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Cited by 714Memory and Neural MechanismsMemory Processes and InfluencesNeural and Behavioral Psychology Studies

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Interaction between the Amygdala and the Medial Temporal Lobe Memory System Predicts Better Memory for Emotional Events

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Dolcos, Florin, LaBar, Kevin S, Cabeza, Roberto·2004·Neuron
DOI 10.1016/s0896-6273(04)00289-2
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Abstract

Emotional events are remembered better than neutral events possibly because the amygdala enhances the function of medial temporal lobe (MTL) memory system (modulation hypothesis). Although this hypothesis has been supported by much animal research, evidence from humans has been scarce and indirect. We investigated this issue using event-related fMRI during encoding of emotional and neutral pictures. Memory performance after scanning showed a retention advantage for emotional pictures. Successful encoding activity in the amygdala and MTL memory structures was greater and more strongly correlated for emotional than for neutral pictures. Moreover, a double dissociation was found along the longitudinal axis of the MTL memory system: activity in anterior regions predicted memory for emotional items, whereas activity in posterior regions predicted memory for neutral items. These results provide direct evidence for the modulation hypothesis in humans and reveal a functional specialization within the MTL regarding the effects of emotion on memory formation.

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Metadata

Authors
Dolcos, F., LaBar, K. S., & Cabeza, R.
Affiliations
  • University of Alberta (CA)
  • Duke University (US)
Corresponding author
Dolcos, Florin
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2004-06
Volume
42
Issue
5
Pages
855-863
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(04)00289-2
OpenAlex
W2156322511
Cited by
714
References
0
Citations by year
2026: 22 · 2025: 24 · 2024: 22 · 2023: 18 · 2022: 18 · 2021: 21 · 2020: 34 · 2019: 27 · 2018: 29 · 2017: 46 · 2016: 34 · 2015: 41 · 2014: 39 · 2013: 40 · 2012: 40
FWCI
15.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG019731, R01 AG19731)
  • National Institute on Drug Abuse (R01DA014094, R01 DA14094)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
amygdala, emotional memory, emotional pictures, memory encoding, functional specialization, event-related fMRI
MeSH terms
Adult, Amygdala, Analysis of Variance, Brain Mapping, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Memory, Models, Neurological, Photic Stimulation, Temporal Lobe, Recognition, Psychology

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