Cited by 25Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

PKA-activated ApAF–ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation

Open access
Lee, Jin-A, Lee, Sue-Hyun, Lee, Changhoon, Chang, Deok-Jin, Lee, Yong, Kim, Hyoung, Cheang, Ye-Hwang, Ko, Hyoung-Gon +5 more·2006·The Journal of Cell Biology

Abstract

Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. Aplysia activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characterized. We found that the functional activation of ApAF required phosphorylation of ApAF by PKA on Ser-266. In addition, ApAF lowered the threshold of LTF by forming a heterodimer with ApCREB2. Moreover, once activated by PKA, the ApAF–ApC/EBP heterodimer transactivates enhancer response element–containing genes and can induce LTF in the absence of CRE- and CREB-mediated gene expression. Collectively, these results suggest that PKA-activated ApAF–ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1083/jcb.200512066

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The induction and consolidation of LTF in vitro depends on the activity of several transcription factors.

    “The induction and consolidation of LTF in vitro depends on the activity of several transcription factors24–27.”

    From Computational design of enhanced learning protocols (2012) · cites this paper as [27]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lee, J.-A., Lee, S.-H., Lee, C., Chang, D.-J., Lee, Y., Kim, H., Cheang, Y.-H., Ko, H.-G., Lee, Y.-S., Jun, H., Bartsch, D., Kandel, E. R., & Kaang, B.-K.
Affiliations
  • Seoul National University (KR)
  • 1Institute of Molecular Biology and Genetics, RIO, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea
  • 2Department of Molecular Biology, Central Institute of Mental Health, J5, 68 159 Mannheim, Germany
  • Columbia University (US)
Venue
The Journal of Cell Biology
Published
2006-09-11
Volume
174
Issue
6
Pages
827-838
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W2113003079
Cited by
25
References
42
Citations by year
2022: 2 · 2021: 1 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
1.78
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Cell Biology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
Aplysia, protein kinase A, heterodimer, long-term facilitation, long-term memory consolidation, transcriptional regulation, gene transactivation
MeSH terms
Animals, Aplysia, Cells, Cultured, Gene Expression Regulation, Memory, Motor Neurons, Nerve Tissue Proteins, Nervous System, Synaptic Transmission, Neurons, Afferent, Phosphorylation, Repressor Proteins, Serine, Synapses, Transcription Factors, Signal Transduction, Transcriptional Activation, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases, Dimerization, Response Elements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review