Developmental Remodeling of the Retinogeniculate Synapse
Open accessAbstract
Anatomical rearrangement of retinogeniculate connections contributes to the refinement of synaptic circuits in the developing visual system, but the underlying changes in synaptic function are unclear. Here, we study such changes in mouse brain slices. Each geniculate cell receives a surprisingly large number of retinal inputs (>20) well after eye-specific zones are formed. All but one to three of these inputs are eliminated over a 3-week period spanning eye opening. Remaining inputs are strengthened approximately 50-fold, in part through an increase in quantal size, but primarily through an increase in the number of release sites. Changes in release probability do not contribute significantly. Thus, a redistribution of release sites from many inputs to few inputs at this late developmental stage contributes to the precise receptive fields of thalamic relay neurons.
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The angled parasagittal brain slice preparation preserves the optic tract and dLGN.
“This method preserves the optic tract and dLGN, and generally only one slice is obtained per animal.”
From Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways (2013) · cites this paper as [23]
By P18, the majority (91%) of wild type dLGN neurons are innervated by between 1-4 inputs.
“As previously reported18,23, we found that by P18 the majority (91%) of wild type neurons were innervated by between 1-4 inputs.”
From Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways (2013) · cites this paper as [23]
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
The development of ocular dominance columns in normal and visually deprived monkeys
Le Vay, S., Wiesel, T. N., & Hubel, D. H. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901910102 · Cited by 1,123 · see citing works
Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Constantine-Paton, M., Cline, H. T., & Debski, E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001021 · Cited by 784 · see citing works
Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.
Shatz, C. J., & Stryker, M. P. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012421 · Cited by 691 · see citing works
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works
“This competition can occur between inputs from the 694 Neuron 74, 691–705, May 24, 2012 ª2012 Elsevier Inc. same eye as well as between inputs from both eyes (Chen and Regehr, 2000; Hooks and Chen, 2006; Jaubert-Miazza et al., 2005; Ziburkus and Guido, 2006).”
InfluentialSchizophrenia risk from complex variation of complement component 4
Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377 · see citing works
Self-citationHensch, T. K. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144327 · Cited by 1,300 · see citing works
Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works
Astrocytes Control Synapse Formation, Function, and Elimination
Chung, W.-S., Allen, N. J., & Eroglu, C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020370 · Cited by 839 · see citing works
Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661 · see citing works
Mechanisms underlying development of visual maps and receptive fields
Huberman, A. D., Feller, M. B., & Chapman, B. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125533 · Cited by 628 · see citing works
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573 · see citing works
Self-citationChung, S., Li, X., & Nelson, S. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00659-1 · Cited by 530 · see citing works
Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function
West, A. E., & Greenberg, M. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005744 · Cited by 532 · see citing works
Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works
Experimental evidence for sparse firing in the neocortex
Barth, A. L., & Poulet, J. F. A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.03.008 · Cited by 364 · see citing works
Microglia Function in Central Nervous System Development and Plasticity
Schafer, D. P., & Stevens, B. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020545 · Cited by 353 · see citing works
Astrocyte regulation of synaptic behavior
Allen, N. J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013053 · Cited by 343 · see citing works
The cell biology of synapse formation
Südhof, T. C. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202103052 · Cited by 358 · see citing works
Distinct roles for spontaneous and visual activity in remodeling of the retinogeniculate synapse
Hooks, B. M., & Chen, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.007 · Cited by 311 · see citing works
Self-citationDevelopment of precise maps in visual cortex requires patterned spontaneous activity in the retina
Cang, J., Rentería, R. C., Kaneko, M., Liu, X., Copenhagen, D. R., & Stryker, M. P. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.015 · Cited by 306 · see citing works
Arcuri, C., Mecca, C., Bianchi, R., Giambanco, I., & Donato, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00191 · Cited by 279 · see citing works
Synapse elimination and learning rules co-regulated by MHC class I H2-Db
Lee, H., Brott, B. K., Kirkby, L. A., Adelson, J. D., Cheng, S., Feller, M. B., Datwani, A., & Shatz, C. J. (2014) · Nature · doi:10.1038/nature13154 · Cited by 228 · see citing works
Diverse Modes of Axon Elaboration in the Developing Neocortex
Portera-Cailliau, C., Weimer, R. M., De Paola, V., Caroni, P., & Svoboda, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030272 · Cited by 225 · see citing works
Butts, D. A., Kanold, P. O., & Shatz, C. J. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050061 · Cited by 208 · see citing works
Grubb, M. S., Rossi, F. M., Changeux, J.-P., & Thompson, I. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00789-x · Cited by 208 · see citing works
Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
Datwani, A., McConnell, M. J., Kanold, P. O., Micheva, K. D., Busse, B., Shamloo, M., Smith, S. J., & Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.015 · Cited by 212 · see citing works
Chandrasekaran, A. R., Plas, D. T., Gonzalez, E., & Crair, M. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1470-05.2005 · Cited by 192 · see citing works
Stafford, B. K., Sher, A., Litke, A. M., & Feldheim, D. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.021 · Cited by 156 · see citing works
Demas, J., Sagdullaev, B. T., Green, E., Jaubert-Miazza, L., McCall, M. A., Gregg, R. G., Wong, R. O. L., & Guido, W. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.033 · Cited by 135 · see citing works
Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice
Dhande, O. S., Hua, E. W., Guh, E., Yeh, J., Bhatt, S., Zhang, Y., Ruthazer, E. S., Feller, M. B., & Crair, M. C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4899-10.2011 · Cited by 126 · see citing works
Experience-Dependent Retinogeniculate Synapse Remodeling Is Abnormal in MeCP2-Deficient Mice
Noutel, J., Hong, Y. K., Leu, B., Kang, E., & Chen, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.001 · Cited by 103 · see citing works
Self-citationYang, J., Yang, H., Liu, Y., Li, X., Qin, L., Lou, H., Duan, S., & Wang, H. (2016) · eLife · doi:10.7554/elife.15043 · Cited by 92 · see citing works
Developmental homeostasis of mouse retinocollicular synapses
Chandrasekaran, A. R., Shah, R. D., & Crair, M. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4383-06.2007 · Cited by 90 · see citing works
The role of glial cells in synapse elimination
Chung, W.-S., & Barres, B. A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.003 · Cited by 89 · see citing works
Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves
Shah, R. D., & Crair, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4276-07.2008 · Cited by 67 · see citing works
Synaptic reorganization in scaled networks of controlled size.
Wilson, N. R., Ty, M. T., Ingber, D. E., Sur, M., & Liu, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3863-07.2007 · Cited by 52 · see citing works
Furman, M., & Crair, M. C. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00943.2011 · Cited by 26 · see citing works
Furman, M., Xu, H.-P., & Crair, M. C. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01066.2012 · Cited by 20 · see citing works
- Authors
- Chen, C., & Regehr, W. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Chen, Chinfei
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 28
- Issue
- 3
- Pages
- 955-966
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2089178397
- Cited by
- 439
- References
- 4
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 19 · 2023: 19 · 2022: 15 · 2021: 17 · 2020: 12 · 2019: 19 · 2018: 20 · 2017: 22 · 2016: 16 · 2015: 20 · 2014: 25 · 2013: 19 · 2012: 18
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns038312-05, 2k08ns002056-05)
- National Institute of Neurological Disorders and Stroke (K08 NS02056, P01-NS-38312, R01NS032405)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- retinogeniculate synapses, synaptic refinement, quantal size, release sites, release probability, thalamocortical neurons, receptive fields, visual system development, mouse brain slices
- MeSH terms
- Aging, Animals, Geniculate Bodies, Nerve Fibers, Synaptic Transmission, Retina, Synapses, Visual Pathways, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques
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