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Cited by 920Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 73 of the 76 references it cites were found in a registry or an index.

Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Brunk, Ulf T, Terman, Alexei·2002·Free Radical Biology and Medicine
DOI 10.1016/s0891-5849(02)00959-0
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Abstract

The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occurring with a rate inversely related to longevity. Lipofuscin is an intralysosomal, polymeric substance, primarily composed of cross-linked protein residues, formed due to iron-catalyzed oxidative processes. Because it is undegradable and cannot be removed via exocytosis, lipofuscin accumulation in postmitotic cells is inevitable, whereas proliferative cells efficiently dilute it during division. The rate of lipofuscin formation can be experimentally manipulated. In cell culture models, oxidative stress (e.g., exposure to 40% ambient oxygen or low molecular weight iron) promotes lipofuscin accumulation, whereas growth at 8% oxygen and treatment with antioxidants or iron-chelators diminish it. Lipofuscin is a fluorochrome and may sensitize lysosomes to visible light, a process potentially important for the pathogenesis of age-related macular degeneration. Lipofuscin-associated iron sensitizes lysosomes to oxidative stress, jeopardizing lysosomal stability and causing apoptosis due to release of lysosomal contents. Lipofuscin accumulation may also diminish autophagocytotic capacity by acting as a sink for newly produced lysosomal enzymes and, therefore, interfere with recycling of cellular components. Lipofuscin, thus, may be much more directly related to cellular degeneration at old age than was hitherto believed.

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Research works printed but not linked: 3

  1. Hannover, 1842, Mikroskopiske undersögelser af nervesystemet, Kgl. Danske Vidensk. Kabernes Selskobs Naturv. Math. Afh. (Copenhagen), 10, 1
  2. Hueck, 1912, Pigmentstudien, Beitr. Pathol. Anat., 54, 68
  3. Jahani, 1985, Cathepsin-B activity in human skin fibroblasts from young, old and premature aging syndromes, Fed. Proc., 44, 876

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Metadata

Authors
Brunk, U. T., & Terman, A.
Affiliations
Linköping University (SE)
Corresponding author
Brunk, Ulf T
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2002-09
Volume
33
Issue
5
Pages
611-619
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/s0891-5849(02)00959-0
OpenAlex
W1538904872
Cited by
919
References
76
Citations by year
2026: 36 · 2025: 49 · 2024: 36 · 2023: 49 · 2022: 31 · 2021: 36 · 2020: 44 · 2019: 42 · 2018: 42 · 2017: 48 · 2016: 41 · 2015: 46 · 2014: 35 · 2013: 34 · 2012: 46
FWCI
20.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
lipofuscin, aging, oxidative stress, iron-catalyzed oxidation, lysosomes, postmitotic cells, age-related macular degeneration, lysosomal stability, apoptosis, autophagy, antioxidants, iron chelators, cell degeneration, longevity
MeSH terms
Age Factors, Aging, Animals, Free Radicals, Humans, Iron, Lipofuscin, Lysosomes, Microscopy, Fluorescence, Models, Biological, Oxygen, Phagocytosis, Oxidative Stress

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