Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies
Open accessAbstract
Because brain structure and function are affected in neurological and psychiatric disorders, it is important to disentangle the sources of variation in these phenotypes. Over the past 15 years, twin studies have found evidence for both genetic and environmental influences on neuroimaging phenotypes, but considerable variation across studies makes it difficult to draw clear conclusions about the relative magnitude of these influences. Here we performed the first meta-analysis of structural MRI data from 48 studies on >1,250 twin pairs, and diffusion tensor imaging data from 10 studies on 444 twin pairs. The proportion of total variance accounted for by genes (A), shared environment (C), and unshared environment (E), was calculated by averaging A, C, and E estimates across studies from independent twin cohorts and weighting by sample size. The results indicated that additive genetic estimates were significantly different from zero for all meta-analyzed phenotypes, with the exception of fractional anisotropy (FA) of the callosal splenium, and cortical thickness (CT) of the uncus, left parahippocampal gyrus, and insula. For many phenotypes there was also a significant influence of C. We now have good estimates of heritability for many regional and lobar CT measures, in addition to the global volumes. Confidence intervals are wide and number of individuals small for many of the other phenotypes. In conclusion, while our meta-analysis shows that imaging measures are strongly influenced by genes, and that novel phenotypes such as CT measures, FA measures, and brain activation measures look especially promising, replication across independent samples and demographic groups is necessary.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In adults, females show stronger positive amygdala connectivity with areas for face monitoring and discrimination, sensory processing, and emotional processing.
“females showing stronger positive connectivity between the amygdala and areas associated with face monitoring and discrimination (middle temporal gyrus and inferior frontal gyrus), sensory processing (postcentral gyrus), and emotional processing (hippocampus)”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [140]
In adults, males show greater amygdala connectivity with areas involved in acquisition of conditioned fear, extinction learning, and extinction memory.
“males showing greater connectivity between the amygdala and areas involved in the acquisition of conditioned fear, extinction learning and extinction memory 139, 140”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [140]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891 · see citing works
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498 · see citing works
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
Choi, M., Scholl, U. I., Ji, W., Liu, T., Tikhonova, I. R., Zumbo, P., Nayır, A., Bakkaloğlu, A., Özen, S., Sanjad, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910672106 · Cited by 1,327 · see citing works
Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness
Panizzon, M. S., Fennema-Notestine, C., Eyler, L. T., Jernigan, T. L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M. J., Grant, M. D., Franz, C. E., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp026 · Cited by 1,304 · see citing works
Winkler, A. M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P. T., Duggirala, R., & Glahn, D. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.028 · Cited by 1,172 · see citing works
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · cited 1× · see citing works
“The challenge of linking specific genetic or environmental risk factors to behaviors and brain disorders has led to interest in using neuroimaging measures of brain structural and functional features as intermediate phenotypes (Boomsma et al., 2002; Glahn et al., 2007).”
Genetic influences on brain structure
Thompson, P. M., Cannon, T. D., Narr, K. L., van Erp, T. G. M., Poutanen, V.-P., HUTTUNEN, M. O., Lönnqvist, J. K., Standertskjöld-Nordenstam, C.-G., Kaprio, J. A., Khaledy, M., et al. (2001) · Nature Neuroscience · doi:10.1038/nn758 · Cited by 1,033 · see citing works
Rare Variants Create Synthetic Genome-Wide Associations
Dickson, S. P., Wang, K., Krantz, I., Hakonarson, H., & Goldstein, D. B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000294 · Cited by 857 · see citing works
Sex differences in the adolescent brain
Lenroot, R., & Giedd, J. N. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.10.008 · Cited by 563 · see citing works
Li, M. D., Cheng, R., Ma, J. Z., & Swan, G. E. (2002) · Addiction · doi:10.1046/j.1360-0443.2003.00295.x · Cited by 554 · see citing works
Jovicich, J., Czanner, S., Han, X., Salat, D. H., van der Kouwe, A. J. W., Quinn, B. T., Pacheco, J., Albert, M., Killiany, R., & Blacker, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.010 · Cited by 549 · see citing works
Genetic control over the resting brain
Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909969107 · Cited by 450 · see citing works
Sacher, J., Neumann, J., Fünfstück, T., Soliman, A., Villringer, A., & Schroeter, M. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.001 · Cited by 410 · see citing works
Genetics of brain fiber architecture and intellectual performance
Chiang, M.-C., Barysheva, M., Shattuck, D. W., Lee, A. D., Madsen, S. K., Avedissian, C., Klunder, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4184-08.2009 · Cited by 406 · see citing works
Self-citationThe association between brain volume and intelligence is of genetic origin
Posthuma, D., De Geus, E. J. C., Baaré, W. F. C., Pol, H. E. H., Kahn, R. S., & Boomsma, D. I. (2002) · Nature Neuroscience · doi:10.1038/nn0202-83 · Cited by 356 · see citing works
Genetic variability of human brain size and cortical gyral patterns
Bartley, A. J. (1997) · Brain · doi:10.1093/brain/120.2.257 · Cited by 355 · see citing works
Twin and family studies of the human electroencephalogram: a review and a meta-analysis.
van Beijsterveldt, C. E. M., & van Baal, G. C. V. (2002) · Biological Psychology · doi:10.1016/s0301-0511(02)00055-8 · Cited by 332 · see citing works
Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
Carmelli, D., DeCarli, C., Swan, G. E., Jack, L. M., Reed, T., Wolf, P. A., & Miller, B. L. (1998) · Stroke · doi:10.1161/01.str.29.6.1177 · Cited by 321 · see citing works
Lenroot, R. K., Schmitt, J. E., Ordaz, S. J., Wallace, G. L., Neale, M. C., Lerch, J. P., Kendler, K. S., Evans, A. C., & Giedd, J. N. (2009) · Human Brain Mapping · doi:10.1002/hbm.20494 · Cited by 320 · see citing works
Quantitative Genetic Modeling of Variation in Human Brain Morphology
Baaré, W. F. C. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.9.816 · Cited by 307 · see citing works
Dickerson, B. C., Fenstermacher, E., Salat, D. H., Wolk, D. A., Maguire, R. P., Desikan, R., Pacheco, J., Quinn, B. T., Van der Kouwe, A., Greve, D. N., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.042 · Cited by 290 · see citing works
Genetic Contributions to Human Brain Morphology and Intelligence
Pol, H. E. H., Schnack, H. G., Posthuma, D., Mandl, R. C. W., Baaré, W. F., van Oel, C. J., van Haren, N. E. M., Collins, D. L., Evans, A. C., Amunts, K., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-06.2006 · Cited by 283 · see citing works
Geschwind, D. H., Miller, B. L., DeCarli, C. S., & Carmelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052494999 · Cited by 279 · see citing works
Bonekamp, D., Nagae, L. M., Degaonkar, M. N., Matson, M., Abdalla, W. M., Barker, P. B., Mori, S., & Horská, A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.020 · Cited by 260 · see citing works
Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function
Glahn, D. C., Thompson, P. M., & Blangero, J. (2007) · Human Brain Mapping · doi:10.1002/hbm.20401 · Cited by 259 · see citing works
Verweij, K. J. H., Zietsch, B. P., Lynskey, M. T., Medland, S. E., Neale, M. C., Martin, N. G., Boomsma, D. I., & Vink, J. M. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02831.x · Cited by 254 · see citing works
Deary, I. J., Spinath, F. M., & Bates, T. C. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201588 · Cited by 254 · see citing works
Genetics of white matter development: A DTI study of 705 twins and their siblings aged 12 to 29
Chiang, M.-C., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Hickie, I. B., Toga, A. W., Wright, M. J., & Thompson, P. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.015 · Cited by 250 · see citing works
Self-citationGenetic variation in white matter hyperintensity volume in the Framingham Study
Atwood, L. D., Wolf, P. A., Heard-Costa, N. L., Massaro, J. M., Beiser, A., D’Agostino, R. B., & DeCarli, C. (2004) · Stroke · doi:10.1161/01.str.0000129643.77045.10 · Cited by 240 · see citing works
Kremen, W. S., Prom‐Wormley, E. C., Panizzon, M. S., Eyler, L. T., Fischl, B. R., Neale, M. C., Franz, C. E., Lyons, M. J., Pacheco, J. L., Perry, M. E., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.043 · Cited by 235 · see citing works
Wright, I. C., Sham, P. C., Murray, R. M., Weinberger, D. R., & Bullmore, E. T. (2002) · NeuroImage · doi:10.1006/nimg.2002.1163 · Cited by 205 · see citing works
Schmitt, J. E., Lenroot, R., Wallace, G. L., Ordaz, S. J., Taylor, K. N., Kabani, N. J., GREENSTEIN, D. K., Lerch, J. P., Kendler, K. S., Neale, M. C., et al. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm211 · Cited by 193 · see citing works
A Twin MRI Study of Size Variations in the Human Brain
Pennington, B. F., Filipek, P. A., Lefly, D. L., Chhabildas, N. A., Kennedy, D. N., Simon, J. H., Filley, C. M., Galaburda, A. M., & DeFries, J. C. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900561850 · Cited by 187 · see citing works
Early detection of Alzheimer’s disease using neuroimaging
Mosconi, L., Bryś, M., Głodzik-Sobańska, L., Santi, S. D., Rusinek, H., & de Leon, M. J. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.016 · Cited by 186 · see citing works
Sullivan, E. V., Pfefferbaum, A., Swan, G. E., & Carmelli, D. (2001) · Hippocampus · doi:10.1002/hipo.1091 · Cited by 180 · see citing works
Peper, J. S., Schnack, H. G., Brouwer, R. M., Van Baal, G. C. M., Pjetri, E., Székely, E., van Leeuwen, M., van den Berg, S. M., Collins, D. L., Evans, A. C., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20660 · Cited by 177 · see citing works
A pediatric twin study of brain morphometry.
Wallace, G. L., Schmitt, J. E., Lenroot, R., Viding, E., Ordaz, S. E., Rosenthal, M. A., Molloy, E. A., Clasen, L., Kendler, K., Neale, M., et al. (2006) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2006.01676.x · Cited by 164 · see citing works
Genetics of microstructure of cerebral white matter using diffusion tensor imaging
Kochunov, P., Glahn, D. C., Lancaster, J. L., Winkler, A. M., Smith, S. M., Thompson, P. M., Almasy, L. A., Duggirala, R., Fox, P. T., & Blangero, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.078 · Cited by 158 · see citing works
Heritability of Working Memory Brain Activation
Blokland, G. A. M., McMahon, K. L., Thompson, P. M., Martin, N. G., de Zubicaray, G. I., & Wright, M. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5334-10.2011 · Cited by 158 · see citing works
Self-citationBrain structure in men remains highly heritable in the seventh and eighth decades of life☆
Pfefferbaum, A., Sullivan, E. V., Swan, G. E., & Carmelli, D. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00086-5 · Cited by 150 · see citing works
Hippocampal Volumes in Schizophrenic Twins
van Erp, T. G. M., Saleh, P. A., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., Salonen, O. L. M., Valanne, L. K., Poutanen, V.-P., Standertskjöld-Nordenstam, C.-G., & Cannon, T. D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.346 · Cited by 147 · see citing works
The outcome of multiple pregnancy
Doyle, P. (1996) · Human Reproduction · doi:10.1093/humrep/11.suppl_4.110 · Cited by 145 · see citing works
Lenroot, R., & Giedd, J. N. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000552 · Cited by 141 · see citing works
Danielle Posthuma, B., Baaré, W. F. C., Pol, H. E. H., Kahn, R. S., Boomsma, D. I., & de Geus, E. J. C. (2003) · Twin Research · doi:10.1375/136905203321536254 · Cited by 139 · see citing works
Genetic and environmental contributions to neonatal brain structure: A twin study
Gilmore, J. H., Schmitt, J. E., Knickmeyer, R. C., Smith, J. K., Lin, W., Styner, M., Gerig, G., & Neale, M. C. (2010) · Human Brain Mapping · doi:10.1002/hbm.20926 · Cited by 136 · see citing works
Genetic influences on brain asymmetry: A DTI study of 374 twins and siblings
Jahanshad, N., Lee, A. D., Marina Barysheva, A., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Wright, M. J., Toga, A. W., & Thompson, P. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.236 · Cited by 133 · see citing works
Self-citationCortical Thickness Is Influenced by Regionally Specific Genetic Factors
Rimol, L. M., Panizzon, M. S., Fennema‐Notestine, C., Eyler, L. T., Fischl, B. R., Franz, C. E., Hagler, D. J., Lyons, M. J., Neale, M. C., Pacheco, J. L., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.032 · Cited by 133 · see citing works
Genetic Influences on Cortical Regionalization in the Human Brain
Chen, C., Panizzon, M. S., Eyler, L. T., Jernigan, T. L., Thompson, W., Fennema‐Notestine, C., Jak, A. J., Neale, M. C., Franz, C. E., Hamza, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.021 · Cited by 129 · see citing works
Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia
Brans, R. G. H., van Haren, N. E. M., van Baal, G. C. M., Schnack, H. G., Kahn, R. S., & Pol, H. E. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1259 · Cited by 129 · see citing works
Blokland, G. A. M., McMahon, K. L., Hoffman, J., Zhu, G., Meredith, M., Martin, N. G., Thompson, P. M., de Zubicaray, G. I., & Wright, M. J. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.03.006 · Cited by 129 · see citing works
Self-citationMultivariate Genetic Analysis of Brain Structure in an Extended Twin Design
Danielle Posthuma, B., de Geus, E. J. C., Neale, M. C., Pol, H. E. H., Baaré, W. E. C., Kahn, R. S., & Boomsma, D. I. (2000) · Behavior Genetics · doi:10.1023/a:1026501501434 · Cited by 124 · see citing works
Functional and effective frontotemporal connectivity and genetic risk for schizophrenia
Winterer, G., Coppola, R., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00532-8 · Cited by 116 · see citing works
van der Schot, A. C., Vonk, R., Brans, R. G. H., van Haren, N. E. M., Koolschijn, P. C. M. P., Nuboer, V., Schnack, H. G., van Baal, G. C. M., Boomsma, D. I., Nolen, W. A., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.541 · Cited by 114 · see citing works
Eyler, L., Prom-Wormley, E., Panizzon, M., Kaup, A., Fennema-Notestine, C., Neale, M. C., Jernigan, T., Fischl, B., Franz, C., Lyons, M. J., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr013 · Cited by 113 · see citing works
Brain Plasticity and Intellectual Ability Are Influenced by Shared Genes
Brans, R. G. H., Kahn, R. S., Schnack, H. G., van Baal, G. C. M., Posthuma, D., van Haren, N. E. M., Lepage, C., Lerch, J. P., Collins, D. L., Evans, A. C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5841-09.2010 · Cited by 109 · see citing works
Genetic regulation of regional microstructure of the corpus callosum in late life
Pfefferbaum, A., Sullivan, E. V., & Carmelli, D. (2001) · Neuroreport · doi:10.1097/00001756-200106130-00032 · Cited by 108 · see citing works
Polk, T. A., Park, J., Smith, M. R., & Park, D. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4001-07.2007 · Cited by 108 · see citing works
Genetic Contribution to Variation in Cognitive Function: An fMRI Study in Twins
Koten, J. W., Wood, G., Hagoort, P., Goebel, R., Propping, P., Willmes, K., & Boomsma, D. I. (2009) · Science · doi:10.1126/science.1167371 · Cited by 105 · see citing works
Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
Kremen, W. S., O’Brien, R. C., Panizzon, M. S., Prom‐Wormley, E. C., Eaves, L. J., Eisen, S. A., Eyler, L. T., Hauger, R. L., Fennema‐Notestine, C., Fischl, B. R., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.026 · Cited by 104 · see citing works
Thompson, P. M., Martin, N. G., & Wright, M. J. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833b764c · Cited by 99 · see citing works
Self-citationGenetic influences on thinning of the cerebral cortex during development
van Soelen, I. L. C., Brouwer, R. M., van Baal, G. C. M., Schnack, H. G., Peper, J. S., Collins, D. L., Evans, A. C., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.044 · Cited by 94 · see citing works
Brain MRI abnormalities in schizophrenia: same genes or same environment?
Rijsdijk, F. V., van Haren, N. E. M., Picchioni, M., McDonald, C., Toulopoulou, T., Pol, H. E. H., Kahn, R. S., Murray, R. M., & Sham, P. C. (2005) · Psychological Medicine · doi:10.1017/s0033291705005167 · Cited by 94 · see citing works
The contribution of genes to cortical thickness and volume
Joshi, A. A., Leporé, N., Joshi, S. H., Lee, A. D., Marina Barysheva, A., Stein, J. L., McMahon, K. L., Johnson, K., de Zubicaray, G. I., Martin, N. G., et al. (2011) · Neuroreport · doi:10.1097/wnr.0b013e3283424c84 · Cited by 91 · see citing works
Self-citationBrun, C., Leporé, N., Pennec, X., Lee, A. D., Marina Barysheva, A., Madsen, S. K., Avedissian, C., Chou, Y., de Zubicaray, G. I., McMahon, K. L., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.022 · Cited by 85 · see citing works
Self-citationMeeting the Challenges of Neuroimaging Genetics
de Zubicaray, G. I., Chiang, M.-C., McMahon, K. L., Shattuck, D. W., Toga, A. W., Martin, N. G., Wright, M. J., & Thompson, P. M. (2008) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9029-0 · Cited by 83 · see citing works
Self-citationLateralized genetic and environmental influences on human brain morphology of 8-year-old twins
Yoon, U., Fahim, C., Pérusse, D., & Evans, A. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.007 · Cited by 78 · see citing works
A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample
Schmitt, J. E., Wallace, G. L., Rosenthal, M. A., Molloy, E. A., Ordaz, S. E., Lenroot, R., Clasen, L., Blumenthal, J., Kendler, K., Neale, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.232 · Cited by 76 · see citing works
Carmelli, D., Swan, G. E., DeCarli, C. S., & Reed, T. (2002) · Biological Psychology · doi:10.1016/s0301-0511(02)00056-x · Cited by 75 · see citing works
Heritability of DTI and MTR in nine-year-old children
Brouwer, R. M., Mandl, R. C. W., Peper, J. S., van Baal, G. C. M., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.017 · Cited by 74 · see citing works
Scamvougeras, A., Kigar, D. L., Jones, D., et al. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01333-2 · Cited by 74 · see citing works
Pfefferbaum, A., Sullivan, E. V., & Carmelli, D. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00045-9 · Cited by 69 · see citing works
Double jeopardy: Twin infant mortality in the United States, 1983 and 1984
Fowler, M. G., Kleinman, J. C., Kiely, J., et al. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90215-d · Cited by 61 · see citing works
The Epigenesis of Planum Temporale Asymmetry in Twins
Eckert, M. A. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.7.749 · Cited by 57 · see citing works
Kochunov, P., Glahn, D., Winkler, A., Duggirala, R., Olvera, R. L., Cole, S., Dyer, T. D., Almasy, L., Fox, P. T., & Blangero, J. (2009) · Stroke · doi:10.1161/strokeaha.109.565390 · Cited by 54 · see citing works
Schmitt, J. E., Lenroot, R., Ordaz, S. J., Wallace, G. L., Lerch, J. P., Evans, A. C., Prom‐Wormley, E. C., Kendler, K. S., Neale, M. C., & Giedd, J. N. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.039 · Cited by 54 · see citing works
Stein, J. L., Hibar, D. P., Madsen, S. K., Khamis, M., McMahon, K. L., de Zubicaray, G. I., Hansell, N. K., Montgomery, G. W., Martin, N. G., Wright, M. J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.32 · Cited by 53 · see citing works
Self-citationTwin–singleton differences in brain structure using structural equation modelling
Pol, H. E. H., Posthuma, D., Baaré, W. F. C., de Geus, E. J. C., Schnack, H. G., van Haren, N. E. M., van Oel, C. J., Kahn, R. S., & Boomsma, D. I. (2002) · Brain · doi:10.1093/brain/awf035 · Cited by 50 · see citing works
Imaging genetics of cognitive functions: Focus on episodic memory
Rasch, B., Papassotiropoulos, A., & de Quervain, D. J. ‐. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.001 · Cited by 49 · see citing works
Eyler, L. T., Prom‐Wormley, E. C., Fennema‐Notestine, C., Panizzon, M. S., Neale, M. C., Jernigan, T. L., Fischl, B. R., Franz, C. E., Lyons, M. J., Stevens, A. A., et al. (2010) · Human Brain Mapping · doi:10.1002/hbm.21054 · Cited by 48 · see citing works
Heritability of anterior cingulate response to conflict: An fMRI study in female twins
Matthews, S. C., Simmons, A. N., Strigo, I. A., Jang, K. L., Stein, M. B., & Paulus, M. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.015 · Cited by 47 · see citing works
Yoon, U., Perusse, D., Lee, J.-M., & Evans, A. C. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.01.070 · Cited by 46 · see citing works
A genetic analysis of brain volumes and IQ in children
van Leeuwen, M., Peper, J. S., van den Berg, S. M., Brouwer, R. M., Pol, H. E. H., Kahn, R. S., & Boomsma, D. I. (2008) · Intelligence · doi:10.1016/j.intell.2008.10.005 · Cited by 44 · see citing works
Heritability of volumetric brain changes and height in children entering puberty
van Soelen, I. L. C., Brouwer, R. M., van Baal, G. C. M., Schnack, H. G., Peper, J. S., Chen, L., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21468 · Cited by 43 · see citing works
Rijsdijk, F. V., Viding, E. M., Brito, S. A. D., Forgiarini, M., Mechelli, A., Bartoli, A. J., & McCrory, E. J. P. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.20 · Cited by 43 · see citing works
Imaging the genetics of brain structure and function
de Geus, E. J. C., Goldberg, T. E., Boomsma, D. I., & Danielle Posthuma, B. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.04.002 · Cited by 42 · see citing works
Carmelli, D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00336-0 · Cited by 41 · see citing works
Mapping genetic influences on ventricular structure in twins
CHOU, Y., Leporé, N., Chiang, M. Y.-H., Avedissian, C., Marina Barysheva, A., McMahon, K. L., de Zubicaray, G. I., Meredith, M., Wright, M. J., & Toga, A. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.036 · Cited by 38 · see citing works
Self-citationWallace, G. L., Lee, N., Prom‐Wormley, E. C., Medland, S. E., Lenroot, R., CLASEN, L. S., Schmitt, J. E., Neale, M. C., & Giedd, J. N. (2010) · Behavior Genetics · doi:10.1007/s10519-009-9329-1 · Cited by 34 · see citing works
Individual variation in neural correlates of sadness in children: A twin fMRI study
Côté, C., Beauregard, M., Girard, A., Mensour, B., Mancini-Marı̈e, A., & Pérusse, D. (2007) · Human Brain Mapping · doi:10.1002/hbm.20400 · Cited by 34 · see citing works
Genetic Covariation Between Brain Volumes and IQ, Reading Performance, and Processing Speed
Betjemann, R. S., Johnson, E. P., Barnard, H. D., Boada, R., Filley, C. M., Filipek, P. A., Willcutt, E. G., DeFries, J. C., & Pennington, B. F. (2010) · Behavior Genetics · doi:10.1007/s10519-009-9328-2 · Cited by 31 · see citing works
Cannon, T. D., Thompson, P. M., van Erp, T. G. M., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., & Toga, A. W. (2006) · Neuroinformatics · doi:10.1385/ni:4:1:5 · Cited by 31 · see citing works
Bivariate Heritability of Total and Regional Brain Volumes
DeStefano, A. L., Seshadri, S. S., Beiser, A., Atwood, L. D., Massaro, J. M., Au, R., Wolf, P. A., & DeCarli, C. S. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cadd8 · Cited by 30 · see citing works
A Twin Study of Intracerebral Volumetric Relationships
Schmitt, J. E., Wallace, G. L., Lenroot, R., Ordaz, S. J., Greenstein, D. K., CLASEN, L. S., Kendler, K. S., Neale, M. C., & Giedd, J. N. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9332-6 · Cited by 28 · see citing works
Prefrontal cortex gyrification index in twins: an MRI study
Hasan, A., McIntosh, A. M., Droese, U.-A., et al. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0198-2 · Cited by 27 · see citing works
Ordaz, S. J., Lenroot, R., Wallace, G. L., CLASEN, L. S., Blumenthal, J. D., Schmitt, J. E., & Giedd, J. N. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00558.x · Cited by 24 · see citing works
A Nonconservative Lagrangian Framework for Statistical Fluid Registration—SAFIRA
Brun, C. C., Leporé, N., Pennec, X., Chou, Y., Lee, A. D., de Zubicaray, G. I., McMahon, K. L., Wright, M. J., Gee, J. C., & Thompson, P. M. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2010.2067451 · Cited by 18 · see citing works
Self-citationPanizzon, M. S., Hauger, R. L., Eaves, L. J., Chen, C., Dale, A. M., Eyler, L. T., Fischl, B. R., Fennema‐Notestine, C., Franz, C. E., Grant, M. D., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.044 · Cited by 16 · see citing works
Lee, A. D., Leporé, N., Marina Barysheva, A., Chou, Y., Brun, C., Madsen, S. K., McMahon, K. L., de Zubicaray, G. I., Meredith, M., Wright, M. J., et al. (2008) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2008.4541153 · Cited by 16 · see citing works
Self-citationPark, J., Shedden, K., & Polk, T. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.066 · Cited by 13 · see citing works
Multivariate variance-components analysis in DTI
Lee, A. D., Leporé, N., de Leeuw, J., Brun, C., Marina Barysheva, A., McMahon, K. L., de Zubicaray, G. I., Martin, N. G., Wright, M. J., & Thompson, P. M. (2010) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2010.5490199 · Cited by 11 · see citing works
Self-citationGenetic Influences on White Matter Architecture in Twins: A Diffusion Tensor Tractography Study
Hageman, N., Thompson, P. M., Shattuck, D., et al. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)71712-4 · Cited by 2 · see citing works
Genetic Influences on Hippocampal Structure Mapped in 288 Twins
Stein, J. L., DeGiorgio, A., Madsen, S., Avedissian, C., Chou, Y. Y., Morra, J. H., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Wright, M. J., et al. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)71388-6 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Neale, M. C., Baker, S. M., Xie, G., & Maes, H. H. (2002). Mx: Statistical modeling (6th ed.). Richmond, VA: Department of Psychiatry, University of Virginia.
- van Soelen, I. L. C., Brouwer, R. M., Schnack, H. G., Kahn, R. S., Hulshoff Pol, H. E., & Boomsma, D. I. (2011b). Associations between intelligence and cortical thickness emerge at the start of puberty. In Genetics of structural brain development and cognition in childhood and early adolescence (Doctoral dissertation). Vrije Universiteit, Amsterdam.
Cited by
Sorted by citations
Imaging structural and functional brain development in early childhood
Gilmore, J. H., Knickmeyer, R. C., & Gao, W. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.1 · Cited by 1,013 · see citing works
Common genetic variants influence human subcortical brain structures
Initiative, T. A. D. N., Hibar, D. P., The CHARGE Consortium, EPIGEN, IMAGEN, SYS, Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., et al. (2015) · Nature · doi:10.1038/nature14101 · Cited by 858 · see citing works
Self-citationColich, N. L., Rosen, M. L., Williams, E. S., & McLaughlin, K. A. (2020) · Psychological Bulletin · doi:10.1037/bul0000270 · Cited by 433 · see citing works
Jahanshad, N., Kochunov, P. V., Sprooten, E., Mandl, R. C., Nichols, T. E., Almasy, L., Blangero, J., Brouwer, R. M., Curran, J. E., de Zubicaray, G. I., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.061 · Cited by 393 · see citing works
Self-citationZhao, B., Luo, T., Li, T., Li, Y., Zhang, J., Shan, Y., Wang, X., Yang, L., Zhou, F., Zhu, Z., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0516-6 · Cited by 295 · see citing works
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Franke, B., Enigma Consortium, Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4228 · Cited by 216 · see citing works
Self-citationJansen, A. G., Mous, S. E., White, T., Posthuma, D., & Polderman, T. J. C. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9278-9 · Cited by 184 · see citing works
Richmond, S., Johnson, K. A., Seal, M. L., Allen, N. B., & Whittle, S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.024 · Cited by 70 · see citing works
Vuoksimaa, E., Panizzon, M. S., Hagler Jr, D. J., Hatton, S. N., Fennema‐Notestine, C., Rinker, D., Eyler, L. T., Franz, C. E., Lyons, M. J., Neale, M. C., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23502 · Cited by 58 · see citing works
Lee, S. J., Steiner, R. J., Yu, Y., Short, S. J., Neale, M. C., Styner, M. A., Zhu, H., & Gilmore, J. H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604658114 · Cited by 51 · see citing works
Avants, B. B., Hackman, D. A., Betancourt, L. M., Lawson, G. M., Hurt, H., & Farah, M. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138217 · Cited by 44 · see citing works
Quantitative tract-based white matter heritability in twin neonates
Lee, S. J., Steiner, R. J., Luo, S., Neale, M. C., Styner, M., Zhu, H., & Gilmore, J. H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.021 · Cited by 45 · see citing works
Genes contributing to subcortical volumes and intellectual ability implicate the thalamus
Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., van Haren, N. E. M., Brans, R. G. H., van Baal, G. C. M., de Geus, E. J. C., Boomsma, D. I., Kahn, R. S., & Hulshoff Pol, H. E. (2014) · Human Brain Mapping · doi:10.1002/hbm.22356 · Cited by 39 · see citing works
Mooney, M. A., Bhatt, P., Hermosillo, R. J. M., Ryabinin, P., Nikolas, M., Faraone, S. V., Fair, D. A., Wilmot, B., & Nigg, J. T. (2021) · Psychological Medicine · doi:10.1017/s0033291719004148 · Cited by 33 · see citing works
Genome-wide association analysis identifies common variants influencing infant brain volumes
Xia, K., Zhang, J., Ahn, M., Jha, S., Crowley, J. J., Szatkiewicz, J., Li, T., Zou, F., Zhu, H., Hibar, D., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.159 · Cited by 30 · see citing works
- Authors
- Blokland, G. A. M., de Zubicaray, G. I., McMahon, K. L., & Wright, M. J.
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- The University of Queensland (AU)
- Corresponding author
- Blokland, Gabriëlla A. M.
- Venue
- Twin Research and Human Genetics
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-06
- Volume
- 15
- Issue
- 3
- Pages
- 351-371
- ISSN
- 1832-4274 (ISSN-L)
- 1839-2628
- PMC
- PMC4291185
- OpenAlex
- W1864565846
- Cited by
- 221
- References
- 104
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 18 · 2022: 12 · 2021: 8 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 20 · 2016: 27 · 2015: 26 · 2014: 16 · 2013: 15 · 2012: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Twin Research and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD050735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- heritability, twin studies, neuroimaging phenotypes, genetic factors, shared environment, nonshared environment, structural MRI, diffusion tensor imaging, fractional anisotropy, cortical thickness, brain structure, uncus, parahippocampal gyrus, insula, brain activation
- MeSH terms
- Adolescent, Adult, Aged, Brain, Brain Mapping, Child, Child, Preschool, Humans, Magnetic Resonance Imaging, Middle Aged, Organ Size, Phenotype, Tomography, X-Ray Computed, Twins, Quantitative Trait, Heritable, Young Adult, Diffusion Tensor Imaging, Gene-Environment Interaction, Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
