Cited by 545Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesMesenchymal stem cell research

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Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

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Gensert, JoAnn M, Goldman, James E·1997·Neuron

DOI 10.1016/s0896-6273(00)80359-1

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Abstract

Remyelination occurs in demyelinated CNS regions in diseases such as multiple sclerosis. Identification of the cell type(s) responsible for this remyelination, however, has been elusive. Here, we examine one potential source of remyelinating oligodendrocytes-immature, cycling cells endogenous to adult white matter-and demonstrate that this population responds to demyelination by differentiating into myelinating oligodendrocytes. Dividing cells in subcortical white matter of adult rats were labeled by stereotactic injection of a replication-deficient lacZ-encoding retrovirus (BAG). Following a focal demyelination induced with lysolecithin, many of the BAG-labeled cells differentiated into myelinating oligodendrocytes engaging in repair of the lesion. Identification of endogenous cells capable of remyelination provides a target for the study of CNS repair processes in demyelinating diseases.

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Authors: Gensert, J. M., & Goldman, J. E.
Affiliations: Columbia University Irving Medical Center (US)
Columbia University (US)
Corresponding author: Gensert, JoAnn M
ORCID: Goldman, James E
Venue: Neuron
Publisher: Elsevier BV
Published: 1997-07
Volume: 19
Issue: 1
Pages: 197-203
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80359-1
OpenAlex: W2005578607
Cited by: 544
References: 40
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 23 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 29 · 2012: 21
FWCI: 5.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1380 d)
Locations: Neuron (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS17125, R01NS017125)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: remyelination, demyelination, oligodendrocyte precursor cells, myelinating oligodendrocytes, white matter, retroviral labeling, subcortical white matter, multiple sclerosis, CNS repair, adult neurogenesis
MeSH terms: Animals, Axons, Central Nervous System, Demyelinating Diseases, Female, Lysophosphatidylcholines, Stem Cells, Rats, Sprague-Dawley, Rats

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Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

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