The genetic basis of individual differences in reward processing and the link to addictive behavior and social cognition
Abstract
Dopaminergic neurotransmission is widely recognized to be critical to the neurobiology of reward, motivation and addiction. Interestingly, social interactions and related behavior also activate the same neuronal system. Consequently, genetic variations of dopamine neurotransmission are thought influence reward processing that in turn may affect distinctive social behavior and susceptibility to addiction. This review focuses on advances made to date in an effort to link genetic individual variations and reward processing as a possible basis for addictive behaviors.
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Individual differences in temperament and achievement/intrinsic motivation tendencies have been documented in ASD and can result in differential responsiveness to reward.
“individual differences in temperament and achievement/intrinsic motivation tendencies have been documented in ASD [220,221], and can result in differential responsiveness to reward [222,223].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [222]
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- Authors
- Yacubian, J., & Büchel, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Yacubian, J.
- ORCID
- Büchel, C.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 164
- Issue
- 1
- Pages
- 55-71
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2080049035
- Cited by
- 53
- References
- 187
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 8 · 2013: 7 · 2012: 6
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- reward processing, individual differences, dopamine signaling, addiction, social cognition, social behavior, genetic variation, motivation
- MeSH terms
- Animals, Catechol O-Methyltransferase, Dopamine, Humans, Reward, Social Behavior, Signal Transduction, Behavior, Addictive, Dopamine Plasma Membrane Transport Proteins
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