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Cited by 319Phytochemicals and Antioxidant ActivitiesNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Youdim, Kuresh A., McDonald, Jane, Kalt, Wilhemina, Joseph, James A.·2002·The Journal of Nutritional Biochemistry
DOI 10.1016/s0955-2863(01)00221-2
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Abstract

Although antioxidant systems help control the level of reactive oxygen species they may be overwhelmed during periods of oxidative stress. Evidence suggests that oxidative stress components as well as inflammatory mediators may be involved in the pathogenesis of vascular disorders, where localized markers of oxidative damage have been found. In this regard we investigated the putative antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H(2)O(2) and TNFalpha induced damage to human microvascular endothelial cells. Polyphenols from both berries were able to localize into endothelial cells subsequently reducing endothelial cells vulnerability to increased oxidative stress at both the membrane and cytosol level. Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. In conclusion, polyphenols isolated from both blueberry and cranberry were able to afford protection to endothelial cells against stressor induced up-regulation of oxidative and inflammatory insults. This may have beneficial actions against the initiation and development of vascular diseases and be a contributing factor in the reduction of age-related deficits in neurological impairments previously reported by us.

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Crossref · 10.1016/s0955-2863(01)00221-2

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Citations

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  1. Gerritsen, 1995, Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression, Am. J Pathol., 147, 278

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Metadata

Authors
Youdim, K. A., McDonald, J., Kalt, W., & Joseph, J. A.
Affiliations
  • Tufts University (US)
  • Agriculture and Agri-Food Canada (CA)
Corresponding author
Youdim, Kuresh A.
ORCID
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2002-05
Volume
13
Issue
5
Pages
282-288
ISSN
0955-2863 (ISSN-L)
DOI
10.1016/s0955-2863(01)00221-2
OpenAlex
W1868361743
Cited by
319
References
40
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 31 · 2012: 20
FWCI
7.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Nutritional Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • Cranberry Institute
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
dietary flavonoids, blueberry polyphenols, cranberry polyphenols, anthocyanins, hydroxycinnamic acids, microvascular endothelial cells, oxidative stress, TNF-α, inflammation, antioxidant activity, interleukin-8, MCP-1, ICAM-1, vascular disease

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