Cited by 677Forensic Toxicology and Drug AnalysisForensic and Genetic ResearchAnalytical chemistry methods development

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Potential problems with the interpretation of hair analysis results

Wennig, R.·2000·Forensic Science International

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Abstract

Due to differences in hair growth rate depending on anatomical region, age, gender, ethnicity and interindividual variability, interpretation of parent drug or/and metabolite concentrations in hair is not easy. Furthermore, as drug incorporation mechanisms into hair matrix is not yet fully understood, it is rather difficult to extrapolate details on time and dose from hair segment analysis. If incorporation sources other than from bloodstream (skin secretions and/or external/environmental contamination) are considered, interpretation becomes even more complicated. For evaluating possible passive contamination, it is essential to consider specific identification of metabolites, use of metabolite-to-parent drug ratios, assays of decontamination washes and analysis of specimens collected from other body parts. Cosmetic hair treatment, natural and artificial hair colour, differences in hair structure and specificity of analytical methodology may represent other bias sources affecting concentrations of drugs in hair. A suitable cut-off level related to the LOD will allow correct identification of drugs or metabolites in hair. Regarding the performance of different hair testing laboratories, little information is available at this time to what extent test results are comparable and their interpretation is consistent. Frequency of drug consumption and time intervals between multiple consumption or lag time between consumption and appearance in the hair has not been fully investigated and needs further research.

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Authors: Wennig, R.
Affiliations: University of Luxembourg (LU)
Corresponding author: Wennig, R.
Venue: Forensic Science International
Publisher: Elsevier BV
Published: 2000-01
Volume: 107
Issue: 1-3
Pages: 5-12
ISSN: 0379-0738 (ISSN-L)
DOI: 10.1016/s0379-0738(99)00146-2
OpenAlex: W2080827705
Cited by: 677
References: 36
Citations by year: 2026: 30 · 2025: 38 · 2024: 47 · 2023: 55 · 2022: 45 · 2021: 52 · 2020: 38 · 2019: 37 · 2018: 39 · 2017: 35 · 2016: 36 · 2015: 27 · 2014: 30 · 2013: 20 · 2012: 26
FWCI: 11.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Forensic Science International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
Keywords: hair analysis, drug incorporation into hair, hair growth rate, hair color, cut-off values, time delay, interlaboratory comparability
MeSH terms: Forensic Medicine, Hair, Humans, Substance Abuse Detection

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