RAP, a novel type of ER chaperone

Bu, Guojun; Schwartz, Alan L.

doi:10.1016/s0962-8924(98)01283-5

Cited by 84

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RAP, a novel type of ER chaperone

Bu, Guojun, Schwartz, Alan L.·1998·Trends in Cell Biology

DOI 10.1016/s0962-8924(98)01283-5

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Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

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RAP binds to the LDLR ligand binding domain in the ER to promote transport along the secretory pathway towards the plasma membrane, and this association reduces the affinity of the receptor for LDL.
“RAP binds to the ligand binding domain of the LDLR (Figure 2) in the ER [35] to promote transport along the secretory pathway towards the plasma membrane (Figure 1A), with this association between RAP and the LDLR also reducing the affinity of the receptor for LDL [36].”
From Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation (2024) · cites this paper as [36]
RAP is responsible for ensuring LRP1's effective transport to the cell surface.
“As a chaperone protein, RAP is responsible for ensuring LRP1's effective transport to the cell surface (Bu & Schwartz, 1998)”
From Alzheimer's amyloid‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue (2020) · cites this paper as Bu & Schwartz, 1998

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
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Alzheimer's amyloid‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue
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Authors: Bu, G., & Schwartz, A. L.
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 1998-12
Volume: 8
Issue: 7
Pages: 272-276
ISSN: 0962-8924
DOI: 10.1016/s0962-8924(98)01283-5
Cited by: 84
References: 1
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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RAP, a novel type of ER chaperone

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