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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Open accessAbstract
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.
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“Therefore, such residues may play a more general role in IRF-containing complexes, including those involving IRF-3”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Wathelet et al., 1998
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Metadata
- Authors
- Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Maniatis, Tom
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 1
- Issue
- 4
- Pages
- 507-518
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2095194341
- Cited by
- 730
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA50661, P01CA050661)
- National Institute of Allergy and Infectious Diseases (AI20642)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
- MeSH terms
- Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2
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