Novel Modulation of Neuronal Nicotinic Acetylcholine Receptors by Association with the Endogenous Prototoxin lynx1
Open accessAbstract
We previously identified lynx1 as a neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs. Here, we show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs. Single-channel recordings show that lynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances desensitization. Macroscopic recordings quantify the enhancement of desensitization onset by lynx1 and further show that it slows recovery from desensitization and increases the EC(50). These experiments establish that direct interaction of lynx1 with nAChRs can result in a novel type of functional modulation and suggest that prototoxins may play important roles in vivo by modulating functional properties of their cognate CNS receptors.
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In the presence of lynx1, α4β2 nAChRs are up to 20-fold less sensitive to ACh in a Xenopus oocyte expression system, desensitize more rapidly, and recover more slowly from desensitization.
“In the presence of lynx1, α4β2 nAChRs are up to 20-fold less sensitive to ACh in a Xenopus oocyte expression system, desensitize more rapidly, and recover more slowly from desensitization (114).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [114]
Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436 · see citing works
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267 · see citing works
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348 · see citing works
Steinlein, O. K., Mulley, J. C., Propping, P., Wallace, R. H., Phillips, H. A., Sutherland, G. R., Scheffer, I. E., & Berkovic, S. F. (1995) · Nature Genetics · doi:10.1038/ng1095-201 · Cited by 1,134 · see citing works
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880 · see citing works
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762 · see citing works
Elgoyhen, A. B., Vetter, D. E., Katz, E., Rothlin, C. V., Heinemann, S. F., & Boulter, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051622798 · Cited by 673 · see citing works
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
Smit, A. B., Syed, N. I., Schaap, D., van Minnen, J., Klumperman, J., Kits, K. S., Lodder, H., van der Schors, R. C., van Elk, R., Sorgedrager, B., et al. (2001) · Nature · doi:10.1038/35077000 · Cited by 563 · see citing works
Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene
Zuo, J., De Jager, P. L., Takahashi, K. A., Jiang, W., Linden, D. J., & Heintz, N. (1997) · Nature · doi:10.1038/42009 · Cited by 554 · see citing works
Self-citationNicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551 · see citing works
Lukas, R. J., Changeux, J., Novère, N. G. L., Albuquerque, E. X., Balfour, D. J. K., Berg, D. K., Bertrand, D., Chiappinelli, V. A., Clarke, P. B. S., Collins, A. C., et al. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01406-6 · Cited by 536 · see citing works
Schoepfer, R., Conroy, W. G., Whiting, P. J., Gore, M., & Lindstrom, J. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90031-a · Cited by 473 · see citing works
Isom, L. L., Ragsdale, D. S., Jongh, K. S. D., Westenbroek, R. E., Reber, B. F. X., Scheuer, T., & Catterall, W. A. (1995) · Cell · doi:10.1016/0092-8674(95)90121-3 · Cited by 461 · see citing works
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443 · see citing works
Functional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
Buisson, B., & Bertrand, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01819.2001 · Cited by 361 · see citing works
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement
Changeux, J.-P., Bertrand, D., Corringer, P.-J., Dehaene, S., Edelstein, S., Léna, C., Le Novère, N., Marubio, L., Picciotto, M., & Zoli, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00040-4 · Cited by 322 · see citing works
Phillips, H. A., Favre, I., Kirkpatrick, M., Zuberi, S. M., Goudie, D. R., Heron, S. E., Scheffer, I. E., Sutherland, G. R., Berkovic, S. F., Bertrand, D., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316946 · Cited by 320 · see citing works
lynx1, an Endogenous Toxin-like Modulator of Nicotinic Acetylcholine Receptors in the Mammalian CNS
Miwa, J. M., Ibáñez-Tallon, I., Crabtree, G. W., Sánchez, R., Šali, A., Role, L. W., & Heintz, N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80757-6 · Cited by 287 · see citing works
Self-citationSnake venom α‐neurotoxins and other ‘three‐finger’ proteins
Tsetlin, V. I. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00623.x · Cited by 281 · see citing works
del Toro, E. D., Juiz, J. M., Peng, X.-D., Lindstrom, J. M., & Criado, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903490302 · Cited by 248 · see citing works
Gerzanich, V., Wang, F., Kuryatov, A., & Lindstrom, J. M. (1998) · PubMed · Cited by 242 · see citing works
Kuryatov, A., Gerzanich, V., Nelson, M. E., Olale, F., & Lindstrom, J. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09035.1997 · Cited by 227 · see citing works
Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit
Hill, J., Zoli, M., Bourgeois, J., & Changeux, J. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01551.1993 · Cited by 220 · see citing works
Zwart, R., & Vijverberg, H. P. M. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.1124 · Cited by 215 · see citing works
Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study
Buisson, B., Gopalakrishnan, M., Arnerić, S. P., Sullivan, J. P., & Bertrand, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-07880.1996 · Cited by 183 · see citing works
Weiland, S., Witzemann, V., Villarroel, A., Propping, P., & Steinlein, O. K. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01215-x · Cited by 151 · see citing works
Whiteaker, P., Sharples, C. G., & Wonnacott, S. (1998) · PubMed · doi:10.7270/q2b856pt · Cited by 147 · see citing works
TheCaenorhabditis elegans odr-2Gene Encodes a Novel Ly-6-Related Protein Required for Olfaction
Chou, J. H., Bargmann, C. I., & Sengupta, P. (2001) · Genetics · doi:10.1093/genetics/157.1.211 · Cited by 111 · see citing works
Rogers, S. W., Gahring, L. C., Collins, A. C., & Marks, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04825.1998 · Cited by 91 · see citing works
Wang, H.-L., Ohno, K., Milone, M., Brengman, J. M., Evoli, A., Batocchi, A. P., Middleton, L. T., Christodoulou, K., Engel, A. G., & Sine, S. M. (2000) · The Journal of General Physiology · doi:10.1085/jgp.116.3.449 · Cited by 79 · see citing works
Self-citationFigl, A., Viseshakul, N., Shafaee, N., Forsayeth, J., & Cohen, B. N. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.655ba.x · Cited by 55 · see citing works
Sine, S. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23521 · Cited by 55 · see citing works
Self-citationThe unusual nature of epibatidine responses at the α4β2 nicotinic acetylcholine receptor
Buisson, B., Vallejo, Y. F., Green, W. N., & Bertrand, D. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00158-1 · Cited by 45 · see citing works
Grant, G. A., Luetje, C. W., Summers, R. J., & Xu, X. L. (1998) · Biochemistry · doi:10.1021/bi981227y · Cited by 45 · see citing works
Immunocytochemical localization of nicotinic acetylcholine receptor in rat cerebral cortex
Nakayama, H., Shioda, S., Okuda, H., Nakashima, T., & Nakai, Y. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00092-7 · Cited by 41 · see citing works
Isolation and Characterization of a New Member of the HumanGene Family( )
Horie, M., Okutomi, K., Taniguchi, Y., Ohbuchi, Y., Suzuki, M., & Takahashi, E. (1998) · Genomics · doi:10.1006/geno.1998.5462 · Cited by 40 · see citing works
α Neurotoxins and Their Relatives
Hall, Z. W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80745-x · Cited by 9 · see citing works
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The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms
Fry, B. G., Roelants, K., Champagne, D. E., Scheib, H., Tyndall, J. D. A., King, G. F., Nevalainen, T. J., Norman, J. A., Lewis, R. J., Norton, R. S., et al. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164356 · Cited by 825 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Fry, B. G. (2005) · Genome Research · doi:10.1101/gr.3228405 · Cited by 486 · see citing works
Cys-loop receptors: new twists and turns
Lester, H. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.002 · Cited by 431 · see citing works
Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex
Morishita, H., Miwa, J. M., Heintz, N., & Hensch, T. K. (2010) · Science · doi:10.1126/science.1195320 · Cited by 365 · see citing works
Self-citationFrahm, S., Ślimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.-F., Tsetlin, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.013 · Cited by 283 · see citing works
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Zoli, M., Pucci, S., Vilella, A., & Gotti, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170912110450 · Cited by 260 · see citing works
Nicotine as a modulator of behavior: beyond the inverted U
Picciotto, M. R. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00230-x · Cited by 257 · see citing works
Williams, D. K., Wang, J., & Papke, R. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.001 · Cited by 247 · see citing works
Roussel, M. F., & Hatten, M. E. (2011) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-380916-2.00008-5 · Cited by 212 · see citing works
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses
Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.014 · Cited by 205 · see citing works
Self-citationUnconventional ligands and modulators of nicotinic receptors
Pereira, E. F. R., Hilmas, C. J., Santos, M. D., Alkondon, M., Maelicke, A., & Albuquerque, E. X. (2002) · Journal of Neurobiology · doi:10.1002/neu.10146 · Cited by 202 · see citing works
Proskocil, B. J., Sekhon, H. S., Jia, Y., Savchenko, V. L., Blakely, R., Lindstrom, J. M., & Spindel, E. R. (2004) · Endocrinology · doi:10.1210/en.2003-1728 · Cited by 200 · see citing works
GABAA receptors and plasticity of inhibitory neurotransmission in the central nervous system
Fritschy, J., & Panzanelli, P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12534 · Cited by 199 · see citing works
Roles of Accessory Subunits in α4β2* Nicotinic Receptors
Kuryatov, A., Onksen, J., & Lindstrom, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046789 · Cited by 195 · see citing works
Pawlak, J., Mackessy, S. P., Sixberry, N. M., Stura, E. A., Du, M. L., Ménez, R., Foo, C. S., Ménèz, A., Nirthanan, S., & Kini, R. M. (2008) · The FASEB Journal · doi:10.1096/fj.08-113555 · Cited by 193 · see citing works
Organization, evolution and functions of the human and mouse Ly6/uPAR family genes
Loughner, C. L., Bruford, E. A., McAndrews-Hill, M., Delp, E. E., Swamynathan, S., & Swamynathan, S. K. (2016) · Human Genomics · doi:10.1186/s40246-016-0074-2 · Cited by 192 · see citing works
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function
Sinkus, M. L., Graw, S. L., Freedman, R., Ross, R. G., Lester, H. A., & Leonard, S. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.006 · Cited by 186 · see citing works
Nicotinic Acetylcholine Receptors of Muscles and Nerves
Lindstrom, J. M. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1254.007 · Cited by 176 · see citing works
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Self-citationMiwa, J. M., Stevens, T. R., King, S. L., Caldarone, B. J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R. M., Pavlides, C., Lester, H. A., Picciotto, M. R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.025 · Cited by 154 · see citing works
Self-citationPfeffer, C. K., Stein, V., Keating, D. J., Maier, H., Rinke, I., Rudhard, Y., Hentschke, M., Rune, G. M., Jentsch, T. J., & Hübner, C. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1377-08.2009 · Cited by 153 · see citing works
Williams, M. E., Burton, B., Urrutia, A., Shcherbatko, A., Chavez-Noriega, L. E., Cohen, C. J., & Aiyar, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410039200 · Cited by 152 · see citing works
Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma
Song, P., Sekhon, H. S., Fu, X. W., Maier, M., Jia, Y., Duan, J., Proskosil, B. J., Gravett, C., Lindstrom, J., Mark, G. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0183 · Cited by 141 · see citing works
Sixma, T. K., & Smit, A. B. (2003) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.142536 · Cited by 141 · see citing works
Tsetlin, V. I., & Hucho, F. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01454-6 · Cited by 137 · see citing works
Acetylcholine signaling system in progression of lung cancers
Friedman, J. R., Richbart, S. D., Merritt, J. C., Brown, K. C., Nolan, N. A., Akers, A. T., Lau, J. K., Robateau, Z. R., Miles, S. L., & Dasgupta, P. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.10.002 · Cited by 124 · see citing works
Evolution and diversification of the Toxicofera reptile venom system
Fry, B. G., Vidal, N., van der Weerd, L., Kochva, E., & Renjifo, C. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.01.009 · Cited by 118 · see citing works
RNA-Seq quantification of the human small airway epithelium transcriptome
Hackett, N. R., Butler, M. W., Shaykhiev, R., Salit, J., Omberg, L., Rodríguez-Flores, J. L., Mezey, J. G., Strulovici‐Barel, Y., Wang, G., Didon, L., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-82 · Cited by 117 · see citing works
Wu, M. N., Joiner, W. J., Dean, T., Yue, Z., Smith, C. J., Chen, D., Hoshi, T., Sehgal, A., & Koh, K. (2009) · Nature Neuroscience · doi:10.1038/nn.2454 · Cited by 113 · see citing works
Romanelli, M. N., & Gualtieri, F. (2003) · Medicinal Research Reviews · doi:10.1002/med.10037 · Cited by 112 · see citing works
A role for LYNX2 in anxiety-related behavior
Tekinay, A. B., Nong, Y., Miwa, J. M., Lieberam, I., Ibáñez-Tallon, I., Greengard, P., & Heintz, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813109106 · Cited by 110 · see citing works
Self-citationKessler, P., Marchot, P., Silva, M., & Servent, D. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13975 · Cited by 108 · see citing works
Tsetlin, V. I. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.11.003 · Cited by 107 · see citing works
Dual Role of the RIC-3 Protein in Trafficking of Serotonin and Nicotinic Acetylcholine Receptors
Castillo, M., Mulet, J. M., Gutiérrez, L. M., Ortiz, J. A., Castelán, F., Gerber, S., Sala, S., Sala, F., & Criado, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503746200 · Cited by 107 · see citing works
Allosteric modulation of nicotinic acetylcholine receptors
Chatzidaki, A., & Millar, N. S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.028 · Cited by 104 · see citing works
Lin, L., Jeanclos, E. M., Treuil, M. W., Braunewell, K., Gundelfinger, E. D., & Anand, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206857200 · Cited by 105 · see citing works
Non-conventional toxins from Elapid venoms
Nirthanan, S., Gopalakrishnakone, P., Gwee, M. C. E., Khoo, H., & Kini, R. M. (2003) · Toxicon · doi:10.1016/s0041-0101(02)00388-4 · Cited by 103 · see citing works
SLURP1 Is a Late Marker of Epidermal Differentiation and Is Absent in Mal de Meleda
Favre, B., Plantard, L., Aeschbach, L., Brakch, N., Christen‐Zaech, S., de Viragh, P. A., Sergeant, A., Huber, M., & Hohl, D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700551 · Cited by 99 · see citing works
Conroy, W. G., Liu, Z., Nai, Q., Coggan, J. S., & Berg, D. K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00324-6 · Cited by 96 · see citing works
Ibáñez-Tallon, I., Wen, H., Miwa, J. M., Xing, J., Tekinay, A. B., Ono, F., Brehm, P., & Heintz, N. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.015 · Cited by 96 · see citing works
Self-citationKumari, S., Borroni, V., Chaudhry, A., Chanda, B., Massol, R., Mayor, S., & Barrantes, F. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709086 · Cited by 95 · see citing works
NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1
Lyukmanova, E. N., Shenkarev, Z. O., Shulepko, M. A., Mineev, K. S., D’hoedt, D., Kasheverov, I. E., Filkin, S. Y., Krivolapova, A. P., Janíčková, H., Doležal, V., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189100 · Cited by 91 · see citing works
SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission
Wu, M., Robinson, J. E., & Joiner, W. J. (2014) · Current Biology · doi:10.1016/j.cub.2014.02.026 · Cited by 89 · see citing works
The cholinergic system and cancer
Paleari, L., Grozio, A., Cesario, A., & Russo, P. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.12.009 · Cited by 85 · see citing works
Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas
Matta, J. A., Gu, S., Davini, W. B., & Bredt, D. S. (2021) · Science · doi:10.1126/science.abg6539 · Cited by 75 · see citing works
Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23
Rangaraju, S., Khoo, K. K., Feng, Z., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Pham, C., Calabresi, P. A., Pennington, M. W., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071266 · Cited by 77 · see citing works
Positive and negative modulation of nicotinic receptors
Arias, H. R. (2010) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-381264-3.00005-9 · Cited by 75 · see citing works
Nirthanan, S. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114168 · Cited by 75 · see citing works
Raybuck, J. D., & Gould, T. J. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.001 · Cited by 72 · see citing works
Tsuneki, H., You, Y., Toyooka, N., Kagawa, S., Kobayashi, S., Sasaoka, T., Nemoto, H., Kimura, I., & Dani, J. A. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.000729 · Cited by 70 · see citing works
Chernyavsky, A. I., Arredondo, J., Galitovskiy, V., Qian, J., & Grando, S. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00216.2010 · Cited by 67 · see citing works
Nicotinic AChR in Subclassified Capsaicin-Sensitive and -Insensitive Nociceptors of the Rat DRG
Rau, K. K., Johnson, R. D., & Cooper, B. Y. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00591.2004 · Cited by 64 · see citing works
Puddifoot, C. A., Wu, M., Sung, R., & Joiner, W. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3630-14.2015 · Cited by 61 · see citing works
α4β2 Nicotinic Acetylcholine Receptors
Mazzaferro, S., Bermúdez, I., & Sine, S. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.764183 · Cited by 61 · see citing works
Self-citationGetting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins
Maher, M. P., Matta, J. A., Gu, S., Seierstad, M., & Bredt, D. S. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.001 · Cited by 64 · see citing works
Levitin, F., Weiss, M., Hahn, Y., Stern, O., Papke, R. L., Matusik, R. J., Nandana, S., Ziv, R., Pichinuk, E., Salame, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801454200 · Cited by 62 · see citing works
Three-finger proteins from the Ly6/uPAR family: Functional diversity within one structural motif
Vasilyeva, N. A., Loktyushov, E. V., Bychkov, M. L., Shenkarev, Z. O., & Lyukmanova, E. N. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917130090 · Cited by 59 · see citing works
Nichols, W. A., Henderson, B. J., Yu, C., Parker, R. L., Richards, C. I., Lester, H. A., & Miwa, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573667 · Cited by 58 · see citing works
Self-citationDessaud, É., Salaün, D., Gayet, O., Chabbert, M., & deLapeyrière, O. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.09.010 · Cited by 58 · see citing works
Grady, S. R., Wageman, C. R., Patzlaff, N. E., & Marks, M. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.026 · Cited by 56 · see citing works
Hruska, M., Keefe, J., Wert, D., Tekinay, A. B., Hulce, J. J., Ibáñez-Tallon, I., & Nishi, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2271-09.2009 · Cited by 55 · see citing works
Allosteric modulation of ligand-gated ion channels
Hogg, R. C., Buisson, B., & Bertrand, D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.06.010 · Cited by 55 · see citing works
Miwa, J. M., Lester, H. A., & Walz, A. (2012) · Physiology · doi:10.1152/physiol.00002.2012 · Cited by 52 · see citing works
Self-citationLyukmanova, E. N., Shulepko, M. A., Buldakova, S., Kasheverov, I. E., Shenkarev, Z. O., Reshetnikov, R. V., Filkin, S. Y., Kudryavtsev, D. S., Ojomoko, L. O., Kryukova, E. V., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436576 · Cited by 51 · see citing works
Prefrontal neuromodulation by nicotinic receptors for cognitive processes
Coura, R., & Granon, S. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2596-6 · Cited by 51 · see citing works
Demars, M. P., & Morishita, H. (2014) · Molecular Brain · doi:10.1186/s13041-014-0075-9 · Cited by 51 · see citing works
Lee, C.-H., & Hung, S.-Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010031 · Cited by 50 · see citing works
Ortiz, J. A., Castillo, M., del Toro, E. D., Mulet, J. M., Gerber, S., Valor, L. M., Sala, S., Sala, F., Gutiérrez, L. M., & Criado, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03473.x · Cited by 49 · see citing works
George, A. A., Bloy, A., Miwa, J. M., Lindstrom, J. M., Lukas, R. J., & Whiteaker, P. (2017) · The FASEB Journal · doi:10.1096/fj.201600733r · Cited by 48 · see citing works
Self-citationNovel Families of Toxin-like Peptides in Insects and Mammals: A Computational Approach
Kaplan, N., Morpurgo, N., & Michal Linial, B. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.02.106 · Cited by 47 · see citing works
Lyukmanova, E. N., Shulepko, M. A., Shenkarev, Z. O., Bychkov, M. L., Paramonov, A. S., Chugunov, A. O., Kulbatskii, D. S., Arvaniti, M., Dolejší, E., Schaer, T., et al. (2016) · Scientific Reports · doi:10.1038/srep30698 · Cited by 47 · see citing works
Miwa, J. M., Anderson, K., & Hoffman, K. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00343 · Cited by 46 · see citing works
Self-citationSnake postsynaptic neurotoxins: gene structure, phylogeny and applications in research and therapy
Siew, J. P. Y., Gong, N., Afifiyan, F., Ma, D., Poh, S. L., Armugam, A., & Jeyaseelan, K. (2004) · Biochimie · doi:10.1016/j.biochi.2003.11.012 · Cited by 47 · see citing works
Angelantonio, S. D., Giniatullin, R. A., Costa, V., Sokolova, E., & Nistri, A. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705337 · Cited by 46 · see citing works
Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans
GOTTSCHALK, A. R., & Schafer, W. R. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.11.016 · Cited by 46 · see citing works
The three-fingered protein domain of the human genome
Gałat, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8473-8 · Cited by 45 · see citing works
Wu, M., Puddifoot, C. A., Taylor, P., & Joiner, W. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.647248 · Cited by 45 · see citing works
Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence
Fowler, C. D., Turner, J. R., & Damaj, M. I. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_252 · Cited by 45 · see citing works
Cholinergic Targets in Lung Cancer
Spindel, E. R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160127114237 · Cited by 45 · see citing works
Palmoplantar Keratoderma along with Neuromuscular and Metabolic Phenotypes in Slurp1-Deficient Mice
Adeyo, O., Allan, B. B., Barnes, R. H., Goulbourne, C. N., Tatar, A., Tu, Y., Young, L. C., Weinstein, M. M., Tontonoz, P., Fong, L. G., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.19 · Cited by 44 · see citing works
Tyson, T., Reardon, W., Browne, J. A., & Burnell, A. M. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.12.015 · Cited by 43 · see citing works
Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6
Darvas, M., Morsch, M., Rácz, I., Ahmadi, S., Swandulla, D., & Zimmer, A. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.03.007 · Cited by 44 · see citing works
McPherson, C. A., Merrick, B. A., & Harry, G. J. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9422-3 · Cited by 38 · see citing works
Kim, N. C., & Marqués, G. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22021 · Cited by 38 · see citing works
Lynx1 and Aβ1–42 bind competitively to multiple nicotinic acetylcholine receptor subtypes
Thomsen, M. S., Arvaniti, M., Jensen, M. M., Shulepko, M. A., Dolgikh, D. A., Pinborg, L. H., Härtig, W., Lyukmanova, E. N., & Mikkelsen, J. D. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.06.009 · Cited by 37 · see citing works
Evolution and Medical Significance of LU Domain−Containing Proteins
Leth, J. M., Leth-Espensen, K. Z., Kristensen, K. K., Kumari, A., Winther, A.-M. L., Young, S. G., & Ploug, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112760 · Cited by 37 · see citing works
Structural answers and persistent questions about how nicotinic receptors work
Gregg, B. W. (2008) · Frontiers in bioscience · doi:10.2741/3094 · Cited by 37 · see citing works
Thomsen, M. S., Cinar, B., Jensen, M. M., Lyukmanova, E. N., Shulepko, M. A., Tsetlin, V. I., Klein, A. B., & Mikkelsen, J. D. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0611-x · Cited by 36 · see citing works
Shenkarev, Z. O., Shulepko, M. A., Bychkov, M. L., Kulbatskii, D. S., Shlepova, O. V., Васильева, Н. А., Andreev-Andrievskiy, A. A., Popova, A. S., Lagereva, E., Loktyushov, E. V., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15018 · Cited by 36 · see citing works
Stürzebecher, A., Hu, J., Smith, E. S. J., Frahm, S., Santos‐Torres, J., Kampfrath, B., Auer, S., Lewin, G. R., & Ibáñez-Tallon, I. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.187112 · Cited by 34 · see citing works
Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1
Bukhari‐Parlakturk, N., Burman, P., Hussein, A., Demars, M. P., Sadahiro, M., Brady, D. M., Tsirka, S. E., Russo, S. J., & Morishita, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4315-14.2015 · Cited by 33 · see citing works
Jensen, M. M., Arvaniti, M., Mikkelsen, J. D., Michalski, D., Pinborg, L. H., Härtig, W., & Thomsen, M. S. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.001 · Cited by 33 · see citing works
Enhancement in Motor Learning through Genetic Manipulation of the Lynx1 Gene
Miwa, J. M., & Walz, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043302 · Cited by 33 · see citing works
Self-citationFunctional interaction between Lypd6 and nicotinic acetylcholine receptors
Arvaniti, M., Jensen, M. M., Soni, N., Wang, H., Klein, A. B., Thiriet, N., Pinborg, L. H., Muldoon, P. P., Wienecke, J., Damaj, M. I., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13718 · Cited by 33 · see citing works
Self-citationFu, X. W., Song, P., & Spindel, E. R. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.05.022 · Cited by 33 · see citing works
Crespi, A., Colombo, S. F., & Gotti, C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13777 · Cited by 32 · see citing works
Girard, F., Mészár, Z., Marti, C., Davis, F. P., & Celio, M. R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07918.x · Cited by 32 · see citing works
Potentiation of α7-Containing Nicotinic Acetylcholine Receptors by Select Albumins
Conroy, W. G., Liu, Q., Nai, Q., Margiotta, J. F., & Berg, D. K. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.419 · Cited by 32 · see citing works
Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure
Sekhon, H. S., Song, P., Jia, Y., Lindstrom, J., & Spindel, E. R. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1077-9 · Cited by 31 · see citing works
- Authors
- Ibañez-Tallon, I., Miwa, J. M., Wang, H.-L., Adams, N. C., Crabtree, G. W., Sine, S. M., & Heintz, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Mayo Clinic (US)
- Rockefeller University (US)
- Columbia University (US)
- Corresponding author
- Heintz, Nathaniel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 33
- Issue
- 6
- Pages
- 893-903
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1966246536
- Cited by
- 200
- References
- 43
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 13 · 2019: 4 · 2018: 5 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 12 · 2013: 7 · 2012: 10
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4156 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2p01ns030532-06a1)
- National Cancer Institute (CA 09673, T32CA009673)
- National Institute of Neurological Disorders and Stroke (P01 NS 30532, NS 31744, NS22061, R01NS022061)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- Lynx1, neuronal nicotinic acetylcholine receptors, alpha4beta2 nAChR, receptor desensitization, receptor modulation, ligand-gated ion channels, central nervous system neurons
- MeSH terms
- Acetylcholine, Animals, Cell Line, Humans, Immunohistochemistry, Membrane Glycoproteins, Neurons, Neuropeptides, Oocytes, Receptors, GABA-A, Receptors, Nicotinic, Transfection, Vasodilator Agents, Xenopus laevis, Protein Structure, Tertiary, Patch-Clamp Techniques, Protein Subunits, Adaptor Proteins, Signal Transducing, GPI-Linked Proteins
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