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Cited by 289

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Nighttime blood pressure dipping: the role of the sympathetic nervous system

Sherwood, A., Steffen, P. R., Blumenthal, J. A., Kuhn, C., Hinderliter, A. L.·2002·American Journal of Hypertension
DOI 10.1016/s0895-7061(01)02251-8
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Abstract

There is a marked diurnal variation in blood pressure (BP), with BP dipping to its lowest levels during nighttime sleep. A day-night dip in systolic BP (SBP) of <10% has been used to characterize individuals as nondippers, and is associated with an increased risk for cardiovascular disease. The present study examined the contribution of the sympathetic nervous system (SNS) to BP dipping in a biracial sample of 172 men and women aged 25 to 45 years. Assessments included 24-h ambulatory BP monitoring and both waking and sleeping urinary catecholamines. In addition, cardiovascular alpha- and beta-adrenergic receptor (AR) responsiveness was determined by the doses of isoproterenol and phenylephrine required to attain an increase in heart rate of 25 points (CD25) and BP (PD25), respectively. Compared with dippers (n = 116), nondippers (n = 56) were more likely to be African American and to have a family history of hypertension as well as a higher body mass index (BMI). The nighttime fall in both norepinephrine (NE) and epinephrine (EPI) excretion rates was reduced in nondippers compared with dippers (NE dip 9.3 v 13.1 microg/mg; EPI dip 2.7 v 4.0 microg/mg; both P < .05). Nondippers also were characterized by heightened alpha1-AR responsiveness compared with dippers (PD25 = 252 v 321 microg, P < .05). These data suggest that the SNS may contribute to individual differences in nighttime BP dipping, and appears to account in part for blunted BP dipping in African Americans.

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Metadata

Authors
Sherwood, A., Steffen, P. R., Blumenthal, J. A., Kuhn, C., & Hinderliter, A. L.
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2002-02-01
Volume
15
Issue
2
Pages
111-118
ISSN
  • 0895-7061 (ISSN-L)
  • 1941-7225
DOI
10.1016/s0895-7061(01)02251-8
OpenAlex
W1977908332
Cited by
289
References
39
FWCI
4.98
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nighttime blood pressure dipping: the role of the sympathetic nervous system. https://app.cochat.ai/papers/10.1016/s0895-7061(01)02251-8
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Sherwood, A., Steffen, P. R., Blumenthal, J. A., Kuhn, C., & Hinderliter, A. L. (2002). Nighttime blood pressure dipping: the role of the sympathetic nervous system. American Journal of Hypertension. https://doi.org/10.1016/s0895-7061(01)02251-8

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.