Cited by 538Neurotransmitter Receptor Influence on BehaviorPharmacogenetics and Drug MetabolismSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.

Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum

Heinz, A·2000·Neuropsychopharmacology

DOI 10.1016/s0893-133x(99)00099-8

Open this paper in CoChat — free account

Abstract

In vivo availability of striatal dopamine transporter (DAT) protein has been reported to be reduced among alcoholics, and allelic variation of the DAT gene (SLC6A3) has been associated with severity of alcohol withdrawal. We examined the VNTR polymorphism of the 3' untranslated region of SLC6A3 and DAT protein availability in 14 abstinent alcoholics and 11 control subjects. Single photon emission computed tomography (SPECT) and plasma levels of the radioligand [I-123]beta-CIT were used to quantify DAT protein availability. Individuals with the 9-repeat/10-repeat genotype had a mean 22% reduction of DAT protein availability in putamen compared with 10-repeat homozygous individuals (t = 2.14, df = 23, p < .05). Consistent with earlier studies, alcoholism, per se, was not significantly associated with either DAT availability or DAT genotype. These findings suggest that the VNTR polymorphism of the DAT gene effects translation of the DAT protein. This effect may explain a variety of clinical associations that have been reported with this polymorphism.

Integrity signals

Registry

Crossref · 10.1016/s0893-133x(99)00099-8

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
The Michigan Alcoholism Screening Test: The Quest for a New Diagnostic Instrument
Selzer, M. L. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.127.12.1653 · Cited by 3,431
Negative Symptoms in Schizophrenia: Definition and Reliability
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070020005 · Cited by 2,247
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203
A Rating Scale for Depression
Ostwald, P. F. (1960) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1960.14.4.817 · Cited by 1,422

Show all 51 references

Sorted by citations

Items 201–300 of 538

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System
Torrisi, S. A., Leggio, G. M., Drago, F., & Salomone, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00404 · Cited by 59
The genetic basis of individual differences in reward processing and the link to addictive behavior and social cognition
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53
Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity
Adriani, W., Romano, E., Pucci, M., Pascale, E., Cerniglia, L., Cimino, S., Tambelli, R., Curatolo, P., Granstrem, O., Maccarrone, M., et al. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1040-9 · Cited by 52
From Disordered Eating to Addiction: The “Food Drug” in Bulimia Nervosa
Umberg, E. N., Shader, R. I., Hsu, L. K. G., & Greenblatt, D. J. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318252464f · Cited by 52
Dopaminergic genotype biases spatial attention in healthy children
Bellgrove, M. A., Chambers, C., Johnson, K. A., Dáibhis, A., Daly, M., Hawi, Z., Lambert, D., Gill, M., & Robertson, I. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002022 · Cited by 52
Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery
Alexander, N., Osinsky, R., Mueller, E., Schmitz, A., Günthert, S. J., Kuepper, Y., & Hennig, J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.003 · Cited by 51
The Influence of Genetic Variants on Striatal Dopamine Transporter and D2 Receptor Binding after TBI
Wagner, A. K., Scanlon, J. M., Becker, C. R., Ritter, A. C., Niyonkuru, C., Dixon, C. E., Conley, Y. P., & Price, J. C. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.176 · Cited by 52
An association between the DAT1 polymorphism and smoking behavior in young adults from the national longitudinal study of adolescent health.
Timberlake, D. S., Haberstick, B. C., Lessem, J. M., Smolen, A., Ehringer, M. A., Hewitt, J. K., & Hopfer, C. J. (2006) · Health Psychology · doi:10.1037/0278-6133.25.2.190 · Cited by 53
Neuroimaging genomics in psychiatry—a translational approach
Mufford, M. S., Stein, D. J., Dalvie, S., Groenewold, N. A., Thompson, P. M., & Jahanshad, N. (2017) · Genome Medicine · doi:10.1186/s13073-017-0496-z · Cited by 55
Exogenous testosterone increases status-seeking motivation in men with unstable low social status
Vermeer, A. B. L., Krol, I., Gausterer, C., Wagner, B., Eisenegger, C., & Lamm, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104552 · Cited by 51
Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders
D’Souza, U. M., & Craig, I. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00904-7 · Cited by 50
Dopamine Transporter Genotype as a Risk Factor for Obesity in African‐American Smokers
Epstein, L. H., Jaroni, J. L., Paluch, R. A., Leddy, J. J., Vahue, H. E., Hawk, L. W., Wileyto, E. P., Shields, P. G., & Lerman, C. E. (2002) · Obesity Research · doi:10.1038/oby.2002.168 · Cited by 50
Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study
Sáiz, P. A., García‐Portilla, M. P., Arango, C., Morales, B., Arias, B., Corcoran, P. E., Fernández, J. M., Álvarez, V., Coto, E., Bobes-Bascarán, T., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.008 · Cited by 50
Allelic association of a dopamine transporter gene polymorphism with antisocial behaviour in heroin‐dependent patients
Gerra, G., Garofano, L., Pellegrini, C., Bòsari, S., Zaimovic, A., Moi, G., Avanzini, P., Talarico, E., Gardini, F., & Donnini, C. (2005) · Addiction Biology · doi:10.1080/13556210500223769 · Cited by 50
Sequence variation in the 3′‐untranslated region of the dopamine transporter gene and attention‐deficit hyperactivity disorder (ADHD)
Feng, Y., Wigg, K. G., Makkar, R., Ickowicz, A., Pathare, T., Tannock, R., Roberts, W., MALONE, M. A., Kennedy, J. L., Schachar, R. J., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30190 · Cited by 50
Dopamine Genes and Nicotine Dependence in Treatment-Seeking and Community Smokers
Bergen, A. W., Conti, D. V., Berg, D. V. D., Lee, W., Liu, J., Li, D., Guo, N., Mi, H., Thomas, P. D., Lessov‐Schlaggar, C. N., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.52 · Cited by 50
Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury
Wagner, A. K., Ren, D., Conley, Y. P., Ma, X., Kerr, M. E., ZAFONTE, R. D., Puccio, A. M., Marion, D. W., & Dixon, C. E. (2007) · Journal of neurosurgery · doi:10.3171/jns.2007.106.4.538 · Cited by 49
Genetic Determinants of Time Perception Mediated by the Serotonergic System
Sysoeva, O., Tonevitsky, A., & Wackermann, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012650 · Cited by 50
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martínez, D., Kim, J., Krystal, J. H., & Abi‐Dargham, A. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.004 · Cited by 50
Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies
Hansson, A. C., Gründer, G., Hirth, N., Noori, H. R., Spanagel, R., & Sommer, W. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.010 · Cited by 55
Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia
Xu, M., Xing, Q., Li, S., Zheng, Y., Wu, S., Gao, R., Yu, L., Guo, T., Yang, Y., Liu, J., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.017 · Cited by 49
Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics
Lafuente, A., Bernardo, M., Mas, S., Crescenti, A., Aparici, M., Gassó, P., Catalán, R., Mateos, J. J., Lomeña, F., & Parellada, E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.031 · Cited by 48
Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT‐1 in striatum of asymptomatic volunteers and patients with Parkinson's disease
Lynch, D. R., Mozley, P. D., Sokol, S. A., Maas, N. M. C., Balcer, L. J., & Siderowf, A. D. (2003) · Movement Disorders · doi:10.1002/mds.10430 · Cited by 48
Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers
Blanchard, M. M., Chamberlain, S. R., Roiser, J. P., Robbins, T. W., & Müller, U. (2010) · Psychological Medicine · doi:10.1017/s003329171000098x · Cited by 51
Case‐Control study of dopamine transporter‐1, monoamine oxidase‐B, and catechol‐O‐methyl transferase polymorphisms in Parkinson's disease
Goudreau, J. L., Maraganore, D. M., Farrer, M. J., Lesnick, T. G., Singleton, A., Bower, J. H., Hardy, J., & Rocca, W. A. (2002) · Movement Disorders · doi:10.1002/mds.10268 · Cited by 47
Nicotine addiction through a neurogenomic prism: Ethics, public health, and smoking
Caron, L., Karkazis, K. A., Raffin, T. A., Swan, G. E., & Koenig, B. A. (2005) · Nicotine & Tobacco Research · doi:10.1080/14622200500055251 · Cited by 46
Spatial Attentional Bias as a Marker of Genetic Risk, Symptom Severity, and Stimulant Response in ADHD
Bellgrove, M. A., Barry, E., Johnson, K. A., Cox, M., Dáibhis, A., Daly, M., Hawi, Z., Lambert, D., Fitzgerald, M., McNicholas, F., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301637 · Cited by 48
Genetics of impulse control disorders in Parkinson’s disease
Cormier‐Dequaire, F., Muellner, J., & Corvol, J. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0934-4 · Cited by 50
Hypofunctional Dopamine Uptake and Antipsychotic Treatment-Resistant Schizophrenia
Amato, D., Kruyer, A., Samaha, A., & Heinz, A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00314 · Cited by 47
Self-citation
Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele
Krause, J., Dresel, S. H. J., Krause, K., la Fougère, C., Zill, P., & Ackenheil, M. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970500518444 · Cited by 47
Measurement of the Striatal Dopamine Transporter Density and Heterogeneity in Type 1 Alcoholics Using Human Whole Hemisphere Autoradiography
Tupala, E., Kuikka, J. T., Hall, H., Bergström, K., Särkioja, T., Räsänen, P. K., Mantere, T., Hiltunen, J. O., Vepsäläinen, J., & Tiihonen, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0793 · Cited by 46
Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems
Hall, F. S., Itokawa, K., Schmitt, A. G., Moessner, R., Sora, I., Lesch, K., & Uhl, G. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.031 · Cited by 45
Early Institutionalization: Neurobiological Consequences and Genetic Modifiers
Sheridan, M. A., Drury, S. S., McLaughlin, K. A., & Almas, A. N. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9152-8 · Cited by 50
The 3′ Part of the Dopamine Transporter GeneDAT1/SLC6A3Is Associated With Withdrawal Seizures in Patients With Alcohol Dependence
Strat, Y. L., Ramoz, N., Pickering, P., Burger, V., Boni, C., Aubin, H., Adès, J., Batel, P., & Gorwood, P. A. P. M. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00552.x · Cited by 45
Segmental linkage disequilibrium within the dopamine transporter gene
Greenwood, T. A., Alexander, M., Keck, P. E., Mcelroy, S. L., Sadovnick, A., Remick, R. A., Shaw, S., & Kelsoe, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000958 · Cited by 50
Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction
Sweitzer, M. M., Donny, E. C., & Hariri, A. R. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.01.017 · Cited by 46
Dopamine transporter, gender, and number of sexual partners among young adults
Guo, G., Tong, Y., Xie, C.-W., & Lange, L. A. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201763 · Cited by 44
Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study
Ton, T. G. N., Rossing, M. A., Bowen, D. J., Srinouanprachan, S., Wicklund, K. G., & Farin, F. M. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-22 · Cited by 44
The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: A case-control association study in a Korean sample
Kim, J.-W., Kim, B., & Cho, S.-C. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.11.002 · Cited by 44
Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders
Miller, G. M., Garza, R. D. L., Novak, M. A., & Madras, B. K. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000809 · Cited by 44
Task demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains
Stephens, J. A., Jones, K. T., & Berryhill, M. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-14030-7 · Cited by 43
Genetic polymorphisms ofDAT1andCOMTdifferentially associate with actigraphy-derived sleep–wake cycles in young adults
Valomon, A., Holst, S. C., Bachmann, V., Viola, A., Schmidt, C., Zuercher, J., Berger, W., Cajochen, C., & Landolt, H. (2014) · Chronobiology International · doi:10.3109/07420528.2014.896376 · Cited by 45
Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
Hong, C.-J., Cheng, C.-Y., Shu, L.-R. R., Yang, C.-Y., & Tsai, S. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0790-8 · Cited by 43
Effect of Dopamine Transporter Genotype on Intrinsic Functional Connectivity Depends on Cognitive State
Gordon, E. M., Stollstorff, M., Devaney, J. M., Bean, S. E., & Vaidya, C. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr305 · Cited by 44
Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function
Singer, B. F., Guptaroy, B., Austin, C. J., Wohl, I., Lovic, V., Seiler, J. L., Vaughan, R. A., Gnegy, M. E., Robinson, T. E., & Aragona, B. J. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13134 · Cited by 43
Integrating genetic, psychopharmacological and neuroimaging studies: A converging methods approach to understanding the neurobiology of ADHD
Durston, S., & Konrad, K. (2007) · Developmental Review · doi:10.1016/j.dr.2007.05.001 · Cited by 46
Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis
Filonzi, L., Magnani, C., Lavezzi, A. M., Rindi, G., Parmigiani, S., Bevilacqua, G., Matturri, L., & Marzano, F. N. (2008) · Neurogenetics · doi:10.1007/s10048-008-0149-x · Cited by 42
Dopamine transporter polymorphisms affect social approach–avoidance tendencies
Enter, D., Colzato, L. S., & Roelofs, K. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00791.x · Cited by 43
Influence of Dopamine Polymorphisms on the Risk for Anorexia Nervosa and Associated Psychopathological Features
Gervasini, G., Gordillo, I., García‐Herráiz, A., Flores, I., Jiménez, M., Monge, M., & Carrillo, J. A. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182970469 · Cited by 42
Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD
Dresler, T., Ehlis, A., Heinzel, S., Renner, T., Reif, A., Baehne, C. G., Heine, M., Boreatti‐Hümmer, A., Jacob, C., Lesch, K., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.91 · Cited by 43
The Association Between the SLC6A3 VNTR 9-Repeat Allele and Alcoholism-A Meta-Analysis
Du, Y., Nie, Y., Li, Y., & Wan, Y. Y. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01509.x · Cited by 42
Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors
Yamamoto, D. J., Nelson, A. M., Mandt, B. H., Larson, G. A., Rorabaugh, J. M., Ng, C. M. C., Barcomb, K., Richards, T. L., Allen, R. M., & Zahniser, N. R. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.002 · Cited by 39
A gene‐based evolutionary explanation for the association between criminal involvement and number of sex partners
Beaver, K. M., WRIGHT, J. P., & Walsh, A. (2008) · Biodemography and Social Biology · doi:10.1080/19485565.2008.9989131 · Cited by 42
Genetic polymorphisms of the dopamine and serotonin systems modulate the neurophysiological response to feedback and risk taking in healthy humans
Heitland, I., Oosting, R. S., Baas, J. M. P., Massar, S. A. A., Kenemans, J. L., & Böcker, K. B. E. (2012) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-012-0108-8 · Cited by 52
Dopamine transporter genotype predicts implicit sequence learning
Simon, J. R., Stollstorff, M., Westbay, L. C., Vaidya, C. J., Howard, J. H., & Howard, D. V. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.043 · Cited by 41
Imaging Receptor Changes in Human Drug Abusers
Cosgrove, K. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_24 · Cited by 41
Dopamine and Serotonin Transporter Availability During Acute Alcohol Withdrawal: Effects of Comorbid Tobacco Smoking
Cosgrove, K., Krantzler, E., Frohlich, E., Stiklus, S. M., Pittman, B. P., Tamagnan, G. D., Baldwin, R. M., Bois, F., Seibyl, J. P., Krystal, J. H., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.49 · Cited by 40
Cortical thickness differences in the prefrontal cortex in children and adolescents with ADHD in relation to dopamine transporter (DAT1) genotype
Fernández‐Jaén, A., López‐Martín, S., Albert, J., Fernández-Mayoralas, D. M., Fernández‐Perrone, A. L., de la Peña, M. J., Calleja‐Pérez, B., Rodríguez, M. R., López-Arribas, S., & Jareño, N. M. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.07.005 · Cited by 43
Genetic association studies of performance monitoring and learning from feedback: The role of dopamine and serotonin
Ullsperger, M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.009 · Cited by 41
Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis
Papenberg, G., Bäckman, L., Nagel, I. E., Nietfeld, W., Schröder, J., Bertram, L., Heekeren, H. R., Lindenberger, U., & Li, S. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00359 · Cited by 40
Altered Effect of Dopamine Transporter 3′UTR VNTR Genotype on Prefrontal and Striatal Function in Schizophrenia
Prata, D. P., Mechelli, A., Picchioni, M., Fu, C. H. Y., Toulopoulou, T., Bramon, E., Walshe, M., Murray, R. M., Collier, D. A., & McGuire, P. K. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.147 · Cited by 40
Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies
Ashok, A. H., Mizuno, Y., & Howes, O. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05196-1 · Cited by 36
Transmission disequilibrium studies in early onset of obsessive–compulsive disorder for polymorphisms in genes of the dopaminergic system
Walitza, S., Scherag, A., Renner, T. J., Hinney, A., Remschmidt, H., Herpertz‐Dahlmann, B., Schulz, E., Schafer, H., Lange, K. W., Wewetzer, C., et al. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0051-6 · Cited by 38
Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems
Heinz, A., & Goldman, D. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00057-7 · Cited by 38
Self-citation
Dopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole
MacDonald, H. J., Stinear, C. M., Ren, A., Coxon, J. P., Kao, J., Macdonald, L., Snow, B. J., Cramer, S. C., & Byblow, W. D. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00946 · Cited by 38
Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females
Heitland, I., Kenemans, J. L., Oosting, R. S., Baas, J. M. P., & Böcker, K. B. E. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.013 · Cited by 36
A promoter polymorphism (−839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children
Genro, J. P., Zeni, C., Polanczyk, G. V., Roman, T., Rohde, L. A., & Hutz, M. H. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30428 · Cited by 36
Genetic substrates of psychosis in patients with Parkinson's disease: A critical review
Lenka, A., Arumugham, S. S., Christopher, R., & Pal, P. K. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.03.005 · Cited by 36
Child dopamine active transporter 1 genotype and parenting: Evidence for evocative gene–environment correlations
Hayden, E. P., Hanna, B., Sheikh, H. I., Laptook, R. S., Kim, J., Singh, S. M., & Klein, D. N. (2013) · Development and Psychopathology · doi:10.1017/s0954579412000971 · Cited by 36
DAT1 Polymorphism Determines L-DOPA Effects on Learning about Others’ Prosociality
Eisenegger, C., Pedroni, A., Rieskamp, J., Zehnder, C., Ebstein, R. P., Fehr, E., & Knoch, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067820 · Cited by 36
Transactional Links Between Teacher–Student Relationships and Adolescent Rule-Breaking Behavior and Behavioral School Engagement: Moderating Role of a Dopaminergic Genetic Profile Score
Laet, S. D., Colpin, H., Leeuwen, K. G. V., Noortgate, W. V. D., Claes, S. J., Janssens, A., Goossens, L., & Verschueren, K. (2016) · Journal of Youth and Adolescence · doi:10.1007/s10964-016-0466-6 · Cited by 43
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 35
Dopamine Transporter Gene Polymorphism, SPECT Imaging, and Levodopa Response in Patients with Parkinson Disease
Contin, M., Martinelli, P., Mochi, M., Albani, F., Riva, R., Scaglione, C. L. M., Dondi, M., Fanti, S., Pettinato, C., & Baruzzi, A. (2004) · Clinical Neuropharmacology · doi:10.1097/00002826-200405000-00004 · Cited by 34
GENETIC STUDY: The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19‐year‐olds
Schmid, B., Blomeyer, D., Becker, K., Treutlein, J., Zimmermann, U. S., Buchmann, A. F., Schmidt, M. H., Esser, G., Banaschewski, T., Rietschel, M., et al. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00171.x · Cited by 36
The Dopamine Transporter Expression Level Differentially Affects Responses to Cocaine and Amphetamine
Cagniard, B., Sotnikova, T. D., Gainetdinov, R. R., & Zhuang, X. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.908191 · Cited by 36
Imaging genetics of schizophrenia in the post-GWAS era
Arslan, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.018 · Cited by 38
Molecular Genetics of Attention-Deficit Hyperactivity Disorder
Retz, W., & Freitag, C. M. (2009) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000258449 · Cited by 35
ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?
Mazei‐Robison, M. S., & Blakely, R. (2006) · Springer eBooks · doi:10.1007/3-540-29784-7_17 · Cited by 34
Genetic influences of dopamine transport gene on alcohol dependence: A pooled analysis of 13 studies with 2483 cases and 1753 controls
Xu, M., & Lin, Z. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.001 · Cited by 33
The Association of a Novel Haplotype in the Dopamine Transporter with Preschool Age Posttraumatic Stress Disorder
Drury, S. S., Brett, Z. H., Henry, C., & Scheeringa, M. S. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0072 · Cited by 33
Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram
Warwick, J., Carey, P. D., Cassimjee, N., Löchner, C., Hemmings, S. M. J., Moolman-Smook, H., Beetge, E., Dupont, P. J., & Stein, D. J. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9280-3 · Cited by 33
Neurochemical Investigation of the Schizophrenic Brain by in Vivo Phosphorus Magnetic Resonance Spectroscopy
Fukuzako, H. (2001) · The World Journal of Biological Psychiatry · doi:10.3109/15622970109027496 · Cited by 32
Effect of dopamine transporter genotype on caudate volume in childhood ADHD and controls
Shook, D., Brady, C., Lee, P. S., Kenealy, L., Murphy, E. R., Gaillard, W. D., VanMeter, J. W., Cook, E. H., Stein, M., & Vaidya, C. J. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31132 · Cited by 31
Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning
Schuck, N. W., Frensch, P. A., Schjeide, B. M., Schröder, J., Bertram, L., & Li, S. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.09.009 · Cited by 31
Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): Relationships to eating- and personality-related psychopathology
Thaler, L., Groleau, P., Badawi, G., Sycz, L., Zeramdini, N., Too, A., Israël, M., Joober, R., Bruce, K. R., & Steiger, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.019 · Cited by 34
Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
Karama, S., Grizenko, N., Sonuga-Barke, E. J. S., Doyle, A. E., Biederman, J., Mbékou, V., Polotskaia, A., Ter-Stepanian, M., de Guzman, R., Bellingham, J., et al. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-45 · Cited by 33
Attention-Deficit/Hyperactivity Disorder: Advancing on Pharmacogenomics
Polanczyk, G. V., Zeni, C., Genro, J. P., Roman, T., Hutz, M. H., & Rohde, L. A. (2005) · Pharmacogenomics · doi:10.1517/14622416.6.3.225 · Cited by 31
No association between VNTR polymorphisms of dopamine transporter gene and attention deficit hyperactivity disorder in Chinese children
Cheuk, D. K., Li, S. Y. H., & Wong, V. C. N. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30280 · Cited by 31
Relation of the multilocus genetic composite reflecting high dopamine signaling capacity to future increases in BMI
Yokum, S., Marti, C. N., Smolen, A., & Stice, E. M. (2014) · Appetite · doi:10.1016/j.appet.2014.12.202 · Cited by 30
Neural coding of computational factors affecting decision making
Dreher, J. (2013) · Progress in brain research · doi:10.1016/b978-0-444-62604-2.00016-2 · Cited by 29
How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal
Hillmer, A. T., Mason, G. F., Fucito, L. M., O’Malley, S. S., & Cosgrove, K. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12893 · Cited by 32
Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson’s disease
Habak, C., Noreau, A., Nagano‐Saito, A., Mejia‐Constain, B., Degroot, C., Strafella, A. P., Chouinard, S., Lafontaine, A., Rouleau, G. A., & Monchi, O. (2014) · Brain · doi:10.1093/brain/awu251 · Cited by 32
Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals
the German Competence Network HIV/AIDS, Horn, A., Scheller, C., du Plessis, S., Arendt, G., Nolting, T., Joska, J. A., Sopper, S., Maschke, M., Obermann, M., et al. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1086-x · Cited by 35
DAT polymorphism and diverse clinical manifestations in methamphetamine abusers
Liu, H., Lin, S., Liu, S.-K., Chen, S.-L., Hu, C., Chang, J., & Leu, S. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200403000-00005 · Cited by 30
The genetics of nicotine dependence: Relationship to pancreatic cancer
MacLeod, S. L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i46.7433 · Cited by 29
A Dopamine Receptor (DRD2) but Not Dopamine Transporter (DAT1) Gene Polymorphism is Associated with Neurocognitive Development of Mexican Preschool Children with Lead Exposure
Kordas, K., Ettinger, A. S., Bellinger, D. C., Schnaas, L., Téllez‐Rojo, M. M., Hernández‐Ávila, M., Hu, H., & Wright, R. O. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.03.043 · Cited by 28
Variants of the SLC6A3 (DAT1) polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD
Althaus, M., Groen, Y., Wijers, A. A., Minderaa, R. B., Kema, I. P., Dijck-Brouwer, J., & Hoekstra, P. J. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.04.007 · Cited by 29
Brain perfusion and dopaminergic genes in boys with attention‐deficit/hyperactivity disorder
Szobot, C. M., Roman, T., Cunha, R. D., Acton, P. D., Hutz, M. H., & Rohde, L. A. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30096 · Cited by 29
Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis
Li, J. J., & Lee, S. S. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02563.x · Cited by 28
“…mRNA expression (Mill, Ascherson, Browes, D’Souza, & Craig, 2002) as well as decreased DA transporter binding compared to non-10-repeat homozygotes (Heinz et al., 2000), although nonassociations with DAT1 expression were reported from in-vitro human studies (Mill, Asherson, Craig, & D’Souza,…”
Background
The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications
Say, Y.-H. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-017-0142-x · Cited by 29

Authors: Heinz, A.
Affiliations: National Institutes of Health (US)
Corresponding author: Heinz, A
ORCID: Heinz, A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2000-02
Volume: 22
Issue: 2
Pages: 133-139
ISSN: 0893-133X (ISSN-L)
DOI: 10.1016/s0893-133x(99)00099-8
OpenAlex: W2092868760
Cited by: 538
References: 51
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 19 · 2018: 14 · 2017: 19 · 2016: 17 · 2015: 20 · 2014: 29 · 2013: 34 · 2012: 34
FWCI: 8.52
Type: journal article
Language: en
Open access: closed
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: dopamine transporter, VNTR polymorphism, 3' untranslated region, alcoholism, striatum, putamen, genotype-phenotype correlation, gene expression regulation, alcohol withdrawal
MeSH terms: Adult, Alcoholism, Carrier Proteins, Cocaine, Corpus Striatum, Genotype, Homozygote, Humans, Iodine Radioisotopes, Membrane Glycoproteins, Nerve Tissue Proteins, Polymorphism, Genetic, Reference Values, Temperance, Tomography, Emission-Computed, Single-Photon, Minisatellite Repeats, 3' Untranslated Regions, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks