The DOI matches its Crossref record; 73 of the 76 references it cites were found in a registry or an index.
Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.
Abstract
The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occurring with a rate inversely related to longevity. Lipofuscin is an intralysosomal, polymeric substance, primarily composed of cross-linked protein residues, formed due to iron-catalyzed oxidative processes. Because it is undegradable and cannot be removed via exocytosis, lipofuscin accumulation in postmitotic cells is inevitable, whereas proliferative cells efficiently dilute it during division. The rate of lipofuscin formation can be experimentally manipulated. In cell culture models, oxidative stress (e.g., exposure to 40% ambient oxygen or low molecular weight iron) promotes lipofuscin accumulation, whereas growth at 8% oxygen and treatment with antioxidants or iron-chelators diminish it. Lipofuscin is a fluorochrome and may sensitize lysosomes to visible light, a process potentially important for the pathogenesis of age-related macular degeneration. Lipofuscin-associated iron sensitizes lysosomes to oxidative stress, jeopardizing lysosomal stability and causing apoptosis due to release of lysosomal contents. Lipofuscin accumulation may also diminish autophagocytotic capacity by acting as a sink for newly produced lysosomal enzymes and, therefore, interfere with recycling of cellular components. Lipofuscin, thus, may be much more directly related to cellular degeneration at old age than was hitherto believed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“cross-linked products that reach the lysosome through their sporadic fusion with the double membrane vesicles, exert a potent inhibitory effect on lysosomal proteolysis by directly inducing undesired posttranslational modifications in the enzymatic machinery and also by changing the properties of the intralysosomal milieu, normally optimal for functioning of these enzymes (Brunk and Terman, 2002;”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Brunk and Terman, 2002
In the citing paper
“Of note, LF accumulation in aged post-mitotic tissues occurs most probably in the context of post-mitotic cellular senescence (PoMiCS), which is suspected to play a significant role in driving tissue aging29,30, but can be present in non-senescent post-mitotic tissues and thus is not strictly senescence-specific31.”
From Algorithmic assessment of cellular senescence in experimental and clinical specimens (2021) · cites this paper as [31]
Citations
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Autophagy as a Regulated Pathway of Cellular Degradation
Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630
de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033
Chain Migration of Neuronal Precursors
Lois, C., García-Verdugo, J.-M., & Alvarez-Buylla, A. (1996) · Science · doi:10.1126/science.271.5251.978 · Cited by 1,331
Neufeld, E. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001353 · Cited by 924
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729
Self-citationPastores, G. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00036-6 · Cited by 641
Sparrow, J. R., Nakanishi, K., & Parish, C. A. (2000) · PubMed · Cited by 566
Retinal age pigments generated by self-assembling lysosomotropic detergents
Eldred, G., & Lasky, M. R. (1993) · Nature · doi:10.1038/361724a0 · Cited by 489
Research works printed but not linked: 3
- Hannover, 1842, Mikroskopiske undersögelser af nervesystemet, Kgl. Danske Vidensk. Kabernes Selskobs Naturv. Math. Afh. (Copenhagen), 10, 1
- Hueck, 1912, Pigmentstudien, Beitr. Pathol. Anat., 54, 68
- Jahani, 1985, Cathepsin-B activity in human skin fibroblasts from young, old and premature aging syndromes, Fed. Proc., 44, 876
Cited by
Sorted by citations
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?
Moore, M. N. (2006) · Environment International · doi:10.1016/j.envint.2006.06.014 · Cited by 1,255
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164
Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
Protein oxidation and peroxidation
Davies, M. J. (2016) · Biochemical Journal · doi:10.1042/bj20151227 · Cited by 952
Cellular senescence and tumor suppressor gene p16
Rayess, H., Wang, M. B., & Srivatsan, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27316 · Cited by 825
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792
Self-citationKalogeris, T. J., Bao, Y., & Korthuis, R. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.05.006 · Cited by 738
Caramés, B., Taniguchi, N., Otsuki, S., Blanco, F. J., & Lotz, M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27305 · Cited by 632
Sohal, R. S., Mockett, R. J., & Orr, W. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00886-9 · Cited by 604
Pattison, D. I., Rahmanto, A. S., & Davies, M. J. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05164d · Cited by 593
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538
Autophagy and aging: keeping that old broom working
Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527
Oxidative Stress and Autophagy
Kiffin, R., Bandyopadhyay, U., & Cuervo, A. M. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.152 · Cited by 529
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U., & Behl, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.29 · Cited by 522
Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520
Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490
Self-citationProtein Homeostasis and Aging: the importance of exquisite quality control
Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476
Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
Collier, T. J., Kanaan, N. M., & Kordower, J. H. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3039 · Cited by 469
Terman, A., & Brunk, U. T. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.009 · Cited by 451
Self-citationFigueira, T. R., de Barros, M. H., Camargo, A. A., Castilho, R. F., Ferreira, J. C. B., Kowaltowski, A. J., Sluse, F. E., de Souza-Pinto, N. C., & Vercesi, A. E. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4729 · Cited by 430
Cancello, R., & Clément, K. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01004.x · Cited by 418
Lipofuscin: Formation, Distribution, and Metabolic Consequences
JUNG, T., BADER, N., & GRUNE, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.008 · Cited by 415
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
Gaeta, A., & Hider, R. C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706416 · Cited by 411
The power and the promise of oncogene-induced senescence markers
Collado, M., & Serrano, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1884 · Cited by 404
The bisretinoids of retinal pigment epithelium
Sparrow, J. R., Gregory-Roberts, E., Yamamoto, K., Blonska, A., Ghosh, S. K., Ueda, K., & Zhou, J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.12.001 · Cited by 392
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 401
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
Wilson, M. A., Shukitt‐Hale, B., Kalt, W., Ingram, D. K., Joseph, J. A., & Wolkow, C. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00192.x · Cited by 380
An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration
Moreno-García, A., Kun, A., Calero, O., Medina, M., & Calero, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00464 · Cited by 372
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339
Cellular metabolic and autophagic pathways: Traffic control by redox signaling
Dodson, M. B., Darley-Usmar, V. M., & Zhang, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.014 · Cited by 333
Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
Lotz, M. K., & Caramés, B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.109 · Cited by 314
Antioxidant capacities of the selenium nanoparticles stabilized by chitosan
Zhai, X., Zhang, C., Zhao, G., Stoll, S., Ren, F., & Leng, X. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0243-4 · Cited by 313
Moore, M. N., Allen, J. I., & McVeigh, A. (2005) · Marine Environmental Research · doi:10.1016/j.marenvres.2005.10.005 · Cited by 306
Lysosomes in iron metabolism, ageing and apoptosis
Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0394-y · Cited by 302
Self-citationLipofuscin: formation, effects and role of macroautophagy
Höhn, A., & Grune, T. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.006 · Cited by 298
Greenhalgh, A. D., & David, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4912-13.2014 · Cited by 296
Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary
Lim, J., & Luderer, U. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.088583 · Cited by 298
Lysosomes and oxidative stress in aging and apoptosis
Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.009 · Cited by 287
Self-citationAutophagy, organelles and ageing
Terman, A., Gustafsson, B., & Brunk, U. T. (2007) · The Journal of Pathology · doi:10.1002/path.2094 · Cited by 287
Self-citationGerstbrein, B., Stamatas, G., Kollias, N., & Driscoll, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00153.x · Cited by 286
Lipofuscin and Aging: A Matter of Toxic Waste
Gray, D. A., & Woulfe, J. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.5.re1 · Cited by 279
Xu, H., Chen, M., Manivannan, A., Lois, N., & Forrester, J. V. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00351.x · Cited by 277
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
Keller, J. N., Dimayuga, E. R., Chen, Q., Thorpe, J. A., Gee, J. R., & Ding, Q. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.003 · Cited by 273
Autophagy in cardiac myocyte homeostasis, aging, and pathology
Terman, A., & Brunk, U. T. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.08.014 · Cited by 270
Self-citationCurcumin-mediated lifespan extension in Caenorhabditis elegans
Liao, V. H., Yu, C., Chu, Y.-J., Li, W.-H., Hsieh, Y., & Wang, T.-T. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.07.008 · Cited by 266
Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
Chen, C., Turnbull, D. M., & Reeve, A. K. (2019) · Biology · doi:10.3390/biology8020038 · Cited by 260
Protein damage, repair and proteolysis
Chondrogianni, N., Petropoulos, I., Grimm, S., Georgila, K., Catalgol, B., Friguet, B., Grune, T., & Gonos, E. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.09.001 · Cited by 271
Perineuronal nets potentially protect against oxidative stress
Morawski, M., Brückner, M. K., Riederer, P., Brückner, G., & Arendt, T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.04.017 · Cited by 246
Aging: Central role for autophagy and the lysosomal degradative system
Rajawat, Y. S., Hilioti, Z., & Bossis, I. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.001 · Cited by 254
Autophagy, lipophagy and lysosomal lipid storage disorders
Ward, C., Martínez-López, N., Otten, E. G., Carroll, B., Maetzel, D., Singh, R., Sarkar, S., & Korolchuk, V. I. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.006 · Cited by 254
Biobased Nanomaterials─The Role of Interfacial Interactions for Advanced Materials
Österberg, M., Henn, A., Farooq, M., & Valle‐Delgado, J. J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00492 · Cited by 260
Schütt, F., Bergmann, M., Holz, F. G., & Kopitz, J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0172 · Cited by 241
Protein oxidation in aging and the removal of oxidized proteins
Höhn, A., König, J., & Grune, T. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.01.004 · Cited by 253
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
Minami, S. S., Min, S.-W., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L. H., Elia, L. P., Ward, M. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3672 · Cited by 237
Yen, K., Le, T. T., Bansal, A., Narasimhan, S. D., Cheng, J., & Tissenbaum, H. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012810 · Cited by 239
Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans
Kim, J., Takahashi, M. M., Shimizu, T., Shirasawa, T., Kajita, M., Kanayama, A., & Miyamoto, Y. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.011 · Cited by 235
Mechanisms of blue light-induced eye hazard and protective measures: a review
Ouyang, X., Yang, J., Hong, Z., Wu, Y., Xie, Y., & Wang, G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110577 · Cited by 240
Kauppinen, A., Niskanen, H., Suuronen, T., Kinnunen, K., Salminen, A., & Kaarniranta, K. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.05.005 · Cited by 232
Autophagy in the eye: Development, degeneration, and aging
Boya, P., Esteban‐Martínez, L., Serrano‐Puebla, A., Gómez‐Sintes, R., & Villarejo‐Zori, B. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.08.001 · Cited by 236
Chu, J., Haynes, R. D., Corbel, S. Y., Li, P., González-González, E., Burg, J. S., Ataie, N., Lam, A. J., Cranfill, P. J., Baird, M. A., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2888 · Cited by 231
Bergmann, M., Schütt, F., Holz, F. G., & Kopitz, J. (2004) · The FASEB Journal · doi:10.1096/fj.03-0289fje · Cited by 226
Lysosomal cell death mechanisms in aging
Gómez-Sintes, R., Ledesma, M. D., & Boya, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.009 · Cited by 216
You say lipofuscin, we say ceroid: Defining autofluorescent storage material
Seehafer, S. S., & Pearce, D. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.006 · Cited by 212
Autophagic Stress in Neuronal Injury and Disease
Chu, C. T. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000229233.75253.be · Cited by 211
The role of lysosomes in iron metabolism and recycling
Kurz, T., Eaton, J. W., & Brunk, U. T. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.08.016 · Cited by 211
Self-citationBinelli, A., Cogni, D., Parolini, M., Riva, G., & Provini, A. (2008) · Aquatic Toxicology · doi:10.1016/j.aquatox.2008.11.008 · Cited by 208
The zebrafish as a vertebrate model of functional aging and very gradual senescence
Kishi, S., Uchiyama, J., Baughman, A. M., Goto, T., Lin, M. C., & Tsai, S. B. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00108-6 · Cited by 210
Pompe disease: from pathophysiology to therapy and back again
Lim, J., Li, L., & Raben, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00177 · Cited by 219
Metals ions and neurodegeneration
Molina‐Holgado, F., Hider, R. C., Gaeta, A., Williams, R., & Francis, P. T. (2007) · BioMetals · doi:10.1007/s10534-006-9033-z · Cited by 206
Oxygen free radicals and redox biology of organelles
Moldovan, L., & Moldovan, N. I. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0676-y · Cited by 213
Iron imbalance in neurodegeneration
Levi, S., Ripamonti, M., Moro, A., & Cozzi, A. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02399-z · Cited by 189
Simon, D., Seznec, H., Gansmuller, A., Carelle, N., Weber, P., Metzger, D., Rustin, P., Koenig, M., & Puccio, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4549-03.2004 · Cited by 205
Cao, L., Leers‐Sucheta, S., & Azhar, S. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.10.007 · Cited by 205
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutantsPreprint
Samuelson, A. V., Carr, C. E., & Ruvkun, G. (2007) · Genes & Development · doi:10.1101/gad.1588907 · Cited by 206
Pathophysiology of chaperone-mediated autophagy
Massey, A. C., Kiffin, R., & Cuervo, A. M. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.010 · Cited by 202
Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover
Sullivan, P. G., Dragicevic, N., Deng, J., Bai, Y., Dimayuga, E. R., Ding, Q., Chen, Q., Bruce‐Keller, A. J., & Keller, J. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313579200 · Cited by 202
Pietsch, K., Saul, N., Chakrabarti, S., Stürzenbaum, S. R., Menzel, R., & Steinberg, C. E. W. (2011) · Biogerontology · doi:10.1007/s10522-011-9334-7 · Cited by 203
Algorithmic assessment of cellular senescence in experimental and clinical specimens
Kohli, J., Wang, B., Brandenburg, S. M., Basisty, N., Evangelou, K., Varela-Eirin, M., Campisi, J., Schilling, B., Gorgoulis, V., & Demaria, M. (2021) · Nature Protocols · doi:10.1038/s41596-021-00505-5 · Cited by 196
Rocheleau, J. V., Head, W. S., & Piston, D. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314005200 · Cited by 195
Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases
Ramalingam, M., & Kim, S. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0758-7 · Cited by 194
Lysosomal Iron, Iron Chelation, and Cell Death
Terman, A., & Kurz, T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4885 · Cited by 192
Self-citationSulzer, D., Mosharov, E. V., Tallóczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05385.x · Cited by 195
Autophagy and Mistargeting of Therapeutic Enzyme in Skeletal Muscle in Pompe Disease
Fukuda, T., Ahearn, M., Roberts, A., Mattaliano, R. J., Zaal, K. J. M., Ralston, E., Plötz, P. H., & Raben, N. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.08.009 · Cited by 190
Protein Oxidation in Aging: Does It Play a Role in Aging Progression?
Reeg, S., & Grune, T. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6062 · Cited by 191
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
Zeng, Q., Gong, Y., Zhu, N., Shi, Y., Zhang, C., & Li, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102294 · Cited by 192
Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis
Roso, A. D. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00002-0 · Cited by 181
The comparative biology of neuromelanin and lipofuscin in the human brain
Double, K. L., Dedov, V. N., Fedorow, H., Kettle, E., Halliday, G. M., Garner, B., & Brunk, U. T. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7581-9 · Cited by 181
Self-citationAge-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels
Ruan, Y., Jiang, S., & Gericke, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031296 · Cited by 198
The ubiquitin-proteasome system in cardiac physiology and pathology
Powell, S. R. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00062.2006 · Cited by 175
Redox control of protein degradation
Pajares, M., Jiménez-Moreno, N., Dias, I. H. K., BÜTÜNER, B. D., Vučetić, M., Fladmark, K. E., Başağa, H., Ribarič, S., Milisav, I., & Cuadrado, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.003 · Cited by 177
Senescence in Post-Mitotic Cells: A Driver of Aging?
von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170
The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers
Kishi, S., Bayliss, P. E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D. S., Amsterdam, A., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000152 · Cited by 173
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 172
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases
Braak, H., Rüb, U., Schultz, C., & Tredici, K. D. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s305 · Cited by 164
Retinal Pigment Epithelium Lipofuscin Proteomics
Ng, K.-P., Gugiu, B., Renganathan, K., Davies, M. W., Gu, X., Crabb, J. S., Kim, S. R., Różanowska, M. B., Bonilha, V. L., Rayborn, M. E., et al. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700525-mcp200 · Cited by 162
Redox changes in obesity, metabolic syndrome, and diabetes
Korać, B., Kalezic, A., Pekovic‐Vaughan, V., Korać, A., & Janković, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101887 · Cited by 168
mTOR's role in ageing: protein synthesis or autophagy?
Hands, S. L., Proud, C. G., & Wyttenbach, A. (2009) · Aging · doi:10.18632/aging.100070 · Cited by 162
Two-Photon Microscopy for Non-Invasive, Quantitative Monitoring of Stem Cell Differentiation
Rice, W. L., Kaplan, D. L., & Georgakoudi, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010075 · Cited by 159
Metadata
- Authors
- Brunk, U. T., & Terman, A.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Brunk, Ulf T
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 33
- Issue
- 5
- Pages
- 611-619
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W1538904872
- Cited by
- 919
- References
- 76
- Citations by year
- 2026: 36 · 2025: 49 · 2024: 36 · 2023: 49 · 2022: 31 · 2021: 36 · 2020: 44 · 2019: 42 · 2018: 42 · 2017: 48 · 2016: 41 · 2015: 46 · 2014: 35 · 2013: 34 · 2012: 46
- FWCI
- 20.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- lipofuscin, aging, oxidative stress, iron-catalyzed oxidation, lysosomes, postmitotic cells, age-related macular degeneration, lysosomal stability, apoptosis, autophagy, antioxidants, iron chelators, cell degeneration, longevity
- MeSH terms
- Age Factors, Aging, Animals, Free Radicals, Humans, Iron, Lipofuscin, Lysosomes, Microscopy, Fluorescence, Models, Biological, Oxygen, Phagocytosis, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
