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Cited by 157Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons

McDonald, A.J, Mascagni, F·2001·Neuroscience
DOI 10.1016/s0306-4522(01)00380-3
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Abstract

The neuronal localization of the CB1 cannabinoid receptor in the rat basolateral amygdala was studied using peroxidase and fluorescence immunohistochemical techniques. All nuclei of the basolateral amygdala contained a large number of lightly stained pyramidal neurons and a small number of more intensely stained non-pyramidal neurons. Most of the latter cells had medium-sized to large multipolar somata and three to four aspiny dendrites, but some exhibited smaller oval somata. The axon initial segments of some of these non-pyramidal neurons exhibited large swollen varicosities in colchicine-injected animals, suggesting that much of the CB1 receptor protein is transported down the axons of these cells. Double-labeling studies using immunofluorescence histochemistry combined with confocal laser scanning microscopy revealed that the great majority of non-pyramidal neurons with CB1 receptor immunoreactivity belonged to a cholecystokinin-containing subpopulation. Whereas none of the other subpopulations of non-pyramidal neurons (exhibiting immunoreactivity for calretinin, parvalbumin, or somatostatin) expressed high levels of CB1 receptor immunoreactivity, a small percentage of these cells exhibited low levels of immunoreactivity. The results indicate that cannabinoids may modulate the activity of pyramidal projection neurons as well as a subpopulation of cholecystokinin-containing non-pyramidal neurons in the basolateral amygdala. Previous studies indicate that most of the latter are inhibitory interneurons that utilize GABA as a neurotransmitter. The intense staining of the cholecystokinin-containing interneurons and the evidence that large amounts of CB1 receptor protein are transported down the axons of these cells suggests that, as in the hippocampus, cannabinoids may inhibit the release of GABA from the axon terminals of these neurons.

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Metadata

Authors
McDonald, A. J., & Mascagni, F.
Affiliations
University of South Carolina (US)
Corresponding author
McDonald, A.J
ORCID
McDonald, A.J
Venue
Neuroscience
Publisher
Elsevier BV
Published
2001-11
Volume
107
Issue
4
Pages
641-652
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(01)00380-3
OpenAlex
W2034121461
Cited by
157
References
51
Citations by year
2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 1
FWCI
4.90
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 41301, P30DK041301)
  • National Institute of Neurological Disorders and Stroke (NS 38998)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
CB1 receptor, basolateral amygdala, cholecystokinin, interneurons, non-pyramidal neurons, axonal transport, calretinin, parvalbumin, somatostatin
MeSH terms
Amygdala, Animals, Antibody Specificity, Cholecystokinin, Fluorescent Antibody Technique, Immunoenzyme Techniques, Interneurons, Male, Receptors, Drug, Rats, Sprague-Dawley, Microscopy, Confocal, Receptors, Cannabinoid, Rats

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