Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033

Chain Migration of Neuronal Precursors

Lois, C., García-Verdugo, J.-M., & Alvarez-Buylla, A. (1996) · Science · doi:10.1126/science.271.5251.978 · Cited by 1,331

LYSOSOMAL STORAGE DISEASES

Neufeld, E. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001353 · Cited by 924

The mitochondrial‐lysosomal axis theory of aging

Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729

Lysosomal Storage Diseases

Pastores, G. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00036-6 · Cited by 641

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Sparrow, J. R., Nakanishi, K., & Parish, C. A. (2000) · PubMed · Cited by 566

Retinal age pigments generated by self-assembling lysosomotropic detergents

Eldred, G., & Lasky, M. R. (1993) · Nature · doi:10.1038/361724a0 · Cited by 489

Lipofuscin in keratinocytes: Production, properties, and consequences of the photosensitization with visible light

Tonolli, P. N., Martins, W. K., Junqueira, H. C., Silva, M. N., Severino, D., Santacruz-Pérez, C., Watanabe, I., & Baptista, M. S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.08.002 · Cited by 30

Capillary Electrophoresis Monitors Enhancement in Subcellular Reactive Oxygen Species Production upon Treatment with Doxorubicin

Eder, A. R., & Arriaga, E. A. (2006) · Chemical Research in Toxicology · doi:10.1021/tx060083i · Cited by 30

Accumulation of senescent cells in the stroma of aged mouse ovary

Maruyama, N., FUKUNAGA, I., Tomoaki, K. O. G. O., Endo, T., Fujii, W., Kanai‐Azuma, M., Naito, K., & Sugiura, K. (2023) · Journal of Reproduction and Development · doi:10.1262/jrd.2023-021 · Cited by 31

Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding

Valdes, P. A., Yu, C.-C., Aronson, J., Ghosh, D., Zhao, Y., An, B., Bernstock, J. D., Bhere, D., Felicella, M. M., Viapiano, M. S., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.abo0049 · Cited by 37

Protective effects of a catechin-rich extract on the hippocampal formation and spatial memory in aging rats

Rodrigues, J., Assunção, M., Lukoyanov, N., Cardoso, A., Carvalho, F. D., & Andrade, J. P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.040 · Cited by 29

The poly-omics of ageing through individual-based metabolic modelling

Yaneske, E., & Angione, C. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2383-z · Cited by 29

Endogenous and Exogenous Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells: An Updated Antioxidant Perspective

Markitantova, Y. V., & Simirskii, V. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310776 · Cited by 30

Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells

Karlsson, M., Frennesson, C. I., Gustafsson, T., Brunk, U. T., NILSSON, S. E. G., & Kurz, T. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.10.014 · Cited by 29

Retinal Histopathology in Eyes from a Patient with Stargardt disease caused by Compound Heterozygous ABCA4 Mutations

Bonilha, V. L., Rayborn, M. E., Bell, B. A., Marino, M. J., Fishman, G. A., & Hollyfield, J. G. (2014) · Ophthalmic Genetics · doi:10.3109/13816810.2014.958861 · Cited by 29

DISCORDANCE BETWEEN BLUE-LIGHT AUTOFLUORESCENCE AND NEAR-INFRARED AUTOFLUORESCENCE IN AGE-RELATED MACULAR DEGENERATION

Heiferman, M. J., & Fawzi, A. A. (2016) · Retina · doi:10.1097/iae.0000000000001254 · Cited by 29

Autophagy and Aging--When "All You Can Eat" Is Yourself

Cuervo, A. M. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.36.pe25 · Cited by 29

Macromolecular deterioration as the ultimate constraint on human lifespan

Truscott, R. J. W. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.12.001 · Cited by 28

Sepsis-induced Cardiac Mitochondrial Damage and Potential Therapeutic Interventions in the Elderly

Zang, Q. S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500137 · Cited by 28

Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels

Barranger, A., Langan, L. M., Sharma, V., Rance, G. A., Aminot, Y., Weston, N. J., Akcha, F., Moore, M. N., Arlt, V. M., Khlobystov, A. N., et al. (2019) · Nanomaterials · doi:10.3390/nano9070987 · Cited by 28

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

Bielczyk-Maczyńska, E., Hung, L. L., Ferreira, L., Fleischmann, T. T., Weis, F., Fernández-Pévida, A., Harvey, S. A., Wali, N., Warren, A. J., Barroso, I., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005677 · Cited by 28

Membrane damage by betulinic acid provides insights into cellular aging

Martins, W. K., Gomide, A. B., Costa, É. T., Junqueira, H. C., Stolf, B. S., Itri, R., & Baptista, M. S. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.10.018 · Cited by 29

Oxidation and Inflammation in the Immune and Nervous Systems, a Link Between Aging and Anxiety

la Fuente, M. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_115-1 · Cited by 27

Betula utilis extract prolongs life expectancy, protects against amyloid-β toxicity and reduces Alpha Synuclien in Caenorhabditis elegans via DAF-16 and SKN-1

Pandey, S., Phulara, S. C., Mishra, S. K., Bajpai, R., Kumar, A., Niranjan, A., Lehri, A., Upreti, D. K., & Chauhan, P. S. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.108647 · Cited by 30

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

He, Y., Fan, Y., Ahmadpoor, X., Wang, Y., Li, Z. A., Zhu, W., & Lin, H. (2024) · Medicinal Research Reviews · doi:10.1002/med.22047 · Cited by 29

Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?

Choi, S.-I., Yoo, S., Lim, J. Y., & Hwang, S. W. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916430 · Cited by 27

Riboflavin storage in earthworm chloragocytes/eleocytes in an eco-immunology perspective

Płytycz, B., & Morgan, A. J. (2011) · Invertebrate survival journal · Cited by 27

Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model

Sun, D., Sun, W., Gao, S., Wei, C., Naderi, A., Schilb, A. L., Scheidt, J. H., Lee, S. J., Kern, T. S., Palczewski, K., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.010 · Cited by 27

Oxidative Stress and Myocardial Remodeling in Chronic Mitral Regurgitation

Gladden, J. D., Ahmed, M. I., Litovsky, S. H., Darley-Usmar, V. M., McGiffin, D. C., Lloyd, S. G., Gupta, H., Dell’Italia, L. J., Schiros, C. G., & Denney, T. S. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318224ab93 · Cited by 27

Imaging of cellular aging in human retinal blood vessels

Catita, J., López‐Luppo, M., Ramos, D., Nacher, V., Navarro, M., Carretero, A., Sánchez‐Chardi, A., Mendes-Jorge, L., Rodríguez‐Baeza, A., & Ruberte, J. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.03.019 · Cited by 25

Label‐Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications

Campbell, J. M., Gosnell, M. E., Agha, A., Handley, S., Knab, A., Anwer, A. G., Bhargava, A., & Goldys, E. M. (2024) · Advanced Materials · doi:10.1002/adma.202403761 · Cited by 29

Growth-related effects of oxidant-induced stress on cultured RPE and choroidal endothelial cells

Eichler, W., Reiche, A., Yafai, Y., Lange, J., & Wiedemann, P. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.06.017 · Cited by 26

Seasonal differences of lysosomal, lipid and lipofuscin parameters in the digestive gland of the mussel Mytilus galloprovincialis

Koukouzika, N., Raftopoulou, E. K., & Dimitriadis, V. K. (2009) · Journal of Molluscan Studies · doi:10.1093/mollus/eyp022 · Cited by 26

Histopathological assessment of the health status of Mytilus chilensis (Hupé 1854) in southern Chile

Lohrmann, K. B., Bustos, E., Rojas, R., Navarrete, F., Robotham, H., & Bignell, J. P. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.12.080 · Cited by 26

Fundus Autofluorescence, Optical Coherence Tomography and Visual Acuity in Adult-Onset Foveomacular Dystrophy

Furino, C., Boscia, F., Cardascia, N., Sborgia, L., & Sborgia, C. (2008) · Ophthalmologica · doi:10.1159/000130427 · Cited by 26

Diazepam administration prevents testosterone decrease and lipofuscin accumulation in testis of mouse exposed to chronic noise stress

Ruffoli, R., Carpi, A., Giambelluca, M. A., Grasso, L., Scavuzzo, M. C., & F, F. G. (2006) · Andrologia · doi:10.1111/j.1439-0272.2006.00732.x · Cited by 26

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids

Rizou, S. V., Evangelou, K., Myrianthopoulos, V., Mourouzis, I., Havaki, S., Athanasiou, A., Vasileiou, P. V. S., Margetis, A., Kotsinas, A., Kastrinakis, N. G., et al. (2019) · Methods in Molecular Biology · doi:10.1007/978-1-4939-8931-7_12 · Cited by 25

The interplay between mitochondrial protein and iron homeostasis and its possible role in ageing

Mallikarjun, V., Sriram, A., Scialò, F., & Sanz, A. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.015 · Cited by 25

Establishment of a Comprehensive List of Candidate Antiaging Medicinal Herb Used in Korean Medicine by Text Mining of the Classical Korean Medical Literature, “Dongeuibogam,” and Preliminary Evaluation of the Antiaging Effects of These Herbs

Choi, M. J., Choi, B. T., Shin, H. K., Shin, B. C., Han, Y. K., & Baek, J. U. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/873185 · Cited by 25

Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration

Julien, S., Illing, B., Tschulakow, A., Taubitz, T., Guezguez, J., Burnet, M. W. M., & Schraermeyer, U. (2020) · Pharmacology Research & Perspectives · doi:10.1002/prp2.683 · Cited by 25

Pyrroloquinoline quinone extends Caenorhabditis elegans ’ longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy

Liu, Y., Qi, Y., Zhang, X., Li, K., Liang, X., Wang, M., Shi, L., Luo, S., Zhang, Q., & Zhang, X. (2021) · Food & Function · doi:10.1039/d1fo02128a · Cited by 27

The rice bran peptide KF-8 extends the lifespan and improves the healthspan of Caenorhabditis elegans via skn-1 and daf-16

Cai, J., Chen, Z., Wu, Y., Chen, Y., Wang, J., Lin, Q., & Liang, Y. (2022) · Food & Function · doi:10.1039/d1fo03718h · Cited by 25

Catalase-deficient mice induce aging faster through lysosomal dysfunction

Dutta, R. K., Lee, J. N., Maharjan, Y., Park, C., Choe, S., Ho, Y., Kwon, H. M., & Park, R. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00969-2 · Cited by 29

A neuronal aging pattern unique to humans and common chimpanzees

Gilissen, E., Leroy, K., Yilmaz, Z., Kövari, E., Bouras, C., Boom, A., Poncelet, L., ERWIN, J. M., Sherwood, C. C., Hof, P. R., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0931-5 · Cited by 26

The biochemical estimation of age in Euphausiids: Laboratory calibration and field comparisons

Harvey, H. R., Ju, S., Son, S.-K., Feinberg, L. R., Shaw, C. T., & Peterson, W. T. (2009) · Deep Sea Research Part II Topical Studies in Oceanography · doi:10.1016/j.dsr2.2009.10.015 · Cited by 25

Manganese-mediated acceleration of age-related hearing loss in mice

Ohgami, N., Yajima, I., Iida, M., Li, X., Oshino, R., Kumasaka, M. Y., & Kato, M. (2016) · Scientific Reports · doi:10.1038/srep36306 · Cited by 25

Age‐associated alterations of lipofuscin, membrane‐bound ATPases and intracellular calcium in cortex, striatum and hippocampus of rat brain: protective role of glutathione monoester

Murali, G., Panneerselvam, K. S., & Panneerselvam, C. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.12.004 · Cited by 25

A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

He, W., Xie, J., Xia, Z., Chen, X., Xiao, J., Cao, Y., & Liu, X. (2023) · Food & Function · doi:10.1039/d3fo00383c · Cited by 25

Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes

Lyamzaev, K. G., He, M., Panteleeva, A. A., Simonyan, R. A., Avetisyan, A. V., & Chernyak, B. V. (2024) · Biomolecules · doi:10.3390/biom14060730 · Cited by 26

Potential Mechanisms of Progranulin-deficient FTLD

Ward, M. E., & Miller, B. L. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9622-3 · Cited by 27

The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in Caenorhabditis elegans

Liu, J., Zheng, R.-Q., Wang, Y., Liu, Y., Jiang, S., Wang, X., He, K., Pan, X., Zhou, T., Li, T., et al. (2022) · Metabolites · doi:10.3390/metabo12020177 · Cited by 24

The immune response of peritoneal macrophages due to exposure to inorganic lead in the house mouse Mus musculus

Bussolaro, D., Neto, F. F., Gargioni, R., Fernandes, L. C., Randi, M. A. F., Pelletier, É., & Ribeiro, C. A. D. O. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.09.003 · Cited by 24

The changes of age-related molecules in the trophocytes and fat cells of queen honeybees (Apis mellifera)

Hsieh, Y.-S., & Hsu, C. (2011) · Apidologie · doi:10.1007/s13592-011-0085-x · Cited by 24

Neuropathological Findings in Brains of Bavarian Cattle Clinically Suspected of Bovine Spongiform Encephalopathy

Miyashita, M., Stierstorfer, B., & Schmahl, W. (2004) · Journal of Veterinary Medicine Series B · doi:10.1111/j.1439-0450.2004.00755.x · Cited by 24

Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants

Hu, R., Shi, J., Xie, C., & Yao, X. (2025) · Global Challenges · doi:10.1002/gch2.202500068 · Cited by 26

Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia

Lane, D. J. R., Huang, M., Ting, S., Sivagurunathan, S., & Richardson, D. R. (2013) · Biochemical Journal · doi:10.1042/bj20130079 · Cited by 24

Autophagy May Be Involved in Fluoride-Induced Learning Impairment in Rats

Zhang, C., Huo, S., Fan, Y., Gao, Y., Yang, Y., & Sun, D. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01735-1 · Cited by 23

Effect of Momordica saponin‑ and Cyclocarya paliurus polysaccharide‐enriched beverages on oxidative stress and fat accumulation in Caenorhabditis elegans

Lin, C., Lin, Y., Xiao, J., Lan, Y., Cao, Y., & Chen, Y. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10966 · Cited by 23

Distinct Types of Lipofuscin Pigment in the Hippocampus and Cerebellum of Aged Cheirogaleid Primates

Gilissen, E., & Staneva-Dobrovski, L. (2013) · The Anatomical Record · doi:10.1002/ar.22809 · Cited by 23

Long term evaluation of morphometric and ultrastructural changes of testes of alloxan-induced diabetic rats

Trindade, A., Simões, A. C. P., da Silva, R. J., de Macedo, C. S., & Spadella, C. T. (2013) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502013000400005 · Cited by 23

Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

Nielsen, M. K., Subhi, Y., Molbech, C. R., Falk, M. K., Singh, A., Nissen, M. H., & Sørensen, T. L. (2018) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.13362 · Cited by 22

Lysosomal responses and metallothionein induction in the blue mussel Mytilus edulis from the south-west coast of Iceland

Ros, L. D., Moschino, V., Guerzoni, S., & Halldórsson, H. P. (2007) · Environment International · doi:10.1016/j.envint.2006.11.016 · Cited by 23

Validation and Application of Lipofuscin‐Based Age Determination for Chesapeake Bay Blue Crabs Callinectes sapidus

Puckett, B. J., Secor, D. H., & Ju, S. (2008) · Transactions of the American Fisheries Society · doi:10.1577/t07-278.1 · Cited by 23

Human Secretary Phospholipase A2 Mutations and Their Clinical Implications

Khan, M. I., & Hariprasad, G. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s269557 · Cited by 22

Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy

Farnoodian, M., Bose, D., Barone, F., Nelson, L. M., Boyle, M. P., Jun, B., Do, K., Gordon, W. C., Kautzmann, M.-A. I., Perera, R. M., et al. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108482 · Cited by 25

Podocyte injury at young age causes premature senescence and worsens glomerular aging

Pereira, B. M. V., Zeng, Y., Maggiore, J. C., Schweickart, R. A., Eng, D. G., Kaverina, N. V., McKinzie, S. R., Chang, A., Loretz, C. J., Thieme, K., et al. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00261.2023 · Cited by 24

Administration with Bushenkangshuai Tang alleviates UV irradiation- and oxidative stress-induced lifespan defects in nematode Caenorhabditis elegans

Rui, Q., Lu, Q., & Wang, D. (2009) · Frontiers of Medicine · doi:10.1007/s11684-009-0002-0 · Cited by 22

Characteristics of spinal microglia in aged and obese mice: potential contributions to impaired sensory behavior

Lee, S., Wu, Y., Shi, X., & Zhang, J. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0049-5 · Cited by 22

Optical Imaging Detects Apoptosis in the Brain and Peripheral Organs of Prion-Infected Mice

Drew, S. C., Haigh, C. L., Klemm, H. M. J., Masters, C. L., Collins, S. J., Barnham, K. J., & Lawson, V. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182084a8c · Cited by 22

Age‐related morphological changes in skeletal muscle cells of acid α‐glucosidase knockout mice

Hesselink, R. P., Schaart, G., Wagenmakers, A. J. M., Drost, M. R., & Vusse, G. J. (2005) · Muscle & Nerve · doi:10.1002/mus.20482 · Cited by 22

Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease

Dougnon, G., & Matsui, H. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00529-x · Cited by 23

Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis

Wen, Z., Xia, G., Liang, C., Wang, X., Huang, J., Zhang, L., Shan, D., Song, W. C., & Cao, X. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0141 · Cited by 22

Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy

Puccio, H. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-35109-2_15 · Cited by 21

Specific RNA Interference in Caenorhabditis elegans by Ingested dsRNA Expressed in Bacillus subtilis

Lezzerini, M., van de Ven, K., Veerman, M., Brul, S., & Budovskaya, Y. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124508 · Cited by 23

Delayed Imatinib Treatment for Acute Spinal Cord Injury: Functional Recovery and Serum Biomarkers

Kjell, J., Finn, A., Hao, J., Wellfelt, K., Josephson, A., Svensson, C. I., Wiesenfeld‐Hallin, Z., Eriksson, U., Abrams, M. B., & Olson, L. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3863 · Cited by 21

Aging on a different scale – chronological versus pathology-related aging

Melis, J. P. M., Jonker, M. J., Vijg, J., Hoeijmakers, J. H. J., Breit, T. M., & STEEG, H. V. (2013) · Aging · doi:10.18632/aging.100606 · Cited by 21

Late-Onset Temperature Reduction Can Retard the Aging Process in Aged Fish Via a Combined Action of an Anti-Oxidant System and the Insulin/Insulin-Like Growth Factor 1 Signaling Pathway

Wang, X., Chang, Q., Wang, Y., Su, F., & Zhang, S. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1581 · Cited by 22

- Linking Lysosomal Biomarkers and Ecotoxicological Effects at Higher Biological Levels

Moore, M. N., Viarengo, A., Somerfield, P. J., & Sforzini, S. (2012) · CRC Press eBooks · doi:10.1201/b13036-9 · Cited by 21

Precision medicine in pantothenate kinase-associated neurodegeneration

Álvarez-Córdoba, M., Paz, M. V., Villalón-García, I., Povea-Cabello, S., Suarez-Rivero, J. M., Talaverón-Rey, M., Abril-Jaramillo, J., Vintimilla-Tosi, A. B., & Sánchez-Alcázar, J. A. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.251203 · Cited by 21

Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence

Kim, J. W., Kuk, M. U., Choy, H. E., Park, S. C., & Park, J. T. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110691 · Cited by 21

Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging

Häseli, S. P., Deubel, S., Jung, T., Grune, T., & Ott, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8141307 · Cited by 23

Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD

Szaflik, J. P. (2012) · Frontiers in bioscience · doi:10.2741/4088 · Cited by 21

FLAVONOIDS FROM GRAPE SEEDS PREVENT INCREASED ALCOHOL-INDUCED NEURONAL LIPOFUSCIN FORMATION

de Freitas, V. A. P. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh069 · Cited by 21

Phloroglucinol protects retinal pigment epithelium and photoreceptor against all‐trans‐retinal–induced toxicity and inhibits A2E formation

Cia, D., Cubizolle, A., Crauste, C., Jacquemot, N., Guillou, L., Vigor, C., Angebault, C., Hamel, C., Vercauteren, J., & Brabet, P. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12857 · Cited by 22

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Hyttinen, J. M. T., Koskela, A. K. J., Błasiak, J., & Kaarniranta, K. (2024) · Acta Ophthalmologica · doi:10.1111/aos.16744 · Cited by 22

Antagonistic cytoprotective effects of C60 fullerene nanoparticles in simultaneous exposure to benzo[a]pyrene in a molluscan animal model

Moore, M. N., Sforzini, S., Viarengo, A., Barranger, A., Aminot, Y., Readman, J. W., Khlobystov, A. N., Arlt, V. M., Bannı, M., & Jha, A. N. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142355 · Cited by 20

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice

Tsantilas, K. A., Cleghorn, W. M., Bisbach, C. M., Whitson, J. D., Hass, D. T., Robbings, B. M., Sadı́lek, M., Linton, J. D., Rountree, A. M., Valencia, A. P., et al. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.14.20 · Cited by 22

Pin1 protein associates with neuronal lipofuscin: Potential consequences in age-related neurodegeneration

Hashemzadeh‐Bonehi, L., Phillips, R., Cairns, N. J., Mosaheb, S., & Thorpe, J. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.030 · Cited by 20

Vitamins in the Prevention or Delay of Cognitive Disability of Aging

Dror, Y., Stern, F., & Gomori, M. J. (2015) · Current Aging Science · doi:10.2174/1874609808666150201214955 · Cited by 20

Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16

Mi, X.-N., Wang, L., Hu, Y., Pan, J., Xin, Y., Wang, J., Geng, H.-J., Hu, S., Gao, Q. F., & Luo, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061670 · Cited by 18

Cerium oxide nanoparticles reduce the accumulation of autofluorescent deposits in light-induced retinal degeneration: Insights for age-related macular degeneration

Tisi, A., Passacantando, M., Lozzi, L., & Maccarone, R. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108169 · Cited by 20

Nuclear Flow FISH: Isolation of cell nuclei improves the determination of telomere lengths

Wieser, M., Stadler, G., Böhm, E., Borth, N., Katinger, H. W. D., Grillari, J., & Voglauer, R. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.013 · Cited by 21

Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration

Sarangarajan, R., & Apte, S. (2005) · Ophthalmic Research · doi:10.1159/000085533 · Cited by 20

Early lipofuscin accumulation in frontal lobe epilepsy

Liu, J. Y. W., Reeves, C., Diehl, B., Coppola, A., Al‐Hajri, A., Hoskote, C., al Mughairy, S., Tachrount, M., Groves, M., Michalak, Z., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24803 · Cited by 22

Grape seed flavanols, but not Port wine, prevent ethanol-induced neuronal lipofuscin formation

Assunção, M., de Freitas, V. A. P., & Paula-Barbosa, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.044 · Cited by 20

An optimised protocol for the detection of lipofuscin, a versatile and quantifiable marker of cellular senescence

Davan-Wetton, C. S. A., & Montero‐Melendez, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306275 · Cited by 20

Diverse Perspectives Illuminate the Intestinal Toxicity of Traditional and Biodegradable Agricultural Film Microplastics to Eisenia fetida under Varying Exposure Sequences

Cao, T., Sun, K., He, E., Cao, X., Zhao, L., Xu, X., & Qiu, H. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c01932 · Cited by 19

Lipofuscin accumulation in tissues of Arctica islandica indicates faster ageing in populations from brackish environments

Basova, L., Strahl, J., Philipp, E. E. R., Brey, T., Sukhotin, A. A., & Abele, D. (2017) · Marine Biology · doi:10.1007/s00227-017-3110-4 · Cited by 19

Stress-induced changes in the aged-rat adrenal cortex. Histological and histomorphometric study

Zaki, S. M., Gawad, F. A.-R. A., El-Shaarawy, E. A. A., Radwan, R. A. K., & Aboulhoda, B. E. (2015) · Folia Morphologica · doi:10.5603/fm.a2018.0035 · Cited by 19

Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19

Lin, M., Stewart, M. T., Zefi, S., Mateti, K. V., Gauthier, A. G., Sharma, B., Martinez, L. R., Ashby, C. R., & Mantell, L. L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.08.004 · Cited by 20

Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence

Kuk, M. U., Lee, H., Song, E. S., Lee, Y. H., Park, J. Y., Jeong, S., Kwon, H. W., Byun, Y., Park, S. C., & Park, J. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112091 · Cited by 20

Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis

Moheimani, F., Kim, C. H. J., Rahmanto, A. S., van Reyk, D. M., & Davies, M. J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.04.026 · Cited by 19

Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons

Braak, H., Thal, D. R., Matschke, J., Ghebremedhin, E., & Tredici, K. D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.031 · Cited by 19

The use of honeybees reared in a thermostatic chamber for aging studies

Hsu, C., & Chan, Y.-P. (2011) · AGE · doi:10.1007/s11357-011-9344-z · Cited by 19

The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish

Ng’oma, E., Reichwald, K., Dorn, A., Wittig, M., Balschun, T. C., Franke, A., Platzer, M., & Cellerino, A. (2014) · Aging · doi:10.18632/aging.100660 · Cited by 20

Transformation, migration and outcome of residual bodies in the seminiferous tubules of the rat testis

Xiao, C.-Y., Wang, Y.-Q., Li, J.-H., Tang, G.-C., & Xiao, S. (2017) · Andrologia · doi:10.1111/and.12786 · Cited by 19

Lipofuscin

Terman, A., & Brunk, U. T. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.009 · Cited by 451

Lipofuscin: Mechanisms of formation and increase with age

TERMAN, A., & BRUNK, U. T. (1998) · APMIS · doi:10.1111/j.1699-0463.1998.tb01346.x · Cited by 387

Lipofuscinogenesis in a model system of cultured cardiac myocytes

Marzabadi, M. R., Yin, D., & Brunk, U. T. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7460-1_9 · Cited by 12

Free radicals in cellular pathology : Mechanisms behind lipofucin formation in cultured myocardial cells

Marzabadi, M. R. (1991)

The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death

Baldensperger, T., Jung, T., Heinze, T., Schwerdtle, T., Höhn, A., & Grune, T. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.311 · Cited by 58