Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Radiosensitivity in ataxia-telangiectasia: a new explanation.

Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 795

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 773

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 766

Structural Consequences of a Cancer-causing BRCA1-BRCT Missense Mutation

Williams, R. S., & Glover, J. N. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210019200 · Cited by 101

Classification of BRCA1 missense variants of unknown clinical significance

Phelan, C. M., Đapic, V., Tice, B., Favis, R., Kwan, E., Barany, F., Manoukian, S., Radice, P., van der Luijt, R. B., van Nesselrooij, B. P. M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024711 · Cited by 101

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

Davalos, A. R., & Campisi, J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200304016 · Cited by 103

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining

Baldeyron, C., Jacquemin, E., Smith, J., Jacquemont, C. F., Oliveira, I. D., Gad, S., Feunteun, J., Stoppa‐Lyonnet, D., & Papadopoulo, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205200 · Cited by 99

Farnesyltransferase Inhibitors Induce DNA Damage via Reactive Oxygen Species in Human Cancer Cells

Pan, J., She, M., Xu, Z., Sun, L., & Yeung, S. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2744 · Cited by 97

Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain

Rodríguez, J. A., Au, W. W. Y., & Henderson, B. R. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.027 · Cited by 96

Role of BRCA1 in brain development

Pao, G. M., Zhu, Q., Pérez‐García, C. G., Chou, S., Suh, H., Gage, F. H., O’Leary, D. D. M., & Verma, I. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400783111 · Cited by 101

BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis

Chen, Q., Lei, J. H., Bao, J., Wang, H., Hao, W., Li, L., Peng, C., Masuda, T., Miao, K., Xu, J., et al. (2020) · Advanced Science · doi:10.1002/advs.201903616 · Cited by 96

Biochemical DSB-repair model for mammalian cells in G1 and early S phases of the cell cycle

Taleei, R., & Nikjoo, H. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.06.004 · Cited by 94

Promoter methylation of BRCA1 in triple-negative breast cancer predicts sensitivity to adjuvant chemotherapy

Xu, Y., Diao, L., Chen, Y., Liu, Y., Wang, C. Y., Ouyang, T., Li, J., Wang, T., Fan, Z., Fan, T., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt011 · Cited by 89

BACH1 is a DNA repair protein supporting BRCA1 damage response

Peng, M., Litman, R., Jin, Z., Fong, G., & Cantor, S. B. (2006) · Oncogene · doi:10.1038/sj.onc.1209257 · Cited by 88

BRCA1 and cell signaling

Wang, Q., Zhang, H., Fishel, R. A., & Greene, M. I. (2000) · Oncogene · doi:10.1038/sj.onc.1203974 · Cited by 87

BRCA1: exploring the links to transcription

Monteiro, Á. N. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01632-7 · Cited by 87

The XIST Noncoding RNA Functions Independently of BRCA1 in X Inactivation

Xiao, C., Sharp, J. A., Kawahara, M., Davalos, A. R., Difilippantonio, M. J., Hu, Y., Li, W., Cao, L., Buetow, K. H., Ried, T., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.034 · Cited by 85

NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons

Higelin, J., Catanese, A., Semelink-Sedlacek, L. L., Oeztuerk, S., Lutz, A.-K., Bausinger, J., Barbi, G., Speit, G., Andersen, P. M., Ludolph, A. C., et al. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.06.005 · Cited by 86

BRCC36 Is Essential for Ionizing Radiation–Induced BRCA1 Phosphorylation and Nuclear Foci Formation

Chen, X., Arciero, C. A., Wang, C., Broccoli, D., & Godwin, A. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4194 · Cited by 82

Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?

Lovelock, P. K., Spurdle, A. B., Mok, M. T. S., Farrugia, D. J., Lakhani, S. R., Healey, S. C., Arnold, S., Buchanan, D. D., kConFab Investigators, Couch, F. J., et al. (2007) · Breast Cancer Research · doi:10.1186/bcr1826 · Cited by 81

Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability

Spiro, C., & McMurray, C. T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6063-6074.2003 · Cited by 78

Role of BRCAgene dysfunction in breast and ovarian cancer predisposition

Scully, R. (2000) · Breast Cancer Research · doi:10.1186/bcr76 · Cited by 78

An ATR- and BRCA1-Mediated Fanconi Anemia Pathway Is Required for Activating the G2/M Checkpoint and DNA Damage Repair upon Rereplication

Zhu, W., & Dutta, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02141-05 · Cited by 79

Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization

Okada, S., & Ouchi, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208685200 · Cited by 76

Detection of single amino acid mutation in human breast cancer by disordered plasmonic self-similar chain

Coluccio, M. L., Gentile, F., Das, G., Nicastri, A., Perri, A., Candeloro, P., Perozziello, G., Zaccaria, R. P., Gongora, J. S. T., Alrasheed, S., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500487 · Cited by 75

p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage

Jiang, J., Yang, E. S.-H., Jiang, G., Nowsheen, S., Wang, H., Wang, T., Wang, Y., Billheimer, D. D., Chakravarthy, A. B., Brown, M. A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3423 · Cited by 76

Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1

Zhou, C., Smith, J. L., & Liu, J. (2003) · Oncogene · doi:10.1038/sj.onc.1206319 · Cited by 74

Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes

Pesaran, T. F., Karam, R., Huether, R., Li, S., Farber-Katz, S., Chamberlin, A. C., Chong, H. K., LaDuca, H., & Elliott, A. M. (2016) · International Journal of Breast Cancer · doi:10.1155/2016/2469523 · Cited by 74

Viral Transport of DNA Damage That Mimics a Stalled Replication Fork

Jurvansuu, J., Raj, K., Stasiak, A., & Beard, P. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.569-580.2005 · Cited by 71

Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80

Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C., & Chiba, N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01075-08 · Cited by 78

Repression of BRCA1 through a Feedback Loop Involving p53

MacLachlan, T. K., Dash, B. C., Dicker, D. T., & El‐Deiry, W. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003338200 · Cited by 70

Sporadic Epithelial Ovarian Cancer: Clinical Relevance of BRCA1 Inhibition in the DNA Damage and Repair Pathway

Weberpals, J. I., Clark-Knowles, K. V., & Vanderhyden, B. C. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.3902 · Cited by 71

X-Ray Structures of the LXRα LBD in Its Homodimeric Form and Implications for Heterodimer Signaling

Fradera, X., Vu, D., Nimz, O., Skene, R. J., Hosfield, D. J., Wynands, R., Cooke, A., Haunsø, A., King, A. W. T., Bennett, D. J., et al. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.04.005 · Cited by 69

DNA polymerase stalling, sister chromatid recombination and the BRCA genes

Scully, R., Puget, N., & Vlasáková, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203971 · Cited by 68

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity

Willers, H., Gheorghiu, L., Liu, Q., Efstathiou, J. A., Wirth, L. J., Krause, M., & von Neubeck, C. (2015) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2015.05.007 · Cited by 69

BRCA1 in the DNA damage response and at telomeres

Rosen, E. M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00085 · Cited by 68

Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells

Francisco, D., Peddi, P., Hair, J. M., Flood, B., Cecil, A. M., Kalogerinis, P. T., Sigounas, G., & Georgakilas, A. G. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.045 · Cited by 67

Altered Proliferation and Differentiation Properties of Primary Mammary Epithelial Cells from BRCA1 Mutation Carriers

Burga, L. N., Tung, N., Troyan, S. L., Bostina, M., Konstantinopoulos, P. A., Fountzilas, H., Spentzos, D., Miron, A., Yassin, Y., Lee, B. T., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2954 · Cited by 68

Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network

Greenberg, R. A. (2008) · Chromosoma · doi:10.1007/s00412-008-0154-8 · Cited by 69

Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.

Yamane, K., Chen, J., & Kinsella, T. J. (2003) · PubMed · Cited by 66

The role of BRCA1 in non-homologous end-joining

Bau, D., Mau, Y.-C., & Shen, C. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.08.003 · Cited by 65

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Sullivan, K., Cramer-Morales, K. L., McElroy, D. L., Ostrov, D. A., Haas, K., Childers, W. E., Hromas, R., & Skórski, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147230 · Cited by 67

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

Nikkilä, J., Coleman, K. A., Morrissey, D., Pylkäs, K., Erkko, H., Messick, T. E., Karppinen, S.-M., Amelina, A., Winqvist, R., & Greenberg, R. A. (2009) · Oncogene · doi:10.1038/onc.2009.33 · Cited by 63

BRCA Gene Structure and Function in Tumor Suppression

Murphy, C. G., & Moynahan, M. E. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181cf0204 · Cited by 63

The BRCA1 RING and BRCT Domains Cooperate in Targeting BRCA1 to Ionizing Radiation-induced Nuclear Foci

Au, W. W. Y., & Henderson, B. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408879200 · Cited by 61

Chk1 is required to maintain Claspin stability

Chini, C. C. S., Wood, J., & Chen, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209447 · Cited by 62

Independence of R/M/N Focus Formation and the Presence of Intact BRCA1

Wu, X. (2000) · Science · doi:10.1126/science.289.5476.11a · Cited by 61

BRCA1 and BRCA2: The genetic testing and the current management options for mutation carriers

Palma, M., Ristori, E., Ricevuto, E., Giannini, G., & Gulino, A. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.05.003 · Cited by 61

BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin

Pageau, G. J., Hall, L. L., & Lawrence, J. B. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21188 · Cited by 60

BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication

Fridlich, R., Annamalai, D., Roy, R., Bernheim, G., & Powell, S. N. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.03.002 · Cited by 67

BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest

Ongusaha, P. P., Ouchi, T., Kim, K., Nytko, E. A., Kwak, J. C., Duda, R. B., Deng, C., & Lee, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206439 · Cited by 56

The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer

Xia, F., & Powell, S. N. (2002) · Seminars in Radiation Oncology · doi:10.1053/srao.2002.35250 · Cited by 57

DNA Damage–Induced Cytotoxicity Is Dissociated from BRCA1's DNA Repair Function but Is Dependent on Its Cytosolic Accumulation

Wang, H., Yang, E. S.-H., Jiang, J., Nowsheen, S., & Xia, F. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4713 · Cited by 58

Basal-Like Breast Cancer: Update on Clinicopathologic, Immunohistochemical, and Molecular Features

Leidy, J., Khan, A. A., & Kandil, D. H. (2013) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012-0439-ra · Cited by 57

Structural Requirements for the BARD1 Tumor Suppressor in Chromosomal Stability and Homology-directed DNA Repair

Reyngold, M., Nandula, S. V., Modi, A. P., Wang, S., Jasin, M., Murty, V. V. V. S., Ludwig, T., & Baer, R. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705198200 · Cited by 56

BRCA1 and p53: compensatory roles in DNA repair

Hartman, A., & Ford, J. M. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0477-0 · Cited by 62

BRCA1 Mutation: A Predictive Marker for Radiation Therapy?

Kan, C. E., & Zhang, J. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.05.037 · Cited by 54

Functional assays for BRCA1 and BRCA2

Carvalho, M. A., Couch, F. J., & Monteiro, Á. N. A. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.08.002 · Cited by 58

The different outcomes between breast-conserving surgery and mastectomy in triple-negative breast cancer: a population-based study from the SEER 18 database

Chen, Q.-X., Wang, X.-X., Lin, P.-Y., Zhang, J., Li, J.-J., Song, C.-G., & Shao, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.13976 · Cited by 54

BRCA1 16 years later: risk‐associated BRCA1 mutations and their functional implications

Linger, R. J., & Kruk, P. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07735.x · Cited by 52

Prediction of BRCA2-association in hereditary breast carcinomas using array-CGH

Joosse, S. A., Brandwijk, K. I. M., Devilee, P., Wesseling, J., Hogervorst, F. B. L., Verhoef, S., & Nederlof, P. M. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1016-7 · Cited by 53

Functional and physical interaction between the mismatch repair and FA-BRCA pathways

Williams, S. A., Wilson, J. B., Clark, A. P., Mitson‐Salazar, A., Tomashevski, A., Ananth, S., Glazer, P. M., Semmes, O. J., Bale, A. E., Jones, N. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr366 · Cited by 52

Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy

Ali, R., McIntosh, S., & Savage, K. I. (2020) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22921 · Cited by 52

Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays

Sadeghi, F., Asgari, M., Matloubi, M., Ranjbar, M., Yousefi, N. K., Azari, T., & Zaki‐Dizaji, M. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00133-5 · Cited by 55

Genome‐wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co‐activation

Gardini, A., Baillat, D., Cesaroni, M., & Shiekhattar, R. (2014) · The EMBO Journal · doi:10.1002/embj.201385567 · Cited by 51

Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

Dever, S. M., Golding, S. E., Rosenberg, E., Adams, B. R., Idowu, M. O., Quillin, J. M., Valerie, N. C. K., Xu, B., Povirk, L. F., & Valerie, K. C. (2011) · Aging · doi:10.18632/aging.100325 · Cited by 50

BRCT Domains: phosphopeptide binding and signaling modules

María, C. (2008) · Frontiers in bioscience · doi:10.2741/3125 · Cited by 51

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

Hair, J. M., Terzoudi, G. I., Hatzi, V. I., Lehockey, K. A., Srivastava, D., Wang, W., Pantelias, G. E., & Georgakilas, A. G. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.046 · Cited by 48

Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG‐1 ovarian cancer cells

Gopala, S., Annab, L. A., Gopinath, G., Banerji, A., & Srinivas, P. (2003) · Molecular Carcinogenesis · doi:10.1002/mc.10164 · Cited by 47

AKT regulates BRCA1 stability in response to hormone signaling

Nelson, A., Lyons, T. R., Young, C. D., Hansen, K. C., Anderson, S. M., & Holt, J. T. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.019 · Cited by 46

BRCA1 Pathway Function in Basal-Like Breast Cancer Cells

Hill, S. J., Clark, A. P., Silver, D. P., & Livingston, D. M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01646-13 · Cited by 44

Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells

Rass, E., Chandramouly, G., Zha, S., Alt, F. W., & Xie, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445825 · Cited by 43

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

Chen, Y., Xu, J., Borowicz, S., Collins, C., Huo, D., & Olopade, O. I. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-246 · Cited by 45

Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach

kConFab, Tischkowitz, M. D., Hamel, N., Carvalho, M. A., Birrane, G., Soni, A., van Beers, E. H., Joosse, S. A., Wong, N., Novak, D. J., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.13 · Cited by 45

Brca1-Deficient Murine Mammary Epithelial Cells have Increased Sensitivity to CDDP and MMS

Sgagias, M. K., Wagner, K., Hamik, B., Stoeger, S. M., Spieker, R. S., Huber, L. J., Chodosh, L. A., & Cowan, K. H. (2004) · Cell Cycle · doi:10.4161/cc.3.11.1211 · Cited by 44

Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1

Grigorova, M., Staines, J. M., Özdağ, H., Caldas, C., & Edwards, P. A. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077512 · Cited by 43

Chromosomal mutagen sensitivity associated with mutations in BRCA genes

Speit, G., & Trenz, K. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077511 · Cited by 43

Association of BRCA1 with the inactive X chromosome and XIST RNA

Ganesan, S., Silver, D. P., Drapkin, R., Greenberg, R. A., Feunteun, J., & Livingston, D. M. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1371 · Cited by 43

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks

Chabalier-Taste, C., Brichese, L., Racca, C., Canitrot, Y., Calsou, P., & Larminat, F. (2016) · Oncotarget · doi:10.18632/oncotarget.6825 · Cited by 42

Characterization of a Novel Trans-Activation Domain of BRCA1 That Functions in Concert with the BRCA1 C-terminal (BRCT) Domain

Hu, Y., Miyake, T., Ye, Q., & Li, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000607200 · Cited by 42

BRCA1 modulates ionizing radiation‐induced nuclear focus formation by the replication protein A p34 subunit

Choudhary, S. K., & Li, R. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10081 · Cited by 42

HumanBRCA1 gene rescues the embryonic lethality ofBrca1 mutant mice

Chandler, J., Hohenstein, P., Swing, D. A., Tessarollo, L., & Sharan, S. K. (2001) · genesis · doi:10.1002/1526-968x(200102)29:2 · Cited by 42

A yeast recombination assay to characterize humanBRCA1missense variants of unknown pathological significance

Caligo, M. A., Bonatti, F., Guidugli, L., Aretini, P., & Galli, A. (2008) · Human Mutation · doi:10.1002/humu.20817 · Cited by 41

Deregulation of BRCA1 Leads to Impaired Spatiotemporal Dynamics of γ-H2AX and DNA Damage Responses in Huntington’s Disease

Jeon, G. S., Kim, K. Y., Hwang, Y. J., Jung, M.-K., An, S., Ouchi, M., Ouchi, T., Kowall, N. W., Lee, J.-H., & Ryu, H. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8274-9 · Cited by 46

Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

Sun, C., Zhang, F., Xiang, T., Chen, Q., Pandita, T. K., Huang, Y., Hu, M. C. ‐., & Yang, Q. (2014) · Oncotarget · doi:10.18632/oncotarget.1952 · Cited by 40

Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization and Recruitment to DNA Damage

Nelson, A., & Holt, J. T. (2010) · Radiation Research · doi:10.1667/rr1290.1 · Cited by 40

MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination

Zhang, F., Bick, G., Park, J., & Andreassen, P. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.111872 · Cited by 42

Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death

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