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Cited by 375Mitochondrial Function and PathologyAutophagy in Disease and TherapyFungal and yeast genetics research

Mitochondrial dynamics and division in budding yeast

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Shaw, Janet M, Nunnari, Jodi·2002·Trends in Cell Biology
DOI 10.1016/s0962-8924(01)02246-2PMC PMC3785940
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Abstract

Mitochondria adopt a variety of different shapes in eukaryotic cells, ranging from multiple, small compartments to elaborate tubular networks. The establishment and maintenance of different mitochondrial morphologies depends, in part, on the equilibrium between opposing fission and fusion events. Recent studies in yeast, flies, worms and mammalian cells indicate that three high-molecular-weight GTPases control mitochondrial membrane dynamics. One of these is a dynamin-related GTPase that acts on the outer mitochondrial membrane to regulate fission. Recently, genetic approaches in budding yeast have identified additional components of the fission machinery. These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution.

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Cited by

Sorted by citations

Authors
Shaw, J. M., & Nunnari, J.
Affiliations
  • University of Utah (US)
  • University of California, Davis (US)
ORCID
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2002-04
Volume
12
Issue
4
Pages
178-184
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/s0962-8924(01)02246-2
PMC
PMC3785940
OpenAlex
W2135853075
Cited by
375
References
4
Citations by year
2026: 6 · 2025: 8 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 15 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 15 · 2012: 13
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • University of Utah
  • Huntsman Cancer Institute
  • National Institute of General Medical Sciences (R01GM053466)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, mitochondrial division, mitochondrial morphology, dynamin-related GTPase, mitochondrial outer membrane, Saccharomyces cerevisiae
MeSH terms
Cell Cycle, Saccharomycetales, Intracellular Membranes, Mitochondria, GTP Phosphohydrolases, Mitochondrial Proteins

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