The DOI matches its Crossref record, with a small difference in title or year; 93 of the 97 references it cites were found in a registry or an index; 1 of the 49 sources its claims cite were checked for support.
Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults
Open accessAbstract
Background The relationship of health risk behavior and disease in adulthood to the breadth of exposure to childhood emotional, physical, or sexual abuse, and household dysfunction during childhood has not previously been described. Methods A questionnaire about adverse childhood experiences was mailed to 13,494 adults who had completed a standardized medical evaluation at a large HMO; 9,508 (70.5%) responded. Seven categories of adverse childhood experiences were studied: psychological, physical, or sexual abuse; violence against mother; or living with household members who were substance abusers, mentally ill or suicidal, or ever imprisoned. The number of categories of these adverse childhood experiences was then compared to measures of adult risk behavior, health status, and disease. Logistic regression was used to adjust for effects of demographic factors on the association between the cumulative number of categories of childhood exposures (range: 0-7) and risk factors for the leading causes of death in adult life. Results More than half of respondents reported at least one, and one-fourth reported > or = 2 categories of childhood exposures. We found a graded relationship between the number of categories of childhood exposure and each of the adult health risk behaviors and diseases that were studied (P or = 50 sexual intercourse partners, and sexually transmitted disease; and 1.4- to 1.6-fold increase in physical inactivity and severe obesity. The number of categories of…
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Claims the paper makes
49 Own result · 12 No full text of the sources · 12 Own interpretation · 10 Own method · 5 Not checked yet · 1 Partly supported · 1 Sources not found · 1 No basis given · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Longitudinal follow-up of adults whose childhood abuse was well documented has shown that their retrospective reports of childhood abuse are likely to under-estimate actual occurrence.47,48”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Partly supportedcites [47] Femina, 1990, Child abuse, Child Abuse Negl sourceExperimental — accuracy not yet measured
The Results report that eight adults with well-documented abuse in their adolescent records denied it at follow-up, and the Discussion says retrospective inaccuracies in this sample were in the direction of under-reporting. The paper limits that finding to a small sample of former delinquents and says its generalizability is uncertain; the claim does not retain that population qualifier. (LLM, conf=0.82)
- Not checked — no full text of the sourcecites [48] Williams, 1995, Recovered memories of abuse in women with documented child sexual victimization histories, J Traumatic Stress source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“More than half of respondents reported at least one, and one-fourth reported Ն2 categories of childhood exposures.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“There was no statistically significant dose-response relationship for a history of stroke or diabetes.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Significance of Dose-Response Relationships
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“we found a strong, dose-response relationship between the number of childhood exposures and each of the 10 risk factors for the leading causes of death that we studied (P Ͻ .001).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Significance of Dose-Response Relationships
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The seven categories of adverse childhood experiences were strongly interrelated and persons with multiple categories of childhood exposure were likely to have multiple health risk factors later in life.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“More than half of respondents reported at least one, and one-fourth reported Ն2 categories of childhood exposures.”
- Also stated in: § Adverse Childhood Exposures · plain
“More than half of respondents (52%) experienced Ն1 category of adverse childhood exposure; 6.2% reported Ն4 exposures.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
plain- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Adverse Childhood Exposures · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and a 1.4-to 1.6-fold increase in physical inactivity and severe obesity.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The seven categories of adverse childhood experiences were strongly interrelated and persons with multiple categories of childhood exposure were likely to have multiple health risk factors later in life.”
- Also stated in: § Relationships between Categories of Childhood Exposure · plain
“The relationship between single categories of exposure was significant for all comparisons (P Ͻ .001;chi-square).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Relationships between Categories of Childhood Exposure · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of categories of adverse childhood exposures showed a graded relationship to the presence of adult diseases including ischemic heart disease, cancer, chronic lung disease, skeletal fractures, and liver disease.”
- Also stated in: § Discussion · plain
“Disease conditions including ischemic heart disease, cancer, chronic lung disease, skeletal fractures, and liver disease, as well as poor self-rated health also showed a graded relationship to the breadth of childhood exposures.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We also found a significant (P Ͻ .05)dose-response relationship between the number of childhood exposures and the following disease conditions: ischemic heart disease, cancer, chronic bronchitis or emphysema, history of hepatitis or jaundice, skeletal fractures, and poor self-rated health.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Significance of Dose-Response Relationships
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 16
- Probably not a substantial claim. 22
- The quote only partly states this claim. 2
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a 2-to 4-fold increase in smoking, poor self-rated health, Ն50 sexual intercourse partners, and sexually transmitted disease;”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, among persons with no childhood exposures, 56% had none of the 10 risk factors whereas only 14% of persons with Ն4 categories of childhood exposure had no risk factors.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Childhood Exposures and Clustering of Health Risk Factors
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The most prevalent of the 7 categories of childhood exposure was substance abuse in the household (25.6%); the least prevalent exposure category was evidence of criminal behavior in the household (3.4%).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Adverse Childhood Exposures
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“By contrast, only 1% of persons with no childhood exposures had four or more risk factors, whereas 7% of persons with Ն4 childhood exposures had four or more risk factors (Table 6).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Childhood Exposures and Clustering of Health Risk Factors
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| Mental illness | | 18.8 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| Ն65 | 2,610 | 60.0 | 24.5 | 8.9 | 4.2 | 2.4 |”
- Also stated in: § Discussion · plain
“| 19-34 | 807 | 35.4 | 25.4 | 17.2 | 11.0 | 10.9 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one. The quote only partly states this claim.
- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| Psychological | | 11.1 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| Mother treated violently | | 12.5 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| 0 | 3,861 | 56 | 29 | 10 | 4 | 1 |”
- Also stated in: § Discussion · plain
“| Ն4 | 545 | 14 | 26 | 28 | 17 | 7 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one. The quote only partly states this claim.
- Rests on an assumption: The number of categories of adverse childhood exposure is a valid cumulative measure of adversity.
- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similarly, the odds ratios for skeletal fractures, hepatitis or jaundice, and poor self-rated health were 1.6, 2.3, and 2.2, respectively (Table 8).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Relationship between Childhood Exposures and Disease Conditions
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“| Substance abuse | | 25.6 |”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The relationship between single categories of exposure was significant for all comparisons (P Ͻ .001;chi-square).For persons reporting any single category of exposure, the probability of exposure to any additional category ranged from 65%-93% (median: 80%); similarly, the probability of Ն2 additional exposures ranged from 40%-74% (median: 54.5%).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Relationships between Categories of Childhood Exposure
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Because adverse childhood experiences are common and they have strong long-term associations with adult health risk behaviors, health status, and diseases, increased attention to primary, secondary, and tertiary prevention strategies is needed.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Respondent (n ϭ 9,508) and nonrespondent (n ϭ 3,986) groups were similar in their percentages of women (53.7% and 51.0%, respectively) and in their mean years of education (14.0 years and 13.6 years, respectively).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Comparison of Respondents and Nonrespondents
plain- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“After second mailings of the questionnaire to persons who did not respond to the first mailing, the response rate for the survey was 70.5% (9,508/13,494).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Survey Methods
plain- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Respondents were slightly more likely to answer affirmatively than nonrespondents (6.1% vs. 5.4%, respectively).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Comparison of Respondents and Nonrespondents
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without measuring these household factors as well, long-term influence might be wrongly attributed solely to single types of abuse and the cumulative influence of multiple categories of adverse childhood experiences would not be assessed.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Conditions such as drug abuse, spousal violence, and criminal activity in the household may co-occur with specific forms of abuse that involve children.
None of the sources cited for this claim have been checked yet.
In the paper
“We used questions from published surveys to construct the ACE Study questionnaire.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Questionnaire Design
What the sources say
- Not checked — no full text of the sourcecites [39] Straus, 1990 source
- Not checked — no full text of the sourcecites [40] Wyatt, 1985, The sexual abuse of Afro-American and White-American women in childhood, Child Abuse Negl source
- Not checked yetcites [41] National Center for Health Statistics. Exposure to alcoholism in the family: United States, 1988. Advance Data, No. 205. U.S. Department of Health and Human Services, Washington, DC; September 30, 1991.
plain- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Respondents were older than nonrespondents (means 56.1 years and 49.3 years) and more likely to be white (83.9% vs. 75.3%)although the actual magnitude of the differences was small.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Comparison of Respondents and Nonrespondents
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Studies of the long-term effects of childhood abuse have usually examined single types of abuse, particularly sexual abuse, and few have assessed the impact of more than one type of abuse.5,24 -28”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
What the sources say
- Not checked — no full text of the sourcecites [5] McCauley, 1997, Clinical characteristics of women with a history of childhood abuse, JAMA source
- Not checked — no full text of the sourcecites [24] Briere, 1988, Multivariate correlates of childhood psychological and physical maltreatment among university women, Child Abuse Negl source
- Not checked — no full text of the sourcecites [25] Briere, 1990, Differential adult symptomatology associated with three types of child abuse histories, Child Abuse Negl source
- Not checked — no full text of the sourcecites [26] Claussen, 1991, Physical and psychological maltreatment, Child Abuse Negl source
- Not checked — no full text of the sourcecites [27] Moeller, 1993, The combined effects of physical, sexual, and emotional abuse during childhood, Child Abuse Negl source
- Not checked — no full text of the sourcecites [28] Bryant, 1995, Suicidality in college women who were sexually and physically punished by parents, Violence Vict source
plain- Asserted: passes — The authors put it forward as true.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Respondents and nonrespondents did not differ with regard to their self-rated health, smoking, other substance abuse, or the presence of common medical conditions such as a history of heart attack or stroke, chronic obstructive lung disease, hypertension, or diabetes, or with regard to marital status or current family, marital, or job-related problems (data not shown).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Comparison of Respondents and Nonrespondents
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“For example, the American Medical Association recommends screening of women for exposure to violence at every entrance to the health system; 66 however, such screening appears to be rare.67”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked yetcites [66] 1992, American Medical Association Diagnostic and Treatment Guidelines on Domestic Violence, Arch Fam Med
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, there may be mediators of the relationship between childhood experiences and adult health status other than the risk factors we examined.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“High levels of exposure to adverse childhood experiences would expectedly produce anxiety, anger, and depression in children.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper may give no reason why it holds.
In the paper
“Although articles in the general medical literature are alerting the medical community to the fact that childhood abuse is common, 59 adolescent health care is often inadequate in terms of psychosocial assessment and anticipatory guidance.60”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked — no full text of the sourcecites [60] Rixey, 1994, Family violence and the adolescent, Maryland Med J
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, nicotine is recognized as having beneficial psychoactive effects in terms of regulating affect 49 and persons who are depressed are more likely to smoke.50,51”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked — no full text of the sourcecites [49] Carmody, 1989, Affect regulation, nicotine addiction, and smoking cessation, J Psychoactive Drugs source
- Not checked — no full text of the sourcecites [50] Anda, 1990, Depression and the dynamics of smoking. A national perspective, JAMA source
- Not checked — no full text of the sourcecites [51] Glassman, 1990, Smoking, smoking cessation, and major depression, JAMA source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“To the degree that behaviors such as smoking, alcohol, or drug use are found to be effective as coping devices, they would tend to be used chronically.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Many physicians may fear that discussions of sexual violence and other sensitive issues are too personal even for the doctor-patient relationship.65”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked — no full text of the sourcecites [65] Sugg, 1992, Primary care physicians’ response to domestic violence. Opening Pandora’s box, JAMA source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“because it is strongly predictive of mortality.45”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > 3.4 Any category reported 52.1%
What the sources say
- Not checked — no full text of the sourcecites [45] Idler, 1990, Self-rated health and mortality in the NHANES I Epidemiologic Follow-up Study, Am J Pub Health source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Second, some persons with health risk behaviors or diseases may have been either more, or less, likely to report adverse childhood experiences.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Moreover, these childhood exposures include emotionally sensitive topics such as family alcoholism 29,30 and sexual abuse.64”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked — no full text of the sourcecites [29] Zeitlen, 1994, Children with alcohol misusing parents, Br Med Bull source
- Not checked — no full text of the sourcecites [30] Dore, 1995, Identifying substance abuse in maltreating families, Child Abuse Negl source
- Not checked yetcites [64] Tabachnick, 1997, Perceptions of child sexual abuse as a public health problem. Vermont, September 1995, Morb Mortal Wkly Rep
plain- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, disease conditions could be either over-or under-reported by patients when they complete the medical questionnaire.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The relationship between childhood experiences and adult health status is likely to be overlooked in medical practice because the time delay between exposure during childhood and recognition of health problems in adult medical practice is lengthy.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The data about adverse childhood experiences are based on self-report, retrospective, and can only demonstrate associations between childhood exposures and health risk behaviors, health status, and diseases in adulthood.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, smoking, which is medically and socially viewed as a “problem” may, from the perspective of the user, represent an effective immediate solution that leads to chronic use.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Although articles in the general medical literature are alerting the medical community to the fact that childhood abuse is common, 59 adolescent health care is often inadequate in terms of psychosocial assessment and anticipatory guidance.60”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
What the sources say
- Not checked — no full text of the sourcecites [59] MacMillan, 1997, Prevalence of child physical and sexual abuse in the community. Results from the Ontario Health Supplement, JAMA source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Logistic regression analysis was employed to adjust for the potential confounding effects of age, sex, race, and educational attainment on the relationship between the number of childhood exposures and health problems.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Statistical Analysis
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The paper relies on this without support.
Conditions such as drug abuse, spousal violence, and criminal activity in the household may co-occur with specific forms of abuse that involve children.
“Conditions such as drug abuse, spousal violence, and criminal activity in the household may co-occur with specific forms of abuse that involve children.”
The paper relies on this without support.
The number of categories of adverse childhood exposure is a valid cumulative measure of adversity.
“Number of categories of adverse childhood exposure and the adjusted odds of risk factors including current smoking, severe obesity, physical inactivity, depressed mood, and suicide attempt”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adverse childhood experiences (ACEs) were documented at baseline using the 10-item ACE Study questionnaire to measure childhood trauma, and were grouped as either “0–3” or “4+” due to the high rate of chronic health problems among individuals with scores of 4 or more 37.”
From Effects of a trauma-informed mindful recovery program on comorbid pain, anxiety, and substance use during primary care buprenorphine treatment: A proof-of-concept study (2023) · cites this paper as [37]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both exposure to IPV and parental separation or divorce are two adverse childhood experiences (ACEs) that are linked in a dose–response relationship to adverse health consequences through the lifespan (Felitti et al., 1998).”
From Post‐separation abuse: A concept analysis (2023) · cites this paper as Felitti et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“There is a strong, graded link between exposure to childhood adversity and risk of negative health, social, and emotional outcomes, including several major categories of chronic disease, lung cancer, various autoimmune diseases, depression and other mental illnesses, and high-risk behaviors (e.g., Felitti et al., 1998).”
From Malleability, plasticity, and individuality: How children learn and develop in context1 (2019) · cites this paper as Felitti et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“on average, the life span of individuals with six or more ACEs is 20 years shorter than that of those with zero ACEs (Felitti et al., 1998).”
From Malleability, plasticity, and individuality: How children learn and develop in context1 (2019) · cites this paper as Felitti et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“while adults with ELS/CT experience could be at increased risk of disease with potentially immune origin (36, 53).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [53]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In one study of more than 9,500 adults, for example, exposure to multiple forms of early life stress was associated with a 4.6-fold increase in risk of being depressed over the past year (Felitti et al., 1998).”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Felitti et al., 1998
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adverse childhood experiences, including growing up in a context of maternal substance use (74), predicts an earlier age of onset for alcohol (62, 75) and other drug use (76, 77), and increased odds for attempting suicide (78).”
From Mothering, Substance Use Disorders and Intergenerational Trauma Transmission: An Attachment-Based Perspective (2019) · cites this paper as [74]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Outcomes associated with early adversity include higher risk of type 2 diabetes, obesity, ischemic heart disease, cancers, depression, addictions, and premature mortality, as well as social outcomes including unemployment and lower educational attainment [1–8].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Epidemiological studies have demonstrated that adverse childhood experiences, namely exposures such as neglect, abuse, caregiver mental illness, and family or community violence, predict poorer long-term outcomes across health and social domains.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Interest in metabolic embedding of ELA stems from epidemiological [1, 69] and clinical [70] studies linking ELA to obesity, dyslipidemia, and type 2 diabetes, raising questions about possible causal pathways.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adverse psychosocial exposures in early life, namely experiences such as child maltreatment, caregiver stress or depression, and domestic or community violence, have been associated in epidemiological studies with increased lifetime risk of adverse outcomes, including diabetes, heart disease, cancers, and psychiatric illnesses.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In full, ELA-induced changes may mediate epidemiological links to key diseases, including, among others, obesity, dyslipidemia, type 2 diabetes, atherosclerosis, asthma, thromboembolic events (myocardial infarction, stroke), cancer onset and progression, as well as addictions, psychopathology, and adverse social outcomes [1–6, 18].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These frequencies are consistent with previous studies documenting elevated rates of childhood adversity among individuals with SUD [3, 5, 9].”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adverse childhood experiences are associated with many negative adult health and health care utilisation outcomes, including cardiovascular illness, depression, suicide attempts, unhealthy substance use, obesity, lung disease, liver disease, cancer and medically unexplained symptoms such as pain or gastrointestinal problems[1–6].”
From Health care utilisation changes among Alaska Native adults after participation in an indigenous community programme to address adverse life experiences: a propensity score-matched analysis (2020) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Dose-response relationships between adverse childhood experiences (ACEs) and multiple risk factors have been documented among AIANs and non-AIANs [51,70].”
From Substance and Behavioral Addictions among American Indian and Alaska Native Populations (2022) · cites this paper as [70]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Rather, the overwhelming majority of studies14 have employed an empirical specification similar to that which has predominated in the literature on childhood adversity, i.e., a sum score of exposures.15–18”
From Co-occurring epidemics, syndemics, and population health (2017) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“Much research associates CT with adverse physical and mental health outcomes (1,2)”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Moreover, there is commonly a dose-response relationship between the number of types of adversity associated and the magnitude of the risk for depression.4-11”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [4]
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, the original ACE study [3] demonstrated that individuals exposed to multiple adverse experiences had a four- to twelve-fold increased risk for alcoholism, drug abuse, depression, and suicide attempts.”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“Exposure to ELA is associated with a clustering of health risks, with increasing exposure related to an increasing number of HRBs.32”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [32]
The cited source says what the claim attributes to it.
In the citing paper
“Such an approach facilitates the synthesis of complex evidence for application, and is supported by observed dose–response effects linking cumulative early adversity to later outcomes [1, 3, 5], and by the “allostatic load” paradigm exploring pathogenic effects of cumulative all-cause stress [15].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Dose-response relationship between number of adversities and health and social effects are observed in large epidemiological studies”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“Adverse childhood experiences (ACEs) considerably increase the likelihood of mental illness, health risk behaviors, and chronic physical illnesses.”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“These findings are consistent with research that has supported the relationship between ACEs and further negative health consequences in the general population (Buckingham & Daniolos, 2013;Cicchetti & Handley, 2019;Felitti et al., 1998;Hughes et al., 2017).”
From Adverse childhood experiences (ACEs) and substance use disorder (SUD): A scoping review (2021) · cites this paper as Felitti et al., 1998
In the citing paper
“Also, adults who were abused as children have been shown to be at increased risk of disease with potential inflammatory origin (9, 10).”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [9]
In the citing paper
“Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult health.”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [9]
In the citing paper
“Given that the effect of stress often appears to be cumulative (2, 9, 19), we derived a cumulative exposure index for each child by counting the number of maltreatment experiences during the first decade of life (31);”
From Childhood maltreatment predicts adult inflammation in a life-course study (2007) · cites this paper as [9]
In the citing paper
“Childhood adversity has been repeatedly and robustly linked to physical and mental illness across the lifespan.”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Felitti et al., 1998
In the citing paper
“Children enter foster care with a sum of adverse childhood experiences.55–57”
In the citing paper
“The first study using the DAWBA-RAD section reported a very high RAD point-prevalence of 63.0% (96/153) in a sample of looked after youth in a variety of placement forms [29].”
From Mental disorders in foster children: a study of prevalence, comorbidity and risk factors (2013) · cites this paper as [29]
In the citing paper
“Compared to another study on RAD using DAWBA in high-risk foster youths [29], our estimate was quite moderate.”
From Mental disorders in foster children: a study of prevalence, comorbidity and risk factors (2013) · cites this paper as [29]
In the citing paper
“Victims of childhood physical or sexual abuse or parental neglect are at considerably greater risk for affective disorders.1-4”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [4]
In the citing paper
“Epidemiological studies provide compelling support for the association between cumulative, adverse childhood experiences and the risk for depression.4,5”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [4]
In the citing paper
“In humans, various forms of ELA are associated with illicit drug use later in life [21,22,23].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [21]
In the citing paper
“In addition, there are established links between ELA and obesity [21,24], however, the exact mechanisms are not understood.”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [21]
In the citing paper
“Strong links between ACEs and the initiation of opioid use have been described (72, 73).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [72]
In the citing paper
“The Adverse Childhood Experiences (ACE) study from 1998 highlighted 5- to 10-fold increase in the risk of AUD and SUD following exposure to four or more ACEs in the first 18 years of life [112].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [112]
In the citing paper
“Indeed, ELA is associated with a greater likelihood of smoking cigarettes,32,43,44 abusing alcohol and drugs,32,45–47 eating a poor diet,48 and being obese.32,49”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [32]
In the citing paper
“ELA has also been associated with physical inactivity, which likely also contributes to the link between ELA and obesity.32”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [32]
In the citing paper
“Research has consistently found that care leavers are more likely to have experienced high levels of adverse childhood experience (ACEs) and are at significantly greater risk for negative outcomes (Felitti et al., 1998; Simkiss, 2019).”
From The relationship between spirituality and resilience and well-being: a study of 529 care leavers from 11 nations. (2023) · cites this paper as Felitti et al., 1998
In the citing paper
“The documented risks of having care experience are substantial and varied (Berlin et al., 2011; Felitti et al., 1998; Simkiss, 2019).”
From The relationship between spirituality and resilience and well-being: a study of 529 care leavers from 11 nations. (2023) · cites this paper as Felitti et al., 1998
In the citing paper
“Early life physical and sexual abuse carry with it a life-long burden of behavioral and pathophysiological problems (Felitti et al., 1998; Heim and Nemeroff, 2001).”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Felitti et al., 1998
In the citing paper
“There are enormous individual differences in the response to stress, based upon the experience of the individual early in life and in adult life.”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [41]
In the citing paper
“Early life physical and sexual abuse imposes a life- long burden of behavioral and pathophysiological problems.41,42”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [41]
In the citing paper
“Early-life events related to maternal care in animals, as well as parental care in humans, play a powerful role in later mental and physical health, as demonstrated by the adverse childhood experiences (ACE) studies”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [77]
In the citing paper
“ACE have a disproportionately powerful effect on life long trajectories of health and disease, 68 and poverty contributes in its own way as well as creating circumstances for ACE, 114 which, however, occurs across all levels of socioeconomic status (SES).”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [77]
In the citing paper
“Boarding schools as a form of cultural genocide and source of historical trauma have had a variety of negative health impacts on Native people, such as high suicide rates, post-traumatic stress disorder, and other illnesses such as heart disease and diabetes that are connected to trauma (Brave Heart et al. 2011;Duran 2019;Felitti et al. 1998).”
From Archaeology and Social Justice in Native America (2022) · cites this paper as Felitti et al. 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
“We found a graded relationship between the number of categories of childhood exposure and each of the adult health risk behaviors and diseases that were studied (P Ͻ .001).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Significance of Dose-Response Relationships
“There was no statistically significant dose-response relationship for a history of stroke or diabetes.”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Exclusions from Analysis
“The mean age of the 8,506 persons included in this analysis was 56.1 years”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Exclusions from Analysis
“After these exclusions, 8,056 of the original 9,508 survey respondents (59.7% of the original sample of 13,494) remained and were included in the analysis.”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Abstract
“a 1.4-to 1.6-fold increase in physical inactivity and severe obesity.”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
“| | 4 or more | 523 | 26.6 | 1.3 | ( 1.1-1.6) |”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Relationship between Childhood Exposures and Disease Conditions
“Similarly, the odds ratios for skeletal fractures, hepatitis or jaundice, and poor self-rated health were 1.6, 2.3, and 2.2, respectively (Table 8).”
§ Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults The Adverse Childhood Experiences (ACE) Study > Discussion
“| | 4 or more | 543 | 10.7 | 2.4 | (1.8-3.3) |”
Citations
Cites
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Mail and Telephone Surveys: The Total Design Method.
Babbie, E. R., & Dillman, D. A. (1982) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2068433 · Cited by 6,859
Physical Activity and Health: A Report of the Surgeon General
(1995) · PsycEXTRA Dataset · doi:10.1037/e525162010-001 · Cited by 5,488
Actual causes of death in the United States
McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219
The traumatic impact of child sexual abuse: A conceptualization.
Finkelhor, D., & Browne, A. (1985) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.1985.tb02703.x · Cited by 1,891
Finkelhor, D., Hotaling, G., Lewis, I. A., & Smith, C. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90077-7 · Cited by 1,754 · cited 1×
“A national telephone survey of adults in 1990 using similar criteria for sexual abuse estimated that 27% of women and 16% of men had been sexually abused.(12) There are several reasons to believe that our estimates of the long-term relationship between adverse childhood experiences and adult health are conservative.”
MethodPhysical Violence in American Families: Risk Factors and Adaptations to Violence in 8,145 Families.
Goetting, A., Straus, M. A., & Gelles, R. J. (1990) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2073234 · Cited by 1,670
Societal change and change in family violence from 1975 to 1985 as revealed by two national surveys
Straus, M. A., & Gelles, R. J. (1986) · Journal of Marriage and the Family · doi:10.2307/352033 · Cited by 1,592
Book Review: Mail and Telephone Surveys
Harris, L. M., & Dillman, D. A. (1979) · Journal of Marketing Research · doi:10.2307/3150885 · Cited by 1,431
Research works printed but not linked: 2
- 1996, Morb Mortal Wkly Rep, 45, 161
- SAS Procedures Guide. SAS Institute Inc. Version 6, 3rd edition, Cary, NC: SAS Institute; 1990.
Cited by
Sorted by citations
Items 2,001–2,100 of 18,888
Health determinants of adolescent criminalisation
Hughes, N., Ungar, M. T., Fagan, A. A., Murray, J., Atilola, O., Nichols, K., Garcia, J. C. R., & Kinner, S. A. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(19)30347-5 · Cited by 67
Children’s prolonged exposure to the toxic stress of war trauma in the Middle East
Samara, M. M., Hammuda, S., Vostanis, P., El-Khodary, B., & Al-Dewik, N. I. E. (2020) · BMJ · doi:10.1136/bmj.m3155 · Cited by 73
Hoogsteder, L. M., Thije, L. T., Schippers, E. E., & Stams, G. J. J. M. (2021) · International Journal of Offender Therapy and Comparative Criminology · doi:10.1177/0306624x211010290 · Cited by 79
“…Journal of Offender Therapy and Comparative Criminology 66(6-7) Worldwide, about 23% of the adolescents are exposed to traumatic events, such as physical or sexual violence, severe accidents, natural disasters, or chronic illnesses (Costello et al., 2002; Felitti et al., 1998; Putnam, 2003).”
BackgroundŠinko, L., He, Y., Kishton, R. E., Ortiz, R., Jacobs, L., & Fingerman, M. (2021) · Journal of Family Violence · doi:10.1007/s10896-021-00290-5 · Cited by 64
Kuhar, M., & Kocjan, G. Z. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1924953 · Cited by 68
“…some of the health outcomes were considered more broadly (e.g. chronic respiratory diseases instead of chronic bronchitis or/and emphysema) or in more detail (e.g. harmful alcohol consumption was determined on the basis of the alcohol units consumed) compared to the study by Felitti et al. (1998).”
BackgroundMethodResultInfluentialParvalbumin interneuron alterations in stress-related mood disorders: A systematic review
Perlman, G., Tanti, A., & Mechawar, N. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100380 · Cited by 71
Jonas, L., de Pablo, G. S., Shum, M., Nosarti, C., Abbott, C., & Vaquerizo‐Serrano, J. (2022) · JCPP Advances · doi:10.1002/jcv2.12079 · Cited by 65
“The first study to assess adverse childhood experiences (ACEs) captured a series of ongoing stressful or traumatic events experienced by an individual before the age of 18 (Felitti et al., 1998).”
BackgroundBrewerton, T. D. (2022) · Journal of Eating Disorders · doi:10.1186/s40337-022-00696-6 · Cited by 76
Oláh, B., Fekete, Z., Szabó, I. K., & Kovács-Tóth, B. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1258798 · Cited by 74
Adverse Childhood Experiences and Autism: A Meta-Analysis
Hartley, G., Sirois, F. M., Purrington, J., & Rabey, Y. (2023) · Trauma Violence & Abuse · doi:10.1177/15248380231213314 · Cited by 78
“Felitti et al. (1998) found that in the general U.S. population, almost two-thirds of adults reported at least one ACE.”
BackgroundChildren growing up in a violent community: The role of the family
Proctor, L. J. (2006) · Aggression and Violent Behavior · doi:10.1016/j.avb.2005.12.004 · Cited by 68
Intimate Partner Violence Identification and Response: Time for a Change in Strategy
Rhodes, K. V., Kothari, C., Dichter, M. E., Cerulli, C., Wiley, J. A., & Marcus, S. C. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1662-4 · Cited by 64
Adverse Childhood Events and Current Depressive Symptoms Among Women in Hawaii: 2010 BRFSS, Hawaii
Remigio‐Baker, R. A., Hayes, D., & Reyes-Salvail, F. (2013) · Maternal and Child Health Journal · doi:10.1007/s10995-013-1374-y · Cited by 70
DNA memories of early social life
Hoffmann, A. H., & Spengler, D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.003 · Cited by 64
Sexual assault in Virginia: A population-based study
Masho, S. W., Odor, R. K., & Adera, T. (2005) · Women s Health Issues · doi:10.1016/j.whi.2005.04.001 · Cited by 64
O’Connor, T. G., Moynihan, J. A., & Caserta, M. T. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12187 · Cited by 68
Young, S. Y. N., Hansen, C. J., Gibson, R. L., & Ryan, M. A. K. (2006) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.160.12.1207 · Cited by 65
Early-life experience affects honey bee aggression and resilience to immune challenge
Rittschof, C. C., Coombs, C. B., Frazier, M. T., Grozinger, C. M., & Robinson, G. E. (2015) · Scientific Reports · doi:10.1038/srep15572 · Cited by 65
Shields, M. E., Hovdestad, W., Pelletier, C., Dykxhoorn, J. L., O’Donnell, S. C., & Tonmyr, L. (2016) · BMC Public Health · doi:10.1186/s12889-016-3491-1 · Cited by 64
Proinflammatory T Cell Status Associated with Early Life Adversity
Elwenspoek, M. M. C., Hengesch, X., Leenen, F. A. D., Schritz, A., Sias, K., Schaan, V., Mériaux, S. B., Schmitz, S., Bonnemberger, F., Schächinger, H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701082 · Cited by 67
Patterns of Adverse Childhood Experiences in Juveniles Who Sexually Offended
Barra, S., Bessler, C., Landolt, M. A., & Aebi, M. (2017) · Sexual Abuse · doi:10.1177/1079063217697135 · Cited by 65
Kia‐Keating, M., Barnett, M. L., Liu, S. R., Sims, G. M., & Ruth, A. B. (2019) · American Journal of Community Psychology · doi:10.1002/ajcp.12366 · Cited by 66
“Cost-effectiveness analyses are needed to identify if this investment in prevention leads to long-term societal savings, which could include healthcare expenditures given the impact of ACEs on health outcomes for children and adults (Felitti et al., 1998; Liu et al., 2018).”
BackgroundMethodPathways Associating Childhood Trauma to the Neurobiology of Schizophrenia.
Ruby, E., Polito, S., McMahon, K. L., Gorovitz, M., Corcoran, C. M., & Malaspina, D. (2014) · PubMed · Cited by 65
Boynton-Jarrett, R., Rich-Edwards, J. W., Jun, H.-J., Hibert, E. N., & Wright, R. J. (2011) · Epidemiology · doi:10.1097/ede.0b013e3181ffb172 · Cited by 64
Adverse childhood experiences in mothers with chronic pain and intergenerational impact on children
Dennis, C. H., Clohessy, D. S., Stone, A. L., Darnall, B. D., & Wilson, A. C. (2019) · The Journal of Pain · doi:10.1016/j.jpain.2019.04.004 · Cited by 64
Kentner, A. C., Cryan, J. F., & Brummelte, S. (2019) · Developmental Psychobiology · doi:10.1002/dev.21775 · Cited by 64
Howe, T. R., Aberson, C. L., Friedman, H. S., Murphy, S. E., Alcazar, E., Vazquez, E. J., & Becker, R. L. (2015) · Self and Identity · doi:10.1080/15298868.2015.1036918 · Cited by 64
Metabolic pathways link childhood adversity to elevated blood pressure in midlife adults
Crowell, J. A., Davis, C. R., Joung, K. E., Usher, N., McCormick, S.-P., Dearing, E., & Mantzoros, C. S. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.10.009 · Cited by 66
O’Donnell, K. J., Chen, L., MacIsaac, J. L., McEwen, L. M., Nguyen, T. T. T., Beckmann, K., Zhu, Y., Chen, L. R., Jeanne Brooks-gunn, B., Goldman, D. A., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0063-9 · Cited by 67
Marryat, L., & Frank, J. W. (2019) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2018-000340 · Cited by 64
“disease.(1) 13–17 ACEs have also been associated with risky lifestyle behaviours, for example, drug and alcohol use, smoking and high numbers of sexual partners(1) as well as job, financial and reproductive problems.”
BackgroundMethodResultInfluentialStapp, E. K., Mendelson, T., Merikangas, K. R., & Wilcox, H. C. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.005 · Cited by 75
The Cambridge Handbook of Psychology and Human Rights
Dudgeon, P., Carey, T. A., Hammond, S., Hirvonen, T., Kyrios, M., Roufeil, L., & Smith, P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108348607 · Cited by 68
ADHD and Exposure to Maltreatment in Children and Youth: a Systematic Review of the Past 10 Years
Craig, S., Bondi, B. C., O'Donnell, K., Pepler, D., & Weiss, M. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-01193-w · Cited by 58
Mason, C., Taggart, D., & Broadhurst, K. (2020) · Societies · doi:10.3390/soc10040093 · Cited by 65
Cumulative Stressors and Adolescent Substance Use: A Review of 21st-Century Literature
Hoffmann, J. P., & Jones, M. S. (2020) · Trauma Violence & Abuse · doi:10.1177/1524838020979674 · Cited by 72
“Adverse childhood experiences (ACEs)—which involve stress-inducing experiences early in the life course, such as physical or emotional abuse or neglect, parental mental illness or behavioral problems, or family dissolution (Felitti et al., 1998)—have been similarly linked to substance use (Shiffler et al.”
BackgroundStress and Cardiometabolic Disease Risk for Indigenous Populations throughout the Lifespan
Lewis, M. E., Volpert‐Esmond, H. I., Deen, J. F., Modde, E., & Warne, D. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041821 · Cited by 71
Pierce, H., & Jones, M. S. (2021) · Journal of Research in Crime and Delinquency · doi:10.1177/00224278211003227 · Cited by 66
“ACEs include abuse, neglect, and household dysfunction in childhood, family mental health, domestic violence, and family criminal behavior (Felitti et al. 1998).”
BackgroundMethodResultInfluentialKiarashi, J., VanderPluym, J. H., Szperka, C. L., Turner, S. B., Minen, M. T., Broner, S. W., Ross, A. C., Wagstaff, A. E., Anto, M. M., Marzouk, M. A., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012261 · Cited by 69
“ACEs include physical abuse, emotional abuse, sexual abuse, physical neglect, emotional neglect, exposure to mental illness in the household, witnessing violence against one’s mother, being the product of divorce, having a substance-abusing household member, or having an incarcerated relative.(46) Additional ACEs have…”
BackgroundImmediate impact of child maltreatment on mental, developmental, and physical health trajectories
Winter, S., Dittrich, K., Dörr, P., Overfeld, J., Moebus, I., Murray, E., Karaboycheva, G., Zimmermann, C., Knop, A. J. J., Voelkle, M. C., et al. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13550 · Cited by 80
Burns, C. J., Borah, L., Terrell, S. M., James, L. N., Erkkinen, E., & Owens, L. E. (2022) · Academic Medicine · doi:10.1097/acm.0000000000005046 · Cited by 64
SUPPORTING POSITIVE PARENTING IN COMMUNITY HEALTH CENTERS: THE ACT RAISING SAFE KIDS PROGRAM
Knox, M. S., Burkhart, K. M., & Cromly, A. (2013) · Journal of Community Psychology · doi:10.1002/jcop.21543 · Cited by 65
Fuller‐Thomson, E., Stefanyk, M., & Brennenstuhl, S. (2009) · Arthritis Care & Research · doi:10.1002/art.24871 · Cited by 64
Witnessing Violence Toward Siblings: An Understudied but Potent Form of Early Adversity
Teicher, M. H., & Vitaliano, G. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028852 · Cited by 63
Translating Developmental Science to Address Childhood Adversity
Garner, A. S., Forkey, H. C., & Szilagyi, M. A. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.05.010 · Cited by 67
Cumulative Adverse Financial Circumstances: Associations with Patient Health Status and Behaviors
Bisgaier, J., & Rhodes, K. V. (2011) · Health & Social Work · doi:10.1093/hsw/36.2.129 · Cited by 64
Wanner, B., Vitaro, F., Tremblay, R. E., & Turecki, G. (2012) · Psychological Medicine · doi:10.1017/s0033291712000438 · Cited by 64
Harden, B. J., Buhler‐Wassmann, A. C., & Parra, L. J. (2016) · Trauma Violence & Abuse · doi:10.1177/1524838016658878 · Cited by 75
Weiss, D., Kassam‐Adams, N., Murray, C., et al. (2017) · Journal of Continuing Education in the Health Professions · doi:10.1097/ceh.0000000000000140 · Cited by 64
Adverse Childhood Experiences and Suicide Risk: Toward Comprehensive Prevention
Ports, K. A., Merrick, M. T., Stone, D. M., Wilkins, N. J., Reed, J., Ebin, J., & Ford, D. C. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2017.03.015 · Cited by 64
Kugler, K. C., Guastaferro, K., Shenk, C. E., Beal, S. J., Zadzora, K. M., & Noll, J. G. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.06.005 · Cited by 85
Heterogeneous effects of adolescent violent victimization on problematic outcomes in early adulthood
Turanovic, J. (2018) · Criminology (Beverly Hills) · doi:10.1111/1745-9125.12198 · Cited by 61
Current State of Trauma-Informed Education in the Health Sciences: Lessons for Nursing
Li, Y., Cannon, L. M., Coolidge, E. M., Darling‐Fisher, C. S., Pardee, M., & Kuzma, E. K. (2019) · Journal of Nursing Education · doi:10.3928/01484834-20190122-06 · Cited by 70
Childhood adversity, mental health, and oxidative stress: A pilot study
Horn, S. R. G.-V., Leve, L. D., Levitt, P. R., & Fisher, P. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215085 · Cited by 64
Persistence of skin-deep resilience in African American adults.
Brody, G. H., Yu, T., Chen, E., & Miller, G. E. (2020) · Health Psychology · doi:10.1037/hea0000945 · Cited by 64
“At age 27 years, participants reported adverse childhood experiences on the Adverse Childhood Experiences (ACEs) questionnaire (Felitti et al., 1998).”
BackgroundRacial/Ethnic Variations in Women’s Health: The Social Embeddedness of Health
Williams, D. R. (2008) · American Journal of Public Health · doi:10.2105/ajph.98.supplement_1.s38 · Cited by 66
Guiney, H., Caspi, A., Ambler, A., Belsky, J., Kokaua, J., Broadbent, J., Cheyne, K., Dickson, N., Hancox, R. J., Harrington, H., et al. (2024) · Development and Psychopathology · doi:10.1017/s0954579422001146 · Cited by 64
“Our adverse childhood experience measures correspond to the categories introduced by the CDC Adverse Childhood Experiences Study (Felitti et al., 1998), which included five types of child harm (physical abuse, emotional abuse, physical neglect, emotional neglect and sexual abuse) and five types of…”
MethodKane, J. C., Skavenski Van Wyk, S., Murray, S. M., Bolton, P., Melendez, F., Danielson, C. K., Chimponda, P., Munthali, S., & Murray, L. K. (2017) · Global Mental Health · doi:10.1017/gmh.2017.10 · Cited by 63
Emotional neglect in childhood and cerebral infarction in older age
Wilson, R. S., Boyle, P. A., Levine, S. R., Yu, L., Anagnos, S. E., Buchman, A. S., Schneider, J. A., & Bennett, D. A. (2012) · Neurology · doi:10.1212/wnl.0b013e31826e25bd · Cited by 63
Wiss, D., & Brewerton, T. (2020) · Nutrients · doi:10.3390/nu12102937 · Cited by 63
“ACEs captured by the various forms of the questionnaire are referred to as a form of ELA; however, it is important to acknowledge there are many other measures used, such as the childhood trauma questionnaire (CTQ) [114,115].”
BackgroundMethodInfluentialLieberman, A. F. (2007) · Infant Mental Health Journal · doi:10.1002/imhj.20145 · Cited by 67
Quality of life in functional movement disorders is as altered as in organic movement disorders
Gendre, T., Carle, G., Mesrati, F., Hubsch, C. A., Mauras, T., Roze, E. F., Houot, M., Degos, B., & Garcin, B. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.006 · Cited by 63
Appleton, A. A., Kiley, K., Holdsworth, E. A., & Schell, L. M. (2019) · Maternal and Child Health Journal · doi:10.1007/s10995-018-02706-z · Cited by 63
Hatch, V., Swerbenski, H. G., & Gray, S. A. O. (2020) · American Journal of Orthopsychiatry · doi:10.1037/ort0000451 · Cited by 64
“…intergenerational continuity, mothers’ ability to provide nurturing experiences may be impacted by parents’ own mental and physical health challenges, which are associated in a dose-response manner with ACEs (e.g., Anda et al., 2006; Dube, Felitti, Dong, Giles, & Anda, 2003; Felitti et al., 1998).”
BackgroundMethodInfluentialWall, C. R. G. (2020) · Journal of Aggression Maltreatment & Trauma · doi:10.1080/10926771.2020.1737292 · Cited by 63
Demaestri, C., Pan, T., Critz, M., Ofray, D., Gallo, M. E., & Bath, K. G. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104763 · Cited by 65
“…early life adversity) and enriching experiences have been associated with increased risk for psychopathology (Dong et al., 2003; Dube et al., 2001; Felitti et al., 1998; Nelson et al., 2011), altered brain maturation (Gee et al., 2013; Honeycutt et al., 2020), impaired performance on learning…”
BackgroundValidity of an expanded assessment of adverse childhood experiences: A replication study
Choi, C., Mersky, J. P., Janczewski, C. E., Lee, C. P., Davies, W. H., & Lang, A. C. (2020) · Children and Youth Services Review · doi:10.1016/j.childyouth.2020.105216 · Cited by 64
Merrick, J., & Narayan, A. J. (2020) · Journal of Children and Poverty · doi:10.1080/10796126.2020.1799338 · Cited by 63
Glickman, E. A., Choi, K. W., Lussier, A. A., Smith, B. J., & Dunn, E. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.681176 · Cited by 65
Prevention of Mental Health Difficulties for Children Aged 0–3 Years: A Review
Izett, E., Rooney, R. M., Prescott, S. L., Palma, M. D., & McDevitt, M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.500361 · Cited by 74
Schnarrs, P. W., Stone, A. L., Bond, M. A., Salcido, R., Dorri, A. A., & Nemeroff, C. B. (2022) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2022.105570 · Cited by 64
Changing the Odds for Vulnerable Children
OECD (2019) · OECD eBooks · doi:10.1787/a2e8796c-en · Cited by 88
Xu, Z., Zhang, D., Ding, H., Zheng, X., Lee, R. C.-M., Yang, Z., Mo, P. K. H., Lee, E. K. P., & Wong, S. Y. S. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2022.2065429 · Cited by 68
“Adverse childhood experiences (ACEs) refer to the events causing actual or potential damage to health, survival, growth, psychology, or physiology before the age of 18, such as physical/emotional abuse and household challenges (Felitti et al., 1998).”
BackgroundInfluentialFouad, I. A., & Labib, F. E.-Z. M. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105266 · Cited by 72
Brown, A., Raynor, P., & Lee, M. (2011) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2010.01145.x · Cited by 63
Crooks, C. V., SCOTT, K. L., Ellis, W. E., & Wolfe, D. A. (2011) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2011.03.002 · Cited by 63
Littrell, J. L. (2008) · Social Work in Health Care · doi:10.1300/j010v46n04_02 · Cited by 63
Davis, C. R., Dearing, E., Usher, N., Trifiletti, S., Zaichenko, L., Ollen, E. W., Brinkoetter, M. T., Crowell-Doom, C., Joung, K. E., Park, K., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.013 · Cited by 65
Beating and insulting children as a risk for adult cancer, cardiac disease and asthma
Hyland, M. E., Alkhalaf, A. M., & Whalley, B. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9457-6 · Cited by 64
Physiologic Changes Associated With Violence and Abuse Exposure
Keeshin, B. R., Cronholm, P. F., & Strawn, J. R. (2011) · Trauma Violence & Abuse · doi:10.1177/1524838011426152 · Cited by 63
Carver, C. S., Johnson, S. L., Joormann, J., LeMoult, J., & Cuccaro, M. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.02.001 · Cited by 64
Fuller‐Thomson, E., Nimigon‐Young, J., & Brennenstuhl, S. (2011) · Rheumatology International · doi:10.1007/s00296-010-1713-x · Cited by 63
Herrenkohl, T. I., Jung, H., Klika, J. B., Mason, W. A., Brown, E. C., Leeb, R. T., & Herrenkohl, R. C. (2016) · American Journal of Orthopsychiatry · doi:10.1037/ort0000136 · Cited by 64
Adverse childhood experiences and later life adult obesity and smoking in the United States
Rehkopf, D. H., Headen, I. E., Hubbard, A., Deardorff, J., Kesavan, Y., Cohen, A. K., Patil, D., Ritchie, L. D., & Abrams, B. F. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.06.003 · Cited by 64
Fang, L., Chuang, D.-M., & Lee, Y. (2016) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2016.05.019 · Cited by 68
Child maltreatment and problem gambling: A systematic review
Lane, W. G., Sacco, P., Downton, K. D., Ludeman, E. M., Levy, L. B., & Tracy, J. K. (2016) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2016.06.003 · Cited by 70
Trauma-Informed Hospice and Palliative Care
Ganzel, B. L. (2016) · The Gerontologist · doi:10.1093/geront/gnw146 · Cited by 69
Paterniti, S., Sterner, I., Caldwell, C., & Bisserbe, J. C. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1270-x · Cited by 67
Thomson, P., & Jaque, S. V. (2017) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2017.06.001 · Cited by 78
Hazards to Early Development: The Biological Embedding of Early Life Adversity
Nelson, C. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.027 · Cited by 68
Albæk, A. U., Kinn, L. G., & Milde, A. M. (2017) · Qualitative Health Research · doi:10.1177/1049732317734828 · Cited by 62
Adverse childhood experiences and adult inflammation: Findings from the 1958 British birth cohort
Chen, M., & Lacey, R. E. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.02.007 · Cited by 73
Maltreatment during childhood: a risk factor for the development of endometriosis?
Liebermann, C., Kohl Schwartz, A. S., Charpidou, T., Geraedts, K., Rauchfuss, M., Wölfler, M., von Orelli, S., Häberlin, F., Eberhard, M., Imesch, P., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey111 · Cited by 63
Patterns of adversity and pathways to health among White, Black, and Latinx youth.
Liu, S. R., Kia-Keating, M., & Nylund-Gibson, K. (2018) · International Journal of Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.09.007 · Cited by 57
Walsh, K., Sarvet, A. L., Wall, M. M., Gilbert, L., Santelli, J. S., Khan, S., Thompson, M. P., Reardon, L., Hirsch, J. S., & Mellins, C. A. (2019) · Journal of Interpersonal Violence · doi:10.1177/0886260518823293 · Cited by 63
“Sexual abuse was assessed with a yes/no item adapted from the Adverse Childhood Experiences study (Felitti et al., 1998): “During your childhood or adolescent years, did an adult or person at least 5 years older than you ever touch or fondle you or have you touch them in a sexual way?”
Characterizing adverse prenatal and postnatal experiences in children
Lebel, C. A., McMorris, C. A., Kar, P., Ritter, C., Andre, Q. R., Tortorelli, C., & Gibbard, W. B. (2019) · Birth Defects Research · doi:10.1002/bdr2.1464 · Cited by 68
“One framework that is increasingly common in research contexts is that of adverse childhood experiences (ACEs), which sums postnatal adverse exposures to provide a cumulative score (Felitti et al., 1998).”
BackgroundJoss, D., Lazar, S. W., & Teicher, M. H. (2020) · Mindfulness · doi:10.1007/s12671-020-01322-9 · Cited by 66
“2015) with ACE (Felitti et al. 1998), MACE (Teicher and Parigger 2015) and Childhood Trauma Questionnaire (CTQ) (Bernstein and Fink 1998).”
MethodInfluentialTransdiagnostic pathways from early social stress to psychopathology: a 20‐year prospective study
Conway, C. C., Raposa, E. B., Hammen, C., & Brennan, P. A. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12862 · Cited by 60
Leserman, J., Zolnoun, D., Meltzer-Brody, S., Lamvu, G., & Steege, J. F. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.03.071 · Cited by 62
Charles, N. E., Ryan, S. R., Acheson, A., Mathias, C. W., Liang, Y., & Dougherty, D. M. (2014) · Psychology of Addictive Behaviors · doi:10.1037/adb0000020 · Cited by 62
Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?
Morton, P. M., Mustillo, S., & Ferraro, K. F. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.11.026 · Cited by 62
Metadata
- Authors
- Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S.
- Affiliations
- Kaiser Permanente (US)
- Centers for Disease Control and Prevention (US)
- Emory University (US)
- University of Arizona (US)
- Corresponding author
- Felitti, Vincent J
- Venue
- American Journal of Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 14
- Issue
- 4
- Pages
- 245-258
- ISSN
- 0749-3797 (ISSN-L)
- OpenAlex
- W2116839388
- Cited by
- 18,943
- References
- 97
- Citations by year
- 2026: 1615 · 2025: 1790 · 2024: 1720 · 2023: 1711 · 2022: 1648 · 2021: 1720 · 2020: 1565 · 2019: 1232 · 2018: 963 · 2017: 825 · 2016: 666 · 2015: 573 · 2014: 446 · 2013: 413 · 2012: 340
- FWCI
- 57.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (TS-44-10/12)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Health › Intimate Partner and Family Violence
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- adverse childhood experiences, childhood abuse, household dysfunction, childhood emotional abuse, child physical abuse, child sexual abuse, alcoholism, drug abuse, depression, suicide attempts, smoking, sexually transmitted infections, obesity, physical inactivity, ischemic heart disease, cancer, chronic lung disease, liver disease, cumulative exposure, leading causes of death
- MeSH terms
- Adult, Aged, Aged, 80 and over, California, Cause of Death, Child, Child Abuse, Family, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Social Problems, Violence, Health Behavior, Logistic Models, Child of Impaired Parents, Domestic Violence
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