Cited by 39Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsMedicinal Plant Research

Altered dendritic arborization of amygdala neurons in young adult rats orally intubated with Clitorea ternatea aqueous root extract

Rai, Kiranmai S., Murthy, K. Dilip, Rao, Muddanna S., Karanth, K. Sudhakar·2005·Phytotherapy Research

Abstract

Young adult (60 day old) Wistar rats of either sex were orally intubated with 50 mg/kg body weight and 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days, along with age-matched saline controls. These rats were then subjected to passive avoidance tests and the results from these studies showed a significant increase in passive avoidance learning and retention. Subsequent to the passive avoidance tests, these rats were killed by decapitation. The amygdala was processed for Golgi staining and the stained neurons were traced using a camera lucida and analysed. The results showed a significant increase in dendritic intersections, branching points and dendritic processes arising from the soma of amygdaloid neurons in CTR treated rats especially in the 100 mg/kg group of rats, compared with age-matched saline controls. This improved dendritic arborization of amygdaloid neurons correlates with the increased passive avoidance learning and memory in the CTR treated rats as reported earlier. The results suggest that Clitoria ternatea aqueous root extract enhances memory by increasing the functional growth of neurons of the amygdala.

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Crossref · 10.1002/ptr.1657

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Authors
Rai, K. S., Murthy, K. D., Rao, M. S., & Karanth, K. S.
Affiliations
  • Kasturba Medical College, Manipal (IN)
  • Melaka Manipal Medical College (IN)
  • K S Hegde Medical Academy (IN)
Corresponding author
Rai, Kiranmai S.
Venue
Phytotherapy Research
Publisher
Wiley
Published
2005-07
Volume
19
Issue
7
Pages
592-598
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
OpenAlex
W1991307753
Cited by
39
References
52
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2013: 2 · 2012: 1
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Clitoria ternatea, aqueous root extract, amygdala, dendritic branching, passive avoidance learning, memory enhancement, neuroprotection
MeSH terms
Administration, Oral, Amygdala, Animals, Avoidance Learning, Dendrites, Phytotherapy, Memory, Plant Extracts, Rats, Wistar, Plant Roots, Clitoria, Rats

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