Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats
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Abstract
Social discrimination in rats requires activation of the intrinsic bulbar vasopressin system, but it is unclear how this system comes into operation, as olfactory nerve stimulation primarily inhibits bulbar vasopressin cells (VPCs). Here we show that stimulation with a conspecific can activate bulbar VPCs, indicating that VPC activation depends on more than olfactory cues during social interaction. A series of in vitro electrophysiology, pharmacology and immunohistochemistry experiments implies that acetylcholine, probably originating from centrifugal projections, can enable olfactory nerve-evoked action potentials in VPCs. Finally, cholinergic activation of the vasopressin system contributes to vasopressin-dependent social discrimination, since recognition of a known rat was blocked by bulbar infusion of the muscarinic acetylcholine receptor antagonist atropine and rescued by additional bulbar application of vasopressin. Thus, our results implicate that top-down cholinergic modulation of bulbar VPC activity is involved in social discrimination in rats.
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A similar process may also occur via vasopressin release from inhibitory olfactory bulb interneurons, in conjunction with cholinergic mechanisms.
“A similar process may also occur via AVP release, from inhibitory OB interneurons, in conjunction with cholinergic mechanisms (76,77).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [77]
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- Authors
- Suyama, H., Egger, V., & Lukas, M.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Lukas, Michael
- Venue
- Communications Biology
- Published
- 2021-05-21
- Volume
- 4
- Issue
- 1
- Pages
- 603-603
- ISSN
- 2399-3642 (ISSN-L)
- PMC
- PMC8140101
- OpenAlex
- W3161781670
- Cited by
- 21
- References
- 83
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2018: 1
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Regensburg Publication Server (University of Regensburg)
- Funders
- Deutsche Forschungsgemeinschaft (EG135/5-1, LU2164/1-1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- acetylcholine, olfactory bulb, social discrimination, cholinergic modulation, muscarinic receptors, atropine, olfactory nerve stimulation, social recognition, rats
- MeSH terms
- Acetylcholine, Action Potentials, Animals, Female, Male, Neurons, Olfactory Bulb, Vasopressins, Rats, Wistar, Rats, Social Discrimination
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