The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway
Open accessAbstract
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation. Although six FA genes (for subtypes A, C, D2, E, F, and G) have been cloned, their relationship to DNA repair remains unknown. In the current study, we show that a nuclear complex containing the FANCA, FANCC, FANCF, and FANCG proteins is required for the activation of the FANCD2 protein to a monoubiquitinated isoform. In normal (non-FA) cells, FANCD2 is monoubiquitinated in response to DNA damage and is targeted to nuclear foci (dots). Activated FANCD2 protein colocalizes with the breast cancer susceptibility protein, BRCA1, in ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes. The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Since BRCA1 interacts with FancD2 and mediates FancD2 foci formation after treatment with MMC (Bunting et al., 2012; Garcia-Higuera et al., 2001; Vandenberg et al., 2003)”
From The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression (2014) · cites this paper as Garcia-Higuera et al., 2001
Experimental — accuracy not yet measuredIn the citing paper
“In addition, DNA damage induces the accumulation of BRCA-FA proteins in nuclear foci [33].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The ubiquitin-proteasome proteolytic pathway
Ciechanover, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90396-4 · Cited by 1,804
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151
Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
Huibregtse, J. M., Scheffner, M., Beaudenon, S. L., & Howley, P. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2563 · Cited by 1,011
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain
Treier, M., Staszewski, L. M., & Bohmann, D. (1994) · Cell · doi:10.1016/s0092-8674(94)90502-9 · Cited by 919
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
Cited by
Sorted by citations
Items 201–300 of 1,000
Henning, W., & Stürzbecher, H.-W. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00291-9 · Cited by 143
Kalb, R., Neveling, K., Hoehn, H., Schneider, H., Linka, Y., Batish, S. D., Hunt, C., Berwick, M., Callén, E., Surrallés, J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/517616 · Cited by 139
Self-citationXPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair
Bhagwat, N. R., Olsen, A. L., Wang, A. T., Hanada, K., Stuckert, P., Kanaar, R., D’Andrea, A. D., Niedernhofer, L. J., & McHugh, P. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00086-09 · Cited by 141
Self-citationCdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage
Johnson, N., Cai, D. D., Kennedy, R. D., Pathania, S., Arora, M., Li, Y.-C., D’Andrea, A. D., Parvin, J. D., & Shapiro, G. I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.036 · Cited by 141
Self-citationA FancD2-Monoubiquitin Fusion Reveals Hidden Functions of Fanconi Anemia Core Complex in DNA Repair
Matsushita, N., Kitao, H., Ishiai, M., Nagashima, N., Hirano, S., Okawa, K., Ohta, T., Yu, D. S., McHugh, P. J., Hickson, I. D., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.018 · Cited by 142
Hazlehurst, L. A., Enkemann, S. A., Beam, C. A., Argilagos, R. F., Painter, J. S., Shain, K. H., Saporta, S., Boulware, D. C., Moscinski, L. C., Alsina, M., et al. (2003) · PubMed · Cited by 138
Fang, S., Lorick, K. L., Jensen, J. P., & Weissman, A. M. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00095-0 · Cited by 148
Pathways for repairing and tolerating the spectrum of oxidative DNA lesions
Berquist, B. R., & Wilson, D. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.02.001 · Cited by 136
RAD51C is a susceptibility gene for ovarian cancer
Pelttari, L. M., Heikkinen, T., Thompson, D. J., Kallioniemi, A. H., Schleutker, J., Holli, K., BLOMQVIST, C. P., Aittomäki, K., Bützow, R. C., & Nevanlinna, H. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr229 · Cited by 141
What is the DNA repair defect underlying Fanconi anemia?
Duxin, J. P., & Walter, J. C. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.09.002 · Cited by 139
Bagby, G. C., & Alter, B. P. (2006) · Seminars in Hematology · doi:10.1053/j.seminhematol.2006.04.005 · Cited by 139
Hodskinson, M. R. G., Šilhán, J., Crossan, G. P., Garaycoechea, J. I., Mukherjee, S., Johnson, C. M., Schärer, O. D., & Patel, K. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.014 · Cited by 141
Yamamoto, K., Hirano, S., Ishiai, M., Morishima, K., Kitao, H., Namikoshi, K., Kimura, M., Matsushita, N., Arakawa, H., Buerstedde, J.-M., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.34-43.2005 · Cited by 136
Targeted disruption of the murine Fanconi anemia gene,Fancg/Xrcc9
Yang, Y., Kuang, Y., Oca, R. M. D., Hays, T., Moreau, L. A., Lu, N., Seed, B., & D’Andrea, A. D. (2001) · Blood · doi:10.1182/blood.v98.12.3435 · Cited by 135
Self-citationThe FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response
Huang, M., Kim, J. M., Shiotani, B., Yang, K., Zou, L., & D’Andrea, A. D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.005 · Cited by 141
Self-citationTNF-α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells
Li, J., Sejas, D. P., Zhang, X., Qiu, Y., Nattamai, K., Rani, R., Rathbun, K. R., Geiger, H., Williams, D. A., Bagby, G. C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31772 · Cited by 141
Chromosomal breakage syndromes and the BRCA1 genome surveillance complex
Futaki, M., & Liu, J. M. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02178-5 · Cited by 135
FANCC interacts with Hsp70 to protect hematopoietic cells from IFN‐γ/TNF‐α‐mediated cytotoxicity
Pang, Q., Keeble, W. W., Christianson, T. A., Faulkner, G. R., & Bagby, G. C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4478 · Cited by 134
Identification of the Fanconi Anemia Complementation Group I Gene, FANCI
Dorsman, J. C., Levitus, M., Rockx, D., Rooimans, M. A., Oostra, A. B., Haitjema, A., Bakker, S. T., Steltenpool, J., Schuler, D., Mohan, S., et al. (2007) · Analytical Cellular Pathology · doi:10.1155/2007/151968 · Cited by 133
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
Oca, R. M. D., Andreassen, P. R., Margossian, S. P., Gregory, R. C., Taniguchi, T., Wang, X., Houghtaling, S. R., Grompe, M., & D’Andrea, A. D. (2004) · Blood · doi:10.1182/blood-2003-11-3997 · Cited by 134
Self-citationBRCA1-independent ubiquitination of FANCD2
Vandenberg, C. J., Gergely, F., Ong, C. Y., Pace, P., Mallery, D. L., Hiom, K., & Patel, K. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00281-8 · Cited by 131
A novel diagnostic screen for defects in the Fanconi anemia pathway
Shimamura, A., Oca, R. M. D., Svenson, J. L., Haining, W. N., Moreau, L. A., Nathan, D. G., & D’Andrea, A. D. (2002) · Blood · doi:10.1182/blood-2002-05-1399 · Cited by 131
Self-citationReduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice
Koomen, M. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.3.273 · Cited by 131
The ubiquitin landscape at DNA double-strand breaks
Messick, T. E., & Greenberg, R. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200908074 · Cited by 134
Caretaker tumour suppressor genes that defend genome integrity
Levitt, N. C., & Hickson, I. D. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02298-0 · Cited by 138
Who's on first in the cellular response to DNA damage?
Cline, S. D., & Hanawalt, P. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1101 · Cited by 129
The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
Rajendra, E., Oestergaard, V. H., Langevin, F., Wang, M., Dornan, G. L., Patel, K. J., & Passmore, L. A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.001 · Cited by 133
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
Bogliolo, M., Lyakhovich, A., Callén, E., Castellà, M., Cappelli, E., Ramı́rez, M. J., Creus, A., Marcos, R., Kalb, R., Neveling, K., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601574 · Cited by 128
An Emerging Model for BAP1’s Role in Regulating Cell Cycle Progression
Eletr, Z. M., & Wilkinson, K. D. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9184-6 · Cited by 133
Cerrato, A., Morra, F., & Celetti, A. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0456-2 · Cited by 132
The Fanconi Anemia Pathway and Fertility
Tsui, V., & Crismani, W. (2019) · Trends in Genetics · doi:10.1016/j.tig.2018.12.007 · Cited by 130
Translesion DNA synthesis polymerases in DNA interstrand crosslink repair
Ho, T. V., & Schärer, O. D. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20573 · Cited by 131
Identification of genes induced by BRCA1 in breast cancer cells
Atalay, A., Crook, T. J., Öztürk, M., & Yuluğ, I. G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02751-1 · Cited by 126
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
Zhang, S., Yajima, H., Huynh, H., Zheng, J., Callén, E., Chen, H. T., Wong, N., Bunting, S. F., Lin, Y., Li, M., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201009074 · Cited by 136
Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway
Martínez, D. L., Liang, C., & Cohn, M. A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2218-x · Cited by 134
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM
Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y. M., Arakawa, H., Buerstedde, J.-M., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600534 · Cited by 127
Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations
Chiu, R. K., Brun, J., Ramaekers, C. H. M. A., Theys, J., Weng, L., Lambin, P., Gray, D. A., & Wouters, B. G. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0020116 · Cited by 128
RTEL1 contributes to DNA replication and repair and telomere maintenance
Uringa, E.-J., Lisaingo, K., Pickett, H. A., Brind’Amour, J., Rohde, J.-H., Zelensky, A. N., Essers, J., & Lansdorp, P. M. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-03-0179 · Cited by 130
TopBP1 assembles nuclear condensates to switch on ATR signaling
Frattini, C., Promonet, A., Alghoul, E., Vidal-Eychenié, S., Lamarque, M., Blanchard, M., Urbach, S., Basbous, J., & Constantinou, A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.049 · Cited by 126
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks
Pichierri, P., Franchitto, A., & Rosselli, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600277 · Cited by 128
Ohta, T., & Fukuda, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207371 · Cited by 123
BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork
Long, D. T., Joukov, V., Budzowska, M., & Walter, J. C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.012 · Cited by 124
FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair
Xue, Y., Li, Y., Guo, R., Ling, C., & Wang, W. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn054 · Cited by 124
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
Lachaud, C., Moreno, A., Marchesi, F., Toth, R. L., Blow, J. J., & Rouse, J. W. (2016) · Science · doi:10.1126/science.aad5634 · Cited by 119
RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer
Somyajit, K., Subramanya, S., & Nagaraju, G. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq210 · Cited by 122
Choreography of recombination proteins during the DNA damage response
Lisby, M., & Rothstein, R. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.007 · Cited by 126
Phosphorylation of FANCD2 on Two Novel Sites Is Required for Mitomycin C Resistance
Ho, G. P. H., Margossian, S. P., Taniguchi, T., & D’Andrea, A. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02018-05 · Cited by 118
Self-citationBRCA1 interacts directly with the Fanconi anemia protein FANCA
Folias, A. E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2591 · Cited by 118
The capacity of oocytes for DNA repair
Stringer, J. M., Winship, A., Liew, S. H., & Hutt, K. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2833-9 · Cited by 121
Gibbs‐Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, J. V., Choudhary, C., Bekker‐Jensen, S., & Mailand, N. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.12.001 · Cited by 116
Zhang, X., Succi, J., Feng, Z., Prithivirajsingh, S., Story, M. D., & Legerski, R. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9207-9220.2004 · Cited by 119
Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1
Hussain, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg266 · Cited by 117
CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
Chen, C. C., Kennedy, R. D., Sidi, S., Look, A. T., & D’Andrea, A. D. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-24 · Cited by 115
Self-citationNew complexities for BRCA1 and BRCA2
Kerr, P., & Ashworth, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00389-x · Cited by 117
Gaymes, T. J., North, P. S., Brady, N., Hickson, I. D., Mufti, G. J., & Rassool, F. V. (2002) · Oncogene · doi:10.1038/sj.onc.1205331 · Cited by 114
Radiosensitivity in Fanconi's anemia patients
Alter, B. P. (2002) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(01)00474-1 · Cited by 114
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1
Parmar, K., Kim, J., Sykes, S. M., Shimamura, A., Stuckert, P., Zhu, K., Hamilton, A., Deloach, M. K., Kutok, J. L., Akashi, K., et al. (2010) · Stem Cells · doi:10.1002/stem.437 · Cited by 113
Self-citationGenomic instability and cancer: Lessons learned from human papillomaviruses
Korzeniewski, N., Spardy, N. A., Duensing, A. U., & Duensing, S. M. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.10.013 · Cited by 118
Knockdown of Zebrafish Fancd2 Causes Developmental Abnormalities via p53-Dependent Apoptosis
Liu, T. X., Howlett, N. G., Deng, M., Langenau, D. M., Hsu, K., Rhodes, J., Kanki, J. P., D’Andrea, A. D., & Look, A. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00339-3 · Cited by 115
Self-citationFANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
Alcón, P., Shakeel, S., Chen, Z. A., Rappsilber, J., Patel, K. J., & Passmore, L. A. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0380-1 · Cited by 112
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Collis, S. J., Barber, L. J., Clark, A. J., Martin, J. S., Ward, J. D., & Boulton, S. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1555 · Cited by 112
The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA
Crossan, G. P., & Patel, K. J. (2011) · The Journal of Pathology · doi:10.1002/path.3002 · Cited by 115
Qiao, F., Moss, A., & Kupfer, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101855200 · Cited by 111
Peng, L. J., Bian, X. W., Li, D. K., Xu, C. S., Wang, G., Xia, Q. Y., & Xiong, Q. (2015) · Scientific Reports · doi:10.1038/srep13413 · Cited by 116
Willers, H., Taghian, A. G., Luo, C., Treszezamsky, A. D., Sgroi, D. C., & Powell, S. N. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0149 · Cited by 110
The FANCM family of DNA helicases/translocases
Whitby, M. C. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.012 · Cited by 109
Inherited aplastic anaemias/bone marrow failure syndromes
Dokal, I. S., & Vulliamy, T. (2008) · Blood Reviews · doi:10.1016/j.blre.2007.11.003 · Cited by 110
Viral Perturbations of Host Networks Reflect Disease Etiology
Gulbahce, N., Yan, H., Dricot, A., Padi, M., Byrdsong, D., Franchi, R., Lee, D., Rozenblatt–Rosen, O., Mar, J. C., Calderwood, M. A., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002531 · Cited by 110
The role of BRCA1 in DNA double-strand repair: Past and present
Caestecker, K. W., & Van de Walle, G. R. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.013 · Cited by 108
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery
Chaudhury, I., Sareen, A., Raghunandan, M., & Sobeck, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt348 · Cited by 115
Structure of the Fanconi anaemia monoubiquitin ligase complex
Shakeel, S., Rajendra, E., Alcón, P., O’Reilly, F. J., Chorev, D. S., Maslen, S., Degliesposti, G., Russo, C. J., He, S., Hill, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1703-4 · Cited by 107
Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1
Cantor, S. B., & Guillemette, S. (2011) · Future Oncology · doi:10.2217/fon.10.191 · Cited by 106
“In addition, DNA damage induces the accumulation of BRCA-FA proteins in nuclear foci [33].”
Futaki, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.1.67 · Cited by 106
Callen, E. (2004) · Blood · doi:10.1182/blood-2004-07-2588 · Cited by 106
Pang, Q., Christianson, T. A., Keeble, W. W., Koretsky, T., & Bagby, G. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209386200 · Cited by 106
Hinz, J. M., Yamada, N. A., Salazar, E. P., Tebbs, R. S., & Thompson, L. H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.03.005 · Cited by 107
Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination
Liang, Z., Liang, F., Teng, Y., Chen, X., Liu, J., Longerich, S., Rao, T., Green, A. M., Collins, N. B., Xiong, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.084 · Cited by 104
How Fanconi anemia proteins promote the four Rs: Replication, recombination, repair, and recovery
Thompson, L. H., Hinz, J. M., Yamada, N. A., & Jones, N. J. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20109 · Cited by 106
DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination
Moldovan, G., Madhavan, M. V., Mirchandani, K. D., McCaffrey, R. M., Vinciguerra, P., & D’Andrea, A. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01124-09 · Cited by 103
Self-citationMinding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks
Nagaraju, G., & Scully, R. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.020 · Cited by 103
The evolution of meiosis: Recruitment and modification of somatic DNA-repair proteins
Marcon, E., & Møens, P. B. (2005) · BioEssays · doi:10.1002/bies.20264 · Cited by 106
Modularized Functions of the Fanconi Anemia Core Complex
Huang, Y., Leung, J. W. C., Lowery, M. G., Matsushita, N., Wang, Y., Shen, X. H., Do, H., Takata, M., Chen, J., & Li, L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.029 · Cited by 109
hMutSβ Is Required for the Recognition and Uncoupling of Psoralen Interstrand Cross-Links In Vitro
Zhang, N., Lu, X., Zhang, X., Peterson, C. A., & Legerski, R. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2388-2397.2002 · Cited by 103
Hematopoietic Dysfunction in a Mouse Model for Fanconi Anemia Group D1
Navarro, S., Meza, N. W., Bustamante, O. Q., Casado, J. A., Jacome, A., McAllister, K. A., Puerto, S., Surrallés, J., Segovia, J. C., & Bueren, J. A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.018 · Cited by 110
Liu, Q., Ghosh, P., Magpayo, N., Testa, M., Tang, S., Gheorghiu, L., Biggs, P. J., Paganetti, H., Efstathiou, J. A., Lu, H., et al. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2014.12.046 · Cited by 101
Current Topics in DNA Double-Strand Break Repair
Kobayashi, J., Iwabuchi, K., Miyagawa, K., Sonoda, E., Suzuki, K., Takata, M., & Tauchi, H. (2008) · Journal of Radiation Research · doi:10.1269/jrr.07130 · Cited by 102
Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents
Tanasova, M., & Sturla, S. J. (2012) · Chemical Reviews · doi:10.1021/cr2001367 · Cited by 101
Toward A variable RBE for proton beam therapy
Willers, H., Allen, A. R., Grosshans, D. R., McMahon, S. J., von Neubeck, C., Wiese, C., & Vikram, B. (2018) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2018.05.019 · Cited by 101
FANCL Replaces BRCA1 as the Likely Ubiquitin Ligase Responsible for FANCD2 Monoubiquitination
Meetei, A. R., Yan, Z., & Wang, W. (2004) · Cell Cycle · doi:10.4161/cc.3.2.656 · Cited by 103
In search of tumor suppressing functions of menin
Yang, Y., & Hua, X. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.032 · Cited by 101
Telomere dysfunction in genome instability syndromes
Callén, E., & Surrallés, J. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.06.003 · Cited by 106
Down-regulation of BRCA1 in BCR-ABL–expressing hematopoietic cells
Deutsch, É., Jarrousse, S., Selimoglu‐Buet, D., Dugray, A., Bonnet, M., Vozenin, M., Guilhot, F., Turhan, A. G., Feunteun, J., & Bourhis, J. (2003) · Blood · doi:10.1182/blood-2002-10-3011 · Cited by 100
Godthelp, B. C., Artwert, F., Joenje, H., & Zdzienicka, M. Z. (2002) · Oncogene · doi:10.1038/sj.onc.1205656 · Cited by 100
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
Wang, H., Xiang, D., Liu, B., He, A., Randle, H. J., Zhang, K. X., Dongre, A., Sachs, N., Clark, A. P., Tao, L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.002 · Cited by 102
Zheng, L., Dai, H., Zhou, M., Li, X., Liu, C., Guo, Z., Wu, X., Wu, J., Wang, C., Zhong, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1825 · Cited by 105
The Fanconi road to cancer: Figure 1.Preprint
D’Andrea, A. D. (2003) · Genes & Development · doi:10.1101/gad.1128303 · Cited by 99
Self-citationEvidence for subcomplexes in the Fanconi anemia pathway
Medhurst, A. L., Laghmani, E. H., Steltenpool, J., Ferrer, M., Fontaine, C., de Groot, J., Rooimans, M. A., Scheper, R. J., Meetei, A. R., Wang, W., et al. (2006) · Blood · doi:10.1182/blood-2005-11-008151 · Cited by 101
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
Callén, E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.4.439 · Cited by 98
Multifaceted Fanconi Anemia Signaling
Che, R., Zhang, J., Nepal, M. K., Han, B., & Fei, P. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.11.006 · Cited by 97
Cheng, W.-H., Kusumoto, R., Opresko, P. L., Sui, X., Huang, S., Nicolette, M. L., Paull, T. T., Campisi, J., Seidman, M. M., & Bohr, V. A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl362 · Cited by 98
Metadata
- Authors
- Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D.
- Affiliations
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Hospital for Sick Children (CA)
- Oregon Health & Science University (US)
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 7
- Issue
- 2
- Pages
- 249-262
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1991841649
- Cited by
- 1,198
- References
- 71
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 25 · 2019: 41 · 2018: 28 · 2017: 20 · 2016: 54 · 2015: 49 · 2014: 51 · 2013: 44 · 2012: 66
- FWCI
- 31.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL54785-04, R01HL52725-04, R01HL052725)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK043889, R01DK43889-09)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- Fanconi anemia, BRCA1, FANCD2 monoubiquitination, FANCA, FANCC, FANCF, FANCG, DNA repair, radiosensitivity, mitomycin C sensitivity, synaptonemal complex, meiotic chromosomes, nuclear foci, cancer susceptibility
- MeSH terms
- Animals, Cell Line, Cell Survival, DNA Damage, DNA-Binding Proteins, Fanconi Anemia, Fluorescent Antibody Technique, Genetic Complementation Test, Humans, Male, Meiosis, Nuclear Proteins, Protein Binding, Proteins, Radiation, Ionizing, Spermatocytes, Synaptonemal Complex, Ubiquitins, Ultraviolet Rays, Mitomycin, Cell Cycle Proteins, BRCA1 Protein, Active Transport, Cell Nucleus, Macromolecular Substances, Mice, Fanconi Anemia Complementation Group Proteins, Fanconi Anemia Complementation Group C Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
