Neuroendocrine basis of social recognition
Abstract
Studies conducted in the past two years have yielded several new insights about neuroendocrine regulation of social recognition. The social recognition deficits seen in oxytocin knockout mice have now been demonstrated in both males and females, as well as in female estrogen receptor knockout mice. The male vasopressin V1A receptor knockout mouse (but not V1B) has a profound social recognition deficit. Preliminary evidence suggests that female V1B receptor knockout mice could also have social memory deficits. Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation.
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Experiments in prairie voles reveal central roles for oxytocin in modulating emotional and social behaviors.
“Experiments in prairie voles have revealed central roles for oxytocin in modulating a variety of emotional and social behaviors [164–166].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [166]
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- Authors
- Winslow, J. T., & Insel, T. R.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- Corresponding author
- Insel, Thomas R
- ORCID
- Insel, Thomas R
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 14
- Issue
- 2
- Pages
- 248-253
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2041863961
- Cited by
- 180
- References
- 55
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 5 · 2020: 3 · 2019: 4 · 2018: 9 · 2017: 12 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- social recognition, neuroendocrine regulation, oxytocin, vasopressin V1a receptor, vasopressin V1b receptor, estrogen receptor, knockout mice, gonadal hormones, corticosteroids, neuropeptides
- MeSH terms
- Animals, Arginine Vasopressin, Behavior, Animal, Brain, Female, Gonads, Male, Neurosecretory Systems, Oxytocin, Social Behavior, Receptors, Neuropeptide, Recognition, Psychology, Mice
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