Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis
Open accessAbstract
INTRODUCTION: Recent studies suggest that in addition to factors such as treatment side effects, suicide, and poor health habits, people with schizophrenia may have an increased risk of diabetes prior to antipsychotic treatment. Diabetes is associated with an increased pulse pressure (PP) and a shortened telomere. We tested the hypothesis that prior to antipsychotic treatment, schizophrenia and related disorders are associated with a shortened telomere, as well as an increased PP. METHODS: Telomere content (which is highly correlated with telomere length) and PP were measured in newly diagnosed, antipsychotic-naive patients with schizophrenia and related disorders on first clinical contact and in matched control subjects. Both groups were also administered an oral glucose tolerance test. RESULTS: Compared with control subjects, the patients with psychosis had decreased telomere content and an increased PP. As previously reported, they also had increased glucose concentrations at 2 hours. These differences could not be attributed to differences in age, ethnicity, smoking, gender, body mass index, neighborhood of residence, socioeconomic status, aerobic conditioning, or an increased cortisol concentration in the psychotic subjects. DISCUSSION: These results suggest that prior to antipsychotic use, nonaffective psychosis is associated with reduced telomere content and increased PP, indices that have been linked to an increased risk of diabetes and hypertension.
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Fernandez-Egea et al. (2009) found newly diagnosed, antipsychotic-naïve individuals with non-affective psychoses showed shortened LTL.
“In another study, newly diagnosed, antipsychotic-naïve individuals with non-affective psychoses also showed shortened LTL (Fernandez-Egea et al., 2009).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Fernandez-Egea et al., 2009
Seven studies have assessed LTL in schizophrenia or other psychotic disorders.
“Seven studies have assessed LTL in schizophrenia or other psychotic disorders (Fernandez-Egea et al., 2009; Kao et al., 2008; Kota et al., In press; Malaspina et al., 2014 Mansour et al., 2011; Nieratschker et al., 2013; Yu et al., 2008) (Table 2).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Fernandez-Egea et al., 2009
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- Authors
- Fernandez-Egea, E., Bernardo, M., Heaphy, C. M., Griffith, J. K., Parellada, E., Esmatjes, E., Conget, I., Nguyen, L., George, V., Stoppler, H., & Kirkpatrick, B.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- University of New Mexico (US)
- Augusta University (US)
- Corresponding author
- Kirkpatrick, B.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-01
- Volume
- 35
- Issue
- 2
- Pages
- 437-442
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2659310
- OpenAlex
- W2143739419
- Cited by
- 103
- References
- 41
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2022: 7 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 8 · 2014: 14 · 2013: 7 · 2012: 11
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Pfizer
- Sanofi
- Dartmouth College
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK069265)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- telomere length
- MeSH terms
- Adolescent, Adult, Aging, Blood Pressure, Diabetes Mellitus, Diastole, Female, Glucose Tolerance Test, Humans, Hydrocortisone, Leukocytes, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Antipsychotic Agents, Telomere
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