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Cited by 490

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A Mechanism for Wnt Coreceptor Activation

Tamai, Keiko, Zeng, Xin, Liu, Chunming, Zhang, Xinjun, Harada, Yuko, Chang, Zhijie, He, Xi·2004·Molecular Cell
DOI 10.1016/s1097-2765(03)00484-2
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Abstract

LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are single-span transmembrane proteins essential for Wnt/beta-catenin signaling, likely via acting as Wnt coreceptors. How Wnt activates LRP5/6/Arrow to initiate signal transduction is not well defined. Here we show that a PPPSP motif, which is reiterated five times in the LRP5/6/Arrow intracellular domain, is necessary and sufficient to trigger Wnt/beta-catenin signaling. A single PPPSP motif, upon transfer to the LDL receptor, fully activates the Wnt pathway, inducing complete axis duplication in Xenopus and TCF/beta-catenin-responsive transcription in human cells. We further show that Wnt signal-ing stimulates, and requires, phosphorylation of the PPPSP motif, which creates an inducible docking site for Axin, a scaffolding protein controlling beta-catenin stability. Our study identifies a critical signaling module and a key phosphorylation-dependent activation step of the Wnt receptor complex and reveals a unifying logic for transmembrane signaling by Wnts, growth factors, and cytokines.

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Crossref · 10.1016/s1097-2765(03)00484-2

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Research works printed but not linked: 29

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Metadata

Authors
Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., & He, X.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2004-01
Volume
13
Issue
1
Pages
149-156
ISSN
1097-2765
DOI
10.1016/s1097-2765(03)00484-2
Cited by
490
References
7
Language
en
Licence

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