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Cited by 596Blood Pressure and Hypertension StudiesCardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

Ambulatory Blood Pressure Is Superior to Clinic Blood Pressure in Predicting Treatment-Induced Regression of Left Ventricular Hypertrophy

Mancia, Giuseppe, Zanchetti, Alberto, Agebiti-Rosei, Enrico, Benemio, Giuseppe, De Cesaris, Raffaele, Fogari, Roberto, Pessino, Achille, Porcellati, Carlo +2 more·1997·Circulation
DOI 10.1161/01.cir.95.6.1464
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Abstract

Background In cross-sectional studies, ambulatory blood pressure (ABP) correlates more closely than clinic BP with the organ damage of hypertension. Whether ABP predicts development or regression of organ damage over time better than clinic BP, however, is unknown. Methods and Results In 206 essential hypertensive subjects with left ventricular hypertrophy (LVH), we measured clinic supine BP, 24-hour ABP, and left ventricular mass index (LVMI, echocardiography) before and after 12 months of treatment with lisinopril (20 mg UID) without or with hydrochlorothiazide (12.5 or 25 mg UID). Measurements included random-zero, clinic orthostatic, and home BP. In all, 184 subjects completed the 12-month treatment period. Before treatment, clinic supine BP was 165±15/105±5 mm Hg (systolic/diastolic), 24-hour average BP was 149±16/95±11 mm Hg, and LVMI was 158±32 g/m 2 . At the end of treatment, they were 139±12/87±7 mm Hg, 131±12/83±10 mm Hg, and 133±26 g/m 2 , respectively ( P <.01 for all). Before treatment, LVMI did not correlate with clinic BP, but it showed a correlation with systolic and diastolic 24-hour average BP ( r =.34/.27, P <.01). The LVMI reduction was not related to the reduction in clinic BP, but it was related to the reduction in 24-hour average BP ( r =.42/.38, P <.01). Treatment-induced changes in average daytime and nighttime BPs correlated with LVMI changes as strongly as 24-hour BP changes. No substantial advantage over clinic supine BP was shown by clinic orthostatic, random-zero, and home BP. Conclusions In hypertensive subjects with LVH, regression of LVH was predicted much more closely by treatment-induced changes in ABP than in clinic BP. This provides the first longitudinally controlled evidence that ABP may be clinically superior to traditional BP measurements.

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Crossref · 10.1161/01.cir.95.6.1464

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Authors
Mancia, G., Zanchetti, A., Agebiti-Rosei, E., Benemio, G., De Cesaris, R., Fogari, R., Pessino, A., Porcellati, C., Salvetti, A., & Trimarco, B.
Affiliations
University of Milan (IT)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-03-18
Volume
95
Issue
6
Pages
1464-1470
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.95.6.1464
OpenAlex
W2011187155
Cited by
596
References
1
Citations by year
2026: 3 · 2025: 8 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 14 · 2017: 12 · 2016: 14 · 2015: 22 · 2014: 27 · 2013: 30 · 2012: 27
FWCI
16.09
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
ambulatory blood pressure, office blood pressure, left ventricular hypertrophy, left ventricular mass index, hypertension, lisinopril, hydrochlorothiazide, antihypertensive therapy, left ventricular hypertrophy regression, 24-hour ambulatory blood pressure, orthostatic blood pressure, home blood pressure monitoring, organ damage
MeSH terms
Adult, Aged, Ambulatory Care, Antihypertensive Agents, Blood Pressure Determination, Echocardiography, Female, Humans, Hypertension, Male, Middle Aged, Prognosis, Prospective Studies, Treatment Outcome, Hypertrophy, Left Ventricular, Blood Pressure Monitoring, Ambulatory

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