Cited by 1,198DNA Repair MechanismsBlood disorders and treatmentsPARP inhibition in cancer therapy

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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

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Garcia-Higuera, Irene, Taniguchi, Toshiyasu, Ganesan, Shridar, Meyn, M.Stephen, Timmers, Cynthia, Hejna, James, Grompe, Markus, D'Andrea, Alan D·2001·Molecular Cell

DOI 10.1016/s1097-2765(01)00173-3

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Abstract

Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation. Although six FA genes (for subtypes A, C, D2, E, F, and G) have been cloned, their relationship to DNA repair remains unknown. In the current study, we show that a nuclear complex containing the FANCA, FANCC, FANCF, and FANCG proteins is required for the activation of the FANCD2 protein to a monoubiquitinated isoform. In normal (non-FA) cells, FANCD2 is monoubiquitinated in response to DNA damage and is targeted to nuclear foci (dots). Activated FANCD2 protein colocalizes with the breast cancer susceptibility protein, BRCA1, in ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes. The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes.

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The ubiquitin-proteasome proteolytic pathway
Ciechanover, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90396-4 · Cited by 1,804
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
RING Finger Proteins
Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
Huibregtse, J. M., Scheffner, M., Beaudenon, S. L., & Howley, P. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2563 · Cited by 1,011
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain
Treier, M., Staszewski, L. M., & Bohmann, D. (1994) · Cell · doi:10.1016/s0092-8674(94)90502-9 · Cited by 919
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

Show all 71 references

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Items 901–1,000 of 1,000

FANCD2: A branch-point in DNA damage response?
Grompe, M. (2002) · Nature Medicine · doi:10.1038/nm0602-555 · Cited by 9
Self-citation
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Yin, G. (2006) · Frontiers in bioscience · doi:10.2741/1899 · Cited by 9
The molecular biology of Fanconi anemia.
Tamary, H., Bar-Yam, R., Zemach, M., Dgany, O., Shalmon, L., & Yaniv, I. (2002) · PubMed · Cited by 9
Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia
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MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair
Marek, L. R., Kottemann, M. C., Glazer, P. M., & Bale, A. E. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.12.009 · Cited by 9
Analysis of baseline and cisplatin-inducible gene expression in Fanconi anemia cells using oligonucleotide-based microarrays
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TOPBP1 , CLSPN and PALB2 genes in familial breast cancer susceptibility
Erkko, H. (2008) · Cited by 9
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Macaisne, N., Touzón, M. S., Rajkovic, A., & Yanowitz, J. L. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02494-0 · Cited by 8
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Zhao, L., Li, Y., He, M., Song, Z. J., Lin, S., Yu, Z., Bai, X., WANG, N., & Wei, M. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2400 · Cited by 8
Retracted
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Expression of FANCD2 in sporadic breast cancer and clinicopathological analysis
Zhang, B., Chen, R., Lu, J., Shi, Q., Zhang, X., & Chen, J. (2010) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-010-0350-7 · Cited by 8
Regulation of Fanconi anemia protein FANCD2 monoubiquitination by miR-302
Suresh, B., Kumar, A. M., Jeong, H.-S., Cho, Y.-H., Ramakrishna, S., & Kim, K.-S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.127 · Cited by 8
Signalling DNA Damage
Joaquin, A., & Fernández-Capetillo, Ó. (2012) · InTech eBooks · doi:10.5772/50863 · Cited by 14
Cell Cycle Control of Germ Cell Differentiation
Spiller, C. M., & Koopman, P. A. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-19065-0_13 · Cited by 8
BRCA1 and BRCA2 in Breast Cancer Predisposition and Recombination Control
Scully, R., & Xie, A. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000048771.93906.3e · Cited by 8
Update on childhood neutropenia: molecular and clinical advances
Dror, Y., & Sung, L. (2004) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2004.06.013 · Cited by 8
Impaired removal of DNA interstrand cross‐link in Nijmegen breakage syndrome and Fanconi anemia, but not in BRCA‐defective group
Tsuchida, K., & Komatsu, K. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00915.x · Cited by 8
Investigation of FANCA gene in Fanconi anaemia patients in Iran
Mahjoubi, F., Moghadam, A. A. S., Reisi, N., & Parvaneh, V. (2016) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.180206 · Cited by 8
Functional Annotation of Deubiquitinating Enzymes Using RNA Interference
Dirac, A. M. G., Nijman, S. M. B., Brummelkamp, T. R., & Bernards, R. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)98045-2 · Cited by 8
De-ubiquitinating enzymes: intracellular signalling and disease
Johnston, J. A., & Burrows, J. F. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340764 · Cited by 8
Identification, developmental expression and regulation of the Xenopus ortholog of human FANCG/XRCC9
Stone, S., Sobeck, A., van Kogelenberg, M., de Graaf, B., Joenje, H., Christian, J. L., & Hoatlin, M. E. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01096.x · Cited by 8
Disruption of the fanconi anemia pathway in human cancer in the general population
Jacquemont, C. F., & Taniguchi, T. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3658 · Cited by 8
Self-citation
The clastogenic response of the 1q12 heterochromatic region to DNA cross-linking agents is independent of the Fanconi anaemia pathway
Callén, E., Ramı́rez, M. J., Creus, A., Marcos, R., Frı́as, S., Molina, B., Badell, I., Olivé, T., Ortega, J., & Surrallés, J. (2002) · Carcinogenesis · doi:10.1093/carcin/23.8.1267 · Cited by 8
Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients
Vikhanskaya, F., & Broggini, M. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)19013-9 · Cited by 8
Fanconi Anemia: Challenges in Diagnosis and Management—A Case Series Report
Eghbali, A., Safdari, S. M., Roozbahani, M. Y., Tavajohi, K., & Hosseini, S. (2024) · Clinical Case Reports · doi:10.1002/ccr3.9583 · Cited by 7
Menin signaling and therapeutic targeting in breast cancer
Liu, P., Shi, C., Qiu, L., Shang, D., Tu, Z., Tu, Z., & Liu, H. (2024) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2024.101118 · Cited by 7
DNA Damage: Placing BRCA1 in the Proper Context
Aressy, B., & Greenberg, R. A. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.046 · Cited by 7
FANCL, as in ligase
Grompe, M. (2003) · Nature Genetics · doi:10.1038/ng1003-113 · Cited by 7
Self-citation
Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure
Vierra, D. A., Garzon, J. L., Rego, M. A., Adroved, M. M., Mauro, M., & Howlett, N. G. (2017) · Oncotarget · doi:10.18632/oncotarget.19470 · Cited by 7
FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair
Paquin, K. L., Mamrak, N. E., Garzon, J. L., Cantres-Velez, J. A., Azzinaro, P. A., Vuono, E. A., Lima, K. E., Camberg, J. L., & Howlett, N. G. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00194-19 · Cited by 7
Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity
Cantres-Velez, J. A., Blaize, J. L., Vierra, D. A., Boisvert, R. A., Garzon, J. L., Piraino, B., Tan, W., Deans, A. J., & Howlett, N. G. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00234-21 · Cited by 8
Activation of the Fanconi anemia/BRCA pathway at low doses of ionization radiation
Bosch, P. C., Bogliolo, M., & Surrallés, J. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.06.010 · Cited by 7
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Madjunkova, S., Kocheva, S. A., & Plaseska‐Karanfilska, D. (2013) · Acta Haematologica · doi:10.1159/000355191 · Cited by 7
The role of ubiquitin-binding domains in human pathophysiology
Sokratous, K., Hadjisavvas, A., Diamandis, E. P., & Kyriacou, K. C. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.915287 · Cited by 7
Fanconi anemia D2 protein is an apoptotic target mediated by caspases
Park, S.-J., Beck, B. D., Saadatzadeh, M. R., Haneline, L. S., Clapp, D. W., & Lee, S. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23161 · Cited by 7
Cross-links between Fanconi anaemia and BRCA2
West, S. C. (2003) · DNA repair · doi:10.1016/s1568-7864(02)00168-4 · Cited by 8
The Fanconi Anemia Pathway of DNA Repair and Human Cancer
Krishnan, V., Tay, L. S., & Ito, Y. (2015) · InTech eBooks · doi:10.5772/59995 · Cited by 7
Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network
Bick, G., Zhang, F., Meetei, A. R., & Andreassen, P. R. (2016) · Chromosoma · doi:10.1007/s00412-016-0602-9 · Cited by 8
Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance
Ghosal, K., Agatemor, C., Han, R. I., Ku, A. T., Thomas, S., & Mukherjee, S. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666200103114556 · Cited by 8
Genetic instability in the RAD51 and BRCA1 regions in breast cancer
Nowacka‐Zawisza, M., Bryś, M., Romanowicz‐Makowska, H., Kulig, A., & Krajewska, W. M. (2006) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-006-0063-x · Cited by 7
Oncofertilité et cancer du sein
Sonigo, C., Grynberg, M., Bringer-Deutsch, S., & Sermondade, N. (2019) · Bulletin du Cancer · doi:10.1016/s0007-4551(20)30047-3 · Cited by 7
The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line
Takata, M., Yamamoto, K., Matsushita, N., Kitao, H., Hirano, S., & Ishaiai, M. (2006) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-4896-8_17 · Cited by 7
Connecting Fanconi's anaemia to breast cancer predisposition
Venkitaraman, A. R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11414-0 · Cited by 7
Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts
Pipaón, C., Casado, J. A., Bueren, J. A., & Fernández-Luna, J. L. (2003) · Blood · doi:10.1182/blood-2003-06-2091 · Cited by 7
BRCA/Fanconi anemia pathway genes in hereditary predisposition to breast cancer
Sólyom, S. (2011) · Cited by 7
Hematopoietic Cell Transplantation for Fanconi Anemia
Wagner, J. E., MacMillan, M. L., & Auerbach, A. D. (2003) · Wiley eBooks · doi:10.1002/9780470987070.ch109 · Cited by 7
Hereditary predisposition to breast cancer – with a focus on AATF , MRG15 , PALB2 , and three Fanconi anaemia genes
Haanpää, M. K. (2014) · Cited by 6
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An unexpected butadiene diolepoxide-mediated genotoxicity implies alternative mechanism for 1,3-butadiene carcinogenicity
Nakamura, J., Carro, S., Gold, A. R., & Zhang, Z. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129149 · Cited by 6
Systemic Therapy for Hereditary Breast Cancers
Harvey-Jones, E. J., Lord, C. J., & Tutt, A. N. J. (2022) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.08.018 · Cited by 6
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Sato, K., Ishiai, M., Takata, M., & Kurumizaka, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114752 · Cited by 6
The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia
Stanley, E. C., Azzinaro, P. A., Vierra, D. A., Howlett, N. G., & Irvine, S. Q. (2016) · Evolutionary Bioinformatics · doi:10.4137/ebo.s37920 · Cited by 6
The role of ubiquitin signaling pathway on liver regeneration in rats
Yaylacı, A. Ö., & Canbek, M. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04482-5 · Cited by 6
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Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair
Andreev, V. I., Hristova, R. H., Asparuhova, M., Danovski, G., Stoynov, S., & Gospodinov, A. G. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.12.007 · Cited by 6
Understanding aplastic anaemia/bone-marrow failure syndromes
Ahmed, M., & Dokal, I. S. (2009) · Paediatrics and Child Health · doi:10.1016/j.paed.2009.04.004 · Cited by 6
Relationship between chromosome fragility, aneuploidy and severity of the haematological disease in Fanconi anaemia
Callén, E., Ramı́rez, M. J., Creus, A., Marcos, R., Ortega, J., Olivé, T., Badell, I., & Surrallés, J. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00081-7 · Cited by 6
Fanconi anemia: genetic analysis of a human disease using chicken system
Takata, M., Kitao, H., & Ishiai, M. (2007) · Cytogenetic and Genome Research · doi:10.1159/000103197 · Cited by 6
Transcription reprogramming and endogenous DNA damage
Li, L. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103754 · Cited by 5
Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
Dhillon, K. K., & Taniguchi, T. (2015) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-14151-0_18 · Cited by 5
Self-citation
Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy
Chen, C. C., Kahle, K. T., Ng, K., Nitta, M., & D’Andrea, A. D. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-553-8_28 · Cited by 5
Self-citation
Proteolytic control of genome integrity at the replication fork
Rageul, J., Weinheimer, A. S., Park, J. J., & Kim, H. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102657 · Cited by 5
Endocrine profiling in patients with Fanconi anemia, homozygous for a FANCG founder mutation
Dillon, B., Feben, C., Segal, D. G., du Plessis, J., Reynders, D. T., Wainwright, R., Poole, J., & Krause, A. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1351 · Cited by 5
DNA Damage Response Pathways and Cancer
Ford, J. M., & Kastan, M. B. (2008) · Elsevier eBooks · doi:10.1016/b978-0-443-06694-8.50013-0 · Cited by 5
Fanconi anemia and breast cancer: what's the connection?
Youssoufian, H. (2001) · Nature Genetics · doi:10.1038/86832 · Cited by 5
Ubiquitin and SUMO pathways in DNA replication and replication-coupled repair
Fiedorowicz, L., Baxley, R. M., Hendrickson, E. A., & Bielinsky, A. (2025) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2025.2574638 · Cited by 4
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Role of various DNA repair pathways in chromosomal inversion formation in CHO mutants
Cartwright, I. M., & Kato, T. A. (2015) · International Journal of Radiation Biology · doi:10.3109/09553002.2015.1101499 · Cited by 4
The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
Bogliolo, M., & Surrallés, J. (2013) · Cited by 4
Aurora A kinase is required for activation of the Fanconi anemia/ BRCA pathway upon DNA damage
Chun, M. J., Hwang, S. K., Kim, H. G., Goh, S., Kim, S., & Lee, C. H. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12087 · Cited by 4
Role of Protein Ubiquitination and its Functional Importance
Wang, X., Wei, X., & Zhang, H. (2015) · Scientia Sinica Vitae · doi:10.1360/n052015-00065 · Cited by 4
Generating New FANCA-Deficient HNSCC Cell Lines by Genomic Editing Recapitulates the Cellular Phenotypes of Fanconi Anemia
Errazquin, R., Sieiro, E., Moreno‐Sanchez, P. M., Ramı́rez, M. J., Lorz, C., Peral, J., Ortiz, J., Casado, J. A., Roman‐Rodriguez, F. J., Hanenberg, H., et al. (2021) · Genes · doi:10.3390/genes12040548 · Cited by 4
“Dub”bing a tumor suppressor pathway
Niedźwiedź, W., & Patel, K. J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.01.018 · Cited by 4
Expression and purification of human FANCI and FANCD2 using Escherichia coli cells
Takahashi, D., Sato, K., Shimomuki, M., Takata, M., & Kurumizaka, H. (2014) · Protein Expression and Purification · doi:10.1016/j.pep.2014.08.012 · Cited by 4
The Ubiquitin/SUMO Pathway and Radial Ray Deficiency Syndromes
Al-Qattan, M. M. (2012) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e318236452b · Cited by 4
Understanding complexity of Fanconi anaemia
Mohanty, D. (2016) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.180196 · Cited by 4
Hereditary Breast and Ovarian Cancer Genes
Scully, R., & Puget, N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-328-3:041 · Cited by 4
Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2−/− mouse long-term bone marrow cultures
Zhang, X., Hou, W., Epperly, M. W., Rigatti, L. H., Wang, H., Franicola, D., Sivanathan, A., & Greenberger, J. S. (2016) · Oncotarget · doi:10.18632/oncotarget.12036 · Cited by 4
Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA cross-linking
Phelps, R. A., Gingras, H., & Hockenbery, D. M. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.034 · Cited by 4
The broken genome: Genetic and pharmacologic approaches to breaking DNA
Woo, L. L., Onel, K., & Ellis, N. A. (2007) · Annals of Medicine · doi:10.1080/08035250601167136 · Cited by 4
Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity
Longmire, P., Zeltzer, S., Zarrella, K., Daigle, O., Svoboda, M., Reitsma, J. M., Terhune, S. S., Bobak, C. A., Bosco, G., & Goodrum, F. D. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1445 · Cited by 3
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Gupta, D., & Maddika, S. (2025) · Essays in Biochemistry · doi:10.1042/ebc20253031 · Cited by 3
BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment
Savage, K. I., & Harkin, D. P. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_18 · Cited by 3
The emergence of a unified mechanism in the Fanconi anemia pathway
Xu, X., Guo, R., & Xu, D. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00053-y · Cited by 3
BRCA1 linked with Fanconi anemia
Holding, C. (2001) · Genome biology · doi:10.1186/gb-2001-2-5-reports0014 · Cited by 3
Milestones in Fanconi Anemia Research
Digweed, M., Hoehn, H., & Sperling, K. (2007) · KARGER eBooks · doi:10.1159/000102546 · Cited by 3
Human Genetic Disorders Associated with Genome Instability, Premature Aging and Cancer Predisposition
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Authors: Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D.
Affiliations: Harvard University (US)
Dana-Farber Cancer Institute (US)
Hospital for Sick Children (CA)
Oregon Health & Science University (US)
ORCID: Taniguchi, Toshiyasu
Ganesan, Shridar
Meyn, M.Stephen
Timmers, Cynthia
Hejna, James
Grompe, Markus
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2001-02
Volume: 7
Issue: 2
Pages: 249-262
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(01)00173-3
OpenAlex: W1991841649
Cited by: 1,198
References: 71
Citations by year: 2026: 14 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 25 · 2019: 41 · 2018: 28 · 2017: 20 · 2016: 54 · 2015: 49 · 2014: 51 · 2013: 44 · 2012: 66
FWCI: 31.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4549 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL54785-04, R01HL52725-04, R01HL052725)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK043889, R01DK43889-09)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: Fanconi anemia, BRCA1, FANCD2 monoubiquitination, FANCA, FANCC, FANCF, FANCG, DNA repair, radiosensitivity, mitomycin C sensitivity, synaptonemal complex, meiotic chromosomes, nuclear foci, cancer susceptibility
MeSH terms: Animals, Cell Line, Cell Survival, DNA Damage, DNA-Binding Proteins, Fanconi Anemia, Fluorescent Antibody Technique, Genetic Complementation Test, Humans, Male, Meiosis, Nuclear Proteins, Protein Binding, Proteins, Radiation, Ionizing, Spermatocytes, Synaptonemal Complex, Ubiquitins, Ultraviolet Rays, Mitomycin, Cell Cycle Proteins, BRCA1 Protein, Active Transport, Cell Nucleus, Macromolecular Substances, Mice, Fanconi Anemia Complementation Group Proteins, Fanconi Anemia Complementation Group C Protein

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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

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