Incidence and clinical course of major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy: a prospective study
Abstract
This study examined the incidence, clinical course and its risk factors for major depression in patients with chronic hepatitis type C undergoing interferon-alpha therapy. Ninety-nine subjects underwent the psychiatric interviews for diagnosis of major depressive episode according to the DSM-IV criteria before the start of interferon therapy, and once every 4 weeks during both the 24-week treatment period and 12 weeks after the end of therapy. Depressive symptoms were also evaluated using the Hamilton Rating Scale for Depression. Major depression occurred during interferon therapy in 23 patients (23.2%). In 73.9% of them depression occurred within 8 weeks after the start of therapy. Twenty-two patients with depression completed the therapy and 59.1% of them achieved remission by the end of therapy with a mean duration of 11.6 weeks. Although the other 40.9% were not in remission at the end of therapy, they achieved remission within 12 weeks thereafter. The only risk factor for depression was advanced age. Depression occurs frequently among patients with hepatitis type C undergoing interferon-alpha therapy. Such patients require careful observation, and psychiatrists should be sufficiently aware of this significant psychiatric complication of interferon therapy.
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Depression occurs frequently in patients with hepatitis C undergoing interferon treatment.
“Depression occurs frequently in patients with hepatitis C undergoing INF treatment.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [20]
In one study, 23% of patients during interferon treatment satisfied the diagnostic criteria for major depressive disorder, and in 74% of them depression occurred within 2 months after the start of interferon treatment.
“Of note in one study, 23% of patients during INF treatment satisfied the diagnostic criteria for major depressive disorders; in 74% of them depression occurred within 2 mo after the start of INF treatment[20].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [20]
When IFN-α was used in cancer patients as immunotherapy, the patients developed depression.
“When IFN-α was used in cancer patients as an immunotherapy, the patients developed depression.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [20]
When IFN-α immunotherapy was discontinued or antidepressants were administered, depressive symptoms improved.
“When the immunotherapy was discontinued or antidepressants were administered, the depressive symptoms improved[20,21].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [20]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813 · see citing works
A personality scale of manifest anxiety
Taylor, J. A. (1953) · The Journal of Abnormal and Social Psychology · doi:10.1037/h0056264 · Cited by 3,131 · see citing works
Winearls, C., Pippard, M. J., Downing, M. R., Oliver, D., Reid, C. D. L., & Cotes, P. M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92192-6 · Cited by 1,401 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
Conry‐Cantilena, C., VanRaden, M. J., Gibble, J. W., Melpolder, J. C., Shakil, A. O., Viladomiu, L., Cheung, L., DIBISCEGLIE, A., Hoofnagle, J. H., Shih, J. W., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606273342602 · Cited by 627 · see citing works
Neuropsychiatric Symptoms Associated With Hepatitis C and Interferon Alpha: A Review
Dieperink, E. W., Willenbring, M., & Ho, S. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.867 · Cited by 417 · see citing works
Psychiatric Complications of Long-term Interferon Alfa Therapy
Renault, P. F. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370090055011 · Cited by 413 · see citing works
Side effects of α interferon in chronic hepatitis C
Dusheiko, G. M. (1997) · Hepatology · doi:10.1002/hep.510260720 · Cited by 394 · see citing works
Depression, fatigue, and functional disability in patients with chronic hepatitis C
Dwight, M. M., Kowdley, K. V., Russo, J. E., Ciechanowski, P. S., Larson, A. M., & Katon, W. J. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(00)00155-0 · Cited by 258 · see citing works
INTERFERONS AS MEDIATORS OF PSYCHIATRIC MORBIDITY
Mcdonald, E. M., Mann, A. H., & Thomas, H. C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91319-5 · Cited by 248 · see citing works
Suicide associated with alfa-interferon therapy for chronic viral hepatitis
Janssen, H. L. A., Brouwer, J. T., van der Mast, R. C., & Schalm, S. W. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80402-7 · Cited by 229 · see citing works
Capuron, L., & Ravaud, A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401716 · Cited by 169 · see citing works
Treatment with interferon-α in patients with chronic hepatitis and mood or anxiety disorders
Pariante, C. M., Orrù, M. G., Baita, A., Farci, M. G., & Carpiniello, B. (1999) · The Lancet · doi:10.1016/s0140-6736(98)04793-x · Cited by 165 · see citing works
Effect of Interferon-α Treatment of Chronic Hepatitis C on Health-Related Quality of Life
Hunt, C. M., Dominitz, J. A., Phillips‐Bute, B. G., Waters, B., Blasi, U., & Williams, D. M. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018852309885 · Cited by 141 · see citing works
Depression From Interferon Therapy in Patients With Hepatitis C
Miyaoka, H., Otsubo, T., Kamijima, K., Ishii, M., ONUKI, M., & Mitamura, K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1120 · Cited by 135 · see citing works
Fluoxetine treatment of depression caused by interferon-alpha.
Levenson, J. L., & Fallon, H. J. (1993) · PubMed · Cited by 126 · see citing works
Hepatitis C Virus and Depression in Drug Users
Johnson, M. E., Fisher, D. G., Fenaughty, A. M., & Theno, S. A. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.225_a.x · Cited by 122 · see citing works
Sertraline treatment of interferon‐alfa‐induced depressive disorder
Schramm, T. M., Lawford, B. R., Cooksley, W. G. E., & Macdonald, G. A. (2000) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2000.tb125687.x · Cited by 106 · see citing works
Long-term prognosis of depression in primary care.
Simon, G. E. (2000) · Europe PMC (PubMed Central) · Cited by 105 · see citing works
Thiel, D. H. V., Friedlander, L., Molloy, P. J., FAGIUOLI, S., Kania, R. J., & Caraceni, P. (1995) · PubMed · Cited by 101 · see citing works
Malaguarnera, M., Fazio, I. D., Restuccia, S., Pistone, G., Ferlito, L., & Rampello, L. (1998) · Neuropsychobiology · doi:10.1159/000026485 · Cited by 95 · see citing works
Five Cases of Interferon-Alpha–Induced Depression Treated With Antidepressant Therapy
Gleason, O. C., & Yates, W. R. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71190-4 · Cited by 80 · see citing works
Drug-Induced Cognitive Impairment
Bowen, J. D., & Larson, E. B. (1993) · Drugs & Aging · doi:10.2165/00002512-199303040-00005 · Cited by 73 · see citing works
Course of Depression During the Initiation of Interferon Beta-1a Treatment for Multiple Sclerosis
Mohr, D. C., Likosky, W., Dwyer, P., Wende, J. V. D., Boudewyn, A. C., & Goodkin, D. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1263 · Cited by 68 · see citing works
Adams, F., Fernandez, F., & Mavligit, G. M. (1988) · Journal of Neuro-Oncology · doi:10.1007/bf00177432 · Cited by 64 · see citing works
Emotional state of patients with relapsing-remitting MS treated with interferon beta-1b
Borrás, C., Río, J., Porcel, J., Barrios, M., Tintoré, M., & Montalbán, X. (1999) · Neurology · doi:10.1212/wnl.52.8.1636 · Cited by 62 · see citing works
Behavioral assessment of patients treated with alpha‐interferon
Niiranen, A., Laaksonen, R. K., Livanainen, M., Mattson, K. V., Färkkilä, M. A., & Cantell, K. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb06395.x · Cited by 61 · see citing works
Noguchi, S., Sata, M., Suzuki, H., Mizokami, M., & Tanikawa, K. (1997) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365549709008659 · Cited by 60 · see citing works
Successful Treatment of Interferon Alfa-Induced Mood Disorder With Nortriptyline
Goldman, L. S. (1994) · Psychosomatics · doi:10.1016/s0033-3182(94)71769-2 · Cited by 59 · see citing works
Mulder, R., Ang, M., CHAPMAN, B. A., Ross, A., Stevens, I., & Edgar, C. L. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02090.x · Cited by 58 · see citing works
Antidepressant Action of Sulpiride. Results of a Placebo-Controlled Double-Blind Trial
Rüther, E., Degner, D., Munzel, U., Brunner, E., Lenhard, G., Biehl, J., & Vögtle-Junkert, U. (1999) · Pharmacopsychiatry · doi:10.1055/s-2007-979218 · Cited by 53 · see citing works
Merimsky, O., & Chaitchik, S. (1992) · Anti-Cancer Drugs · doi:10.1097/00001813-199212000-00002 · Cited by 52 · see citing works
The efficacy of drug treatments for dysthymia: a systematic review and meta-analysis
de Lima, M. S., HOTOPH, M., & Wessely, S. C. (1999) · Psychological Medicine · doi:10.1017/s0033291799001324 · Cited by 48 · see citing works
Csako, G., McGriff, N. J., Rotman-Pikielny, P., Sarlis, N. J., & Pucino, F. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.1a031 · Cited by 40 · see citing works
Burns in a suicide attempt related to psychiatric side effects of interferon
Fukunishi, K., Tanaka, H., Maruyama, J., Takahashi, H., Kitagishi, H., Ueshima, T., Maruyama, K., & Sakata, I. (1998) · Burns · doi:10.1016/s0305-4179(98)00073-4 · Cited by 37 · see citing works
Horikawa, N., Yamazaki, T., Sagawa, M., & Nagata, T. (1999) · General Hospital Psychiatry · doi:10.1016/s0163-8343(98)00082-6 · Cited by 14 · see citing works
Self-citationTsukamoto, T., Asakura, M., Tsuneizumi, T., Yuko, S., Takahiro, S., & Hasegawa, K. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90017-5 · Cited by 13 · see citing works
A Double-Blind Comparison of Sulpiride with Chlordiazepoxide in Neurosis
Toru, M., Moriya, H., Yamamoto, K., Shimazono, Y., Ishiguro, T., Sugano, K., Isse, K., & Miyasaka, M. (1976) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1976.tb00118.x · Cited by 13 · see citing works
Interferon ß and suicide in multiple sclerosis
O'Connor, N. T. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91064-8 · Cited by 8 · see citing works
Caraceni (1998) · doi:10.1002/(sici)1097-0142(19980801)83:3
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Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483 · see citing works
Depression During Pegylated Interferon-Alpha Plus Ribavirin Therapy
Raison, C. L., Borisov, A. S., Broadwell, S. D., Capuron, L., Woolwine, B. J., Jacobson, I. M., Nemeroff, C. B., & Miller, A. H. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0106 · Cited by 298 · see citing works
Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works
Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works
Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement
Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.037 · Cited by 225 · see citing works
The phenomenology and treatment of interferon-induced depression
Loftis, J. M., & Hauser, P. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.04.002 · Cited by 227 · see citing works
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
Heathcote, J., & Main, J. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00600.x · Cited by 183 · see citing works
Asnis, G. M., & Garza, R. D. L. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000210099.36500.fe · Cited by 170 · see citing works
Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., & Kanba, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301137 · Cited by 152 · see citing works
Wager‐Smith, K., & Markou, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.010 · Cited by 150 · see citing works
RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J., HENDERSON, M. A., REINUS, J. F., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03316.x · Cited by 142 · see citing works
Yates, W. R., Mitchell, J. R., Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Warden, D., Hauger, R. B., D, M. F. M., Gaynes, B. N., Husain, M. M., et al. (2004) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.06.008 · Cited by 131 · see citing works
Depression and chronic liver diseases: are there shared underlying mechanisms?
Huang, X., Liu, X., & Yu, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00134 · Cited by 121 · see citing works
A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
Davies, Christmas, D. M., & Potokar, J. P. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s17573 · Cited by 119 · see citing works
Kraus, M. R., Schäfer, A., Schöttker, K., Keicher, C., Weißbrich, B., Hofbauer, I., & Scheurlen, M. (2007) · Gut · doi:10.1136/gut.2007.131607 · Cited by 118 · see citing works
Depression following pegylated interferon-alpha: Characteristics and vulnerability
Lotrich, F. E., Rabinovitz, M., Gironda, P., & Pollock, B. G. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.013 · Cited by 100 · see citing works
Evaluation of depression as a risk factor for treatment failure in chronic hepatitis C†
Leutscher, P. D. C., Lagging, M., Buhl, M. R., Pedersen, C., Norkrans, G., Langeland, N., Mørch, K., Färkkilä, M. A., Hjerrild, S., Hellstrand, K., et al. (2010) · Hepatology · doi:10.1002/hep.23699 · Cited by 97 · see citing works
The emerging tale of microglia in psychiatric disorders
Rahimian, R., Wakid, M., O’Leary, L. A., & Mechawar, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.023 · Cited by 91 · see citing works
Réus, G. Z., Manosso, L. M., Quevedo, J., & Carvalho, A. F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105425 · Cited by 89 · see citing works
Wichers, M., Kenis, G., Leue, C., Koek, G. H., Robaeys, G., & Maes, M. H. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.024 · Cited by 83 · see citing works
Recurrence of depressive disorders after interferon-induced depression
Chiu, W.-C., Su, Y.-P., Su, K.-P., & Chen, P.-C. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.274 · Cited by 80 · see citing works
Suicide risk in hepatitis C and during interferon-alpha therapy: a review and clinical update
Sockalingam, S., Links, P. S., & Abbey, S. E. (2010) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01393.x · Cited by 79 · see citing works
Martín‐Santos, R., Díez, C., Castellví, P., Navinés, R., Miquel, M., Masnou, H., Soler, A., Ardévol, M., GARCÍA, F., Galeras, J. A., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03568.x · Cited by 79 · see citing works
Antonucci, G., Longo, M. A., Angeletti, C., Vairo, F., Oliva, A., Comandini, U. V., Tocci, G., Boumis, E., Noto, P., Solmone, M. C., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01201.x · Cited by 73 · see citing works
Major depression during interferon-α treatment: vulnerability and prevention
Lotrich, F. E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/felotrich · Cited by 71 · see citing works
Su, K., Lai, H., Peng, C., Su, W., Chang, J. P., & Pariante, C. M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.032 · Cited by 70 · see citing works
Prospective Analysis of Depression During Peginterferon and Ribavirin Therapy of Chronic Hepatitis C
Evon, D. M., Ramcharran, D., Belle, S. H., Terrault, N. A., Fontana, R. J., & Fried, M. W. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.528 · Cited by 63 · see citing works
Managing Depression during Hepatitis C Treatment
Sockalingam, S., & Abbey, S. E. (2009) · The Canadian Journal of Psychiatry · doi:10.1177/070674370905400906 · Cited by 60 · see citing works
Oxidative stress: a potential link between emotional wellbeing and immune response
Salim, S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.06.006 · Cited by 68 · see citing works
Interferon-induced depression: Strategies in treatment
Asnis, G. M., & Garza, R. D. L. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.006 · Cited by 57 · see citing works
Symptomatic Treatment of Interferon-α–Induced Depression in Hepatitis C
Baraldi, S., Hepgul, N., Mondelli, V., & Pariante, C. M. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31825d9982 · Cited by 54 · see citing works
Schäfer, A., Wïttchen, H., Seufert, J., & Kraus, M. R. (2007) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.229 · Cited by 53 · see citing works
Gentilucci, U. V. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i24.7412 · Cited by 47 · see citing works
Russo, S., Kema, I. P., Haagsma, E. B., Boon, J. C., Willemse, P. H. B., den Boer, J. A., de Vries, E. G. E., & Korf, J. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000171193.28044.d8 · Cited by 48 · see citing works
Lucaciu, L., & Dumitrascu, D. L. (2015) · PubMed Central · Cited by 45 · see citing works
Interferon therapy and its association with depressive disorders – A review
Lai, J. Y., Ho, J. X., Kow, A. S. F., Liang, G., Tham, C. L., Ho, Y.-C., & Lee, M. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1048592 · Cited by 46 · see citing works
Reddy, K. R., Messinger, D., Popescu, M., & Hadziyannis, S. (2009) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2009.01122.x · Cited by 44 · see citing works
Beratis, S., Katrivanou, A., Georgiou, S., Monastirli, A., Pasmatzi, E., Gourzis, P., & Tsambaos, D. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.03.010 · Cited by 43 · see citing works
A Review of Sleep Disturbance in Hepatitis C
Sockalingam, S., Abbey, S. E., Alosaimi, F. D., & Novák, M. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181b314ea · Cited by 41 · see citing works
Casaril, A. M., Domingues, M., Lourenço, D. D. A., Birmann, P. T., Padilha, N. B., Vieira, B. M., Begnini, K. R., Seixas, F. K., Collares, T. V., Lenardao, E. J., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.006 · Cited by 41 · see citing works
Chronic Hepatitis C Virus Infection in Older Adults
High, K. P., Marcus, E., & Tur‐Kaspa, R. (2005) · Clinical Infectious Diseases · doi:10.1086/497597 · Cited by 40 · see citing works
Quelhas, R., & Lopes, A. (2009) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000358313.06858.ea · Cited by 40 · see citing works
Neri, S., Bertino, G., Petralia, A., Giancarlo, C., Rizzotto, A., Calvagno, G. S., Mauceri, B., Abate, G., Boemi, P., Di Pino, A., et al. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181d88af5 · Cited by 37 · see citing works
Neuropsychiatric side effects of HCV therapy and their treatment: focus on IFNα-induced depression
Hauser, P. (2004) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2003.12.005 · Cited by 37 · see citing works
Risk factors for the development of depression in patients with hepatitis C taking interferon-α
Smith, K. J. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s13917 · Cited by 35 · see citing works
Ehret, M. J., & Sobieraj, D. M. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12268 · Cited by 33 · see citing works
Depression Treatment in Patients With General Medical Conditions: Results From the CO-MED Trial
Morris, D. W., Budhwar, N., Husain, M. M., Wisniewski, S. R., Kurian, B. T., Luther, J., Kerber, K. A., Rush, A. J., & Trivedi, M. H. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1316 · Cited by 32 · see citing works
Psychiatric treatment considerations with direct acting antivirals in hepatitis C
Sockalingam, S., Tseng, A. L.-I., Giguère, P., & Wong, D. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-86 · Cited by 31 · see citing works
Quarantini, L. C., Bressan, R. A., Galvão, A., Batista-Neves, S. C., Paraná, R., & Miranda‐Scippa, Â. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01532.x · Cited by 29 · see citing works
Psychiatric management of the hepatitis C patient
Rifai, M. A., Indest, D. W., Loftis, J. M., & Hauser, P. (2006) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-006-0007-6 · Cited by 29 · see citing works
Inflammatory insults and mental health consequences: does timing matter when it comes to depression?
Preez, A. D., Leveson, J., Zunszain, P. A., & Pariante, C. M. (2016) · Psychological Medicine · doi:10.1017/s0033291716000672 · Cited by 29 · see citing works
Hepatitis C Virus Infection in the Elderly
Cainelli, F. (2008) · Drugs & Aging · doi:10.2165/00002512-200825010-00002 · Cited by 28 · see citing works
Oramasionwu, C. U., Moore, H., & Toliver, J. C. (2014) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0033 · Cited by 27 · see citing works
Friebe, A., Schwarz, M., Schmid-Wendtner, M.-H., Volkenandt, M., Schmidt, F., Horn, M., Janssen, G., & Schaefer, M. (2007) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211346.19330.c9 · Cited by 26 · see citing works
Pavlović, Z., Delić, D., Marić, N. P., Vuković, O., & Jašović‐Gašić, M. (2011) · PubMed · Cited by 25 · see citing works
Lu, Y., An, T., Tian, H., Gao, X., Wang, F., Wang, S., & Ma, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.596362 · Cited by 26 · see citing works
Schmidt, F., Janssen, G., Martin, G., Lorenz, R., Loeschke, K., Soyka, M., Folwaczny, C., & Schaefer, M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04123.x · Cited by 24 · see citing works
Systemic inflammation alters central 5-HT function as determined by pharmacological MRI
Couch, Y., Martin, C. J., Howarth, C., Raley, J., Khrapitchev, A. A., Stratford, M. R. L., Sharp, T., Sibson, N. R., & Anthony, D. C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.046 · Cited by 22 · see citing works
Almeida, A. G.-D., Quarantini, L. C., Sampaio, A. S., Lyra, A. C., Parise, C. L., Paraná, R., de Oliveira, I. R., Koenen, K. C., Miranda-Scippa, Â. M. D. A., & Guindalini, C. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.001 · Cited by 22 · see citing works
Sockalingam, S., Blank, D., Jarad, A. A., Alosaimi, F. D., Hirschfield, G. M., & Abbey, S. E. (2011) · Psychosomatics · doi:10.1016/j.psym.2011.02.006 · Cited by 21 · see citing works
Alian, S., Masoudzadeh, A., Khoddad, T., Dadashian, A., & Mohammadpour, R. A. (2013) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Ramsey, S. E., Engler, P. A., Stein, M. D., Brown, R. A., & Cioe, P. A. (2011) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000109 · Cited by 21 · see citing works
Evidence-informed assessment and treatment of depression in HCV and interferon-treated patients
Angelino, A. F., & Treisman, G. J. (2005) · International Review of Psychiatry · doi:10.1080/02646830500381567 · Cited by 21 · see citing works
Drugs acting on the immune system
Vial, T., Descotes, J., Screaton, G. R., Behrend, M., & Ludwig, C. (2003) · Side effects of drugs annual · doi:10.1016/s0378-6080(03)80044-2 · Cited by 21 · see citing works
Major Depressive Disorder in Hepatitis C
Gleason, O. C., Yates, W. R., & Philipsen, M. A. (2005) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v07n0503 · Cited by 20 · see citing works
Wu, S., Chen, W.-J., Chang, J. P., Guu, T., Hsin, M.-C., Huang, C., Mischoulon, D., Capuron, L., & Su, K. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13061003 · Cited by 18 · see citing works
Robaeys, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i43.5736 · Cited by 19 · see citing works
Depressive Störungen bei körperlich Kranken
Arolt, V., & Rothermundt, M. (2003) · Der Nervenarzt · doi:10.1007/s00115-003-1629-8 · Cited by 40 · see citing works
Persistent Psychosis After Treatment With Interferon Alfa
Telio, D., Sockalingam, S., & Stergiopoulos, V. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000227348.59912.5d · Cited by 18 · see citing works
Psychiatric Implications of Hepatitis-C Infection
Giunta, B. N., Somboonwit, C., Nikolic, W. V., Rrapo, E., Tan, J. R., Shapshak, P., & Fernandez, F. (2007) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v19.i2-3.20 · Cited by 18 · see citing works
Çiçek, İ. E., Çíçek, E., Kayhan, F., Uğuz, F., Erayman, İ., Kurban, S., Yerlikaya, F. H., & Kaya, N. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.01.003 · Cited by 17 · see citing works
Interferon-α in Oncology Patients: Fewer Psychiatric Side Effects Than Anticipated
Bannink, M., Kruit, W. H. J., Gool, A. R. V., Sleijfer, S., van der Holt, B., Eggermont, A. M. M., Stoter, G., & Hengeveld, M. W. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.1.56 · Cited by 16 · see citing works
Prevalence of Hepatitis C in Two Inpatient Psychiatry Populations
Gunewardene, R., Lampe, L. A., & Ilchef, R. (2010) · Australasian Psychiatry · doi:10.3109/10398561003763273 · Cited by 15 · see citing works
Psychological comorbidities in Chinese patients with acute-on-chronic liver failure
Duan, Z., Kong, Y., Zhang, J., & Guo, H. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.11.012 · Cited by 15 · see citing works
Shakoor, A., Shafqat, F., Mehmud, T. E. H., Akram, M., Riaz, S., Iqbal, Z., & Khan, A. A. (2010) · PubMed · Cited by 14 · see citing works
The Role of Attachment Style and Depression in Patients with Hepatitis C
Sockalingam, S., Blank, D., Jarad, A. A., Alosaimi, F. D., Hirschfield, G. M., & Abbey, S. E. (2012) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-012-9335-y · Cited by 12 · see citing works
Whale, R., Fialho, R., Rolt, M., Eccles, J., Pereira, M., Keller, M., File, A., Haq, I., & Tibble, J. A. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.06.003 · Cited by 12 · see citing works
Miarons, M., Sánchez, A., Sempere, G., Marín, S., & Castellví, J. M. S. (2018) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2017-001352 · Cited by 12 · see citing works
Neurobehavioral Correlates of Chronic Hepatitis C
Hilsabeck, R. C., & Malek-Ahmadi, P. (2004) · Journal of Psychopathology and Behavioral Assessment · doi:10.1023/b:joba.0000022113.60976.4a · Cited by 12 · see citing works
Depression and pegylated interferon-based hepatitis C treatment
Papafragkakis, H., Rao, M. S., Moehlen, M., Dhillon, S., & Martin, P. (2012) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s28901 · Cited by 10 · see citing works
van de Putte, D. E. F., Fischer, K., Posthouwer, D., van Erpecum, K. J., & Mauser‐Bunschoten, E. P. (2009) · Haemophilia · doi:10.1111/j.1365-2516.2008.01940.x · Cited by 11 · see citing works
Vignau, J., Costisella, O., Canva, V., Imbenotte, M., Duhamel, A., & Lhermitte, M. (2008) · L Encéphale · doi:10.1016/j.encep.2007.09.007 · Cited by 11 · see citing works
Manifestations psychiatriques au cours du traitement de l’hépatite chronique C
Castéra, L., Constant, A., Henry, C., & Couzigou, P. (2005) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(05)80714-6 · Cited by 10 · see citing works
Sockalingam, S., & Balderson, K. (2005) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000170263.46008.54 · Cited by 11 · see citing works
Interferon-induced depression in patients with hepatitis C: an epidemiologic study
de Medeiros, L. P. J., Kayo, M., Medeiros, R. B. V., Lima, M. B. C., & Brandão‐Mello, C. E. (2014) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.60.01.009 · Cited by 9 · see citing works
Almeida, A. G.-D., Quarantini, L. C., Tartaglioni, A. G., Lyra, A. C., Parise, C. L., Paraná, R., de Oliveira, I. R., Miranda‐Scippa, Â., & Guindalini, C. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.12.007 · Cited by 9 · see citing works
Depression bei körperlichen Erkrankungen
Arolt, V., & Rothermundt, M. (2004) · Steinkopff eBooks · doi:10.1007/978-3-662-12845-9_19 · Cited by 9 · see citing works
Lin, C. Y., Guu, T., Lai, H., Peng, C., Chiang, J. Y.-J., Chen, H., Li, T., Yang, S.-Y., Su, K., & Chang, J. P. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2019.100035 · Cited by 8 · see citing works
Herrmann‐Lingen, C. (2003) · Zeitschrift für psychosomatische Medizin und Psychotherapie · doi:10.13109/zptm.2003.49.4.391 · Cited by 8 · see citing works
Bassiony, M. M., Yousef, A. M., Youssef, U. M., El-deen, G. M. S., Abdelghani, M., Al-Gohari, H., Fouad, E., & El-Shafaey, M. (2015) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217415605029 · Cited by 7 · see citing works
Fang, Y., Chen, C., Yu, H., & Lin, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1191843 · Cited by 7 · see citing works
Fábregas, B. C., Moura, A. S., Marciano, R. C., Carmo, R. A., & Teixeira, A. L. (2009) · The Brazilian Journal of Infectious Diseases · doi:10.1590/s1413-86702009000500015 · Cited by 7 · see citing works
Traitements complémentaires de l’hépatite chronique virale C
Thévenot, T., Martino, V. D., Lunel, F., Vanlemmens, C., Becker, M.-C., Bronowicki, J., Bresson‐Hadni, S., & Miguet, J. (2006) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(06)73154-2 · Cited by 8 · see citing works
Wang, L., Chen, S., Chen, C., Yen, C., Chang, J.-J., Lee, T.-S., Liu, C., Chen, L., & Chien, R. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1135-8 · Cited by 6 · see citing works
Choi, J., Kim, W. K., Sohn, B. K., Lee, J., Jung, H. Y., Oh, S., Joo, S. K., Kim, H. Y., & Jung, Y. J. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.3.314 · Cited by 6 · see citing works
Managing the neuropsychiatric complications of hepatitis C treatment
Sockalingam, S., Shammi, C., & Stergiopoulos, V. (2007) · British Journal of Hospital Medicine · doi:10.12968/hmed.2007.68.10.27321 · Cited by 6 · see citing works
Neurodevelopmental and Neuropsychiatric Disorders
Traetta, M. E., Filho, A. M. C., Akinluyi, E. T., & Tremblay, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_26 · Cited by 4 · see citing works
Marcellin, P., Roberts, S. K., Reddy, K. R., Harrison, S. A., Jensen, D. M., Hadziyannis, S. J., Moisés Diago, M., Weltman, M., Messinger, D., Tatsch, F., et al. (2012) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2012.721927 · Cited by 4 · see citing works
McGinn, L. K., Meter, A. V., Kronish, I. M., Gashin, J., Burns, K. E. A., Kil, N., & McGinn, T. G. (2019) · Cognitive Therapy and Research · doi:10.1007/s10608-018-09990-7 · Cited by 4 · see citing works
- Authors
- Horikawa, N., Yamazaki, T., Izumi, N., & Uchihara, M.
- Affiliations
- Tokyo Women's Medical University (JP)
- Musashino Red Cross Hospital (JP)
- Corresponding author
- Horikawa, Naoshi
- ORCID
- Izumi, Namiki
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 25
- Issue
- 1
- Pages
- 34-38
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2130844638
- Cited by
- 140
- References
- 42
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 14
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, chronic hepatitis C, interferon-alpha therapy, antidepressant side effects, depression incidence, clinical course, remission, risk factors, old age
- MeSH terms
- Antiviral Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Prospective Studies, Incidence, Interferon-alpha, Hepatitis C, Chronic
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