Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
Abstract
Density of dopamine transporter (DAT) and serotonin transporter (5-HTT) membrane proteins in the caudate-putamen (CPu) and nucleus accumbens (NAc) of rat brain was assessed at seven ages at postnatal days (PD) 7-60, by in vitro quantitative autoradiography. Binding of [3H]GBR-12935 (to DAT) and [3H]paroxetine (to 5-HTT) increased steadily and very similarly, from low levels at PD-7 to maximal levels, to 6-7-fold higher density at PD-60 in both regions. These findings indicate that DAT and 5-HTT follow a synchronized course of development in rat CPu and NAc. In contrast to reported elimination of excessive receptors in CPu and NAc during maturation, there was no evidence of pruning of DAT or 5-HTT in these regions of rat forebrain.
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Dopamine receptor expression is highest in the accumbens during early adolescence.
“Dopamine receptor expression is highest in the accumbens during early adolescence (Tarazi et al. 1998).”
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- Authors
- Tarazi, F. I., Tomasini, E. C., & Baldessarini, R. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Tarazi, Frank I
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 254
- Issue
- 1
- Pages
- 21-24
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1970518640
- Cited by
- 179
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 13 · 2012: 10
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh047370-25, 5t32mh019905-05, 5r01mh034006-18)
- National Institute of Mental Health (MH-34006, MH47370, MH-19905)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- dopamine transporter, serotonin transporter, postnatal development, caudate-putamen, nucleus accumbens, striatum, receptor density, receptor maturation, forebrain development, GBR 12935, paroxetine
- MeSH terms
- Animals, Carrier Proteins, Caudate Nucleus, Dopamine, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Nucleus Accumbens, Putamen, Serotonin, Rats, Sprague-Dawley, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Rats
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