The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo
Open accessAbstract
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.
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“Therefore, such residues may play a more general role in IRF-containing complexes, including those involving IRF-3”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Wathelet et al., 1998
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Cites
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CREB-binding protein/p300 are transcriptional coactivators of p65
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Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849
Metadata
- Authors
- Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Maniatis, Tom
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 1
- Issue
- 4
- Pages
- 507-518
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2095194341
- Cited by
- 730
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 23 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 25 · 2013: 24 · 2012: 23
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA50661, P01CA050661)
- National Institute of Allergy and Infectious Diseases (AI20642)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- IRF3, IRF7, interferon regulatory factors, P300, CBP, NF-κB, transcriptional coactivator, virus-induced gene expression, interferon-beta promoter
- MeSH terms
- Animals, Base Sequence, Cell Nucleus, DNA, DNA-Binding Proteins, Enhancer Elements, Genetic, Fungal Proteins, Cricetinae, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Respirovirus Infections, Phosphorylation, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Viral, NF-kappa B, Leucine Zippers, CHO Cells, Interferon-beta, Cyclic AMP Response Element-Binding Protein, Respirovirus, Saccharomyces cerevisiae Proteins, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, CREB-Binding Protein, Activating Transcription Factor 2
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