The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Open accessAbstract
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, such residues may play a more general role in IRF-containing complexes, including those involving IRF-3”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Wathelet et al., 1998
Citations
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014
Self-citationTranscriptional Regulation by Extracellular signals: Mechanisms and Specificity
Hill, C. S., & Treisman, R. (1995) · Cell · doi:10.1016/0092-8674(95)90403-4 · Cited by 1,012
CREB-binding protein/p300 are transcriptional coactivators of p65
Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 820
Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649
Analysis of Chromatin Structure byin VivoFormaldehyde Cross-Linking
Orlando, V., Strutt, H. L., & Paro, R. (1997) · Methods · doi:10.1006/meth.1996.0407 · Cited by 607
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533
Research works printed but not linked: 3
- Bannister, 1995, Stimulation of c-Jun activity by CBP, Oncogene, 11, 2509
- Ness, 1996, The Myb oncoprotein, Biochim. Biophys. Acta, 1288, F123
- Wathelet, M.G., Clauss, I.M., Paillard, F., Content, J., and Huez, G.A. (1988b). Regulation of interferon-inducible genes by interferon, poly(rI)·poly(rC), and viruses. In The Biology of the Interferon System, Y. Kawade and S. Kobayashi, eds. (Tokyo: Kodansha Scientific Ltd.), pp. 11–17. · DOI
Cited by
Sorted by citations
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
Self-citationChen, X., Han, X., Yuan, P., Fang, F., Huss, M., Vega, V. B., Wong, E., Orlov, Y. L., Zhang, W., Jiang, J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.043 · Cited by 2,547
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849
Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,716
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,685
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658
Randall, R. E., & Goodbourn, S. (2007) · Journal of General Virology · doi:10.1099/vir.0.83391-0 · Cited by 1,609
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,514
Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00053-4 · Cited by 1,342
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B. G., Pitha, P. M., & Golenbock, D. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031023 · Cited by 1,193
Multiple control of interleukin-8 gene expression
Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058
Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
Goodbourn, S., Didcock, L., & Randall, R. E. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-10-2341 · Cited by 977
Sen, G. C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.255 · Cited by 969
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science · doi:10.1126/science.aaa3650 · Cited by 966
Self-citationType 1 Interferons and the Virus-Host Relationship: A Lesson in Detente
García‐Sastre, A., & Biron, C. A. (2006) · Science · doi:10.1126/science.1125676 · Cited by 880
CREB-binding Protein and p300 in Transcriptional Regulation
Vo, N., & Goodman, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000025200 · Cited by 875
IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program
Doyle, S. E., Vaidya, S. A., O’Connell, R. M., Dadgostar, H., Dempsey, P. W., Wu, T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00390-4 · Cited by 847
Stojdl, D., Lichty, B., TENOEVER, B., Paterson, J., Power, A., Knowles, S., Marius, R., Reynard, J., Poliquin, L., Atkins, H., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00241-1 · Cited by 894
Activation of innate immune antiviral responses by Nod2
Sabbah, A., Chang, T. H., Harnack, R., Frohlich, V. C., Tominaga, K., Dube, P. H., Xiang, Y., & Bose, S. (2009) · Nature Immunology · doi:10.1038/ni.1782 · Cited by 754
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H. I., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., et al. (2002) · Nature · doi:10.1038/416744a · Cited by 719
The interferon response circuit: Induction and suppression by pathogenic viruses
Haller, O., Kochs, G., & Weber, F. (2005) · Virology · doi:10.1016/j.virol.2005.09.024 · Cited by 679
Ghisletti, S., Barozzi, I., Mietton, F., Polletti, S., De Santa, F., Venturini, E., Gregory, L., Lonie, L., Chew, A., Wei, C.-L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.008 · Cited by 666
Inhibition of interferon signaling by dengue virus
Muñoz‐Jordán, J. L., Sánchez-Burgos, G., Laurent-Rolle, M., & García‐Sastre, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335168100 · Cited by 666
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647
Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M. (1998) · Genes & Development · doi:10.1101/gad.12.13.2061 · Cited by 631
Self-citationIRF7: activation, regulation, modification and function
Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 611
Transcriptional Cross Talk between NF-κB and p53
Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598
RNA recognition and signal transduction by RIG‐I‐like receptors
Yoneyama, M., & Fujita, T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00727.x · Cited by 595
Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells
Pérez-Caballero, D., Zang, T. M., Ebrahimi, A., McNatt, M. W., Gregory, D. A., Johnson, M. C., & Bieniasz, P. D. (2009) · Cell · doi:10.1016/j.cell.2009.08.039 · Cited by 590
An Atomic Model of the Interferon-β Enhanceosome
Panne, D., Maniatis, T., & Harrison, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.05.019 · Cited by 625
Self-citationHost defense, viruses and apoptosis
Barber, G. N. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400823 · Cited by 576
Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.7989-7996.2000 · Cited by 578
Interferon regulatory factors: the next generation
Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 576
Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
Muñoz‐Jordán, J. L., Laurent-Rolle, M., Ashour, J., Martínez‐Sobrido, L., Ashok, M. S., Lipkin, W. I., & García‐Sastre, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.13.8004-8013.2005 · Cited by 560
Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7
Sato, M., Hata, N., Asagiri, M., Nakaya, T., Taniguchi, T., & Tanaka, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01514-2 · Cited by 553
Roles of the NFI/CTF gene family in transcription and development
Gronostajski, R. M. (2000) · Gene · doi:10.1016/s0378-1119(00)00140-2 · Cited by 546
McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 542
Self-citationInfluenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon
Wang, X., Li, M. O., Zheng, H., Muster, T., Palese, P., Beg, A. A., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11566-11573.2000 · Cited by 536
Grandvaux, N., Servant, M. J., tenOever, B. R., Sen, G. C., Balachandran, S., Barber, G. N., Lin, R., & Hiscott, J. B. (2002) · Journal of Virology · doi:10.1128/jvi.76.11.5532-5539.2002 · Cited by 521
The Human Papillomavirus E6 protein and its contribution to malignant progression
Mantovani, F., & Banks, L. (2001) · Oncogene · doi:10.1038/sj.onc.1204869 · Cited by 519
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
Bidwell, B. N., Slaney, C. Y., Withana, N. P., Forster, S., Cao, Y., Loi, S., Andrews, D., Mikeska, T., Mangan, N. E., Samarajiwa, S. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2830 · Cited by 487
Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 476
The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3
Basler, C. F., Mikulasova, A., Martínez‐Sobrido, L., Paragas, J., Mühlberger, E., Bray, M., Klenk, H., Palese, P., & García‐Sastre, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.7945-7956.2003 · Cited by 476
Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
van Dam, H., & Castellazzi, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204239 · Cited by 462
Cheung, C. Y., Poon, L. L. M., Ng, I. H. Y., Luk, W., Sia, S. F., Wu, M. H. S., Chan, K., Yuen, K., Gordon, S., Guan, Y., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7819-7826.2005 · Cited by 461
Induction and Regulation of IFNs During Viral Infections
Malmgaard, L. (2004) · Journal of Interferon & Cytokine Research · doi:10.1089/1079990041689665 · Cited by 456
Orzalli, M. H., DeLuca, N. A., & Knipe, D. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211302109 · Cited by 422
Interferon-Lambda: A New Addition to an Old Family
Donnelly, R. P., & Kotenko, S. V. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0078 · Cited by 427
Molecular Pathways in Virus-Induced Cytokine Production
Mogensen, T. H., & Paludan, S. R. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.1.131-150.2001 · Cited by 418
Immune Response in Stat2 Knockout Mice
Park, C. Y., Li, S. C., Cha, E., & Schindler, C. (2000) · Immunity · doi:10.1016/s1074-7613(00)00077-7 · Cited by 415
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome
Xu, Q. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf492 · Cited by 418
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412584200 · Cited by 411
Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1876 · Cited by 409
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389
Kaiser, W. J., & Offermann, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4942 · Cited by 378
Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease
Edwards, M. R., Bartlett, N. W., Clarke, D., Birrell, M., Belvisi, M., & Johnston, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.003 · Cited by 375
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
Smith, G. L., Benfield, C. T. O., de Motes, C. M., Mazzon, M., Ember, S. W., Ferguson, B. J., & Sumner, R. P. (2013) · Journal of General Virology · doi:10.1099/vir.0.055921-0 · Cited by 364
Billecocq, A., Spiegel, M., Vialat, P., Kohl, A., Weber, F., Bouloy, M., & Haller, O. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.9798-9806.2004 · Cited by 364
Julkunen, I. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00026-5 · Cited by 354
Regulation of the type I IFN induction: a current view
Honda, K., Yanai, H., Takaoka, A., & Taniguchi, T. (2005) · International Immunology · doi:10.1093/intimm/dxh318 · Cited by 357
Izaguirre, A. G., Barnes, B. J., Amrute, S. B., Yeow, W.-S., Megjugorac, N. J., Dai, J., Feng, D., Chung, E., Pitha, P. M., & Fitzgerald-Bocarsly, P. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603255 · Cited by 346
Wathelet, M. G., Orr, M., Frieman, M. B., & Baric, R. S. (2007) · Journal of Virology · doi:10.1128/jvi.00702-07 · Cited by 339
Self-citationHermance, N. M., Khurana, S., Lee, T. H.-Y., Fitzgerald, K. A., & Kelliher, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506831200 · Cited by 359
Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity
tenOever, B. R., Ng, S., Chua, M. A., McWhirter, S. M., García‐Sastre, A., & Maniatis, T. (2007) · Science · doi:10.1126/science.1136567 · Cited by 342
Self-citationInactivation of Interferon Regulatory Factor-1 Tumor Suppressor Protein by HPV E7 Oncoprotein
Park, J. S., Kim, E., Kwon, H.-J., Hwang, E.-S., Namkoong, S.-E., & Um, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6764 · Cited by 333
Brzózka, K. D., Finke, S., & Conzelmann, K. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7673-7681.2005 · Cited by 322
Lin, R., Mamane, Y., & Hiscott, J. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2465 · Cited by 321
Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome
Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80145-8 · Cited by 325
García‐Sastre, A. (2001) · Virology · doi:10.1006/viro.2000.0756 · Cited by 321
Review: On the Role of IRF in Host Defense
Barnes, B. J., Lubyová, B., & Pitha, P. M. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452665 · Cited by 318
Selective Transcription in Response to an Inflammatory Stimulus
Smale, S. T. (2010) · Cell · doi:10.1016/j.cell.2010.01.037 · Cited by 327
Mukherjee, A., Morosky, S. A., Delorme‐Axford, E., Dybdahl-Sissoko, N., Oberste, M. S., Wang, T., & Coyne, C. B. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001311 · Cited by 316
Regulation of immunity and oncogenesis by the IRF transcription factor family
Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298
Noah, D. L., Twu, K. Y., & Krug, R. M. (2003) · Virology · doi:10.1016/s0042-6822(02)00127-7 · Cited by 302
Au, W.-C., Moore, P. A., LaFleur, D. W., TOMBAL, B. F., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29210 · Cited by 295
RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2
Komuro, A., & Horvath, C. M. (2006) · Journal of Virology · doi:10.1128/jvi.01325-06 · Cited by 298
A FADD-dependent innate immune mechanism in mammalian cells
Balachandran, S., Thomas, E., & Barber, G. N. (2004) · Nature · doi:10.1038/nature03124 · Cited by 300
Pandey, A. K., Yang, Y., Jiang, Z., Fortune, S. M., Coulombe, F., Behr, M. A., Fitzgerald, K. A., Sassetti, C. M., & Kelliher, M. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000500 · Cited by 292
Lin, R.-J., Chang, B.-L., Yu, H.-P., Liao, C., & Lin, Y. (2006) · Journal of Virology · doi:10.1128/jvi.02714-05 · Cited by 286
Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation
Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., & Akira, S. (2002) · International Immunology · doi:10.1093/intimm/dxf089 · Cited by 287
Spiegel, M., Pichlmair, A., Martínez‐Sobrido, L., Cros, J. F., García‐Sastre, A., Haller, O., & Weber, F. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2079-2086.2005 · Cited by 279
Lin, R., Génin, P., Mamane, Y., & Hiscott, J. B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6342-6353.2000 · Cited by 279
Paun, A., & Pitha, P. M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.01.014 · Cited by 277
Jones, C., & Chowdhury, S. I. (2007) · Animal Health Research Reviews · doi:10.1017/s146625230700134x · Cited by 274
Lin, R., Heylbroeck, C., Génin, P., Pitha, P., & Hiscott, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.959 · Cited by 325
Lin, R., Noyce, R. S., Collins, S. E., Everett, R. D., & Mossman, K. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1675-1684.2004 · Cited by 268
Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response
Mossman, K. L., Macgregor, P. F., Rozmus, J., Goryachev, A. B., Edwards, A. M., & Smiley, J. R. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.750-758.2001 · Cited by 268
Juang, Y.-T., Lowther, W. J., Kellum, M. J., Au, W.-C., Lin, R., Hiscott, J. B., & Pitha, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9837 · Cited by 266
Iwamura, T., Yoneyama, M., Yamaguchi, K., Suhara, W., Mori, W., Shiota, K., Okabe, Y., Namiki, H., & Fujita, T. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00426.x · Cited by 265
Krug, R. M., Yuan, W., Noah, D. L., & Latham, A. G. (2003) · Virology · doi:10.1016/s0042-6822(03)00119-3 · Cited by 263
Chromatin Immunoprecipitation (ChIP)Preprint
Carey, M., Peterson, C. L., & Smale, S. T. (2009) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5279 · Cited by 264
Panne, D. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.12.002 · Cited by 257
Heppner, C., Bilimoria, K. Y., Agarwal, S. K., Kester, M. B., Whitty, L., Guru, S. C., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Marx, S. J., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204529 · Cited by 264
Tsai, E. Y., Falvo, J. V., Tsytsykova, A. V., Barczak, A. K., Reimold, A. M., Glimcher, L. H., Fenton, M. J., Gordon, D. C., Dunn, I. F., & Goldfeld, A. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6084-6094.2000 · Cited by 260
Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter
Parekh, B. S., & Maniatis, T. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80181-1 · Cited by 255
Self-citation
Metadata
- Authors
- Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Maniatis, Tom
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 1
- Issue
- 4
- Pages
- 507-518
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2095194341
- Cited by
- 730
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA50661, P01CA050661)
- National Institute of Allergy and Infectious Diseases (AI20642)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
- MeSH terms
- Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review