CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741 · see citing works

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., & Silva, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90400-6 · Cited by 1,800 · see citing works

Current Protocols in Molecular Biology

(2018) · Current Protocols in Molecular Biology · doi:10.1002/(issn)1934-3647 · Cited by 1,395 · see citing works

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

Bito, H., Deisseroth, K. A., & Tsien, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81816-4 · Cited by 1,123 · see citing works

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

Gonzalez, G. A., Yamamoto, K. K., Fischer, W. H., Karr, D., Menzel, P., Biggs, W., Vale, W., & Montminy, M. (1989) · Nature · doi:10.1038/337749a0 · Cited by 893 · see citing works

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in <i>Aplysia</i>

Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769 · see citing works

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.Preprint

Sun, P., Enslen, H., Myung, P. S., & Maurer, R. A. (1994) · Genes & Development · doi:10.1101/gad.8.21.2527 · Cited by 736 · see citing works

Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity

Deisseroth, K., Bito, H., & Tsien, R. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80026-4 · Cited by 698 · see citing works

Toward a molecular definition of long-term memory storage

Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 689 · see citing works

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

Foulkes, N. S., Borrelli, E., & Sassone‐Corsi, P. (1991) · Cell · doi:10.1016/0092-8674(91)90503-q · Cited by 656 · see citing works

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642 · see citing works

Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

Molina, C. A., Foulkes, N. S., Lalli, E., & Sassone‐Corsi, P. (1993) · Cell · doi:10.1016/0092-8674(93)90532-u · Cited by 601 · see citing works

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545 · see citing works

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523 · see citing works

Morphological Basis of Long-Term Habituation and Sensitization in Aplysia

Bailey, C. H., & Chen, M. (1983) · Science · doi:10.1126/science.6828885 · Cited by 420 · see citing works

Bifunctional messenger RNAs in eukaryotes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90609-4 · Cited by 402 · see citing works

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

Hümmler, E., Cole, T. J., Blendy, J. A., Ganß, R., Aguzzi, A., Schmid, W., Beermann, F., & Schütz, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5647 · Cited by 389 · see citing works

Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons

Kaang, B., Kandel, E. R., & Grant, S. G. N. (1993) · Neuron · doi:10.1016/0896-6273(93)90331-k · Cited by 347 · see citing works

A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

Fiol, C. J., Williams, J. S., Chou, C. H., Wang, Q. M., Roach, P. J., & ANDRISANI, O. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31619-3 · Cited by 278 · see citing works

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

Ruppert, S., Cole, T. J., Boshart, M., Schmid, E., & Schütz, G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05195.x · Cited by 189 · see citing works

Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.

Widnell, K. L., Self, D. W., Lane, S. B., Russell, D., Vaidya, V. A., Miserendino, M. J. D., Rubin, C. S., Duman, R. S., & Nestler, E. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12267-2 · Cited by 156 · see citing works

Developmental Stage-Specific Expression of Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein CREB during Spermatogenesis Involves Alternative Exon Splicing

Waeber, G., Meyer, T. E., LeSieur, M., Hermann, H. L., Gérard, N., & Habener, J. F. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1418 · Cited by 147 · see citing works

Alternative Exon Splicing Controls a Translational Switch from Activator to Repressor Isoforms of Transcription Factor CREB during Spermatogenesis

Walker, W. H., Girardet, C., & Habener, J. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.20219 · Cited by 129 · see citing works

A Drosophila CREB/CREM Homolog Encodes Multiple Isoforms, Including a Cyclic AMP-Dependent Protein Kinase-Responsive Transcriptional Activator and Antagonist

Yin, J. C. P., Wallach, J. S., Wilder, E. L., Klingensmith, J., Dang, D. T., Perrimon, N., Zhou, H., Tully, T., & Quinn, W. G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.5123 · Cited by 111 · see citing works

cAMP-Dependent Regulation of Gene Transcription by cAMP Response Element-Binding Protein and cAMP Response Element Modulator

Habener, J. F., Miller, C. P., & Vallejo, M. (1995) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61037-7 · Cited by 93 · see citing works

The cAMP Response Element Binding protein is involved in hydra regeneration

Galliot, B., Welschof, M., Schuckert, O., Hoffmeister, S. A. H., & Schaller, H. (1995) · Development · doi:10.1242/dev.121.4.1205 · Cited by 64 · see citing works

Cytoplasmic CREBα-like Antigens in Specific Regions of the Rat Brain

Hermanson, O., Gustavsson, J., Strålfors, P., & Blomqvist, A. G. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1163 · Cited by 6 · see citing works

Multiple mRNA isoforms of the transcription activator protein CREB

Ruppert, S., Cole, T. J., Boshart, M., Schmidt, E., & Schütz, G. (1992) · Open access LMU (Ludwid Maxmilian's Universitat Munchen) · Cited by 3 · see citing works

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works

Transcriptional regulation by the phosphorylation-dependent factor CREB

Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works

Function and regulation of CREB family transcription factors in the nervous system

Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works

Regulation of histone acetylation during memory formation in the hippocampus

Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131 · see citing works

Transcription Factors in Long-Term Memory and Synaptic Plasticity

Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991 · see citing works

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works

Neuronal competition and selection during memory formation

Han, J.-H., Kushner, S. A., Yiu, A. P., Cole, C. J., Matynia, A., Brown, R. A., Neve, R. L., Guzowski, J. F., Silva, A. J., & Josselyn, S. A. (2007) · Science · doi:10.1126/science.1139438 · Cited by 682 · see citing works

Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture.

Barco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595 · see citing works

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803072105 · Cited by 559 · see citing works

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81653-0 · Cited by 503 · see citing works

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497 · see citing works

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

Wong, S. T., Athos, J., Figueroa, X. A., Pineda, V. V., Schaefer, M. L., Chavkin, C. C., Muglia, L. J., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(01)80036-2 · Cited by 486 · see citing works

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works

Mathematical modeling of gene networks.

Smolen, P., Baxter, D., & Byrne, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81194-0 · Cited by 466 · see citing works

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

Josselyn, S. A., Shi, C., Carlezon, W. A., Neve, R. L., Nestler, E. J., & Davis, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02404.2001 · Cited by 451 · see citing works

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works

Is Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory

Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382 · see citing works

The molecular and cellular biology of enhanced cognition

Lee, Y.-S., & Silva, A. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2572 · Cited by 361 · see citing works

Calcium signaling in neurodegeneration

Marambaud, P., Dreses‐Werringloer, U., & Vingtdeux, V. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-20 · Cited by 352 · see citing works

Modeling transcriptional control in gene networks—methods, recent results, and future directions

Smolen, P., Baxter, D., & Byrne, J. (2000) · Bulletin of Mathematical Biology · doi:10.1006/bulm.1999.0155 · Cited by 386 · see citing works

Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV

Impey, S., Fong, A. L., Wang, Y., Cardinaux, J.-R., Fass, D. M., Obrietan, K., Wayman, G. A., Storm, D. R., Soderling, T. R., & Goodman, R. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00654-2 · Cited by 335 · see citing works

The right time to learn: Mechanisms and optimization of spaced learning

Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312 · see citing works

Signaling routes to CREM and CREB: plasticity in transcriptional activation

Cesare, D. D., Fimia, G. M., & Sassone‐Corsi, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01414-0 · Cited by 311 · see citing works

Regulation of Nuclear Localization: A Key to a Door

Kaffman, A., & O’Shea, E. K. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.291 · Cited by 299 · see citing works

The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses

Kandel, E. R. (2004) · Bioscience Reports · doi:10.1007/s10540-005-2742-7 · Cited by 279 · see citing works

NOBEL LECTURE: The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses

Kandel, E. R. (2001) · Bioscience Reports · doi:10.1023/a:1014775008533 · Cited by 278 · see citing works

γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

Ma, H., Groth, R. D., Cohen, S. M., Emery, J. F., Li, B., Hoedt, E., Zhang, G., Neubert, T. A., & Tsien, R. W. (2014) · Cell · doi:10.1016/j.cell.2014.09.019 · Cited by 279 · see citing works

Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins

Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works

Genetic approaches to memory storage

Mayford, M. R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01846-6 · Cited by 256 · see citing works

Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism

Chase, T. N., & Oh, J. D. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00018-5 · Cited by 250 · see citing works

Prolonged Activation of cAMP-Dependent Protein Kinase during Conditioning Induces Long-Term Memory in Honeybees

Müller, U. (2000) · Neuron · doi:10.1016/s0896-6273(00)00017-9 · Cited by 249 · see citing works

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum

Levine, A. A., Guan, Z., Barco, Á., Xu, S., Kandel, E. R., & Schwartz, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509735102 · Cited by 249 · see citing works

Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP

Wang, H., Ferguson, G. D., Pineda, V. V., Cundiff, P. E., & Storm, D. R. (2004) · Nature Neuroscience · doi:10.1038/nn1248 · Cited by 244 · see citing works

Beyond transcription factors: The role of chromatin modifying enzymes in regulating transcription required for memoryPreprint

Barrett, R. M., & Wood, M. A. (2008) · Learning & Memory · doi:10.1101/lm.917508 · Cited by 239 · see citing works

Molecular Mechanisms of Memory Storage inAplysia

Hawkins, R. D., Kandel, E. R., & Bailey, C. H. (2006) · Biological Bulletin · doi:10.2307/4134556 · Cited by 231 · see citing works

The roles of protein kinases in learning and memoryPreprint

Giese, K.-P., & Mizuno, K. (2013) · Learning & Memory · doi:10.1101/lm.028449.112 · Cited by 229 · see citing works

Transcriptional regulation by cyclic AMP-responsive factors

Cesare, D. D., & Sassone‐Corsi, P. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64009-6 · Cited by 232 · see citing works

An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling

Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T. R., Goodman, R. H., & Wayman, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.005 · Cited by 270 · see citing works

Common molecular mechanisms in explicit and implicit memory

Barco, Á., Bailey, C. H., & Kandel, E. R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03870.x · Cited by 217 · see citing works

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

Wang, J., Ferruzzi, M. G., Ho, L., Blount, J. W., Janle, E. M., Gong, B., Pan, Y., Gowda, G. A. N., Raftery, D., Arrieta‐Cruz, I., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6437-11.2012 · Cited by 206 · see citing works

Identification of brain‐targeted bioactive dietary quercetin‐3‐ O ‐glucuronide as a novel intervention for Alzheimer's disease

Ho, L., Ferruzzi, M. G., Janle, E. M., Wang, J., Gong, B., Chen, T., Lobo, J., Cooper, B. R., Wu, Q. L., Talcott, S. T., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-212118 · Cited by 204 · see citing works

CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects

Barco, Á., Pittenger, C., & Kandel, E. R. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.1.101 · Cited by 201 · see citing works

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

Rexach, J. E., Clark, P. M., Mason, D. E., Neve, R. L., Peters, E. C., & Hsieh‐Wilson, L. C. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.770 · Cited by 199 · see citing works

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80686-8 · Cited by 186 · see citing works

Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding Protein β and δ Co-Localizes with Phosphorylated cAMP Response Element-Binding Protein and Accompanies Long-Term Memory Consolidation

Taubenfeld, S. M., Wiig, K. A., Monti, B., Dolan, B., Pollonini, G., & Alberini, C. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00084.2001 · Cited by 179 · see citing works

Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

Sutton, M. A., Masters, S. E., Bagnall, M. W., & Carew, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00342-7 · Cited by 177 · see citing works

The role of protein synthesis during the labile phases of memory: Revisiting the skepticism

Alberini, C. M. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.007 · Cited by 178 · see citing works

In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus

Pittenger, C., & Kandel, E. R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1247 · Cited by 174 · see citing works

An Unbiased cDNA Library Prepared from IsolatedAplysiaSensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs

Moccia, R., Chen, D., Lyles, V., Kapuya, E., Yaping, E., Kalachikov, S. M., Spahn, C. M. T., Frank, J., Kandel, E. R., Barad, M., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09409.2003 · Cited by 172 · see citing works

A Late Phase of Cerebellar Long-Term Depression Requires Activation of CaMKIV and CREB

Ahn, S., Ginty, D. D., & Linden, D. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80808-9 · Cited by 170 · see citing works

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

Bitner, R. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.11.009 · Cited by 163 · see citing works

CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA

Yao, B., Zhang, Q., Yang, Z., An, F., Nie, H., Wang, H., Cheng, Y., Sun, J., Chen, K., Zhou, J., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01608-7 · Cited by 153 · see citing works

Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat Dentate GyrusIn Vivo

Schulz, S., Siemer, H., Krug, M., & Höllt, V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05683.1999 · Cited by 153 · see citing works

Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity

Hegde, A. N. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.005 · Cited by 141 · see citing works

Natural variation in learning rate and memory dynamics in parasitoid wasps: opportunities for converging ecology and neuroscience

Hoedjes, K. M., Kruidhof, H. M., Huigens, M. E., Dicke, M., Vet, L. E. M., & Smid, H. M. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.2199 · Cited by 142 · see citing works

Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons

Lewin, M. R., & Walters, E. T. (1999) · Nature Neuroscience · doi:10.1038/4520 · Cited by 138 · see citing works

The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening

Zhao, Y., Hegde, A. N., & Martin, K. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00332-4 · Cited by 136 · see citing works

The past, the future and the biology of memory storage

Kandel, E. R., & Pittenger, C. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0542 · Cited by 134 · see citing works

Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2

Alberini, C. M., & Chen, D. Y. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.12.007 · Cited by 127 · see citing works

Chapter 10 Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia

Bailey, C. H., & Kandel, E. R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00010-6 · Cited by 130 · see citing works

Untitled work

Alberini (2006) · doi:10.1007/s00018-006-6025-7 · Cited by 158 · see citing works

Two overlapping reading frames in a single exon encode interacting proteins—a novel way of gene usage

Klemke, M., Kehlenbach, R. H., & Huttner, W. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3849 · Cited by 123 · see citing works

Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila

Jacob, P. F., & Waddell, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.013 · Cited by 112 · see citing works

Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia

Purcell, A. L., Sharma, S. K., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00030-8 · Cited by 117 · see citing works

Continuing the search for the engram: examining the mechanism of fear memories

Josselyn, S. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100015 · Cited by 116 · see citing works

Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalonPreprint

Spieler, D., Kaffe, M., Knauf, F., Bessa, J., Tena, J. J., Giesert, F., Schormair, B., Tilch, E., Lee, H., Horsch, M., et al. (2014) · Genome Research · doi:10.1101/gr.166751.113 · Cited by 110 · see citing works

Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background

Graves, L. A., Dalvi, A., Lucki, I., Blendy, J. A., & Abel, T. G. (2002) · Hippocampus · doi:10.1002/hipo.10003 · Cited by 109 · see citing works

Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: Implications for pain and memory

Rahn, E. J., Karlsson, M. G., & Sweatt, J. D. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.008 · Cited by 108 · see citing works

cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory Factor Differentially Control Hippocampal GABABR1a and GABABR1b Subunit Gene Expression through Alternative Promoters

Steiger, J. L., Bandyopadhyay, S., Farb, D. H., & Russek, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1200-04.2004 · Cited by 105 · see citing works

latheo Encodes a Subunit of the Origin Recognition Complex and Disrupts Neuronal Proliferation and Adult Olfactory Memory When Mutant

Pinto, S., Quintana, D. G., Smith, P., Mihalek, R., Hou, Z.-H., Boynton, S., Jones, C. J., Hendricks, M., Velinzon, K., Wohlschlegel, J. A., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80752-7 · Cited by 105 · see citing works

Dorsal hippocampal CREB is both necessary and sufficient for spatial memoryPreprint

Sekeres, M. J., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2010) · Learning & Memory · doi:10.1101/lm.1785510 · Cited by 104 · see citing works

Acute and long-term synaptic modulation by neurotrophins

Lu, B. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46010-x · Cited by 102 · see citing works

Genes to remember

Alberini, C. M. (1999) · Journal of Experimental Biology · doi:10.1242/jeb.202.21.2887 · Cited by 99 · see citing works

Disorders of memory and plasticity in psychiatric disease

Pittenger, C. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.4/cpittenger · Cited by 92 · see citing works

Increasing CRTC1 Function in the Dentate Gyrus during Memory Formation or Reactivation Increases Memory Strength without Compromising Memory Quality

Sekeres, M. J., Mercaldo, V., Richards, B. A., Sargin, D., Mahadevan, V., Woodin, M. A., Frankland, P. W., & Josselyn, S. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-12.2012 · Cited by 99 · see citing works

Neural Science

Albright, T. D., Jessell, T. M., Kandel, E. R., & Posner, M. I. (2000) · Cell · doi:10.1016/s0092-8674(00)00251-8 · Cited by 98 · see citing works

The Roles of MAPK Cascades in Synaptic Plasticity and Memory in <i>Aplysia</i>: Facilitatory Effects and Inhibitory Constraints: Figure 1

Sharma, S. K., & Carew, T. J. (2004) · Learning &amp; Memory · doi:10.1101/lm.81104 · Cited by 95 · see citing works

Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease

Hegde, A. N., & Upadhya, S. C. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.07.006 · Cited by 96 · see citing works

Nuclear Calcium Signaling

Bengtson, C. P., & Bading, H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_17 · Cited by 96 · see citing works

CREB in the pond snail Lymnaea stagnalis: Cloning, gene expression, and function in identifiable neurons of the central nervous system

Sadamoto, H., Sato, H., Kobayashi, S., Murakami, J., Aonuma, H., Ando, H., Fujito, Y., Hamano, K., Awaji, M., Lukowiak, K., et al. (2003) · Journal of Neurobiology · doi:10.1002/neu.10296 · Cited by 94 · see citing works

SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children

Butcher, L. M., Meaburn, E. L., Knight, J., Sham, P. C., Schalkwyk, L. C., Craig, I., & Plomin, R. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi142 · Cited by 92 · see citing works

Increasing CREB Function in the CA1 Region of Dorsal Hippocampus Rescues the Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease

Yiu, A. P., Rashid, A. J., & Josselyn, S. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.107 · Cited by 92 · see citing works

The CRE/CREB Pathway Is Transiently Expressed in Thalamic Circuit Development and Contributes to Refinement of Retinogeniculate Axons

Pham, T. A., Rubenstein, J. L. R., Silva, A. J., Storm, D. R., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00381-6 · Cited by 88 · see citing works

pCREB in the Neonate Rat Olfactory Bulb Is Selectively and Transiently Increased by Odor Preference–Conditioned TrainingPreprint

McLean, J. H., Harley, C. W., Darby‐King, A., & Yuan, Q. (1999) · Learning & Memory · doi:10.1101/lm.6.6.608 · Cited by 90 · see citing works

Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis

Karagas, N. E., & Venkatachalam, K. (2019) · Cells · doi:10.3390/cells8101232 · Cited by 92 · see citing works

Transcriptional regulation of long-term memory in the marine snail Aplysia

Lee, Y., Bailey, C. H., Kandel, E. R., & Kaang, B. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-3 · Cited by 84 · see citing works

Molecular and cellular mechanisms of memory allocation in neuronetworks

Won, J., & Silva, A. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.017 · Cited by 82 · see citing works

Computational design of enhanced learning protocols

Zhang, Y., Liu, R.-Y., Heberton, G. A., Smolen, P., Baxter, D. A., Cleary, L. J., & Byrne, J. H. (2012) · Nature Neuroscience · doi:10.1038/nn.2990 · Cited by 80 · see citing works

Overexpression of and RNA Interference with the CCAAT Enhancer-Binding Protein on Long-Term Facilitation ofAplysiaSensory to Motor SynapsesPreprint

Lee, J. A., Kim, H. K., Kim, K., Han, J., Lee, Y., Lim, C., Chang, D., Kubo, T., & Kaang, B. (2001) · Learning & Memory · doi:10.1101/lm.40201 · Cited by 78 · see citing works

Striatal glutamatergic mechanisms and extrapyramidal movement disorders

Chase, T. N., Bibbiani, F., & Oh, J. D. (2003) · Neurotoxicity Research · doi:10.1007/bf03033378 · Cited by 77 · see citing works

Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2

Bartsch, D., Ghirardi, M., Casadio, A., Giustetto, M., Karl, K. A., Zhu, H., & Kandel, E. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00163-x · Cited by 76 · see citing works

Aca1 and Aca2, ATF/CREB Activators in Saccharomyces cerevisiae , Are Important for Carbon Source Utilization but Not the Response to Stress

García-Gimeno, M. A., & Struhl, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4340-4349.2000 · Cited by 77 · see citing works

Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism‐induced defects in memory function and cerebral cyclic AMP signal transduction system in rats

Nagakura, A., Niimura, M., & Takeo, S. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704629 · Cited by 76 · see citing works

Ca2+-Independent Protein Kinase C Apl II Mediates the Serotonin-Induced Facilitation at DepressedAplysiaSensorimotor Synapses

Manseau, F., Fan, X., Hueftlein, T., Sossin, W. S., & Castellucci, V. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01247.2001 · Cited by 76 · see citing works

cAMP Response Element-Binding Protein 1 Feedback Loop Is Necessary for Consolidation of Long-Term Synaptic Facilitation in<i>Aplysia</i>

Liu, R.-Y., Fioravante, D., Shah, S., & Byrne, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3848-07.2008 · Cited by 73 · see citing works

cAMP-response Elements in Aplysia creb1, creb2, and Ap-uch Promoters

Mohamed, H. A., Yao, W., Fioravante, D., Smolen, P. D., & Byrne, J. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502541200 · Cited by 73 · see citing works

Single and repeated immobilization stress differentially trigger induction and phosphorylation of several transcription factors and mitogen‐activated protein kinases in the rat locus coeruleus

Hebert, M. A., Serova, L. I., & Sabban, E. L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03386.x · Cited by 75 · see citing works

The genetic basis of cognition

Flint, J. (1999) · Brain · doi:10.1093/brain/122.11.2015 · Cited by 74 · see citing works

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works

The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons of<i>Aplysia</i>

Liu, R.-Y., Cleary, L. J., & Byrne, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5071-10.2011 · Cited by 60 · see citing works

Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2

Bartsch, D., Ghirardi, M., Casadio, A., Giustetto, M., Karl, K. A., Zhu, H., & Kandel, E. R. (2000) · Cell · doi:10.1016/s0092-8674(00)00163-x · Cited by 76 · see citing works

Roles of transcription factor CREB in short and long-term memory formation

Kida, S. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.09.1673

Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses

Lee, J.-A., Kim, H., Lee, Y.-S., & Kaang, B.-K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01285-5 · Cited by 25 · see citing works