Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus
Abstract
Researchers in clinical and basic neuroscience frequently target structures of the human medial temporal lobe (MTL) for volumetric analysis with magnetic resonance imaging (MRI). In neurodegenerative diseases, a precise volumetric analysis of MTL structures can assist in differential diagnosis and can be used in guiding early treatment. Also, in functional neuroimaging, exact localization is crucial for the correct interpretation of focal MTL activations with respect to specific memory functions. In presently available protocols, precise and consistent volumetric analysis of MTL structures is compromised in numerous ways. Most importantly, in order to cover all structures of the MTL, the researcher is presently forced to combine independently developed segmentation protocols for different structures from different laboratories. This approach limits anatomical precision because these protocols are based on different anatomical guidelines and descriptions that cannot easily be integrated. The segmentation approach presented in this paper was designed to address this issue by presenting segmentation guidelines for all major structures of the parahippocampal gyrus (PHG). It was developed directly to complement a volumetric protocol for hippocampus and amygdala (Pruessner et al., 2000, Cereb Cortex 10:433-442), thus allowing volumetric assessment of all major MTL structures in an integrated and consistent manner. Furthermore, it takes into consideration the neuroanatomical appearance of the collateral sulcus by presenting a method to correct the volumes of the surrounding cortices for the variability of this sulcus. The protocol was validated using MR images of 40 healthy normal control subjects (20 men and 20 women, age range 18-42 years). Intra- and interrater coefficients are presented, together with mean values for the volumes of all PHG structures, correlations with age and sex, and tests for hemispheric differences.
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The segmentation protocol for the assessment of hippocampal volume has been validated in a number of projects.
“The segmentation protocol for the assessment of hippocampal volume has recently been developed by our group, and we have since been able to validate it in a number of projects (Pruessner et al., 2000(Pruessner et al., , 2001(Pruessner et al., , 2002)).”
From Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood (2005) · cites this paper as Pruessner et al., 2002
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- Authors
- Pruessner, J. C.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Pruessner, J. C.
- ORCID
- Pruessner, J. C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 12
- Issue
- 12
- Pages
- 1342-1353
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2109217740
- Cited by
- 297
- References
- 40
- Citations by year
- 2025: 6 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 24 · 2016: 12 · 2015: 19 · 2014: 8 · 2013: 19 · 2012: 22
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- medial temporal lobe, parahippocampal gyrus, collateral sulcus, volumetry, perirhinal cortex, entorhinal cortex, hippocampus, amygdala, inter-rater reliability, hemispheric lateralization, age and sex effects
- MeSH terms
- Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Reference Values, Temporal Lobe, Entorhinal Cortex, Parahippocampal Gyrus
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