Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Radiosensitivity in ataxia-telangiectasia: a new explanation.

Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 795

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 773

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 766

Potential mechanisms involved in resistant phenotype of MCF-7 breast carcinoma cells to ionizing radiation induced apoptosis

Wang, Y., Zhang, H., Li, N., Wang, X., Hao, J., & Zhao, W. (2009) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2009.02.014 · Cited by 3

The BRCA1 Variant p.Ser36Tyr Abrogates BRCA1 Protein Function and Potentially Confers a Moderate Risk of Breast Cancer

Christou, C. M., Hadjisavvas, A., Kyratzi, M., Flouri, C., Neophytou, I., Anastasiadou, V., Loizidou, M. A., & Kyriacou, K. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093400 · Cited by 3

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells

Datta, A., Jackson, J., Morozov, Y. I., Qiu, J., Vindigni, A., & Greenberg, R. A. (2026) · Nature Communications · doi:10.1038/s41467-026-75271-7 · Cited by 2

Insights into Extrachromosomal DNA in Cancer: Biogenesis, Methodologies, Functions, and Therapeutic Potential

Mao, X., Rao, G., Li, G., & Chen, S. (2025) · Advanced Biology · doi:10.1002/adbi.202400433 · Cited by 2

DNA Damage Sensing and Signaling

Wood, J. L., & Chen, J. (2007) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812706782_0001 · Cited by 2

Surgical Management of High-Risk Patients

Rhei, E., Nixon, A. J., & Iglehart, J. D. (2001) · Breast Disease · doi:10.3233/bd-2001-12102 · Cited by 2

An hGCN5/TRRAP Histone Acetyltransferase Complex Co-activates BRCA1 Transactivation Function through

Oishi, H., Kitagawa, H., Wada, O., Takezawa, S., Kouzu‐Fujita, M., Takada, I., Yano, T., Yanagisawa, J., & Kato, S. (2006) · Cited by 2

BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment

Savage, K. I., & Harkin, D. P. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_18 · Cited by 3

Efficacy of neoadjuvant cisplatin and oral capecitabine in triple-negative breast cancers: a pilot study.

Tariq, K. B., Rana, F. N., Samiian, L., Kilkenny, J. W., Khan, R., & Latif, N. (2013) · PubMed · Cited by 2

Use of novel assays to measure in vivo base excision DNA repair

Sundaresakumar, P. (2009) · doi:10.31979/etd.5cd3-pbbv · Cited by 2

Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3

Zhang, C., Zhou, J.-B., Lei, J. H., Ang, I. L., Miao, K., Xu, X., Poon, T. C. W., Cheung, E. C. W., & Deng, C. (2026) · Protein & Cell · doi:10.1093/procel/pwaf104 · Cited by 1

Roles of the BRCA1 and BRCA2 Breast Cancer Susceptibility Proteins in DNA Repair

Gudmundsdottir, K. K., Witt, E., & Ashworth, A. (2006) · Springer eBooks · doi:10.1007/0-387-36802-7_4 · Cited by 1

Commentary Role of BRCA gene dysfunction in breast and ovarian cancer predisposition

Scully, R. (2000) · Cited by 1

Methods to Classify BRCA1 Variants of Uncertain Clinical Significance

Monteiro, Á. N. A., Lee, H., Coyne, R. S., McDonald, H. B., & Brody, L. C. (2004) · Cited by 1

Western Analysis of Breast Cancer 1 Protein (BRCA1)

Drake, D. M., & Wells, P. G. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9182-2_23 · Cited by 1

Somatic Genetic Development in Epithelial Ovarian Cancer

Lawrenson, K., Ramus, S. J., & Gayther, S. A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0477-5_10 · Cited by 1

Validation of a Gene-Expression Based Assay for BRCA1 Function

Uy, P. (2013) · QSpace (Queen's University Library) · Cited by 1

HUMAN DNA POLYMERASE ε

Tuusa, J. T., & Oulu, B. (2001) · Cited by 1

BRCA1 et BRCA2 : des échafaudages de réparation des lésions de l'ADN ?

Feunteun, J. (2001) · médecine/sciences · doi:10.4267/10608/1824 · Cited by 1

Novel Roles for 185delAG Mutant BRCA1 in Ovarian Cancer Pathology

Linger, R. J. (2010) · Digital Commons - University of South Florida (University of South Florida)

Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation

Flynn, R. L. (2007) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/ad72-xg56

A Proteomic Approach to Identify Phosphorylation-Dependent Targets of BRCT Domains

Songyang, Z. (2006) · Defense Technical Information Center (DTIC) · doi:10.21236/ada458980

Centriolar and ciliary responses to DNA damage

Conroy, P. C. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16788

Étude du transcriptome des cellules non tumorales de l’épithélium de surface de l’ovaire des femmes porteuses d’une mutation des gènes BRCA1 et BRCA2

Abd-Rabbo, D. (2009) · doi:10.71781/29680

Nuevas aportaciones a la caracterización de genes de susceptibilidad en cáncer de mama

Rodrigo, M. (2008) · Gredos (University of Salamanca) · doi:10.14201/gredos.22496

Investigation of a novel +ACA BRCA1 promoter polymorphism and its impact on the breast cancer susceptibility phenotype

White, K. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/nxcq-nc04

IMPLICATION DE CERTAINES MUTATIONS DANS LES GENES BRCA1 ET BRCA2 SUR LA PRÉDISPOSITION AU CANCER DU SEIN ET AU CANCER OVARIEN

Negură, L., Huma, A.-M., Artenie, V., & Carasievici, E. (2007) · DOAJ (DOAJ: Directory of Open Access Journals)

CBX2 and DNA damage repair: development of CBX2-specific reagents

Piso, K. (2008) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3zg6sk1

DNA damage response activated by anti-cancer agent, irofulven

Wiltshire, T. D. (2007) · doi:10.33915/etd.2601

Report PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009)

DNA Damage Signalling in BRCA1-Deficient Mammary Progenitor Cells Activates Autologous p52/RelB NF-κB

Sau, A. (2015) · uO Research (University of Ottawa) · doi:10.20381/ruor-4050

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ANALYSIS OF BRCA1 ACCUMULATION AT DNA DOUBLE-STRAND BREAKS USING A MOLECULAR IMAGING TECHNIQUE

Wei, L., & Chiba, N. (2009) · Nano-Biomedical Engineering (Tohoku University Global COE Programme) · doi:10.1142/9781848163539_0049

LE RÔLE DES PROTÉINES BRCA1 ET BRCA2 DANS LA RÉPARATION DES ALTÉRATIONS MOLÉCULAIRES DE L’ADN

Carasievici, E., Artenie, V., Huma, A. M., & Negură, L. (2007) · DOAJ (DOAJ: Directory of Open Access Journals)

DEVELOPMENT OF A FUNCTIONAL ASSAY FOR DETERMINATION OF BRCA1 CARRIER STATUS

Bathurst, L. (2014) · QSpace (Queen's University Library)

Modulating DNA Damage Responses for Improved Breast Cancer Therapy

Ilcheva, M. (2015)

Molecular Mechanisms of Chemotherapy Resistance in Oestrogen Receptor Positive Breast Cancer

Baxter, D. E. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with VeliparibPreprint

Alvarado-Cruz, I., Mahmoud, M. M., Khan, M., Zhao, S., Oeck, S., Meas, R., Clairmont, K., Quintana, V., Zhu, Y., Porciuncula, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.08.982785

Contribuição das variantes missense e não codificantes dos gener BRCA1/2 para a predisposição hereditária e resposta ao tratamento dos cânceres de mama e ovário

Santos, E. S. D. (2020) · theses.fr (ABES) · doi:10.11606/t.5.2020.tde-19012021-130303

Next-generation Sequencing-based Test for Resectable Colorectal Cancer in Real-world Clinical PracticePreprint

Ogiri, M., Seishima, R., Nakamura, K., Aimono, E., Matsui, S., Shigeta, K., Chiyoda, T., Tanishima, S., Okabayashi, K., Nishihara, H., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1157481/v1

BRCA1 Variant Assessment Using a Simple Analytic Assay

Kim, D. M., Feilotter, H. E., & Davey, S. K. (2021) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfab163

Managing DNA Strand Breaks in Eukaryotic Cells

Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch18

Next-Generation Sequencing-based Test for Resectable Colorectal Cancer in Real-World Clinical PracticePreprint

Ogiri, M., Seishima, R., Nakamura, K., Aimono, E., Matsui, S., Shigeta, K., Chiyoda, T., Tanishima, S., Okabayashi, K., Nishihara, H., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1157481/v2

Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

Wang, H., Chou, W., Shieh, S.-Y., & Shen, C. (2023) · doi:10.1158/0008-5472.c.6495231.v1

Data from Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

Wang, H., Chou, W., Shieh, S.-Y., & Shen, C. (2023) · doi:10.1158/0008-5472.c.6495231

Data from Functional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants

Wu, K., Hinson, S. R., Ohashi, A., Farrugia, D. J., Wendt, P., Tavtigian, S. V., Deffenbaugh, A. M., Goldgar, D. E., & Couch, F. J. (2023) · doi:10.1158/0008-5472.c.6493062

Data from Functional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants

Wu, K., Hinson, S. R., Ohashi, A., Farrugia, D. J., Wendt, P., Tavtigian, S. V., Deffenbaugh, A. M., Goldgar, D. E., & Couch, F. J. (2023) · doi:10.1158/0008-5472.c.6493062.v1

Data from The BRCA1 Pseudogene Negatively Regulates Antitumor Responses through Inhibition of Innate Immune Defense Mechanisms

Han, Y. J., Zhang, J., Lee, J. H., Mason, J. M., Karginova, O. A., Yoshimatsu, T. F., Hao, Q., Hurley, I. W., Paré, L., Prat, A., et al. (2023) · doi:10.1158/0008-5472.c.6513133.v1

Community co-designed workshops build confidence in use of functional evidence for variant classificationPreprint

Villani, R. M., Terrill, B., Tudini, E., Matotek, E., Mattiske, T., Cliffe, C. C., Thompson, B. A., Satgunaseelan, L., Hahn, C. N., Lundie, B., et al. (2025) · medRxiv · doi:10.1101/2025.11.10.25339935

Germline mutations of BRCA1 and BRCA2 genes - founder effects and contribution to ovarian carcinoma in Finland

Sarantaus, L. (2002) · Työväentutkimus Vuosikirja

Influence des hormones stéroïdes et potentiel préventif d'un antiprogestatif, l'ulpristal acétate, dans la tumorigenèse liée à la mutation du gène BRCA1

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Role of Lamin B1 dysregulation in two Enabling Forces of Cancer : Genome Instability and Inflammation

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Development of an enzymatic assay on biochip measuring DNA double strand breaks repair capacity : biological validation and applications

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BindingDB Entry 50023729: Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators.

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The Role of BRCA1 in DNA Double-strand Break Repair

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Conservation of the BRCA1 gene

Wronkowski, M. G. (2007) · RIT Scholar Works (Rochester Institute of Technology)

DNA REPAIR PATHWAYS INVOLVED IN THE FORMATION OF ANAPHASE BRIDGES

Açılan, C. (2007) · D-Scholarship@Pitt (University of Pittsburgh)

MOLECULAR TARGETS FOR RADIOSENSITIZATION

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211 BRCA1 functions as a differential modulator of chemotherapy induced apoptosis

Quinn, J. E., Kennedy, R. D., Mullan, P. B., Johnston, P. G., & Harkin, D. P. (2004) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(04)80219-2 · Cited by 215

Progress in role of breast cancer susceptibility gene 1 in DNA damage repair

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BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228

BRCA1 Promotes Induction of ssDNA by Ionizing Radiation

Schlegel, B. P., Jodelka, F. M., & Núñez, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3209 · Cited by 107

The Role of BRCA1 in DNA Double-strand Break Repair

Dever, S. M. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/f775-c418