Mitochondria, free radicals, and neurodegeneration

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779

Mitochondrial defect in Huntington's disease caudate nucleus

Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703

Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity

Tsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315

Ultrastructural study of synapses in the anterior horn neurons of patients with amyotrophic lateral sclerosis

Sasaki, S., & Iwata, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12314-4 · Cited by 173

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243

Complex iii releases superoxide to both sides of the inner mitochondrial membrane

Muller, F. L., Liu, Y., & Van Remmen, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407715200 · Cited by 1,036

Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Brunk, U. T., & Terman, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00959-0 · Cited by 919

Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802

Cross talk between mitochondria and NADPH oxidases

Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783

Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress

Tretter, L., & Adam-Vizi, V. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1764 · Cited by 434

The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

Wong, A. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.3.425 · Cited by 374

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

Schipper, H. M., Song, W., Zukor, H., Hascalovici, J. R., & Zeligman, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06160.x · Cited by 298

Rotenone Model of Parkinson Disease

Panov, A., Dikalov, S., Shalbuyeva, N., Taylor, G., Sherer, T., & Greenamyre, J. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508628200 · Cited by 288

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., Müller-Spahn, F., Haass, C., Czech, C., Pradier, L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405600200 · Cited by 287

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease

Sheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., & Tuttle, J. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04612.1997 · Cited by 249

The Role of Iron in Neurodegeneration: Prospects for Pharmacotherapy of Parkinson??s Disease

Jellinger, K. A. (1999) · Drugs & Aging · doi:10.2165/00002512-199914020-00004 · Cited by 218

Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Castilho, R. F., Hansson, O., Ward, M. W., Budd, S. L., & Nicholls, D. G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10277.1998 · Cited by 197

F4 ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease

Nourooz‐Zadeh, J., Liu, E. H. C., Yhlen, B., Änggåard, E. E., & Halliwell, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720734.x · Cited by 187

Increased basal ganglia iron levels in Huntington disease

Bartzokis, G., Cummings, J., Perlman, S., Hance, D. B., & Mintz, J. (1999) · Archives of Neurology · doi:10.1001/archneur.56.5.569 · Cited by 183

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

Muller, F. L., Liu, Y., Abdul-Ghani, M. A., Lustgarten, M. S., Bhattacharya, A., Jang, Y. C., & Van Remmen, H. (2008) · Biochemical Journal · doi:10.1042/bj20071162 · Cited by 150

Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice

Xie, Y., Zhou, B., Lin, M.-Y., Wang, S., Foust, K. D., & Sheng, Z.-H. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.026 · Cited by 149

Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

Sharma, D. R., Wani, W. Y., Sunkaria, A., Kandimalla, R. J., Sharma, R. K., Verma, D., Bal, A., & Gill, K. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.055 · Cited by 144

Ca2+‐induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I

Votyakova, T. V., & Reynolds, I. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03042.x · Cited by 101

Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study

Cherubini, A., Martin, A., Andres-Lacueva, C., Di Iorio, A., Lamponi, M., Mecocci, P., Bartali, B., Corsi, A., Senin, U., & Ferrucci, L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.002 · Cited by 94

A review of creatine supplementation in age-related diseases: more than a supplement for athletes

Smith, R. N., Agharkar, A. S., & Gonzales, E. B. (2014) · F1000Research · doi:10.12688/f1000research.5218.1 · Cited by 82

Neuroprotective strategies in Alzheimer’s disease

Longo, F. M., & Massa, S. M. (2004) · NeuroRx · doi:10.1602/neurorx.1.1.117 · Cited by 83

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

Carvalho, C., Correia, S. C., Santos, R. X., Cardoso, S., Moreira, P. I., Clark, T. A., Zhu, X., Smith, M. A., & Perry, G. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9247-1 · Cited by 72

Modes of Metabolic Compensation during Mitochondrial Disease Using the Drosophila Model of ATP6 Dysfunction

Celotto, A. M., Chiu, W. K., Van Voorhies, W., & Palladino, M. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025823 · Cited by 70

Alternative platelet activation pathways and their role in neurodegenerative diseases

Ferrer-Raventós, P., & Beyer, K. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105512 · Cited by 39