Perseveration induced by methylphenidate in children: preliminary findings
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Excessive doses of stimulants impair PFC function, which may account for the cognitive inflexibility observed when patients with ADHD are administered these doses of stimulant medication.
“However, excessive doses of stimulants impair PFC function, which may account for the cognitive inflexibility observed when patients with ADHD are administered these doses of stimulant medication (Dyme et al., 1982).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Dyme et al., 1982
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- Authors
- Dyme, I. Z., Sahakian, B. J., Golinko, B. E., & Rabe, E. F.
- Affiliations
- Tufts Medical Center (US)
- ORCID
- Sahakian, Barbara J.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1982-01
- Volume
- 6
- Issue
- 3
- Pages
- 269-273
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2051969024
- Cited by
- 56
- References
- 12
- Citations by year
- 2026: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- methylphenidate, perseveration, psychostimulants, cognitive flexibility, children, adverse drug reactions, stimulant medication
- MeSH terms
- Attention, Child, Child, Preschool, Double-Blind Method, Female, Humans, Hyperkinesis, Male, Mental Processes, Methylphenidate
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