Cited by 1,198DNA Repair MechanismsBlood disorders and treatmentsPARP inhibition in cancer therapy

The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Open access

Garcia-Higuera, Irene, Taniguchi, Toshiyasu, Ganesan, Shridar, Meyn, M.Stephen, Timmers, Cynthia, Hejna, James, Grompe, Markus, D'Andrea, Alan D·2001·Molecular Cell

DOI 10.1016/s1097-2765(01)00173-3

Open this paper in CoChat — free account Open PDF

Abstract

Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation. Although six FA genes (for subtypes A, C, D2, E, F, and G) have been cloned, their relationship to DNA repair remains unknown. In the current study, we show that a nuclear complex containing the FANCA, FANCC, FANCF, and FANCG proteins is required for the activation of the FANCD2 protein to a monoubiquitinated isoform. In normal (non-FA) cells, FANCD2 is monoubiquitinated in response to DNA damage and is targeted to nuclear foci (dots). Activated FANCD2 protein colocalizes with the breast cancer susceptibility protein, BRCA1, in ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes. The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s1097-2765(01)00173-3

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The ubiquitin-proteasome proteolytic pathway
Ciechanover, A. J. (1994) · Cell · doi:10.1016/0092-8674(94)90396-4 · Cited by 1,804
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
RING Finger Proteins
Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
Huibregtse, J. M., Scheffner, M., Beaudenon, S. L., & Howley, P. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2563 · Cited by 1,011
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain
Treier, M., Staszewski, L. M., & Bohmann, D. (1994) · Cell · doi:10.1016/s0092-8674(94)90502-9 · Cited by 919
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

Show all 71 references

Sorted by citations

Items 401–500 of 1,000

FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis
Kato, Y., Alavattam, K. G., Sin, H., Meetei, A. R., Pang, Q., Andreassen, P. R., & Namekawa, S. H. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv244 · Cited by 68
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Tonzi, P., Yin, Y., Lee, C. W. T., Rothenberg, E., & Huang, T. T. (2018) · eLife · doi:10.7554/elife.41426 · Cited by 69
DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity
Willers, H., Gheorghiu, L., Liu, Q., Efstathiou, J. A., Wirth, L. J., Krause, M., & von Neubeck, C. (2015) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2015.05.007 · Cited by 69
ATR–ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway
Shigechi, T., Tomida, J., Sato, K., Kobayashi, M., Eykelenboom, J. K., Pessina, F., Zhang, Y., Uchida, E., Ishiai, M., Lowndes, N. F., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2904 · Cited by 69
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
Sharma, S., Helchowski, C. M., & Canman, C. E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.11.002 · Cited by 71
Monoubiquitylation in the Fanconi anemia DNA damage response pathway
Alpi, A. F., & Patel, K. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.019 · Cited by 67
The Molecular Basis of the Sodium Dodecyl Sulfate Effect on Human Ubiquitin Structure: A Molecular Dynamics Simulation Study
Jafari, M., Mehrnejad, F., Rahimi, F., & Asghari, S. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20669-7 · Cited by 67
Bone marrow failure syndromes in children
Alter, B. P. (2002) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(02)00031-7 · Cited by 67
Structural basis of generic versus specific E2–RING E3 interactions in protein ubiquitination
Gundogdu, M., & Walden, H. (2019) · Protein Science · doi:10.1002/pro.3690 · Cited by 67
Role of homologous recombination in DNA interstrand crosslink repair
Hinz, J. M. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20577 · Cited by 68
The structure of the FANCM–MHF complex reveals physical features for functional assembly
Tao, Y., Jin, C., Li, X., Qi, S., Chu, L., Niu, L., Yao, X., & Teng, M. (2012) · Nature Communications · doi:10.1038/ncomms1779 · Cited by 66
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
Jacquemont, C. F., Simon, J. A., D’Andrea, A. D., & Taniguchi, T. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-26 · Cited by 69
Self-citation
Fanconi anemia group A and C double-mutant mice
Noll, M., Battaile, K. P., Bateman, R. L., Lax, T. P., Rathbun, K., Reifsteck, C. A., Bagby, G. C., Finegold, M. J., Olson, S. B., & Grompe, M. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00838-x · Cited by 66
Self-citation
The DNA double-strand break response pathway: becoming more BRCAish than ever
Ting, N. S. Y., & Lee, W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.026 · Cited by 67
Dynamic targeting of the replication machinery to sites of DNA damage
Solomon, D. A., Cardoso, M. C., & Knudsen, E. S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312048 · Cited by 67
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance
Engel, J. L., Zhang, X., Wu, M., Wang, Y., Valle-Inclán, J. E., Hu, Q., Woldehawariat, K. S., Sanders, M. A., Smogorzewska, A., Chen, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.001 · Cited by 66
Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture
Hoskins, E. E., Morris, T. A., Higginbotham, J. M., Spardy, N. A., Cha, E., Kelly, P. N., Williams, D., Wikenheiser‐Brokamp, K. A., Duensing, S. M., & Wells, S. I. (2008) · Oncogene · doi:10.1038/onc.2008.416 · Cited by 65
The Fanconi anemia pathway: Repairing the link between DNA damage and squamous cell carcinoma
Romick‐Rosendale, L. E., Lui, V. W. Y., Grandis, J. R., & Wells, S. I. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2013.01.001 · Cited by 66
Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair
Sato, K., Ishiai, M., Toda, K., Furukoshi, S., Osakabe, A., Tachiwana, H., Takizawa, Y., Kagawa, W., Kitao, H., Dohmae, N., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.197 · Cited by 65
Involvement of Homologous Recombination in Carcinogenesis
Reliene, R., Bishop, A. J. R., & Schiestl, R. H. (2007) · Advances in genetics · doi:10.1016/s0065-2660(06)58003-4 · Cited by 66
Structural Basis of Ubiquitin Recognition by the Ubiquitin-associated (UBA) Domain of the Ubiquitin Ligase EDD
Kozlov, G., Nguyen, L., Lin, T., Crescenzo, G. D., Park, M., & Gehring, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705655200 · Cited by 65
Crosslinks and crosstalk
Risinger, M. A., & Groden, J. L. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.12.001 · Cited by 65
Dedicated to the core: Understanding the Fanconi anemia complex
Gurtan, A. M., & D’Andrea, A. D. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.009 · Cited by 67
Self-citation
FANCI Protein Binds to DNA and Interacts with FANCD2 to Recognize Branched Structures
Yuan, F., Hokayem, J. A. E., Zhou, W., & Zhang, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016006 · Cited by 64
A role for WRN in telomere-based DNA damage responses
Eller, M. S., Liao, X., Liu, S., Hanna, K., Bäckvall, H., Opresko, P. L., Bohr, V. A., & Gilchrest, B. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607332103 · Cited by 65
Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
Ceccaldi, R., Briot, D., Larghero, J., Vasquez, N., d’Enghien, C. D., Chamousset, D., Noguera, M., Waisfisz, Q., Hermine, O., Pondarré, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43836 · Cited by 71
Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway
Song, I. Y., Palle, K., Gurkar, A. U., Tateishi, S., Kupfer, G. M., & Vaziri, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138206 · Cited by 67
A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network
Yan, Z., Guo, R., Paramasivam, M., Shen, W., Ling, C., Fox, D., Wang, Y., Oostra, A. B., Kuehl, J., Lee, D., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.026 · Cited by 64
Fanconi anemia proteins stabilize replication forks
Wang, L. C., Stone, S., Hoatlin, M. E., & Gautier, J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.005 · Cited by 67
C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair
Collis, S. J., Barber, L. J., Ward, J. D., Martin, J. S., & Boulton, S. J. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.06.010 · Cited by 67
The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
Swuec, P., Renault, L. L. R., Borg, A. J., Shah, F., Murphy, V. J., van Twest, S., Snijders, A. P., Deans, A. J., & Costa, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.013 · Cited by 63
New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant
Tebbs, R. S., Hinz, J. M., Yamada, N. A., Wilson, J. B., Salazar, E. P., Thomas, C. B., Jones, I. M., Jones, N. J., & Thompson, L. H. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.013 · Cited by 62
Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase
Sareen, A., Chaudhury, I., Adams, N., & Sobeck, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks638 · Cited by 62
FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Park, E., Kim, H., Kim, J. M., Primack, B., Vidal-Cardenas, S. L., Xu, Y., Price, B. D., Mills, A. A., & D’Andrea, A. D. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.017 · Cited by 66
Self-citation
Specificity and disease in the ubiquitin system
Chaugule, V. K., & Walden, H. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150209 · Cited by 65
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway
Hoskins, E. E., Gunawardena, R. W., Habash, K. B., Wise-Draper, T. M., Jansen, M., Knudsen, E. S., & Wells, S. I. (2008) · Oncogene · doi:10.1038/onc.2008.121 · Cited by 63
Yeast two-hybrid screens imply involvement of fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport
Reuter, T., Medhurst, A. L., Waisfisz, Q., Zhi, Y., Herterich, S., Hoehn, H., Gross, H. J., Joenje, H., Hoatlin, M. E., Mathew, C. G., et al. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00261-1 · Cited by 62
A Growing Network of Cancer-Susceptibility Genes
Venkitaraman, A. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmcibr023150 · Cited by 65
Targeting abnormal DNA double strand break repair in cancer
Rassool, F. V., & Tomkinson, A. E. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0493-5 · Cited by 62
Numerical chromosomal changes and risk of development of myelodysplastic syndrome–acute myeloid leukemia in patients with Fanconi anemia
Mehta, P. A., Harris, R. E., Davies, S. M., Kim, M., Mueller, R. A., Lampkin, B. C., Mo, J., Myers, K. C., & Smolarek, T. A. (2010) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2010.07.127 · Cited by 61
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
Lensch, M. W. (2003) · Blood · doi:10.1182/blood-2002-09-2781 · Cited by 61
The Fanconi anemia pathway and ubiquitin
Jacquemont, C. F., & Taniguchi, T. (2007) · BMC Biochemistry · doi:10.1186/1471-2091-8-s1-s10 · Cited by 63
Self-citation
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-linksPreprint
Rickman, K. A., Noonan, R. J., Lach, F. P., Sridhar, S., Wang, A. T., Abhyankar, A., Huang, A. L., Kelly, M. C., Auerbach, A. D., & Smogorzewska, A. (2020) · Genes & Development · doi:10.1101/gad.336446.120 · Cited by 65
Recent advances in understanding hematopoiesis in Fanconi Anemia
Bagby, G. C. (2018) · F1000Research · doi:10.12688/f1000research.13213.1 · Cited by 61
The Fanconi anemia pathway and ICL repair: implications for cancer therapy
Wang, L. C., & Gautier, J. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.502166 · Cited by 63
Functional Interaction between the Fanconi Anemia D2 Protein and Proliferating Cell Nuclear Antigen (PCNA) via a Conserved Putative PCNA Interaction Motif
Howlett, N. G., Harney, J. A., Rego, M. A., Kolling, F. W., & Glover, T. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016352 · Cited by 61
Hsp90 regulates the Fanconi anemia DNA damage response pathway
Oda, T., Hayano, T., Miyaso, H., Takahashi, N., & Yamashita, T. (2007) · Blood · doi:10.1182/blood-2006-08-038638 · Cited by 61
Ubiquitylation and the Fanconi anemia pathway
Garner, E., & Smogorzewska, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.078 · Cited by 62
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications
Alavattam, K. G., Kato, Y., Sin, H., Maezawa, S., Kowalski, I. J., Zhang, F., Pang, Q., Andreassen, P. R., & Namekawa, S. H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.073 · Cited by 62
Correct mRNA Processing at a Mutant TT Splice Donor in FANCC Ameliorates the Clinical Phenotype in Patients and Is Enhanced by Delivery of Suppressor U1 snRNAs
Hartmann, L., Neveling, K., Borkens, S., Schneider, H., Freund, M., Grassman, E., Theiss, S., Wawer, A., Burdach, S. E. G., Auerbach, A. D., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.08.016 · Cited by 60
Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair
Sengerová, B., Wang, A. T., & McHugh, P. J. (2011) · Cell Cycle · doi:10.4161/cc.10.23.18385 · Cited by 59
HES1 is a novel interactor of the Fanconi anemia core complex
Tremblay, C. S., Huang, F. F., Habi, O., Huard, C., Godin, C., Lévesque, G., & Carreau, M. (2008) · Blood · doi:10.1182/blood-2008-04-152710 · Cited by 59
DNA interstrand crosslink repair in mammalian cells
McCabe, K. M., Olson, S. B., & Moses, R. E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21811 · Cited by 59
Atg19p Ubiquitination and the Cytoplasm to Vacuole Trafficking Pathway in Yeast
Baxter, B. K., Abeliovich, H., Zhang, X., Stirling, A. G., Burlingame, A. L., & Goldfarb, D. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508064200 · Cited by 59
MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double‐strand break repair
Lopez‐Roques, C., Coulombe, Y., Delannoy, M., Vignard, J., Grossi, S., Brodeur, I., Rodrigue, A., Gautier, J., Stasiak, A. Z., Stasiak, A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.193 · Cited by 64
HPV-16 E7 Reveals a Link between DNA Replication Stress, Fanconi Anemia D2 Protein, and Alternative Lengthening of Telomere–Associated Promyelocytic Leukemia Bodies
Spardy, N. A., Duensing, A. U., Hoskins, E. E., Wells, S. I., & Duensing, S. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0224 · Cited by 59
Heterozygosity for p53 (Trp53 +/−) Accelerates Epithelial Tumor Formation in Fanconi Anemia Complementation Group D2 (Fancd2) Knockout Mice
Houghtaling, S. R., Granville, L. A., Akkari, Y. M. N., Torimaru, Y., Olson, S. B., Finegold, M. J., & Grompe, M. (2005) · Cancer Research · doi:10.1158/0008-5472.85.65.1 · Cited by 61
Self-citation
Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues
Birkelbach, M. A., Ferraiolo, N., Gheorghiu, L., Pfäffle, H. N., Daly, B. D. T., Ebright, M. I., Spencer, C., O’Hara, C., Whetstine, J. R., Benes, C. H., et al. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31827ecf83 · Cited by 59
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks
Ling, C., Huang, J., Yan, Z., Li, Y., Ohzeki, M., Ishiai, M., Xu, D., Takata, M., Seidman, M. M., & Wang, W. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.47 · Cited by 59
An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability
Mitxelena, J., Apraiz, A., Vallejo-Rodríguez, J., García‐Santisteban, I., Fullaondo, A., Álvarez‐Fernández, M., Malumbres, M., & Zubiaga, A. M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky218 · Cited by 61
DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
Liang, F., Miller, A. S., Longerich, S., Tang, C., Maranon, D. G., Williamson, E. A., Hromas, R., Wiese, C., Kupfer, G. M., & Sung, P. (2019) · Nature Communications · doi:10.1038/s41467-019-10408-5 · Cited by 59
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11
Digweed, M., Demuth, I., Rothe, S., Scholz, R., Jordan, A., Grötzinger, C., Schindler, D., Grompe, M., & Sperling, K. (2002) · Oncogene · doi:10.1038/sj.onc.1205616 · Cited by 59
Self-citation
USP45 deubiquitylase controls ERCC1–XPF endonuclease‐mediated DNA damage responses
Pérez‐Oliva, A. B., Lachaud, C., Szyniarowski, P., Munoz, I. M., Macartney, T., Hickson, I., Rouse, J. W., & Alessi, D. R. (2014) · The EMBO Journal · doi:10.15252/embj.201489184 · Cited by 58
Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex
Liang, F., Longerich, S., Miller, A. S., Tang, C., Buzovetsky, O., Xiong, Y., Maranon, D. G., Wiese, C., Kupfer, G. M., & Sung, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.007 · Cited by 58
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
Pulliam, A. C., Ciccone, S. L. M., Nalepa, G., Li, X., Si, Y. C., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., et al. (2010) · Blood · doi:10.1182/blood-2009-08-240747 · Cited by 58
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response
Suhasini, A. N., Sommers, J. A., Muniandy, P. A., Coulombe, Y., Cantor, S. B., Masson, J., Seidman, M. M., & Brosh, R. M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01256-12 · Cited by 57
Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2
Huang, J., Zhang, J., Bellani, M. A., Pokharel, D., Gichimu, J., James, R. C., Gali, H., Ling, C., Yan, Z., Xu, D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.032 · Cited by 57
Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia
Croop, J. M., Cooper, R. J., Fernandez, C. M., Graves, V. L., Kreissman, S. G., Hanenberg, H., Smith, F. O., & Williams, D. A. (2001) · Blood · doi:10.1182/blood.v98.10.2917 · Cited by 57
Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining
Houghtaling, S. R., Newell, A. H., Akkari, Y. M. N., Taniguchi, T., Olson, S. B., & Grompe, M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi334 · Cited by 57
Self-citation
The Fanconi Anemia Core Complex Forms Four Complexes of Different Sizes in Different Subcellular Compartments
Tomashevski, A., High, A. A., Drozd, M., Shabanowitz, J., Hunt, D. F., Grant, P. A., & Kupfer, G. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400091200 · Cited by 59
The Fanconi anemia core complex associates with chromatin during S phase
Mi, J., & Kupfer, G. M. (2004) · Blood · doi:10.1182/blood-2004-01-0001 · Cited by 60
Expanded Roles for Chk1 in Genome Maintenance
Enders, G. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800021200 · Cited by 56
Structural basis of FANCD2 deubiquitination by USP1−UAF1
Rennie, M. L., Arkinson, C., Chaugule, V. K., Toth, R. L., & Walden, H. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00576-8 · Cited by 57
BRCA1 and p53: compensatory roles in DNA repair
Hartman, A., & Ford, J. M. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0477-0 · Cited by 62
Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer
Lyakhovich, A., & Surrallés, J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.038 · Cited by 56
The Fanconi anaemia genome stability and tumour suppressor network
Bogliolo, M. (2002) · Mutagenesis · doi:10.1093/mutage/17.6.529 · Cited by 56
Holding All the Cards—How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability
Datta, A., & Brosh, R. M. (2019) · Genes · doi:10.3390/genes10020170 · Cited by 56
Oxidative stress–specific interaction between FANCD2 and FOXO3a
Li, J., Du, W., Maynard, S., Andreassen, P. R., & Pang, Q. (2009) · Blood · doi:10.1182/blood-2009-07-234385 · Cited by 55
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2.
Ikeda, H., Matsushita, M., Waisfisz, Q., Kinoshita, A., Oostra, A. B., Nieuwint, A. W. M., de Winter, J. P., Hoatlin, M. E., Kawai, Y., Sasaki, M. S., et al. (2003) · PubMed · Cited by 55
Self-citation
ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
Rainey, M. D., Bennett, D., O’Dea, R., Zanchetta, M. E., Voisin, M., Seoighe, C., & Santocanale, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108096 · Cited by 54
The Role of Fanconi Anemia/BRCA Genes in Zebrafish Sex Determination
Rodríguez‐Marí, A., & Postlethwait, J. H. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-381320-6.00020-5 · Cited by 57
REV1 and DNA polymerase zeta in DNA interstrand crosslink repair
Sharma, S., & Canman, C. E. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21736 · Cited by 56
Fanconi DNA repair pathway is required for survival and long‐term maintenance of neural progenitors
Sii-Felice, K., Etienne, O., Hoffschir, F., Mathieu, C., Riou, L., Barroca, V., Haton, C., Arwert, F., Fouchet, P., Boussin, F. D., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.14 · Cited by 59
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.
Wang, X., & Weaver, D. T. (2011) · Europe PMC (PubMed Central) · Cited by 54
Preservation of Caspase-3 Subunits from Degradation Contributes to Apoptosis Evoked by Lactacystin: Any Single Lysine or Lysine Pair of the Small Subunit Is Sufficient for Ubiquitination
Chen, L., Smith, L., Wang, Z., & Smith, J. B. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.334 · Cited by 54
Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers
Cheung, R. S., & Taniguchi, T. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2283-4 · Cited by 54
Self-citation
FANCP/SLX4
Cybulski, K. E., & Howlett, N. G. (2011) · Cell Cycle · doi:10.4161/cc.10.11.15818 · Cited by 53
The Fanconi Anemia Proteins Functionally Interact with the Protein Kinase Regulated by RNA (PKR)
Zhang, X., Li, J., Sejas, D. P., Rathbun, K. R., Bagby, G. C., & Pang, Q. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403884200 · Cited by 54
Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin
Burkitt, K., & Ljungman, M. E. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-24 · Cited by 53
αII-Spectrin interacts with five groups of functionally important proteins in the nucleus
Sridharan, D., McMahon, L., & LAMBERT, M. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.06.005 · Cited by 53
A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network
Casado, J. A., Callén, E., Jacome, A., Rı́o, P., Castellà, M., Lobitz, S., Ferró, T., Muñoz, A., Sevilla, J., Cantalejo, A., et al. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.044719 · Cited by 56
Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest
Yun, J., Zhong, Q., Kwak, J., & Lee, W. (2005) · Oncogene · doi:10.1038/sj.onc.1208575 · Cited by 53
The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly
Gurtan, A. M., Stuckert, P., & D’Andrea, A. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511411200 · Cited by 53
Self-citation
Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas
Jeon, J., Lee, S.-M., Kim, H., Kang, H., Youn, H., Jo, S., Youn, B., & Kim, H. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105111 · Cited by 52
Ubiquitin and SUMO in DNA repair at a glance
Ulrich, H. D. (2012) · Journal of Cell Science · doi:10.1242/jcs.091801 · Cited by 56
Ubiquitination of PCNA and Its Essential Role in Eukaryotic Translesion Synthesis
Chen, J., Bozza, W. P., & Zhuang, Z. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9187-3 · Cited by 58
The BRCA1 ubiquitin ligase and homologous recombination repair
Ohta, T., Sato, K., & Wu, W. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.005 · Cited by 53
Functional and physical interaction between the mismatch repair and FA-BRCA pathways
Williams, S. A., Wilson, J. B., Clark, A. P., Mitson‐Salazar, A., Tomashevski, A., Ananth, S., Glazer, P. M., Semmes, O. J., Bale, A. E., Jones, N. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr366 · Cited by 52
Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome
Casorelli, I. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00020-x · Cited by 52
Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer
van der Groep, P., Hoelzel, M., Buerger, H., Joenje, H., de Winter, J. P., & van Diest, P. J. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9534-7 · Cited by 53

Authors: Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D.
Affiliations: Harvard University (US)
Dana-Farber Cancer Institute (US)
Hospital for Sick Children (CA)
Oregon Health & Science University (US)
ORCID: Taniguchi, Toshiyasu
Ganesan, Shridar
Meyn, M.Stephen
Timmers, Cynthia
Hejna, James
Grompe, Markus
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2001-02
Volume: 7
Issue: 2
Pages: 249-262
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(01)00173-3
OpenAlex: W1991841649
Cited by: 1,198
References: 71
Citations by year: 2026: 14 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 25 · 2019: 41 · 2018: 28 · 2017: 20 · 2016: 54 · 2015: 49 · 2014: 51 · 2013: 44 · 2012: 66
FWCI: 31.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4549 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL54785-04, R01HL52725-04, R01HL052725)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK043889, R01DK43889-09)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: Fanconi anemia, BRCA1, FANCD2 monoubiquitination, FANCA, FANCC, FANCF, FANCG, DNA repair, radiosensitivity, mitomycin C sensitivity, synaptonemal complex, meiotic chromosomes, nuclear foci, cancer susceptibility
MeSH terms: Animals, Cell Line, Cell Survival, DNA Damage, DNA-Binding Proteins, Fanconi Anemia, Fluorescent Antibody Technique, Genetic Complementation Test, Humans, Male, Meiosis, Nuclear Proteins, Protein Binding, Proteins, Radiation, Ionizing, Spermatocytes, Synaptonemal Complex, Ubiquitins, Ultraviolet Rays, Mitomycin, Cell Cycle Proteins, BRCA1 Protein, Active Transport, Cell Nucleus, Macromolecular Substances, Mice, Fanconi Anemia Complementation Group Proteins, Fanconi Anemia Complementation Group C Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks