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Nanoparticulate systems for brain delivery of drugs.
Abstract
The blood--brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to the brain using nanoparticles. Drugs that have successfully been transported into the brain using this carrier include the hexapeptide dalargin, the dipeptide kytorphin, loperamide, tubocurarine, the NMDA receptor antagonist MRZ 2/576, and doxorubicin. The nanoparticles may be especially helpful for the treatment of the disseminated and very aggressive brain tumors. Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8. The mechanism of the nanoparticle-mediated transport of the drugs across the blood-brain barrier at present is not fully elucidated. The most likely mechanism is endocytosis by the endothelial cells lining the brain blood capillaries. Nanoparticle-mediated drug transport to the brain depends on the overcoating of the particles with polysorbates, especially polysorbate 80. Overcoating with these materials seems to lead to the adsorption of apolipoprotein E from blood plasma onto the nanoparticle surface. The particles then seem to mimic low density lipoprotein (LDL) particles and could interact with the LDL receptor leading to their uptake by the endothelial cells. After this the drug may be released in these cells and diffuse into the brain interior or the particles may be transcytosed. Other processes such as tight junction modulation or P-glycoprotein (Pgp) inhibition also may occur. Moreover, these mechanisms may run in parallel or may be cooperative thus enabling a drug delivery to the brain.
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Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
Brain drug delivery of small molecules using immunoliposomes
Huwyler, J., Wu, D., & Pardridge, W. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14164 · Cited by 660
An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro
Dehouck, M., Méresse, S., Delorme, P., Fruchart, J., & Cecchelli, R. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01236.x · Cited by 548
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521
A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
Dehouck, B., Fenart, L., Dehouck, M.-P., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 490
Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli
Frederickson, R. C. A., Burgis, V., & Edwards, J. D. (1977) · Science · doi:10.1126/science.561998 · Cited by 379
Pardridge, W. M., Buciak, J. L., & Friden, P. M. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20567-5 · Cited by 358
Alyautdin, R. N., Petrov, V. E., Langer, K., Berthold, A., Kharkevich, D. A., & Kreuter, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012098005098 · Cited by 352
Research works printed but not linked: 6
- Kreuter, 1994, Nanoparticles, Vol. 10, 165
- Alyautdin, 1995, Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles, Eur. J. Pharm. Biopharm., 41, 44
- Ramge, 2000, Polysorbate 80-coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human, bovine and murine primary brain capilary endothelial cells, Eur. J. Neuro., 12, 1935
- Steiniger, 1999, The influence of polysorbate 80-coated nanoparticles on bovine brain capillary endothelial cells in vitro, Proc. Int. Symp. Control. Rel. Bioact. Mater., 26, 789
- Fenart, 1999, Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood–brain barrier, J. Pharmacol. Exp. Ther., 291, 1017
- Cecchelli, 1997, Receptor-mediated transcytosis of blood-borne molecules through blood–brain barrier endothelial cells: Drug targeting by endogenous transport routes, Proc. Intl. Symp. Control. Rel. Bioact. Mater., 24, 221
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Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
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de Jong (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s596 · Cited by 3,854
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Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699
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Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Omid Veiseh, A., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,854
Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Nanocarriers’ entry into the cell: relevance to drug delivery
Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,620
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Rabinow, B. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1494 · Cited by 1,529
Nanoparticles – known and unknown health risks
Hoet, P., Brüske‐Hohlfeld, I., & Salata, O. V. (2004) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-2-12 · Cited by 1,407
Biodegradable nanoparticles for drug delivery and targeting
Hans, M. L., & Lowman, A. M. (2002) · Current Opinion in Solid State and Materials Science · doi:10.1016/s1359-0286(02)00117-1 · Cited by 1,324
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)
Honary, S., & Zahir, F. (2013) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v12i2.19 · Cited by 1,144
Therapeutic efficacy of nanoparticles and routes of administration
Chenthamara, D., Sadhasivam, S., Ramakrishnan, S. G., Krishnaswamy, S., Essa, M. M., Lin, F., & Qoronfleh, M. W. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0166-x · Cited by 1,103
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Shubayev, V. I., Pisanic, T. R., & Jin, S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.007 · Cited by 1,052
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Duncan, R., & Gaspar, R. S. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200394t · Cited by 1,009
Toxicology of nanoparticles: A historical perspective
Oberdörster, G., Stone, V., & Donaldson, K. (2007) · Nanotoxicology · doi:10.1080/17435390701314761 · Cited by 989
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Brigger, I., Dubernet, C., & Couvreur, P. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.006 · Cited by 958
Nanosuspensions: a promising drug delivery strategy
Patravale, V. B., Date, A. A., & Kulkarni, R. M. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357023691 · Cited by 931
Nanoparticles in cellular drug delivery
Faraji, A. H., & Wipf, P. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.02.043 · Cited by 937
Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective
Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N. V. R. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.015 · Cited by 885
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
Nanodiamond Particles: Properties and Perspectives for Bioapplications
Schrand, A. M., Hens, S. A. C., & Shenderova, O. A. (2009) · Critical reviews in solid state and materials sciences/CRC critical reviews in solid state and materials sciences · doi:10.1080/10408430902831987 · Cited by 810
Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells
Vinogradov, S. V., Bronich, T. K., & Kabanov, A. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00245-9 · Cited by 776
Nanostructured lipid carriers: Promising drug delivery systems for future clinics
Beloqui, A., Solinís, M. Á., Rodríguez‐Gascón, A., Almeida, A. J., & Véronique Préat, A. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.09.004 · Cited by 790
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36663 · Cited by 771
Deposition and biokinetics of inhaled nanoparticles
Geiser, M., & Kreyling, W. G. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-2 · Cited by 747
Parameters influencing the stealthiness of colloidal drug delivery systems
Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
Transport of drugs across the blood–brain barrier by nanoparticles.
Wohlfart, S., Gelperina, S., & Kreuter, J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.017 · Cited by 715
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708
Mahapatro, A., & Singh, D. K. (2011) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-9-55 · Cited by 685
Delivery of therapeutic agents to the central nervous system: the problems and the possibilities
Begley, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.001 · Cited by 679
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
Löscher, W., & Potschka, H. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.006 · Cited by 631
Potential of solid lipid nanoparticles in brain targeting.
Kaur, I. P., Bhandari, R., Bhandari, S., & Kakkar, V. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.018 · Cited by 615
Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591
Interaction of Nanoparticles with Cells
Mailänder, V., & Landfester, K. (2009) · Biomacromolecules · doi:10.1021/bm900266r · Cited by 576
Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions
Du, W., Niu, S.-S., Xu, Y., Xu, Z., & Fan, C.-L. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.07.039 · Cited by 575
Polymeric nanoparticles for drug delivery to the central nervous system
Patel, T., Zhou, J., Piepmeier, J. M., & Saltzman, W. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.006 · Cited by 592
Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas
Omid Veiseh, A., Sun, C., Gunn, J., Kohler, N., Gabikian, P., Lee, D., Bhattarai, N., Ellenbogen, R. G., Sze, R. W., Hallahan, A. R., et al. (2005) · Nano Letters · doi:10.1021/nl0502569 · Cited by 564
Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?
Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554
Üner, M., & Yener, G. (2007) · PubMed Central · Cited by 536
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications
Vauthier, C., Dubernet, C., Fattal, E., Pinto‐Alphandary, H., & Couvreur, P. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(03)00041-3 · Cited by 537
Nanoparticles and targeted drug delivery in cancer therapy
Bahrami, B., Hojjat‐Farsangi, M., Mohammadi, H., Anvari, E., Ghalamfarsa, G., Yousefi, M., & Jadidi‐Niaragh, F. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.07.015 · Cited by 521
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Magnetic nanoparticle drug delivery systems for targeting tumor
Mody, V. V., Cox, A. G., Shah, S., Singh, A., Wesley, B., & Parihar, H. S. (2013) · Applied Nanoscience · doi:10.1007/s13204-013-0216-y · Cited by 500
Bhaskar, S. M. M., Tian, F., Stoeger, T., Kreyling, W. G., de la Fuente, J. M., Grazú, V., Borm, P. J. A., Estrada, G. G., Ntziachristos, V., & Razansky, D. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-3 · Cited by 510
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
Lockman, P. R., Mumper, R. J., Khan, M. A., & Allen, D. D. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120001481 · Cited by 592
Nanoparticles in Drug Delivery: From History to Therapeutic Applications
Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., et al. (2022) · Nanomaterials · doi:10.3390/nano12244494 · Cited by 468
Small Bioactive Peptides for Biomaterials Design and Therapeutics
Hamley, I. W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00522 · Cited by 466
Sociogenomics: social life in molecular terms
Robinson, G. E., Grozinger, C. M., & Whitfield, C. W. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1575 · Cited by 465
Nanocarriers: Promising Vehicle for Bioactive Drugs
Rawat, M. S., Singh, D., Saraf, S., & Saraf, S. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1790 · Cited by 449
Drug transport to brain with targeted nanoparticles
Olivier, J. (2004) · NeuroRx · doi:10.1602/neurorx.2.1.108 · Cited by 452
Bootz, A., Vogel, V., Schubert, D., & Kreuter, J. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00193-0 · Cited by 431
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Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430
Active targeting of brain tumors using nanocarriers
Béduneau, A., Saulnier, P., & Benoît, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.011 · Cited by 433
Catalytic properties and biomedical applications of cerium oxide nanoparticles
Walkey, C., Das, S., Seal, S., Erlichman, J. S., Heckman, K. L., Ghibelli, L., Traversa, E., McGinnis, J. F., & Self, W. T. (2014) · Environmental Science Nano · doi:10.1039/c4en00138a · Cited by 420
Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer's disease
Roney, C. A., Kulkarni, P. V., Arora, V., Antich, P. P., Bonte, F. J., Wu, A., Mallikarjuana, N. N., Manohar, S. K., Liang, H., Kulkarni, A. R., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.07.024 · Cited by 411
Magnetic Nanoparticles and Their Applications in Medicine
Duguet, É., Vasseur, S., Mornet, S., & Devoisselle, J. (2006) · Nanomedicine · doi:10.2217/17435889.1.2.157 · Cited by 396
Liu, H.-L., Hua, M., Yang, H., Huang, C.-Y., Chu, P., Wu, J.-S., Tseng, I.-C., Wang, J., Yen, T., Chen, P., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003388107 · Cited by 396
Neuroscience nanotechnology: progress, opportunities and challenges
Silva, G. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1827 · Cited by 383
Nanodrugs: pharmacokinetics and safety
Onoue, S., Yamada, S., & Chan, H. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s38378 · Cited by 383
Manjunath, K., & Venkateswarlu, V. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.006 · Cited by 381
Omid Veiseh, A., Sun, C., Fang, C., Bhattarai, N., Gunn, J., Kievit, F. M., Du, K. N., Pullar, B. J., Lee, D., Ellenbogen, R. G., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1157 · Cited by 378
Nanogels for Oligonucleotide Delivery to the Brain
Vinogradov, S. V., Batrakova, E. V., & Kabanov, A. V. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034164r · Cited by 381
Wilson, B., Samanta, M. K., Santhi, K., Kumar, K. P. S., Paramakrishnan, N., & Suresh, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.039 · Cited by 363
Drug delivery from gelatin-based systems
Foox, M., & Zilberman, M. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1037272 · Cited by 362
Han, L., & Jiang, C. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.023 · Cited by 358
Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility
Fournier, E., Passirani, C., Montero‐Menei, C. N., & Benoît, J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00161-3 · Cited by 353
Nanomedicines and nanotoxicology: some physiological principles
Garnett, M. C., & Kallinteri, P. (2006) · Occupational Medicine · doi:10.1093/occmed/kql052 · Cited by 352
Current approaches to enhance CNS delivery of drugs across the brain barriers
Lu, C.-T., Zhao, Y.-Z., Wong, H. L., Cai, J., Peng, L., & Tian, X.-Q. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s61288 · Cited by 350
Drug nanocrystals: in vivo performances.
Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.013 · Cited by 347
Applications of nanotechnology in drug delivery to the central nervous system
Saeedi, M., Eslamifar, M., Khezri, K., & Dizaj, S. M. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.133 · Cited by 342
Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges
Elmowafy, M., Shalaby, K., Elkomy, M. H., Alsaidan, O. A., Gomaa, H. A. M., Abdelgawad, M. A., & Mostafa, E. M. (2023) · Polymers · doi:10.3390/polym15051123 · Cited by 373
Vladimirov, S. V., & Ostrikov, K. (2004) · Physics Reports · doi:10.1016/j.physrep.2003.12.003 · Cited by 332
Shenoy, D. B., & Amiji, M. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.12.010 · Cited by 331
Role of metal dyshomeostasis in Alzheimer's disease
Bonda, D., Lee, H., Blair, J. A., Zhu, X., Perry, G. L., & Smith, M. A. (2011) · Metallomics · doi:10.1039/c0mt00074d · Cited by 316
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
Satapathy, M. K., Yen, T.-L., Jan, J.-S., Tang, R.-D., Wang, J.-Y., Taliyan, R., & Yang, C.-H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081183 · Cited by 318
Protein nanoparticle: A unique system as drug delivery vehicles
Jahanshahi, M., & Babaei, Z. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i25.59701 · Cited by 319
Building nanostructures using RAFT polymerization
Boyer, C. A., Stenzel, M. H., & Davis, T. P. (2010) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.24482 · Cited by 318
Protein Nanoparticles: Promising Platforms for Drug Delivery Applications
Jain, A., Singh, S. K., Arya, S. K., Kundu, S. C., & Kapoor, S. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01098 · Cited by 315
Strategies for transporting nanoparticles across the blood–brain barrier
Zhang, T.-T., Li, W., Meng, G., Wang, P., & Liao, W. (2016) · Biomaterials Science · doi:10.1039/c5bm00383k · Cited by 308
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
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Brambilla, D., Droumaguet, B. L., Nicolas, J., Hashemi, S. H., Wu, L., Moghimi, S. M., Couvreur, P., & Andrieux, K. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.03.008 · Cited by 302
Ultrafine particles in the urban air: to the respiratory tract--and beyond?
Oberdörster, G., & Utell, M. J. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.110-1240959 · Cited by 287
Nano carriers for drug transport across the blood–brain barrier
Li, X., Tsibouklis, J., Weng, T., Zhang, B., Yin, G., Feng, G., Cui, Y., Savina, I. N., Mikhalovska, L. I., Sandeman, S. R., et al. (2016) · Journal of drug targeting · doi:10.1080/1061186x.2016.1184272 · Cited by 289
Delivery of peptide and protein drugs over the blood–brain barrier
Brasnjevic, I., Steinbusch, H. W. M., Schmitz, C., & Martinez-Martinez, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.12.002 · Cited by 279
Nanomedicine in the diagnosis and therapy of neurodegenerative disorders
Kabanov, A. V., & Gendelman, H. E. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.014 · Cited by 279
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
Zhou, J., Patel, T., Sirianni, R. W., Strohbehn, G. W., Zheng, M., Duong, N. T., Schafbauer, T., Huttner, A. J., Huang, Y. H., Carson, R. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304504110 · Cited by 277
Gao, K., & Jiang, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.11.040 · Cited by 274
Jain, K. K. (2008) · Springer eBooks · doi:10.1007/978-1-4939-6966-1 · Cited by 269
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Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)
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Electrohydrodynamic atomization for biodegradable polymeric particle production
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Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine
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Cytotoxicity of water-soluble fullerene in vascular endothelial cells
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Metadata
- Authors
- Kreuter, J.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Kreuter, Jörg
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 47
- Issue
- 1
- Pages
- 65-81
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2072229818
- Cited by
- 1,107
- References
- 50
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 26 · 2023: 39 · 2022: 32 · 2021: 43 · 2020: 47 · 2019: 40 · 2018: 47 · 2017: 53 · 2016: 63 · 2015: 57 · 2014: 55 · 2013: 65 · 2012: 76
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- blood-brain barrier, nanoparticle drug delivery, brain drug delivery, apolipoprotein E, glioblastoma, doxorubicin, neuropeptides, P-glycoprotein inhibition, tight junction modulation, transcytosis, central nervous system drugs
- MeSH terms
- Animals, Antineoplastic Agents, Blood-Brain Barrier, Brain, Brain Neoplasms, Capsules, Cells, Cultured, Doxorubicin, Drug Carriers, Endothelium, Vascular, Humans, Male, Polysorbates, Surface-Active Agents, Mice, Rats
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