Cited by 199Schizophrenia research and treatmentStress Responses and CortisolMaternal Mental Health During Pregnancy and Postpartum

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Glucocorticoid Hormones and Early Brain Development in Schizophrenia

Ph.D., J·2002·Neuropsychopharmacology

DOI 10.1016/s0893-133x(01)00396-7

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Abstract

While genetic factors play a role in the etiology of schizophrenia, environmental factors contribute to the etiology of the disorder as well. If a woman is exposed during the second trimester of gestation to stressors such as the death of a loved one, influenza infection, or natural and man-made disasters, her baby has an increased risk of developing schizophrenia later in life. A common mechanism may mediate the effects of these diverse risk factors: a stress response during a restricted period of gestation may affect fetal brain development and, given the appropriate genetic predisposition, result in schizophrenia in adult life. Findings in animals exposed to prenatal stress strengthen the hypothesis that exposure to high glucocorticoid levels and/or other components of the stress response increases the risk of schizophrenia. These clinical and preclinical studies could be used to develop hypotheses that could then be tested in patients with schizophrenia.

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Authors: Ph.D., J.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Ph.D., J
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2002-08
Volume: 27
Issue: 2
Pages: 309-318
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(01)00396-7
OpenAlex: W2131140619
Cited by: 199
References: 124
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 15 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 13
FWCI: 1.67
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Whitehall Foundation
National Alliance for Research on Schizophrenia and Depression
National Institutes of Health (5r01dk052382-03)
Novartis Pharma
National Institute of Mental Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK52382)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords: schizophrenia, glucocorticoids, prenatal stress, fetal brain development, maternal stress exposure, stress response, environmental risk factors, genetic susceptibility, prenatal glucocorticoid exposure
MeSH terms: Animals, Brain, Environmental Exposure, Female, Glucocorticoids, Humans, Influenza, Human, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Schizophrenia, Stress, Physiological, Neurotransmitter Agents

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Glucocorticoid Hormones and Early Brain Development in Schizophrenia

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