Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

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Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.

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Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

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Proliferation and differentiation of rat neuroepithelial precursor cells in vivo

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Identification of an adult-specific glial progenitor cell

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Proliferating bipotential glial progenitor cells in adult rat optic nerve

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Multiple Sclerosis: Remyelination in Acute Lesions

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The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord

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Sequential Contribution of Parenchymal and Neural Stem Cell-Derived Oligodendrocyte Precursor Cells toward Remyelination

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VEGF- and PDGF-dependent proliferation of oligodendrocyte progenitor cells in the medulla oblongata after LPC-induced focal demyelination

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Chapter 18 Oligodendrocyte regeneration in the adult rodent CNS and the failure of this process in multiple sclerosis

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Electrical signalling properties of oligodendrocyte precursor cells

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Terahertz Spectroscopic Diagnosis of Myelin Deficit Brain in Mice and Rhesus Monkey with Chemometric Techniques

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Protective Effect of Electroacupuncture on Neural Myelin Sheaths is Mediated via Promotion of Oligodendrocyte Proliferation and Inhibition of Oligodendrocyte Death After Compressed Spinal Cord Injury

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Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2

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Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells

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Endogenous neural stem cells modulate microglia and protect against demyelination

Brousse, B., Mercier, O., Magalon, K., Daian, F., Durbec, P., & Cayre, M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.002 · Cited by 38

Prospects and Limitations of Using Endogenous Neural Stem Cells for Brain Regeneration

Kaneko, N., Kako, E., & Sawamoto, K. (2011) · Genes · doi:10.3390/genes2010107 · Cited by 39

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation

Schlüter, A., Sandoval, J., Fourcade, S., Díaz‐Lagares, Á., Ruíz, M., Casaccia, P., Esteller, M., & Pujol, A. (2018) · Brain Pathology · doi:10.1111/bpa.12595 · Cited by 35

Early Proliferation Does Not Prevent the Loss of Oligodendrocyte Progenitor Cells during the Chronic Phase of Secondary Degeneration in a CNS White Matter Tract

Payne, S. C., Bartlett, C. A., Savigni, D. L., Harvey, A. R., Dunlop, S. A., & Fitzgerald, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065710 · Cited by 36

Reaction of mouse brain oligodendrocytes and their precursors, astrocytes and microglia, to proinflammatory mediators circulating in the cerebrospinal fluid

Kong, G., Kristensson, K., & Bentivoglio, M. (2002) · Glia · doi:10.1002/glia.10030 · Cited by 34

New mouse oligodendrocyte precursor (mOP) cells for studies on oligodendrocyte maturation and function.

Lin, T., Xiang, Z.-M., Cui, L.-B., Stallcup, W., & Reeves, S. A. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.04.014 · Cited by 38

Determinants of central nervous system adult neurogenesis are sex, hormones, mouse strain, age, and brain region

Tatar, C. L., Bessert, D. A., Tse, H. Y., & Skoff, R. P. (2012) · Glia · doi:10.1002/glia.22426 · Cited by 32

Oligodendrocyte Progenitor Cells in the Adult Rat CNS Express Myelin Oligodendrocyte Glyco‐protein (MOG)

Li, G., Crang, A. J., Rundle, J., & Blakemore, W. F. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00463.x · Cited by 33

Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord

Atkinson, S., Li, Y.-Q., & Wong, C. S. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.01.061 · Cited by 33

Many roles for oligodendrocyte precursor cells in physiology and pathology

Nishiyama, A., Serwanski, D. R., & Pfeiffer, F. (2021) · Neuropathology · doi:10.1111/neup.12732 · Cited by 31

4‐Hydroxynonenal, a lipid peroxidation byproduct of spinal cord injury, is cytotoxic for oligodendrocyte progenitors and inhibits their responsiveness to PDGF

Gard, A. L., Solodushko, V., Waeg, G., & Majic, T. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1055 · Cited by 32

Developmental regulation of neuroligand-induced responses in cultured oligodendroglia

Belachew, S. M., Malgrange, B., Rigo, J., Rogister, B., Coucke, P. J., Mazy‐Servais, C., & Moonen, G. (1998) · Neuroreport · doi:10.1097/00001756-199804200-00004 · Cited by 32

Stroke Induces Nuclear Shuttling of Histone Deacetylase 4

Kassis, H., Shehadah, A., Chopp, M., Roberts, C. J., & Zhang, Z. G. (2015) · Stroke · doi:10.1161/strokeaha.115.009046 · Cited by 31

Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment

Mellai, M., Casalone, C., Corona, C., Crociara, P., Favole, A., Cassoni, P., Schiffer, D., & Boldorini, R. L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-48457-6_5 · Cited by 31

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

Romero, J. C., Berlinicke, C. A., Chow, S., Duan, Y., Wang, Y., Chamling, X., & Smirnova, L. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1094291 · Cited by 34

Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages

Michalski, D., Keck, A. L., Grosche, J., Martens, H., & Härtig, W. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00023 · Cited by 31

Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells after Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

Liang, A. C., Mandeville, E. T., Maki, T., Shindo, A., Som, A. T., Egawa, N., Itoh, K., Chuang, T. T., McNeish, J. D., Holder, J. C., et al. (2016) · Cell Transplantation · doi:10.3727/096368916x690557 · Cited by 30

Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts

Flygt, J., Clausen, F., & Marklund, N. (2016) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-160675 · Cited by 29

Activated T cells induce proliferation of oligodendrocyte progenitor cells via release of vascular endothelial cell growth factor‐A

Choi, E. H., Xu, Y., Medynets, M., Monaco, M. C., Major, E. O., Nath, A., & Wang, T. (2018) · Glia · doi:10.1002/glia.23501 · Cited by 30

Number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip‐1

Crockett, D. P., Burshteyn, M., Garcia, C. I., Muggironi, M., & Casaccia‐Bonnefil, P. (2004) · Glia · doi:10.1002/glia.20111 · Cited by 30

Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil

Shiraki, A., Saito, F., Akane, H., Takeyoshi, M., Imatanaka, N., Itahashi, M., Yoshida, T., & Shibutani, M. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.04.018 · Cited by 30

Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

Zhang, J., Chen, J., Li, Y., Cui, X., Zheng, X., Roberts, C. J., Lü, M., Elias, S. B., & Chopp, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.07.011 · Cited by 30

Prospects for Neural Stem Cell-Based Therapies for Neurological Diseases

Imitola, J. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.08.005 · Cited by 29

Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: Defining cellular targets

Zhao, C., Zawadzka, M., Roulois, A., Bruce, C. C., & Franklin, R. J. M. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.05.008 · Cited by 29

Olanzapine stimulates proliferation but inhibits differentiation in rat oligodendrocyte precursor cell cultures

Kimoto, S., Okuda, A., Toritsuka, M., Yamauchi, T., Makinodan, M., Okuda, H., Tatsumi, K., Nakamura, Y., Wanaka, A., & Kishimoto, T. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.07.011 · Cited by 29

Heterogeneity of NG2-expressing cells in the newborn mouse cerebellum

Bouslama‐Oueghlani, L., Wehrlé, R., Sotelo, C., & Dusart, I. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.07.003 · Cited by 29

Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain

Paez, P. M., Cheli, V. T., Ghiani, C. A., Spreuer, V., Handley, V., & Campagnoni, A. T. (2012) · Glia · doi:10.1002/glia.22336 · Cited by 30

Cellular connections, microenvironment and brain angiogenesis in diabetes: Lost communication signals in the post-stroke period

Ergul, A., Valenzuela, J. P., Fouda, A. Y., & Fagan, S. C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.045 · Cited by 26

Axonal degeneration stimulates the formation of NG2+ cells and oligodendrocytes in the mouse

Nielsen, H. H., Ladeby, R., Drøjdahl, N., Peterson, A. C., & Finsen, B. R. (2006) · Glia · doi:10.1002/glia.20357 · Cited by 28

Using biomaterials to promote pro-regenerative glial phenotypes after nervous system injuries

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Chapter 7 Reconstruction of cortical circuitry

Gates, M. A., Fricker‐Gates, R. A., & Macklis, J. D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)27008-8 · Cited by 27

What roles do growth factors play in CNS remyelination?

Franklin, R. J. M., Hinks, G. L., Woodruff, R. H., & O'Leary, M. T. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32075-7 · Cited by 28

Myelination, Dysmyelination, and Demyelination

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Paving the Axonal Highway: From Stem Cells to Myelin Repair

Peru, R. L., Mandrycky, N., Nait-Oumesmar, B., & Lu, Q. R. (2008) · Stem Cell Reviews · doi:10.1007/s12015-008-9043-z · Cited by 28

ERK1/2 Pathway-Mediated Differentiation of IGF-1-Transfected Spinal Cord-Derived Neural Stem Cells into Oligodendrocytes

Shi, B., Ding, J., Liu, Y., Zhuang, X., Zhuang, X., Chen, X., & Fu, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106038 · Cited by 27

Hes1 functions downstream of growth factors to maintain oligodendrocyte lineage cells in the early progenitor stage

Ogata, T., Ueno, T., Hoshikawa, S., Ito, J., Okazaki, R., Hayakawa, K., Morioka, K., Yamamoto, S., Nakamura, K., Tanaka, S., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.015 · Cited by 28

Growth factor regulation of remyelination: behind the growing interest in endogenous cell repair of the CNS

Armstrong, R. C. (2007) · Future Neurology · doi:10.2217/14796708.2.6.689 · Cited by 27

Activation of endogenous neural stem cells for multiple sclerosis therapy

Michailidou, I., de Vries, H. E., Hol, E. M., & van Strien, M. E. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00454 · Cited by 28

Axonal sprouting regulates myelin basic protein gene expression in denervated mouse hippocampus

Jensen, M. B., Poulsen, F. R., & Finsen, B. R. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(99)00091-x · Cited by 27

Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation

Melià-Sorolla, M., Castaño, C., DeGregorio‐Rocasolano, N., Rodríguez‐Esparragoza, L., Dávalos, A., Martı́, O., & Gasull, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186568 · Cited by 31

T-Cells in Neuronal Injury and Repair: Semaphorins and Related T-Cell Signals

Giraudon, P., Vincent, P., & Vuaillat, C. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:3:207 · Cited by 27

Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis

Kulbatski, I., Mothe, A. J., Parr, A. M., Kim, H. S., Kang, C. E., Bozkurt, G., & Tator, C. H. (2008) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2008.04.001 · Cited by 26

Chapter 31 Spinal cord injury: Bridging the lesion and the role of neurotrophic factors in repair

Houweling, D. A., Bär, P. R., Gispen, W. H., & Joosten, E. A. J. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64032-7 · Cited by 26

Oligogenesis and Oligodendrocyte Progenitor Maturation Vary in Different Brain Regions and Partially Correlate with Local Angiogenesis after Ischemic Stroke

Jiang, L., Shen, F., Degos, V., Schonemann, M. D., Pleasure, S. J., Mellon, S. H., Young, W. L., & Su, H. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0078-0 · Cited by 25

Metabolism and Distribution of Guanosine Given Intraperitoneally: Implications for Spinal Cord Injury

Jiang, S., Fischione, G., Guiliani, P., Romano, S., Caciagli, F., & DiIorio, P. (2008) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770802143962 · Cited by 25

The Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage

Nguyen, L., Borgs, L., Vandenbosch, R., Mangin, J., Beukelaers, P., Moonen, G., Gallo, V., Malgrange, B., & Belachew, S. M. (2006) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20103 · Cited by 25

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

Mironova, Y. A., Dang, B., Heo, D., Xu, Y. K. T., Hsu, A. T.-W., von Bernhardi, J. E., Molina-Castro, G. C., Kim, A. A., LIN, J., Reich, D. S., et al. (2026) · Science · doi:10.1126/science.adu2896 · Cited by 28

Injury programs shape glioblastoma

Brooks, L. J., Ragdale, H. S., Hill, C. S., Clements, M., & Parrinello, S. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.08.006 · Cited by 22

Remyelinating strategies in multiple sclerosis

Luessi, F., Kuhlmann, T., & Zipp, F. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.969241 · Cited by 24

Elucidating the Inability of Functionalized Nanoparticles to Cross the Blood–Brain Barrier and Target Specific Cells in Vivo

Naidu, P. S. R., Gavriel, N., Gray, C. G. G., Bartlett, C. A., Toomey, L. M., Kretzmann, J. A., Patalwala, D., McGonigle, T. A., Denham, E. M., Hee, C., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b01356 · Cited by 24

Engineering biomaterial microenvironments to promote myelination in the central nervous system

Unal, D. B., Caliari, S. R., & Lampe, K. J. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.013 · Cited by 24

Two Temporal Stages of Oligodendroglial Response to Excitotoxic Lesion in the Gray Matter of the Adult Rat Brain

Jamin, N., Junier, M., Grannec, G., & Cadusseau, J. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7752 · Cited by 24

Exogenous Neural Precursor Cell Transplantation Results in Structural and Functional Recovery in a Hypoxic-Ischemic Hemiplegic Mouse Model

Rumajogee, P., Altamentova, S. M., Li, L., Li, J., Wang, J., Kuurstra, A. B., Khazaei, M., Beldick, S. R., Menon, R. S., van der Kooy, D., et al. (2018) · eNeuro · doi:10.1523/eneuro.0369-18.2018 · Cited by 24

Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration

Mei, F., Chong, S. Y. C., & Chan, J. R. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1319-x · Cited by 26

Migration and remyelination by oligodendrocyte progenitor cells transplanted adjacent to focal areas of spinal cord inflammation

Wang, Y., Piao, J., Larsen, E. C., Kondo, Y., & Duncan, I. D. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22716 · Cited by 23

Targeting Oligodendrocyte Protection and Remyelination in Multiple Sclerosis

Zhang, J., Kramer, E. G., Mahase, S. S., Dutta, D. J., Bonnamain, V., Argaw, A. T., & John, G. R. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20244 · Cited by 21

The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke

Xu, M., Wang, M. M., Gao, Y., Keep, R. F., & Shi, Y. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.008 · Cited by 22

Oligodendrocyte progenitors as environmental biosensors

Dansu, D. K., Sauma, S., & Casaccia, P. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.012 · Cited by 21

The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination

Smith, P. M., & Franklin, R. J. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00396-4 · Cited by 22

Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain

Radecki, D. Z., & Samanta, J. (2022) · Cells · doi:10.3390/cells11132101 · Cited by 21

Promoting myelin repair and return of function in multiple sclerosis

Zhang, J., Kramer, E. G., Asp, L., Dutta, D. J., Navrazhina, K., Pham, T., Mariani, J. N., Argaw, A. T., Melendez‐Vasquez, C. V., & John, G. R. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.017 · Cited by 21

STAT 3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis

Sun, Y., Lehmbecker, A., Kalkuhl, A., Deschl, U., Sun, W., Röhn, K., Tzvetanova, I. D., Nave, K., Baumgärtner, W., & Ulrich, R. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12133 · Cited by 21

Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?

Ornelas, I. M., McLane, L. E., Saliu, A., Evangelou, A. V., Khandker, L., & Wood, T. L. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23900 · Cited by 22

Mechanism of White Matter Injury and Promising Therapeutic Strategies of MSCs After Intracerebral Hemorrhage

Li, J., Xiao, L., He, D., Luo, Y., & Sun, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.632054 · Cited by 21

Re-Expression of a Developmentally Restricted Potassium Channel in Autoimmune Demyelination

Herrero-Herranz, E., Pardo, L. A., Bunt, G., Gold, R., Stühmer, W., & Linker, R. A. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061241 · Cited by 23

Bench to Bedside of Neural Stem Cell in Traumatic Brain Injury

Ugoya, S. O., & Tu, J. (2012) · Stem Cells International · doi:10.1155/2012/141624 · Cited by 20

Simvastatin interferes with process outgrowth and branching of oligodendrocytes

Smolders, I., Smets, I., Maier, O., vandeVen, M., Steels, P., & Ameloot, M. M. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22490 · Cited by 20

Microglial Activation Induces Generation of Oligodendrocyte Progenitor Cells from the Subventricular Zone after Focal Demyelination in the Corpus Callosum

Naruse, M., Shibasaki, K., Shimauchi‐Ohtaki, H., & Ishizaki, Y. (2018) · Developmental Neuroscience · doi:10.1159/000486332 · Cited by 20

Structural adaption of axons during de‐ and remyelination in the Cuprizone mouse model

Pfeiffer, F., Frommer‐Kaestle, G., & Fallier‐Becker, P. (2019) · Brain Pathology · doi:10.1111/bpa.12748 · Cited by 22

From Stem Cells to Oligodendrocytes: Prospects for Brain Therapy

Chen, C. P., Kiel, M. E., Sadowski, D. H., & McKinnon, R. D. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-9006-9 · Cited by 18

Investigation of the proteolipid protein promoter activity during demyelination and repair

Ferent, J., Ruat, M., & Traiffort, É. (2013) · Differentiation · doi:10.1016/j.diff.2013.05.002 · Cited by 19

Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.

Chen, L.-P., Li, Z.-Y., Ping, M., Li, R., Liu, J., Xie, X., Song, X.-J., & Guo, L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.063 · Cited by 17

Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis

Farias, A. S., Martins‐de‐Souza, D., Guimarães, L., Pradella, F. M., Moraes, A. S., Facchini, G., Novello, J. C., & dos Santos, L. M. B. (2012) · PROTEOMICS · doi:10.1002/pmic.201200044 · Cited by 18

Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair

Sabo, J. K., & Cate, H. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011031 · Cited by 18

Approaches to repairing the damaged spinal cord: overview

Becker, D., & McDonald, J. W. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52137-8.00028-0 · Cited by 19

In situ characterisation of oligodendrocyte progenitor cells in adult mammalian optic nerve

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Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire

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