direction of Movement in Ganglion Cells of the Rabbit Retina
Barlow, H. B., & Hill, R. M. (1963) · Science · doi:10.1126/science.139.3553.412 · Cited by 435 · see citing works
Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414 · see citing works
Self-citationThe accessory optic system of rabbit. II. Spatial organization of direction selectivity
Simpson, J. I., Leonard, C. S., & Soodak, R. E. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.6.2055 · Cited by 333 · see citing works
Direction selectivity in the retina: symmetry and asymmetry in structure and function
Vaney, D. I., Sivyer, B., & Taylor, W. R. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3165 · Cited by 330 · see citing works
Forward genetic analysis of visual behavior in zebrafish
Muto, A., Orger, M. B., Wehman, A. M., Smear, M. C., Kay, J. N., Page-McCaw, P. S., Gahtan, E., Xiao, T., Nevin, L. M., Gosse, N. J., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010066 · Cited by 321 · see citing works
Self-citationControl of visually guided behavior by distinct populations of spinal projection neurons
Orger, M. B., Kampff, A. R., Severi, K. E., Bollmann, J. H., & Engert, F. (2008) · Nature Neuroscience · doi:10.1038/nn2048 · Cited by 274 · see citing works
Assessing bimodality to detect the presence of a dual cognitive process
Freeman, J. B., & Dale, R. A. C. (2012) · Behavior Research Methods · doi:10.3758/s13428-012-0225-x · Cited by 268 · see citing works
The termination of retinal axons in the pretectal region of mammals
Scalia, F. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901450208 · Cited by 264 · see citing works
Burrill, J. D., & Easter, S. S. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903460410 · Cited by 248 · see citing works
Optical control of zebrafish behavior with halorhodopsin
Arrenberg, A. B., Bene, F. D., & Baier, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906252106 · Cited by 244 · see citing works
Self-citationVisuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum
Roeser, T., & Baier, H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03726.2003 · Cited by 222 · see citing works
Self-citationPerception of Fourier and non-Fourier motion by larval zebrafish
Orger, M. B., Smear, M. C., Anstis, S., & Baier, H. (2000) · Nature Neuroscience · doi:10.1038/80649 · Cited by 211 · see citing works
Self-citationThe accessory optic system of Rana pipiens: Neuroanatomical connections and intrinsic organization
Montgomery, N., Fite, K. V., & Bengston, L. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902030404 · Cited by 206 · see citing works
Oculomotor areas in the rabbit's midbrain and pretectum
Collewijn, H. (1975) · Journal of Neurobiology · doi:10.1002/neu.480060106 · Cited by 197 · see citing works
Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish
Schoonheim, P. J., Arrenberg, A. B., Del Bene, F., & Baier, H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5193-09.2010 · Cited by 185 · see citing works
Self-citationKarten, J. H., Fite, K. V., & Brecha, N. C. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1753 · Cited by 175 · see citing works
Morphological aspects of the teleostean visual system: A review
Vanegas, H., & Ito, H. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90036-x · Cited by 171 · see citing works
Parametric Functional Maps of Visual Inputs to the Tectum
Nikolaou, N., Lowe, A., Walker, A., Abbas, F. H., Hunter, P. R., Thompson, I. D., & Meyer, M. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.040 · Cited by 162 · see citing works
Contrast Sensitivity, Spatial and Temporal Tuning of the Larval Zebrafish Optokinetic Response
Rinner, O., Rick, J. M., & Neuhauss, S. C. F. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0682 · Cited by 158 · see citing works
Eyecup scope—optical recordings of light stimulus-evoked fluorescence signals in the retina
Euler, T., Hausselt, S. E., Margolis, D. J., Breuninger, T., Castell, X., Detwiler, P. B., & Denk, W. T. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0603-5 · Cited by 156 · see citing works
The optokinetic response in zebrafish and its applications
Huang, Y. (2007) · Frontiers in bioscience · doi:10.2741/2810 · Cited by 142 · see citing works
ViBE-Z: a framework for 3D virtual colocalization analysis in zebrafish larval brains
Ronneberger, O., Liu, K., Rath, M., Rueβ, D., Mueller, T., Skibbe, H., Drayer, B., Schmidt, T., Filippi, A., Nitschke, R., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2076 · Cited by 138 · see citing works
Self-citationMiri, A., Daie, K., Burdine, R. D., Aksay, E., & Tank, D. W. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00702.2010 · Cited by 138 · see citing works
Nystagmus induced by stimulation of the nucleus of the optic tract in the monkey
Schiff, D., Cohen, B., & Raphan, T. (1988) · Experimental Brain Research · doi:10.1007/bf00271841 · Cited by 132 · see citing works
On the pathway mediating optokinetic responses in vestibular nuclear neurons
Precht, W., & Strata, P. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90170-0 · Cited by 122 · see citing works
Pathways mediating optokinetic responses of vestibular nucleus neurons in the rat
Cazin, L., Precht, W., & Lannou, J. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00589510 · Cited by 121 · see citing works
Mueller, T., & Wullimann, M. F. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00194-6 · Cited by 112 · see citing works
Genetic and optical targeting of neural circuits and behavior — zebrafish in the spotlight
Baier, H., & Scott, E. K. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.08.001 · Cited by 109 · see citing works
Self-citationFite, K. V. (2008) · Brain Behavior and Evolution · doi:10.1159/000118769 · Cited by 108 · see citing works
Schiff, D., Cohen, B., B�ttner-Ennever, J. A., & Matsuo, V. (1990) · Experimental Brain Research · doi:10.1007/bf00608231 · Cited by 101 · see citing works
Comparative Neurobiology of the Optokinetic Reflex
Masseck, O. A., & Hoffmann, K. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03854.x · Cited by 92 · see citing works
Optogenetics: A new enlightenment age for zebrafish neurobiology
Bene, F. D., & Wyart, C. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20914 · Cited by 87 · see citing works
Optokinetic Nystagmus and the Accessory Optic System of Pigeon and Turtle
Fite, K. V., Reiner, A. J., & Hunt, S. P. (2008) · Brain Behavior and Evolution · doi:10.1159/000121836 · Cited by 86 · see citing works
Gioanni, H., Rey, J., Villalobos, J., Richard, D., & Dalbera, A. (1983) · Experimental Brain Research · doi:10.1007/bf00239188 · Cited by 84 · see citing works
Hunter, P. R., Lowe, A., Thompson, I. D., & Meyer, M. P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1493-13.2013 · Cited by 75 · see citing works
Kato, I., Harada, K., Hasegawa, T., & Ikarashi, T. (1988) · Brain Research · doi:10.1016/0006-8993(88)90665-8 · Cited by 69 · see citing works
WYLIE, D. R. W., & Frost, B. J. (1990) · Visual Neuroscience · doi:10.1017/s0952523800000614 · Cited by 61 · see citing works
Movement, technology and discovery in the zebrafish
McLean, D. L., & Fetcho, J. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.09.011 · Cited by 60 · see citing works
Two-photon imaging of neural population activity in zebrafish
Renninger, S. L., & Orger, M. B. (2013) · Methods · doi:10.1016/j.ymeth.2013.05.016 · Cited by 58 · see citing works
Huang, Y., Rinner, O., Hedinger, P., Liu, S., & Neuhauss, S. C. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2886-06.2006 · Cited by 49 · see citing works
Let there be light: zebrafish neurobiology and the optogenetic revolution
Wyart, C., & Bene, F. D. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.013 · Cited by 48 · see citing works
Independent and conjugate eye movements during optokinesis in teleost fish
Fritsches, K. A., & Marshall, N. J. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.9.1241 · Cited by 42 · see citing works
Lauter, G., Söll, I., & Hauptmann, G. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23221 · Cited by 32 · see citing works
Masseck, O. A., & Hoffmann, K. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00415.2009 · Cited by 30 · see citing works
Directional Asymmetries in the Optokinetic Response of Larval Zebrafish ( Danio rerio )
Qian, H., Zhu, Y., Ramsey, D. J., Chappell, R. L., Dowling, J. E., & Ripps, H. (2005) · Zebrafish · doi:10.1089/zeb.2005.2.189 · Cited by 26 · see citing works
Visual direction-selective neurons in the pretectum of the rainbow trout
Klar, M., & Hoffmann, K. ‐. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00706-7 · Cited by 26 · see citing works
Masseck, O. A., & Hoffmann, K. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00926.2007 · Cited by 23 · see citing works
Markner, C., & Hoffmann, K. ‐. (1985) · Experimental Brain Research · doi:10.1007/bf00235627 · Cited by 20 · see citing works
Binocularity in the nucleus of the optic tract of the opossum
Pereira, A., Volchan, E., Bernardes, R. F., & Rocha‐Miranda, C. E. (1994) · Experimental Brain Research · doi:10.1007/bf00227519 · Cited by 17 · see citing works
Vargas, C. D., Volchan, E., Hokoç, J. N., Pereira, A., Bernardes, R. F., & Rocha‐Miranda, C. E. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00356-9 · Cited by 16 · see citing works
Reber, A., Sarrau, J. M., Carnet, J., Magnin, M., & Stelz, T. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130406 · Cited by 16 · see citing works
WYLIE, D. R. W. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01367-7 · Cited by 14 · see citing works
Cortical and subcortical influences on the nucleus of the optic tract of the opossum
Pereira, A., Volchan, E., Vargas, C. D., Penetra, L., & Rocha‐Miranda, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00463-7 · Cited by 12 · see citing works
The commissural transfer of the horizontal optokinetic signal in the rat: a c-Fos study
Ferrari, R., Fonda, S., Corradini, M., & Biral, G. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1935-x · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neural circuits underlying visually evoked escapes in larval zebrafish
Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., & Del Bene, F. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.021 · Cited by 347 · see citing works
“…of tectal processing have remained descriptive and treat single cells in isolation (Gabriel et al., 2012; Grama and Engert, 2012), independent of behavior and the activity of other visual, motion-sensitive midbrain structures such as the pretectum (Kubo et al., 2014; Portugues et al., 2014).”
Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans
Nguyen, J. P., Shipley, F. B., Linder, A. N., Plummer, G. S., Liu, M., Setru, S. U., Shaevitz, J. W., & Leifer, A. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507110112 · Cited by 399 · see citing works
Mapping brain activity at scale with cluster computing
Freeman, J., Vladimirov, N., Kawashima, T., Mu, Y., Sofroniew, N. J., Bennett, D. V., Rosen, J., Yang, C.-T., Looger, L. L., & Ahrens, M. B. (2014) · Nature Methods · doi:10.1038/nmeth.3041 · Cited by 299 · see citing works
“This analysis revealed a coordinated sequence of events after the onset of stimulus across the brain ( Fig.”
BackgroundKey, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318 · see citing works
“Whole brain imaging during visuomotor reflexes reveals widespread neural activity in the diencephalon, midbrain and hindbrain in zebrafish, but these regions appear to act mostly as feedforward pathways (Sarvestani et al., 2013; Kubo et al., 2014; Portugues et al., 2014).”
BackgroundFrom Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response
Naumann, E. A., Fitzgerald, J. E., Dunn, T. W., Rihel, J., Sompolinsky, H., & Engert, F. (2016) · Cell · doi:10.1016/j.cell.2016.10.019 · Cited by 315 · see citing works
“In zebrafish, OMR circuitry overlaps with circuits activated in other stabilizing reflexes, such as the optokinetic reflex (OKR) of the eyes (Kubo et al., 2014; Portugues et al., 2014).”
Neural control and modulation of swimming speed in the larval zebrafish
Severi, K. E., Portugues, R., Marques, J. C., O’Malley, D. M., Orger, M. B., & Engert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.032 · Cited by 239 · see citing works
“This suggests connections are indirect and via nontectal retino-recipient areas such as the pretectum, recently identified to be involved in processing whole-field motion in zebrafish (Kubo et al., 2014; Portugues et al., 2014).”
Zebrafish Behavior: Opportunities and Challenges
Orger, M. B., & de Polavieja, G. G. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033857 · Cited by 285 · see citing works
“Several clusters of neurons in a pretectal area respond to horizontal motion and integrate inputs from the two eyes in ways that could distinguish rotational and translational flow, suggesting that this region could provide a common input for OMR and OKR behaviors (Kubo et al. 2014).”
BackgroundA Cellular-Resolution Atlas of the Larval Zebrafish Brain
Kunst, M., Laurell, E., Mokayes, N., Kramer, A., Kubo, F., Fernandes, A. M., Förster, D., Maschio, M. D., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2019.04.034 · Cited by 272 · see citing works
Self-citationMolecular psychiatry of zebrafish
Stewart, A. M., Ullmann, J. F. P., Norton, W., Parker, M. O., Brennan, C. H., Gerlai, R. T., & Kalueff, A. V. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.128 · Cited by 229 · see citing works
Chen, X., Mu, Y., Hu, Y., Kuan, A. T., Nikitchenko, M., Randlett, O., Chen, A. B., Gavornik, J. P., Sompolinsky, H., Engert, F., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.042 · Cited by 199 · see citing works
Zebrafish models in neuropsychopharmacology and CNS drug discovery
Khan, K. M., Collier, A. D., Мешалкина, Д. А., Kysil, E. V., Khatsko, S. L., Kolesnikova, T. O., Morzherin, Y. Y., Warnick, J. E., Kalueff, A. V., & Echevarria, D. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13754 · Cited by 206 · see citing works
“To date, optogenetic studies in zebrafish have largely focused on several simpler behaviours, such as escape (Douglass et al., 2008), locomotion (Arrenberg et al., 2009; Ljunggren et al., 2014) and sensory processing (Kubo et al., 2014).”
BackgroundRobles, E., Laurell, E., & Baier, H. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.080 · Cited by 201 · see citing works
Self-citationdal Maschio, M., Donovan, J. C., Helmbrecht, T. O., & Baier, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.034 · Cited by 169 · see citing works
Self-citationNeural circuits for evidence accumulation and decision making in larval zebrafish
Bahl, A., & Engert, F. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0534-9 · Cited by 166 · see citing works
Sensorimotor Decision Making in the Zebrafish Tectum
Barker, A. J., & Baier, H. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.055 · Cited by 138 · see citing works
“Whereas more than 95% of RGC axons make synaptic connections in the tectum, visually guided behaviors can be mediated by other retinorecipient brain areas [2, 26].”
Self-citationMolecular Spies for Bioimaging—Fluorescent Protein-Based Probes
Miyawaki, A., & Niino, Y. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.002 · Cited by 143 · see citing works
“(Portugues et al., 2014; Kubo et al., 2014; Freeman et al., 2014), and GCaMP6s (Freeman et al.”
Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway
Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115 · see citing works
Topography of a Visuomotor Transformation
Helmbrecht, T. O., dal Maschio, M., Donovan, J. C., Koutsouli, S., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.021 · Cited by 113 · see citing works
Self-citationAutomated synapse-level reconstruction of neural circuits in the larval zebrafish brain
Svara, F., Förster, D., Kubo, F., Januszewski, M., dal Maschio, M., Schubert, P. J., Kornfeld, J., Wanner, A. A., Laurell, E., Denk, W., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01621-0 · Cited by 124 · see citing works
“https://doi.org/10.1038/s41592-022-01621-0 of eight drifting grating stimuli, designed to cover all combinations of horizontal optic flow 25 .”
BackgroundMethodInfluentialSelf-citationThe Zebrafish Visual System: From Circuits to Behavior
Bollmann, J. H. (2019) · Annual Review of Vision Science · doi:10.1146/annurev-vision-091718-014723 · Cited by 123 · see citing works
A faithful internal representation of walking movements in the Drosophila visual system
Fujiwara, T., Cruz, T. L., Bohnslav, J. P., & Chiappe, M. E. (2016) · Nature Neuroscience · doi:10.1038/nn.4435 · Cited by 102 · see citing works
A Convergent and Essential Interneuron Pathway for Mauthner-Cell-Mediated Escapes
Lacoste, A. M. B., Schoppik, D., Robson, D. N., Haesemeyer, M., Portugues, R., Li, J., Randlett, O., Wee, C. L., Engert, F., & Schier, A. F. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.025 · Cited by 103 · see citing works
Classification of Object Size in Retinotectal Microcircuits
Preuß, S., Trivedi, C. A., Berg, C. V., Ryu, S., & Bollmann, J. H. (2014) · Current Biology · doi:10.1016/j.cub.2014.09.012 · Cited by 100 · see citing works
Functional Assembly of Accessory Optic System Circuitry Critical for Compensatory Eye Movements
Sun, L. O., Brady, C. M., Cahill, H. B., Al‐Khindi, T., Sakuta, H., Dhande, O. S., Noda, M., Huberman, A. D., Nathans, J., & Kolodkin, A. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.064 · Cited by 95 · see citing works
“cessory Optic System”
Cellular-Resolution Imaging of Vestibular Processing across the Larval Zebrafish Brain
Favre‐Bulle, I. A., Vanwalleghem, G. C., Taylor, M. A., Rubinsztein-Dunlop, H. H., & Scott, E. K. (2018) · Current Biology · doi:10.1016/j.cub.2018.09.060 · Cited by 89 · see citing works
Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging
Dragomir, E. I., Štih, V., & Portugues, R. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0535-8 · Cited by 89 · see citing works
Large-scale imaging in small brains
Ahrens, M. B., & Engert, F. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.01.007 · Cited by 76 · see citing works
“Here we review several imaging techniques that have been used to advance our understanding of different aspects of brain function, including sensorimotor processing [5,16,17 ,18,19,20 ], learning [21], sensation [16,22 ,23 ,24 ,25,26] and the development of functional circuits [27].”
Förster, D., Arnold-Ammer, I., Laurell, E., Barker, A. J., Fernandes, A. M., Finger‐Baier, K., Filosa, A., Helmbrecht, T. O., Kölsch, Y., Kuehn, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04657-x · Cited by 76 · see citing works
Self-citationPanser, K., Tirián, L., Schulze, F., Villalba, S. D., Jefferis, G. S. X. E., Bühler, K., & Straw, A. D. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.052 · Cited by 80 · see citing works
“Such an effort in Zebrafish could be used to suggest driver lines corresponding to functional units identified in brain-wide activity-based experiments (Ahrens et al., 2012; Kubo et al., 2014; Portugues et al., 2014; Randlett et al., 2015).”
Comparison of optomotor and optokinetic reflexes in mice
Kretschmer, F., Tariq, M., Chatila, W. K., Wu, B. P., & Badea, T. C. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00055.2017 · Cited by 80 · see citing works
Neuronal Architecture of a Visual Center that Processes Optic Flow
Kramer, A., Wu, Y., Baier, H., & Kubo, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.018 · Cited by 78 · see citing works
Self-citationParallel Channels for Motion Feature Extraction in the Pretectum and Tectum of Larval Zebrafish
Wang, K., Hinz, J., Zhang, Y., Thiele, T. R., & Arrenberg, A. B. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.031 · Cited by 66 · see citing works
Self-citationT-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse
Dong, H., Othy, S., Jairaman, A., Skupsky, J., Zavala, A., Parker, I., Dynes, J. L., & Cahalan, M. D. (2017) · eLife · doi:10.7554/elife.32417 · Cited by 76 · see citing works
“The high brightness and dynamic range of modern GECIs like Salsa6f contribute to detection of rare Ca signaling events inside intact tissues or even whole transgenic animals (Kubo et al., 2014; Portugues et al., 2014).”
BackgroundThe Descending Diencephalic Dopamine System Is Tuned to Sensory Stimuli
Reinig, S., Driever, W., & Arrenberg, A. B. (2017) · Current Biology · doi:10.1016/j.cub.2016.11.059 · Cited by 64 · see citing works
Self-citationLuminance Changes Drive Directional Startle through a Thalamic Pathway.
Heap, L. A., Vanwalleghem, G., Thompson, A. W., Favre-Bulle, I. A., & Scott, E. K. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.013 · Cited by 70 · see citing works
“Wethenperformed morphological segmentation to identify regions of interest (ROIs) roughly corresponding to individual neurons and used a Boolean based ‘‘bar code’’ approach (Kubo et al., 2014; Naumannet al., 2016) to identifyROIs responding toeachstimulus (FigureS3).”
A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Markov, D., Petrucco, L., Kist, A., & Portugues, R. (2020) · Nature Communications · doi:10.1038/s41467-021-26988-0 · Cited by 70 · see citing works
Rules for Shaping Neural Connections in the Developing Brain
Kutsarova, E., Munz, M., & Ruthazer, E. S. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00111 · Cited by 62 · see citing works
“In fish and frogs the RGCs project to at least 10 distinct tectal and pretectal arborization fields believed to mediate important behavioral responses such as eye movements and prey capture (Easter and Taylor, 1989; Burrill and Easter, 1994; Kubo et al., 2014; Semmelhack et al., 2014).”
BackgroundAn interhemispheric neural circuit allowing binocular integration in the optic tectum
Gebhardt, C., Auer, T. O., Henriques, P. M., Rajan, G., Duroure, K., Bianco, I. H., & Bene, F. D. (2019) · Nature Communications · doi:10.1038/s41467-019-13484-9 · Cited by 65 · see citing works
Wang, K., Hinz, J., Haikala, V., Reiff, D. F., & Arrenberg, A. B. (2019) · BMC Biology · doi:10.1186/s12915-019-0648-2 · Cited by 60 · see citing works
Self-citationA brainstem integrator for self-location memory and positional homeostasis in zebrafish
Yang, E., Zwart, M., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B. D., Fitzgerald, J. E., & Ahrens, M. B. (2022) · Cell · doi:10.1016/j.cell.2022.11.022 · Cited by 61 · see citing works
Kist, A. M., & Portugues, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.024 · Cited by 55 · see citing works
Methods for studying the zebrafish brain: past, present and future
Wyatt, C., Bartoszek, E. M., & Yaksi, E. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12932 · Cited by 53 · see citing works
Feierstein, C. E., Portugues, R., & Orger, M. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.046 · Cited by 52 · see citing works
“…functional types in the population, and their locations, they were able to propose, based on minimal Boolean logic, the simplest connectivity pattern that could explain the observed responses, providing a straightforward circuit hypothesis which can now be tested experimentally (Kubo et al., 2014).”
BackgroundMethodResultInfluentialThe Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors
Palumbo, F., Serneels, B., Pelgrims, R., & Yaksi, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108054 · Cited by 46 · see citing works
“Series of recent studies highlight the increasing popularity of zebrafish for studying diverse aspects of animal behavior [30-39], including complex behaviors such as learning [25, 26, 40-46] and social interactions”
Anatomy and function of retinorecipient arborization fields in zebrafish
Baier, H., & Wullimann, M. F. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25204 · Cited by 51 · see citing works
“The cell body-rich region dorsal to AF5/AF6 and ventral to AF9 responds strongly and selectively to binocular optic flow and is necessary and sufficient for optokinetic and optomotor responses (Kramer et al., 2019; Kubo et al., 2014).”
BackgroundSelf-citationCalcium Imaging and the Curse of Negativity
Vanwalleghem, G. C., Constantin, L., & Scott, E. K. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.607391 · Cited by 49 · see citing works
“Another approach that we and others have used, the binarization of the data based on a threshold of activity to generate “bar codes” of the brain activity, also has an intrinsic non-negative assumption (Kubo et al., 2014; Naumann et al., 2016; Heap et al., 2018; Daviu et al., 2020; Etter et al., 2020).”
MethodNeural connections of the pretectum in zebrafish ( Danio rerio )
Yáñez, J., Suárez, T., Quelle‐Regaldie, A., Folgueira, M., & Anadón, R. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24388 · Cited by 45 · see citing works
“Functional studies suggest that pretectal centers in zebrafish larvae are involved in the generation of stereotyped movements (Fajardo, Zhu, & Friedrich, 2013; Kubo et al., 2014; Portugues, Feierstein, Engert, & Orger, 2014) and in prey detection (Semmelhack et al., 2014; Muto et al., 2017).”
BackgroundAncestral photoreceptor diversity as the basis of visual behaviour
Baden, T. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-023-02291-7 · Cited by 44 · see citing works
“This organization is perhaps particularly obvious in zebrafish, where the dendrites of retinal ganglion cells associated with widefield motion processing stratify towards the outer edges of the inner retina 57,74,77 (Fig.”
BackgroundThe study of psychiatric disease genes and drugs in zebrafish
Haesemeyer, M., & Schier, A. F. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.12.002 · Cited by 40 · see citing works
Conserved subcortical processing in visuo-vestibular gaze control
Wibble, T., Pansell, T., Grillner, S. E., & Pérez‐Fernández, J. (2022) · Nature Communications · doi:10.1038/s41467-022-32379-w · Cited by 39 · see citing works
An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing
Wu, Y., Maschio, M. D., Kubo, F., & Baier, H. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.027 · Cited by 37 · see citing works
Self-citationDense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish
Friedrich, R. W., & Wanner, A. A. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110220-013050 · Cited by 33 · see citing works
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain
Yildizoglu, T., Riegler, C., Fitzgerald, J. E., & Portugues, R. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.043 · Cited by 34 · see citing works
Spike Burst Coding of Translatory Optic Flow and Depth from Motion in the Fly Visual System
Longden, K. D., Wicklein, M., Hardcastle, B., Huston, S. J., & Krapp, H. G. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.044 · Cited by 34 · see citing works
Using a variant of the optomotor response as a visual defect detection assay in zebrafish
LeFauve, M. K., Rowe, C. J., Crowley-Perry, M., Wiegand, J. L., & Shapiro, A. (2021) · Journal of Biological Methods · doi:10.14440/jbm.2021.341 · Cited by 34 · see citing works
“Zebrafish OMR is generated by several separate visual and motor circuits, many of which overlap with the circuits activated by the OKR in the eyes [9].”
BackgroundThe world according to zebrafish: how neural circuits generate behavior
Sumbre, G., & de Polavieja, G. G. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00091 · Cited by 34 · see citing works
“Meyer, A., and Schartl, M. (1999). Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene”
BackgroundDehmelt, F. A., Meier, R., Hinz, J., Yoshimatsu, T., Simacek, C. A., Huang, R., Wang, K., Baden, T., & Arrenberg, A. B. (2021) · eLife · doi:10.7554/elife.63355 · Cited by 33 · see citing works
Self-citationNeurons Responsive to Global Visual Motion Have Unique Tuning Properties in Hummingbirds
Gaede, A. H., Goller, B., Lam, J., WYLIE, D. R. W., & Altshuler, D. L. (2017) · Current Biology · doi:10.1016/j.cub.2016.11.041 · Cited by 32 · see citing works
A robust receptive field code for optic flow detection and decomposition during self-motion
Zhang, Y., Huang, R., Nörenberg, W., & Arrenberg, A. B. (2022) · Current Biology · doi:10.1016/j.cub.2022.04.048 · Cited by 29 · see citing works
Self-citationInformation processing in the CNS: a supramolecular chemistry?
Tozzi, A. (2015) · Cognitive Neurodynamics · doi:10.1007/s11571-015-9337-1 · Cited by 31 · see citing works
“We now list some recent studies linking neuronal types to specific active molecules and well-defined behaviours: • A new neuron type within the area pretectalis helps zebrafish coordinates their eye and swimming move- ments, to compensate for self-motion (Kubo et al. 2014).”
BackgroundSustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish
Pérez-Schuster, V., Kulkarni, A., Nouvian, M., Romano, S. A., Lygdas, K., Jouary, A., Dipoppa, M., Pietri, T., Haudrechy, M., Candat, V., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.065 · Cited by 30 · see citing works
“To inhibit eye movements during OKR using optogenetics and spatially selected illumination via an optic fiber (Arrenberg et al., 2009; Schoonheim et al., 2010) we used the Tg(HuC:Gal4);Tg(UAS:eNpHR-mCherry)s1988t (E. Baier) zebrafish line, referred as to the HuC:Gal4;UAS:eNpHR-mCherry line.”
InfluentialCircuit Organization Underlying Optic Flow Processing in Zebrafish
Matsuda, K., & Kubo, F. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.709048 · Cited by 30 · see citing works
Self-citationEvoking and tracking zebrafish eye movement in multiple larvae with ZebEyeTrack
Dehmelt, F. A., von Daranyi, A., Leyden, C., & Arrenberg, A. B. (2018) · Nature Protocols · doi:10.1038/s41596-018-0002-0 · Cited by 30 · see citing works
Self-citationThe Cellular Organization of Zebrafish Visuomotor Circuits
Orger, M. B. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.054 · Cited by 28 · see citing works
“For example, orientation to prey depends on sensory motor maps in the optic tectum, a homolog of the mammalian superior colliculus, while whole-field motion signals originating in direction-selective ganglion cells are processed in a set of specialized nuclei, with similarities to the accessory optic system [18].”
BackgroundResponses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish
Scalise, K., Shimizu, T., Hibi, M., & Sawtell, N. B. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00042.2016 · Cited by 27 · see citing works
“Direction-selective visual responses have been observed in areas of the larval zebrafish brain, including the pretectum, and have been suggested to play a role in the OMR (Kubo et al. 2014; Portugues et al. 2014).”
BackgroundFallani, F. D. V., Corazzol, M., Sternberg, J. R., Wyart, C., & Chávez, M. (2014) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2014.2341632 · Cited by 26 · see citing works
“resolution level [3], [4], [18], [19], [39], [40].”
Brysch, C., Leyden, C., & Arrenberg, A. B. (2019) · BMC Biology · doi:10.1186/s12915-019-0720-y · Cited by 26 · see citing works
“In short, stimuli were presented as vertical gratings (12 roughly equally spaced, red, vertical bars per 360°) rotating horizontally around the larvae on a custom-made LED arena (described in the supplemental information under the “Visual Stimulation” section in [1]).”
BackgroundMethodInfluentialSelf-citationGeometric framework to predict structure from function in neural networks
Tirthabir Biswas, A., & Fitzgerald, J. E. (2022) · Physical Review Research · doi:10.1103/physrevresearch.4.023255 · Cited by 22 · see citing works
“This description is useful because many systems neuroscience experiments measure representations directly, and it is important to build mechanistic models that explain these data in terms of neural network interactions [12, 15, 18, 77].”
BackgroundFu, R., Liu, H., Zhang, Y., Mao, L., Zhu, L., Jiang, H., Zhang, L. H., & Liu, X. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168572 · Cited by 24 · see citing works
Lin, X., Li, V. W. T., Chen, S., Chan, C.-Y., Cheng, S. H., & Shi, P. (2016) · Biomicrofluidics · doi:10.1063/1.4946013 · Cited by 23 · see citing works
Input from torus longitudinalis drives binocularity and spatial summation in zebrafish optic tectum
Tesmer, A. L., Fields, N. P., & Robles, E. (2022) · BMC Biology · doi:10.1186/s12915-021-01222-x · Cited by 20 · see citing works
Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits
Barnhart, E. L., Wang, I. E., Wei, H., Desplan, C., & Clandinin, T. R. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.022 · Cited by 21 · see citing works
“, 2015) and are under active investigation in vertebrates (Hedges et al., 2011; Kubo et al., 2014).”
Fornetto, C., Tiso, N., Pavone, F. S., & Vanzi, F. (2020) · BMC Biology · doi:10.1186/s12915-020-00903-3 · Cited by 19 · see citing works
Binocular integration of retinal motion information underlies optic flow processing by the cortex
Rasmussen, R. N., Matsumoto, A., Arvin, S., & Yonehara, K. (2021) · Current Biology · doi:10.1016/j.cub.2020.12.034 · Cited by 21 · see citing works
Peripheral and central sensation: multisensory orienting and recognition across species
Li Zhaoping, A. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.03.001 · Cited by 23 · see citing works
Multilevel visuomotor control of locomotion in Drosophila
Cruz, T. L., & Chiappe, M. E. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102774 · Cited by 17 · see citing works
A noninvasive light driven technique integrated microfluidics for zebrafish larvae transportation
Mani, K., Hsieh, Y.-C., Panigrahi, B., & Chen, C. (2018) · Biomicrofluidics · doi:10.1063/1.5027014 · Cited by 20 · see citing works
Zebrafishdscaml1Deficiency Impairs Retinal Patterning and Oculomotor Function
Ma, M., Ramirez, A. D., Wang, T., Roberts, R. L., Harmon, K. E., Schoppik, D., Sharma, A., Kuang, C., Goei, S. L., Gagnon, J. A., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1783-19.2019 · Cited by 20 · see citing works
“Zebrafish oculomotor behavior is robust at the larval stage; the small size and optical translucency of zebrafish larvae make it possible to use two-photon calcium imaging to record neuronal activity en masse while the animal is behaving (Kubo et al., 2014; Daie et al., 2015; Kawashima et al., 2016).”
BackgroundPositive taxis and sustained responsiveness to water motions in larval zebrafish
Groneberg, A. H., Herget, U., Ryu, S., & Marco, R. J. D. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00009 · Cited by 19 · see citing works
Visual Search Efficiency Evaluation Method for Potential Connected Vehicles on Sharp Curves
Peng, J., Wang, C., Shao, Y., & Xu, J. H. (2018) · IEEE Access · doi:10.1109/access.2018.2861940 · Cited by 17 · see citing works
“In addition, when driving along a sharp bend of a mountain road (the radius of a bend is less than 50 m), the driving horizon is seriously inadequate, the level of traffic safety facilities is low, and traffic accidents easily happen; thus, higher visual searching requirements are put forth [21], [22].”
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior
Sylvester, S., Lee, M. M., Ramirez, A. D., Lim, S., Goldman, M. S., & Aksay, E. R. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-15938-w · Cited by 17 · see citing works
“Many pretectal neurons sensitive to movement in the horizontal plane fire in a reciprocal manner, increasing firing for stimulation in one direction, and decreasing firing for the other (Mustari and Fuchs, 1990; Kubo et al., 2014).”
Fouke, K. E., He, Z., Loring, M. D., & Naumann, E. A. (2024) · Current Biology · doi:10.1016/j.cub.2025.04.027 · Cited by 16 · see citing works
Gutiérrez‐Ibáñez, C., WYLIE, D. R. W., & Altshuler, D. L. (2023) · Journal of Comparative Physiology A · doi:10.1007/s00359-023-01663-5 · Cited by 16 · see citing works
Dowell, C. K., Hawkins, T. A., & Bianco, I. H. (2025) · Current Biology · doi:10.1016/j.cub.2024.12.010 · Cited by 16 · see citing works
“…stimulation of this region of pretectum (and electrical stimulation of its supposed mammalian equivalent) evokes slow phase eye movements, 43,81 it is possible that AF5-pretectal neurons might mediate the early direct component of the OKR in which the eye responds to the onset of visual…”
Leyden, C., Brysch, C., & Arrenberg, A. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-90315-2 · Cited by 15 · see citing works
Self-citationBrożko, N., Baggio, S., Lipiec, M. A., Jankowska, M., Szewczyk, Ł. M., Gabriel, M., Chakraborty, C., Ferrán, J. L., & Wisniewska, M. B. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.838567 · Cited by 15 · see citing works
Structural and functional organization of visual responses in the inferior olive of larval zebrafish
Félix, R., Markov, D. A., Renninger, S. L., Tomás, A. R., Laborde, A., Carey, M. R., Orger, M. B., & Portugues, R. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2352-21.2023 · Cited by 15 · see citing works
“…neurons are monocular but mechanisms for binocular integration of the optic fl ow have been proposed to be computed at the pretectum circuit level (Kubo et al., 2014; Naumann et al., 2016; Kramer et al., 2019; Wang et al., 2019), and a topographic organization of PD in a population of binocular…”
BackgroundWang, R., Wang, B., & Chen, A. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124473 · Cited by 15 · see citing works
Ali, M. A., Lischka, K., Preuß, S., Trivedi, C. A., & Bollmann, J. H. (2023) · Nature Communications · doi:10.1038/s41467-023-43255-6 · Cited by 12 · see citing works
Zebrafish Optokinetic Reflex: Minimal Reporting Guidelines and Recommendations
Rodwell, V., Patil, M., Kuht, H. J., Neuhauss, S. C. F., Norton, W., & Thomas, M. G. (2023) · Biology · doi:10.3390/biology13010004 · Cited by 15 · see citing works
“The most common time of day was between 12 and 6 pm, with 37.5% of these papers performing an OKR exclusively in the afternoon [53,101,102].”
BackgroundInfluentialMethods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish
Wanner, A. A., & Vishwanathan, A. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00089 · Cited by 15 · see citing works
“, 2013) and two photon microscopy (O’Malley et al., 1996; Friedrich and Korsching, 1997; Ritter et al., 2001; Brustein et al., 2003; Niell and Smith, 2005; Yaksi and Friedrich, 2006; Orger et al., 2008; Ramdya and Engert, 2008; Sumbre et al., 2008; Naumann et al., 2010, 2016; Niessing and Friedrich, 2010; Blumhagen et…”
BackgroundRetina-derived signals control pace of neurogenesis in visual brain areas but not circuit assembly
Sherman, S., Arnold-Ammer, I., Schneider, M., Kawakami, K., & Baier, H. (2023) · Nature Communications · doi:10.1038/s41467-023-40749-1 · Cited by 14 · see citing works
“Similarly, OKR-like eye movements could be elicited by photo-stimulating the accessory optic system in the pretectum 47,48 .”
BackgroundSelf-citationZebrafish as a Model for Revealing the Neuronal Basis of Behavior
McArthur, K. L., Chow, D. M., & Fetcho, J. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812431-4.00046-4 · Cited by 13 · see citing works
Visual escape in larval zebrafish: stimuli, circuits, and behavior
Legorreta, E. M., Piber, M., & Scott, E. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817528-6.00004-8 · Cited by 13 · see citing works
Holman, J. G., Lai, W. W. K., Pichler, P., Saska, D., Lagnado, L., & Buckley, C. L. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010924 · Cited by 12 · see citing works
“There is neurobiological evidence for the first [11,12,14,35,36] and last of these [16,42] but less evidence relevant to the proposed intermediate processes.”
Genoarchitectonics of the larval zebrafish diencephalon
Wullimann, M. F., Mokayes, N., Shainer, I., Kuehn, E., & Baier, H. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25549 · Cited by 12 · see citing works
“These neurons were shown to drive optokinetic and optomotor responses (Kubo et al., 2014; Sherman et al., 2023; Wu et al., 2020).”
BackgroundSelf-citationBarker, A. J., Helmbrecht, T. O., Grob, A. A., & Baier, H. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25082 · Cited by 13 · see citing works
“2021;529:2159–2175. wileyonlinelibrary.com/journal/cne 2159 et al., 2014; Portugues & Engert, 2009; Kubo et al., 2014; Mearns et al., 2020).”
Self-citationFiber Optic-Based Photostimulation of Larval Zebrafish
Arrenberg, A. B. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3771-4_24 · Cited by 12 · see citing works
Self-citationIn Vivo Whole-Cell Patch-Clamp Recording in the Zebrafish Brain
Zhang, R., & Du, J. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3771-4_19 · Cited by 11 · see citing works
Feierstein, C. E., de Goeij, M. H. M., Ostrovsky, A. D., Laborde, A., Portugues, R., Orger, M. B., & Machens, C. K. (2023) · Current Biology · doi:10.1016/j.cub.2023.08.037 · Cited by 10 · see citing works
- Authors
- Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- University of Freiburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Baier, Herwig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 81
- Issue
- 6
- Pages
- 1344-1359
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2067473018
- Cited by
- 182
- References
- 60
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 12 · 2020: 21 · 2019: 16 · 2018: 12 · 2017: 19 · 2016: 14 · 2015: 13 · 2014: 10
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (EXC‐294‐BIOSS, SFB780, (EXC 294))
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- optical flow, horizontal eye movements, optokinetic response, optomotor response, zebrafish, direction selectivity, binocular vision, neural circuit organization, optogenetic manipulation, in vivo calcium imaging
- MeSH terms
- Animals, Eye Movements, Motion Perception, Neurons, Photic Stimulation, Visual Fields, Visual Pathways, Zebrafish, Nystagmus, Optokinetic, Optic Flow
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
