Cited by 545Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

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Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

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Gensert, JoAnn M, Goldman, James E·1997·Neuron

DOI 10.1016/s0896-6273(00)80359-1

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Abstract

Remyelination occurs in demyelinated CNS regions in diseases such as multiple sclerosis. Identification of the cell type(s) responsible for this remyelination, however, has been elusive. Here, we examine one potential source of remyelinating oligodendrocytes-immature, cycling cells endogenous to adult white matter-and demonstrate that this population responds to demyelination by differentiating into myelinating oligodendrocytes. Dividing cells in subcortical white matter of adult rats were labeled by stereotactic injection of a replication-deficient lacZ-encoding retrovirus (BAG). Following a focal demyelination induced with lysolecithin, many of the BAG-labeled cells differentiated into myelinating oligodendrocytes engaging in repair of the lesion. Identification of endogenous cells capable of remyelination provides a target for the study of CNS repair processes in demyelinating diseases.

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Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
Bignami, A., Eng, L. F., Dahl, D. R., & Uyeda, C. T. (1972) · Brain Research · doi:10.1016/0006-8993(72)90398-8 · Cited by 1,456
Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.
Sanes, J. R., Rubenstein, J. L. R., & Nicolas, J. F. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04620.x · Cited by 1,116
Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species
Deibler, G. E., Martenson, R. E., & Kies, M. W. (1972) · Preparative Biochemistry · doi:10.1080/00327487208061467 · Cited by 939
Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.
Price, J., Turner, D., & Cepko, C. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.156 · Cited by 870
Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions
Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574
Proliferation and differentiation of rat neuroepithelial precursor cells in vivo
Frederiksen, K., & McKay, R. D. G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01144.1988 · Cited by 551
Identification of an adult-specific glial progenitor cell
Wolswijk, G., & Noble, M. (1989) · Development · doi:10.1242/dev.105.2.387 · Cited by 487
Proliferating bipotential glial progenitor cells in adult rat optic nerve
ffrench‐Constant, C., & RAFF, M. C. (1986) · Nature · doi:10.1038/319499a0 · Cited by 385
Multiple Sclerosis: Remyelination in Acute Lesions
Raine, C. S., & WU, E. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199305000-00003 · Cited by 285
The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord
Hall, S. M. (1972) · Journal of Cell Science · doi:10.1242/jcs.10.2.535 · Cited by 271

Show all 40 references

Research works printed but not linked: 7

Allen, I.V., and Kirk, J. (1992). Demyelinating diseases. In Greenfield's Neuropathology, J.H. Adams and L.W. Duchen, eds. (New York: Oxford University Press), pp. 447–520.
Prineas, 1989, Multiple sclerosis, Lab. Invest, 61, 489
Raine, C.S. (1991). Demyelinating diseases. In Textbook of Neuropathology, R.L. Davis and D.M. Robertson, eds. (Baltimore: Williams and Wilkins), pp. 535–620.
Raine, 1981, Multiple sclerosis, Lab. Invest, 45, 534
Ramon y Cajal, S. (1995). Pathways from the temporal olfactory cortex. In Histology of the Nervous System of Man and Vertebrates, Volume II (New York: Oxford University Press), pp. 589–602.
Szuchet, S. (1995). The morphology and ultrastructure of oligodendrocytes and their functional implications. In Neuroglia, H. Kettenmann and B.R. Ransom, eds. (New York: Oxford University Press), pp. 23–43.
Wu, 1992, Multiple sclerosis, Lab. Invest, 67, 88

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Xiao, L., Saiki, C., & Ide, R. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.137570 · Cited by 44
Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination
Watzlawik, J. O., Warrington, A. E., & Rodriguez, M. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.13 · Cited by 46
Role of Endogenous Neural Stem Cells in Neurological Disease and Brain Repair
Dietrich, J., & Kempermann, G. (2007) · Springer eBooks · doi:10.1007/0-387-30128-3_12 · Cited by 44
Remyelination in multiple sclerosis: a new role for neurotrophins?
Althaus, H. H. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46026-3 · Cited by 43
An experimental electro-acupuncture study in treatment of the rat demyelinated spinal cord injury induced by ethidium bromide.
Huang, S.-F., Ding, Y., Ruan, J.-W., Zhang, W., Wu, J.-L., He, B., Zhang, Y.-J., Li, Y., & Zeng, Y.-S. (2011) · Neurosciences research · doi:10.1016/j.neures.2011.03.010 · Cited by 46
Guanosine promotes myelination and functional recovery in chronic spinal injury
Jiang, S., Khan, M. I., Lu, Y., Wang, J., Buttigieg, J. A., Werstiuk, E. S., Ciccarelli, R., Caciagli, F., & Rathbone, M. P. (2003) · Neuroreport · doi:10.1097/00001756-200312190-00034 · Cited by 44
Numb rats walk – a behavioural and fMRI comparison of mild and moderate spinal cord injury
Hofstetter, C. P., Schweinhardt, P., Klason, T., Olson, L., & Spenger, C. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03062.x · Cited by 43
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Duffy, C. P., & McCoy, C. E. (2020) · Cells · doi:10.3390/cells9071711 · Cited by 42
Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis
Imitola, J., Snyder, E. Y., & Khoury, S. J. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00021.2002 · Cited by 43
Loss of Polysialic Residues Accelerates CNS Neural Precursor Differentiation in Pathological Conditions
Decker, L., Durbec, P. L., Rougon, G. N., & Evercooren, A. B. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1072 · Cited by 42
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Glezer, I., & Rivest, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.005 · Cited by 42
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Cuprizone‐induced demyelination in CNP::GFP transgenic mice
Silvestroff, L., Bartucci, S., Soto, E., Gallo, V., Pasquini, J., & Franco, P. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22330 · Cited by 40
Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke
Kassis, H., Shehadah, A., Li, C., Zhang, Y., Cui, Y., Roberts, C. J., Sadry, N., Liu, X., Chopp, M., & Zhang, Z. G. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.04.006 · Cited by 40
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Alshehri, B., Pagnin, M., Lee, J. Y., Petratos, S., & Richardson, S. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-60699-8 · Cited by 43
Strategies for spinal cord injury repair
McTigue, D. M., Popovich, P. G., Jakeman, L. B., & Stokes, B. T. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)28002-3 · Cited by 40
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Faria, D. D. P., de Vries, E. F. J., Sijbesma, J. W. A., Buchpiguel, C. A., Dierckx, R., & Copray, S. C. V. M. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514526941 · Cited by 41
CNTF-Activated Astrocytes Release a Soluble Trophic Activity for Oligodendrocyte Progenitors
Albrecht, P. J., Enterline, J. C., Cromer, J. A., & Levison, S. W. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9151-6 · Cited by 40
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Authors: Gensert, J. M., & Goldman, J. E.
Affiliations: Columbia University Irving Medical Center (US)
Columbia University (US)
Corresponding author: Gensert, JoAnn M
ORCID: Goldman, James E
Venue: Neuron
Publisher: Elsevier BV
Published: 1997-07
Volume: 19
Issue: 1
Pages: 197-203
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80359-1
OpenAlex: W2005578607
Cited by: 544
References: 40
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 29 · 2012: 21
FWCI: 5.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1380 d)
Locations: Neuron (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS17125, R01NS017125)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: remyelination, demyelination, oligodendrocyte precursor cells, myelinating oligodendrocytes, white matter, retroviral labeling, subcortical white matter, multiple sclerosis, CNS repair, adult neurogenesis
MeSH terms: Animals, Axons, Central Nervous System, Demyelinating Diseases, Female, Lysophosphatidylcholines, Stem Cells, Rats, Sprague-Dawley, Rats

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Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

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