The human forebrain has discrete estrogen receptor α messenger RNA expression: high levels in the amygdaloid complex
Abstract
Estrogen is considered to play an important role in neuropsychiatric disorders and the estrogen receptors mediate the action of the hormone. In the present study, the messenger RNA expression pattern of the estrogen receptor alpha subtype was identified in the post mortem human brain. High stringent in situ hybridization histochemistry was performed using a riboprobe specific for the estrogen receptor alpha subtype. The human brain was mainly characterized by abundant estrogen receptor alpha messenger RNA expression in the amygdala and hypothalamus, but labeling (lower) was also found in the extended sublenticular amygdala, cerebral cortex, and hippocampus. In the amygdala, the estrogen receptor alpha messenger RNA was preferentially expressed in medially-localized nuclei suggesting that estrogen regulates distinct human amygdala-mediated functions. The Cynomologous monkey brain was also examined in the present study and a similar distribution of the estrogen receptor alpha messenger RNA signal was observed in the human and monkey brain. However, the primate expression pattern differed in part from the known distribution in the rat. The current results show that estrogen receptor alpha messenger RNA is expressed in discrete areas of the human brain not only related to neuroendocrine function, but also emotion, memory, and cognition, which is consistent with the hypothesized involvement of estrogen in schizophrenia, affective disorders, and Alzheimers disease.
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One mRNA labeling study found low and diffuse expression of ERalpha mRNA in human temporal cortex and restricted expression in deep layers of entorhinal cortex.
“but one mRNA labeling study found low and diffuse expression of ERalpha mRNA in temporal cortex and restricted expression in deep layers of entorhinal cortex (Osterlund et al., 2000).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Osterlund et al., 2000
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- Authors
- Österlund, M. K., Keller, E., & Hurd, Y. L.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Hurd, Y.L
- ORCID
- Hurd, Y.L
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 95
- Issue
- 2
- Pages
- 333-342
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2052883666
- Cited by
- 174
- References
- 47
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 17 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 12
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- estrogen receptor alpha, mRNA expression, human brain, amygdala, hypothalamus, extended amygdala, cerebral cortex, hippocampus, estrogen, emotions, memory, cognition, schizophrenia, mood disorders, Alzheimer's disease, in situ hybridization
- MeSH terms
- Adolescent, Adult, Aged, Amygdala, Animals, Haplorhini, Female, Humans, Hypothalamus, Male, Middle Aged, Receptors, Estrogen, RNA, Messenger, Species Specificity, Gene Expression, In Situ Hybridization, Rats
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