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Nanoparticulate systems for brain delivery of drugs.
Abstract
The blood--brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to the brain using nanoparticles. Drugs that have successfully been transported into the brain using this carrier include the hexapeptide dalargin, the dipeptide kytorphin, loperamide, tubocurarine, the NMDA receptor antagonist MRZ 2/576, and doxorubicin. The nanoparticles may be especially helpful for the treatment of the disseminated and very aggressive brain tumors. Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8. The mechanism of the nanoparticle-mediated transport of the drugs across the blood-brain barrier at present is not fully elucidated. The most likely mechanism is endocytosis by the endothelial cells lining the brain blood capillaries. Nanoparticle-mediated drug transport to the brain depends on the overcoating of the particles with polysorbates, especially polysorbate 80. Overcoating with these materials seems to lead to the adsorption of apolipoprotein E from blood plasma onto the nanoparticle surface. The particles then seem to mimic low density lipoprotein (LDL) particles and could interact with the LDL receptor leading to their uptake by the endothelial cells. After this the drug may be released in these cells and diffuse into the brain interior or the particles may be transcytosed. Other processes such as tight junction modulation or P-glycoprotein (Pgp) inhibition also may occur. Moreover, these mechanisms may run in parallel or may be cooperative thus enabling a drug delivery to the brain.
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Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
Brain drug delivery of small molecules using immunoliposomes
Huwyler, J., Wu, D., & Pardridge, W. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14164 · Cited by 660
An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro
Dehouck, M., Méresse, S., Delorme, P., Fruchart, J., & Cecchelli, R. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01236.x · Cited by 548
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521
A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
Dehouck, B., Fenart, L., Dehouck, M.-P., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 490
Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli
Frederickson, R. C. A., Burgis, V., & Edwards, J. D. (1977) · Science · doi:10.1126/science.561998 · Cited by 379
Pardridge, W. M., Buciak, J. L., & Friden, P. M. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20567-5 · Cited by 358
Alyautdin, R. N., Petrov, V. E., Langer, K., Berthold, A., Kharkevich, D. A., & Kreuter, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012098005098 · Cited by 352
Research works printed but not linked: 6
- Kreuter, 1994, Nanoparticles, Vol. 10, 165
- Alyautdin, 1995, Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles, Eur. J. Pharm. Biopharm., 41, 44
- Ramge, 2000, Polysorbate 80-coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human, bovine and murine primary brain capilary endothelial cells, Eur. J. Neuro., 12, 1935
- Steiniger, 1999, The influence of polysorbate 80-coated nanoparticles on bovine brain capillary endothelial cells in vitro, Proc. Int. Symp. Control. Rel. Bioact. Mater., 26, 789
- Fenart, 1999, Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood–brain barrier, J. Pharmacol. Exp. Ther., 291, 1017
- Cecchelli, 1997, Receptor-mediated transcytosis of blood-borne molecules through blood–brain barrier endothelial cells: Drug targeting by endogenous transport routes, Proc. Intl. Symp. Control. Rel. Bioact. Mater., 24, 221
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Influence of titanium dioxide nanoparticles on speciation and bioavailability of arsenite
Sun, H., Zhang, X., Zhang, Z., Chen, Y., & Crittenden, J. C. (2008) · Environmental Pollution · doi:10.1016/j.envpol.2008.08.022 · Cited by 132
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Kreuter, J., & Gelperina, S. E. (2008) · Tumori Journal · doi:10.1177/030089160809400220 · Cited by 131
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Aktaş, Y., Andrieux, K., Alonso, M. J., Calvo, P., Gürsoy, R. N., Couvreur, P., & Çapan, Y. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.027 · Cited by 135
Particle Targeting in Complex Biological Media
Dai, Q., Bertleff‐Zieschang, N., Braunger, J. A., Björnmalm, M., Cortez‐Jugo, C., & Caruso, F. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700575 · Cited by 132
Monge-Fuentes, V., Mayer, A. B., Lima, M. R., Geraldes, L., Zanotto, L., Moreira, K., Martins, O., Piva, H. L., Felipe, M., Amaral, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94175-8 · Cited by 105
Wang, C., Le-song, H., Hou, L., Jiang, L., Yan, Z.-T., Wang, Y.-L., & Chen, Z.-L. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.011 · Cited by 129
Elkhoury, K., Koçak, P., Kang, A., Arab‐Tehrany, E., Ward, J. E., & Shin, S. R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090849 · Cited by 132
Azadi, A., Hamidi, M., & Rouini, M. R. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.10.004 · Cited by 127
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Dual and multi-targeted nanoparticles for site-specific brain drug delivery
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Hasadsri, L., Kreuter, J., Hattori, H., Iwasaki, T., & George, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805956200 · Cited by 129
Lindner, G. D. R., Santos, D. B., Colle, D., Moreira, E. L. G., Prediger, R. D., Farina, M., Khalil, N. M., & Mainardes, R. M. (2015) · Nanomedicine · doi:10.2217/nnm.14.165 · Cited by 126
Anti-fouling magnetic nanoparticles for siRNA delivery
Boyer, C. A., Priyanto, P., Davis, T. P., Pissuwan, D., Bulmuş, V., Kavallaris, M., Teoh, W. Y., Amal, R., Carroll, M., Woodward, R. C., et al. (2009) · Journal of Materials Chemistry · doi:10.1039/b914063h · Cited by 125
Voigt, N., Henrich‐Noack, P., Kockentiedt, S., Hintz, W., Tomas, J., & Sabel, B. A. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.02.013 · Cited by 124
Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.
Markoutsa, E., Pampalakis, G., Niarakis, A., Romero, I. A., Weksler, B., Couraud, P.-O., & Antimisiaris, S. G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.015 · Cited by 122
Nanotechnology and Nanotoxicology
Curtis, J. A., Greenberg, M., Kester, J. E., Phillips, S., & Krieger, G. R. (2006) · Toxicological Reviews · doi:10.2165/00139709-200625040-00005 · Cited by 124
Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier
Silva, G. A. (2007) · Surgical Neurology · doi:10.1016/j.surneu.2006.08.033 · Cited by 119
Yemisci, M., Caban, S., Gursoy-Ozdemir, Y., Lule, S., Novoa-Carballal, R., Riguera, R., Fernandez-Megia, E., Andrieux, K., Couvreur, P., Capan, Y., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.220 · Cited by 118
Martins, S., Tho, I., Reimold, I., Fricker, G., Souto, E. B., Ferreira, D., & Brandl, M. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.09.054 · Cited by 117
Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines
Wang, J., Hu, X.-B., & Xiang, D. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1477857 · Cited by 117
Das, D., & Lin, S. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20357 · Cited by 117
Zu, Y., Zhang, Y., Wang, W., Zhao, X., Han, X., Wang, K., & Ge, Y. (2014) · Drug Delivery · doi:10.3109/10717544.2014.924167 · Cited by 116
Bhujbal, S. V., de Vos, P., & Niclou, S. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.010 · Cited by 116
Nanoparticles for antiparasitic drug delivery
Sun, Y., Chen, D., Pan, Y., Qu, W., Hao, H., Wang, X., Liu, Z., & Xie, S. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1692968 · Cited by 116
Kaur, A., Jain, S. K., & Tiwary, A. K. (2008) · Acta Pharmaceutica · doi:10.2478/v10007-007-0045-1 · Cited by 116
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.762354 · Cited by 119
Singh, S. K., Dadhania, P., Vuddanda, P. R., Jain, A., Velaga, S. P., & Singh, S. K. (2016) · RSC Advances · doi:10.1039/c5ra19793g · Cited by 116
Patel, M., Souto, E. B., & Singh, K. K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.784742 · Cited by 114
Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
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Shah, B., Khunt, D., Misra, M., & Padh, H. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.04.076 · Cited by 112
Sanati, M., Khodagholi, F., Aminyavari, S., Ghasemi, F., Gholami, M., Kebriaeezadeh, A., Sabzevari, O., Hajipour, M. J., Imani, M., Mahmoudi, M., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00622 · Cited by 113
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Cupaioli, F. A., Zucca, F. A., Boraschi, D., & Zecca, L. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.05.002 · Cited by 139
Kuo, Y., & Ko, H.-F. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.013 · Cited by 110
Liu, Y., Zhou, H., Yin, T., Gong, Y., Yuan, G., Chen, L., & Liu, J. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.05.066 · Cited by 113
Kulkarni, S. A., & Feng, S. (2011) · Nanomedicine · doi:10.2217/nnm.10.131 · Cited by 111
Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration
Cai, Z., Hou, S., Li, Y., Zhao, B., Yang, Z., Xu, S., & Pu, J. (2008) · Journal of drug targeting · doi:10.1080/10611860701794395 · Cited by 110
In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma
de Mendoza, A. E., Véronique Préat, A., Mollinedo, F., & Blanco‐Prieto, M. J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.030 · Cited by 110
Drug Delivery to the Ischemic Brain
Thompson, B. J., & Ronaldson, P. T. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.013 · Cited by 111
Kuo, Y., & Chen, H.-H. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.044 · Cited by 109
Nanotechnology-based drug delivery for the treatment of CNS disorders
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Nanoparticulate Vanadium Oxide Potentiated Vanadium Toxicity in Human Lung Cells
Wörle‐Knirsch, J. M., Kern, K., Schleh, C., Adelhelm, C., Feldmann, C., & Krug, H. F. (2006) · Environmental Science & Technology · doi:10.1021/es061140x · Cited by 108
N‐vinylcaprolactam‐based microgels for biomedical applications
Imaz, A., & Forcada, J. (2010) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.23876 · Cited by 108
Application of nanoparticles for the delivery of drugs to the brain
Kreuter, J. (2005) · International Congress Series · doi:10.1016/j.ics.2005.02.014 · Cited by 107
Modulation of Drug Transporters at the Blood-Brain Barrier
Fricker, G., & Miller, D. S. (2004) · Pharmacology · doi:10.1159/000075545 · Cited by 106
Chen, Y., Hsieh, W.-Y., Lee, W., & Zeng, D.-T. (2011) · Journal of Biomaterials Applications · doi:10.1177/0885328211429495 · Cited by 107
Vlieghe, P., & Khrestchatisky, M. (2012) · Medicinal Research Reviews · doi:10.1002/med.21252 · Cited by 109
Kratzer, I., Wernig, K., Panzenboeck, U., Bernhart, E. M., Reicher, H., Wronski, R., Windisch, M., Hammer, A., Malle, E., Zimmer, A., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.11.020 · Cited by 106
Agyare, E. K., Curran, G. L., Ramakrishnan, M., Yu, C. C., Poduslo, J. F., & Kandimalla, K. K. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9688-y · Cited by 104
Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents
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Manjunath, K., & Venkateswarlu, V. (2006) · Journal of drug targeting · doi:10.1080/10611860600888850 · Cited by 103
Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery
Shubhra, Q. T. H., Tóth, J. S., Gyenis, J., & Feczkó, T. (2014) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2013.862544 · Cited by 102
Magnetic nanoparticles in cancer diagnosis and treatment: a review
Fathi‐karkan, S., Mohammadhosseini, M., Panahi, Y., Milani, M., Zarghami, N., Akbarzadeh, A., Abasi, E., Hosseini, A., & Davaran, S. (2016) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2016.1153483 · Cited by 102
Biosynthesis of Yttrium oxide nanoparticles using Acalypha indica leaf extract
Kannan, S. K., & Sundrarajan, M. (2015) · Bulletin of Materials Science · doi:10.1007/s12034-015-0927-7 · Cited by 101
Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?
Costantino, L., & Boraschi, D. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.028 · Cited by 103
Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles
Han, L., Cai, Q., Tian, D., Kong, D. K., Gou, X., Chen, Z., Strittmatter, S. M., Wang, Z., Sheth, K. N., & Zhou, J. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.03.005 · Cited by 101
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Hamano, N., Li, S., Chougule, M. B., Shoyele, S., Gupta, U. D., Ajazuddin, M., et al. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1471058 · Cited by 101
Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons
Townsend, S. A., Evrony, G. D., Gu, F., Schulz, M. P., Brown, R. H., & Langer, R. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.011 · Cited by 101
Convection-enhanced delivery of maghemite nanoparticles: Increased efficacy and MRI monitoring
Perlstein, B., Ram, Z., Daniels, D., Ocherashvilli, A., Roth, Y., Margel, S., & Mardor, Y. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-002 · Cited by 101
Use of nanoparticles for drug delivery in glioblastoma multiforme
Jain, K. K. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.4.363 · Cited by 99
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Sandoval, D. A., Obici, S., & Seeley, R. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2874 · Cited by 101
Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective
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Vicario‐de‐la‐Torre, M., & Forcada, J. (2017) · Gels · doi:10.3390/gels3020016 · Cited by 104
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Singh, K., Ejaz, W., Dutta, K., & Thayumanavan, S. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00025 · Cited by 104
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Artificial cells: building bioinspired systems using small-scale biology
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Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system
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Drug delivery strategies for the treatment of malignant gliomas
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Ambruosi, A., Gelperina, S. E., Khalansky, A. S., Tanski, S., Theisen, A., & Kreuter, J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788080 · Cited by 106
Kinetics of transport of doxorubicin bound to nanoparticles across the blood–brain barrier
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Nafisi, S., & Maibach, H. I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802005-0.00022-7 · Cited by 99
Dilnawaz, F., Singh, A., Mewar, S., Sharma, U., Jagannathan, N. R., & Sahoo, S. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.046 · Cited by 102
Transport Of Surface‐Modified Nanoparticles Through Cell Monolayers
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Yao, Z., Zhang, C., Ping, Q., & Yu, L. L. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.08.023 · Cited by 99
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Rip, J., Schenk, G., & de Boer, A. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902806383 · Cited by 98
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Khan, Z. A., & Bagad, M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s80706 · Cited by 98
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Đorđević, S. M., Cekic, N. D., Savić, M. M., Isailović, T. M., Randjelovic, D. V., Marković, B. D., Savic, S. R., Stamenić, T. T., Daniels, R., & Savic, S. D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.07.007 · Cited by 95
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Liu, G., Men, P., Perry, G. L., & Smith, M. A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-029-8_8 · Cited by 96
Le, X., Poinern, G. E. J., Ali, N., Berry, C., & Fawcett, D. (2013) · International Journal of Biomaterials · doi:10.1155/2013/782549 · Cited by 94
Yang, C., Chang, C.-H., Tsai, P., Chen, W., Tseng, F., & Lo, L. (2004) · Analytical Chemistry · doi:10.1021/ac035491v · Cited by 95
Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge
Busquets, M. A., Espargaró, A., Sabaté, R., & Estelrich, J. (2015) · Nanomaterials · doi:10.3390/nano5042231 · Cited by 100
Transcellular brain drug delivery: A review on recent advancements
Azarmi, M., Maleki, H., Nikkam, N., & Malekinejad, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119582 · Cited by 96
Pharmacokinetics and biodistribution of surface modification polymeric nanoparticles
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Metadata
- Authors
- Kreuter, J.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Kreuter, Jörg
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 47
- Issue
- 1
- Pages
- 65-81
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2072229818
- Cited by
- 1,107
- References
- 50
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 26 · 2023: 39 · 2022: 32 · 2021: 43 · 2020: 47 · 2019: 40 · 2018: 47 · 2017: 53 · 2016: 63 · 2015: 57 · 2014: 55 · 2013: 65 · 2012: 76
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- blood-brain barrier, nanoparticle drug delivery, brain drug delivery, apolipoprotein E, glioblastoma, doxorubicin, neuropeptides, P-glycoprotein inhibition, tight junction modulation, transcytosis, central nervous system drugs
- MeSH terms
- Animals, Antineoplastic Agents, Blood-Brain Barrier, Brain, Brain Neoplasms, Capsules, Cells, Cultured, Doxorubicin, Drug Carriers, Endothelium, Vascular, Humans, Male, Polysorbates, Surface-Active Agents, Mice, Rats
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